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Author |
Di Gregorio, E.; Staelens, M.; Hosseinkhah, N.; Karimpoor, M.; Liburd, J.; Lim, L.; Shankar, K.; Tuszynski, J.A. |
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Title |
Raman Spectroscopy Reveals Photobiomodulation-Induced α-Helix to β-Sheet Transition in Tubulins: Potential Implications for Alzheimer's and Other Neurodegenerative Diseases |
Type |
Journal Article |
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Year  |
2024 |
Publication |
Nanomaterials |
Abbreviated Journal |
Nanomaterials |
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Volume |
14 |
Issue |
13 |
Pages |
1093 - 21pp |
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Keywords |
proteins; protein dynamics; protein structure; non-invasive therapies; low-level laser therapy; spectroscopy; amide bands; amide I; spectral decomposition |
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Abstract |
In small clinical studies, the application of transcranial photobiomodulation (PBM), which typically delivers low-intensity near-infrared (NIR) to treat the brain, has led to some remarkable results in the treatment of dementia and several neurodegenerative diseases. However, despite the extensive literature detailing the mechanisms of action underlying PBM outcomes, the specific mechanisms affecting neurodegenerative diseases are not entirely clear. While large clinical trials are warranted to validate these findings, evidence of the mechanisms can explain and thus provide credible support for PBM as a potential treatment for these diseases. Tubulin and its polymerized state of microtubules have been known to play important roles in the pathology of Alzheimer's and other neurodegenerative diseases. Thus, we investigated the effects of PBM on these cellular structures in the quest for insights into the underlying therapeutic mechanisms. In this study, we employed a Raman spectroscopic analysis of the amide I band of polymerized samples of tubulin exposed to pulsed low-intensity NIR radiation (810 nm, 10 Hz, 22.5 J/cm2 dose). Peaks in the Raman fingerprint region (300-1900 cm-1)-in particular, in the amide I band (1600-1700 cm-1)-were used to quantify the percentage of protein secondary structures. Under this band, hidden signals of C=O stretching, belonging to different structures, are superimposed, producing a complex signal as a result. An accurate decomposition of the amide I band is therefore required for the reliable analysis of the conformation of proteins, which we achieved through a straightforward method employing a Voigt profile. This approach was validated through secondary structure analyses of unexposed control samples, for which comparisons with other values available in the literature could be conducted. Subsequently, using this validated method, we present novel findings of statistically significant alterations in the secondary structures of polymerized NIR-exposed tubulin, characterized by a notable decrease in alpha-helix content and a concurrent increase in beta-sheets compared to the control samples. This PBM-induced alpha-helix to beta-sheet transition connects to reduced microtubule stability and the introduction of dynamism to allow for the remodeling and, consequently, refreshing of microtubule structures. This newly discovered mechanism could have implications for reducing the risks associated with brain aging, including neurodegenerative diseases like Alzheimer's disease, through the introduction of an intervention following this transition. |
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Address |
[Di Gregorio, Elisabetta; Staelens, Michael; Tuszynski, Jack A.] Univ Alberta, Fac Sci, Dept Phys, Edmonton, AB T6G 2E1, Canada, Email: michael.staelens@ific.uv.es |
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Mdpi |
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English |
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WOS:001269841000001 |
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no |
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yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6204 |
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Author |
Paredes-Torres, G.; Gutierrez-Guerrer, L.X.; Bashir, A.; Miramontes, A.S. |
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Title |
First radial excitations of mesons and diquarks in a contact interaction |
Type |
Journal Article |
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Year |
2024 |
Publication |
Physical Review D |
Abbreviated Journal |
Phys. Rev. D |
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Volume |
109 |
Issue |
11 |
Pages |
114006 - 12pp |
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Keywords |
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Abstract |
We present a calculation for the masses of the first radially excited states of 40 mesons and diquarks made up of u , d , s , c , and b quarks, including states that contain one or both heavy quarks. To this end, we employ a combined analysis of the Bethe-Salpeter and Schwinger-Dyson equations within a self-consistent and symmetry-preserving vector-vector contact interaction. The same set of parameters describes ground and excited states of mesons and their diquark partners. The wave function of the first radial excitation contains a zero whose location is correlated with an additional parameter d F which is a function of dressed quark masses. Our results satisfy the equal spacing rules given by the Gell-Mann Okubo mass relations. Wherever possible, we make comparisons of our findings with known experimental observations as well as theoretical predictions of several other models and approaches including lattice quantum chromodynamics, finding a very good agreement. We report predictions for a multitude of radial excitations not yet observed in experiments. |
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Address |
[Paredes-Torres, G.; Gutierrez-Guerrer, L. X.; Bashir, A.; Miramontes, angel S.] Univ Michoacana, Inst Fis & Matemat, Edificio C-3,Ciudad Univ, Morelia 58040, Michoacan, Mexico, Email: gustavo.paredes@umich.mx; |
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Amer Physical Soc |
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English |
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2470-0010 |
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WOS:001251290500007 |
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no |
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yes |
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yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6206 |
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Author |
Mata, R.; Cros, A.; Gimeno, B.; Raboso, D. |
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Title |
Secondary electron emission yield in thick dielectric materials: a comparison between Kelvin probe and capacitive methods |
Type |
Journal Article |
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Year |
2024 |
Publication |
Journal of Physics D |
Abbreviated Journal |
J. Phys. D |
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Volume |
57 |
Issue |
40 |
Pages |
405302 - 9pp |
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Keywords |
dielectrics; secondary electron emission yield; Multipactor in space devices |
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Abstract |
The recent high demand of secondary electron emission yield (SEY) measurements in dielectric materials from space industry has driven SEY laboratories to improve their facilities and measurement techniques. SEY determination by the common capacitive method, also known as pulsed method, is well accepted and has given satisfactory results in most cases. Nevertheless, the samples under study must be prepared according to the experimental limitations of the technique, i.e. they should be manufactured separated from the devices representing faithfully the surface state of the own device and be as thin as possible. A method based on the Kelvin probe (KP) is proposed here to obtain the SEY characteristics of electrically floating Platinum, Kapton and Teflon placed over dielectric spacers with thicknesses ranging from 1.6 to 12.1 mm. The results are compared with those of the capacitive method and indicate that KP SEY curves are less sensitive to spacer thickness. An explanation based on the literature is also given. In all, we have established that KP is better suited for the analysis of dielectric samples thicker than 3 mm. |
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Address |
[Mata, R.; Gimeno, B.] Ciudad Politecn Innovac, Val Space Consortium, Edificio 8G,Acceso B,Planta B, Valencia 46022, Spain, Email: rafael.mata@uv.es |
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IOP Publishing Ltd |
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English |
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0022-3727 |
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Notes |
WOS:001269188200001 |
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no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6203 |
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Author |
LHCb Collaboration (Aaij, R. et al); Jaimes Elles, S.J.; Jashal, B.K.; Martinez-Vidal, F.; Oyanguren, A.; Rebollo De Miguel, M.; Sanderswood, I.; Zhuo, J. |
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Title |
Search for CP violation in the phase space of D0 → KS0 K± π∓ decays with the energy test |
Type |
Journal Article |
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Year |
2024 |
Publication |
Journal of High Energy Physics |
Abbreviated Journal |
J. High Energy Phys. |
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Volume |
03 |
Issue |
3 |
Pages |
107 - 20pp |
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Keywords |
Charm Physics; CP Violation; Hadron-Hadron Scattering |
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Abstract |
A search for CP violation in D-0 -> (KSK+)-K-0 pi(-) and D-0 -> (KSK-)-K-0 pi(+) decays is reported. The search is performed using an unbinned model-independent method known as the energy test that probes local CP violation in the phase space of the decays. The data analysed correspond to an integrated luminosity of 5.4 fb(-1) collected in proton-proton collisions by the LHCb experiment at a centre-of-mass energy of root s = 13TeV, amounting to approximately 950 thousand and 620 thousand signal candidates for the D-0 -> (KSK-)-K-0 pi(+) and D-0 -> (KSK+)-K-0 pi(-) modes, respectively. The method is validated using D-0 -> K-pi(+)pi(-)pi(+) and D-0 -> K-S(0)pi(+)pi(-) decays, where CP-violating effects are expected to be negligible, and using background-enhanced regions of the signal decays. The results are consistent with CP symmetry in both the D-0 -> (KSK-)-K-0 pi(+) and the D-0 -> (KSK+)-K-0 pi(-) decays, with p-values for the hypothesis of no CP violation of 70% and 66%, respectively. |
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Address |
[Egede, U.; Fujii, Y.; Hadavizadeh, T.; Henderson, R. D. L.; Lane, J. J.; Monk, M.; Singla, M.; Song, R.; Walton, E. J.; Ward, J. A.] Monash Univ, Sch Phys & Astron, Melbourne, Vic, Australia, Email: gianluca.zunica@epfl.ch |
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Springer |
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English |
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ISSN |
1029-8479 |
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Notes |
WOS:001190072500001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6124 |
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Author |
ATLAS Collaboration (Aad, G. et al); Aikot, A.; Amos, K.R.; Aparisi Pozo, J.A.; Bailey, A.J.; Bouchhar, N.; Cabrera Urban, S.; Cantero, J.; Cardillo, F.; Castillo Gimenez, V.; Chitishvili, M.; Costa, M.J.; Didenko, M.; Escobar, C.; Fiorini, L.; Fuster, J.; Garcia, C.; Garcia Navarro, J.E.; Gomez Delegido, A.J.; Gonzalez de la Hoz, S.; Gonzalvo Rodriguez, G.R.; Guerrero Rojas, J.G.R.; Lacasta, C.; Marti-Garcia, S.; Martinez Agullo, P.; Miralles Lopez, M.; Mitsou, V.A.; Monsonis Romero, L.; Moreno Llacer, M.; Munoz Perez, D.; Navarro-Gonzalez, J.; Poveda, J.; Prades Ibañez, A.; Rubio Jimenez, A.; Ruiz-Martinez, A.; Sabatini, P.; Saibel, A.; Salt, J.; Sanchez Sebastian, V.; Sayago Galvan, I.; Senthilkumar, V.; Soldevila, U.; Sanchez, J.; Torro Pastor, E.; Valero, A.; Valiente Moreno, E.; Valls Ferrer, J.A.; Varriale, L.; Villaplana Perez, M.; Vos, M. |
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Title |
Study of High-Transverse-Momentum Higgs Boson Production in Association with a Vector Boson in the qqbb Final State with the ATLAS Detector |
Type |
Journal Article |
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Year |
2024 |
Publication |
Physical Review Letters |
Abbreviated Journal |
Phys. Rev. Lett. |
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Volume |
132 |
Issue |
13 |
Pages |
131802 - 23pp |
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Abstract |
This Letter presents the first study of Higgs boson production in association with a vector boson (V = W or Z) in the fully hadronic qqbb final state using data recorded by the ATLAS detector at the LHC in ffiffiproton-proton collisions at root root s= 13 TeV and corresponding to an integrated luminosity of 137fb(-1). The vector bosons and Higgs bosons are each reconstructed as large-radius jets and tagged using jet substructure techniques. Dedicated tagging algorithms exploiting b-tagging properties are used to identify jets consistent with Higgs bosons decaying into b (b) over bar. Dominant backgrounds from multijet production are determined directly from the data, and a likelihood fit to the jet mass distribution of Higgs boson candidates is used to extract the number of signal events. The VH production cross section is measured inclusively and differentially in several ranges of Higgs boson transverse momentum: 250-450, 450-650, and greater than 650 GeV. The inclusive signal yield relative to the standard model expectation is observed to be μ= 1.4(-0.9)(+1.0) and the corresponding cross section is 3.1 +/- 1.3(stat)(-1.4)(+1.8) (syst) pb. |
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Address |
[Fedin, O. L.; Filmer, E. K.; Grant, C. M.; Jackson, P.; Kong, A. X. Y.; Kulchitsky, Y.; Myagkov, A. G.; Nikolaenko, V.; Pandya, H. D.; Potti, H.; Ruggeri, T. A.; Smirnova, L. N.; Tikhomirov, V.; Ting, E. X. L.; White, M. J.] Univ Adelaide, Dept Phys, Adelaide, SA, Australia |
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Publisher |
Amer Physical Soc |
Place of Publication |
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English |
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Series Issue |
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Edition |
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ISSN |
0031-9007 |
ISBN |
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Notes |
WOS:001202030300001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6121 |
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Author |
D'Auria, G. et al; Gonzalez-Iglesias, D.; Gimeno, B.; Pereira, D.E. |
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Title |
The CompactLight Design Study |
Type |
Journal Article |
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Year |
2024 |
Publication |
European Physical Journal-Special Topics |
Abbreviated Journal |
Eur. Phys. J.-Spec. Top. |
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Volume |
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Pages |
1-208 |
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Abstract |
CompactLight is a Design Study funded by the European Union under the Horizon 2020 research and innovation funding programme, with Grant Agreement No. 777431. CompactLight was conducted by an International Collaboration of 23 international laboratories and academic institutions, three private companies, and five third parties. The project, which started in January 2018 with a duration of 48 months, aimed to design an innovative, compact, and cost-effective hard X-ray FEL facility complemented by a soft X-ray source to pave the road for future compact accelerator-based facilities. The result is an accelerator that can be operated at up to 1 kHz pulse repetition rate, beyond today's state of the art, using the latest concepts for high brightness electron photoinjectors, very high gradient accelerating structures in X-band, and novel short-period undulators. In this report, we summarize the main deliverable of the project: the CompactLight Conceptual Design Report, which overviews the current status of the design and addresses the main technological challenges. |
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Address |
[D'Auria, G.; Danailov, M.; Mitri, S. Di; Ferianis, M.; Gioppo, R.; Rochow, R.; Tabacco, C.; Zangrando, M.] Elettra Sincrotrone Trieste SCpA, AREA Sci Pk, I-34149 Trieste, Italy, Email: gerardo.dauria@elettra.eu |
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Springer Heidelberg |
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English |
Summary Language |
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Original Title |
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ISSN |
1951-6355 |
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Conference |
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Notes |
WOS:001198683900001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6122 |
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Author |
Nacher, E.; Briz, J.A.; Nerio, A.N.; Perea, A.; Tavora, V.G.; Tengblad, O.; Ciemala, M.; Cieplicka-Orynczak, N.; Maj, A.; Mazurek, K.; Olko, P.; Zieblinski, M.; Borge, M.J.G. |
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Title |
Characterization of a novel proton-CT scanner based on Silicon and LaBr3(Ce) detectors |
Type |
Journal Article |
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Year |
2024 |
Publication |
European Physical Journal Plus |
Abbreviated Journal |
Eur. Phys. J. Plus |
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Volume |
139 |
Issue |
5 |
Pages |
404 - 9pp |
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Keywords |
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Abstract |
Treatment planning systems at proton-therapy centres entirely use X-ray computed tomography (CT) as primary imaging technique to infer the proton treatment doses to tumour and healthy tissues. However, proton stopping powers in the body, as derived from X-ray images, suffer from important proton-range uncertainties. In order to reduce this uncertainty in range, one could use proton-CT images instead. The main goal of this work is to test the capabilities of a newly-developed proton-CT scanner, based on the use of a set of tracking detectors and a high energy resolution scintillator for the residual energy of the protons. Different custom-made phantoms were positioned at the field of view of the scanner and were irradiated with protons at the CCB proton-therapy center in Krakow. We measured with the phantoms at different angles and produced sinograms that were used to obtain reconstructed images by Filtered Back-Projection. The obtained images were used to determine the capabilities of our scanner in terms of spatial resolution and proton Relative Stopping Power (RSP) mapping and validate its use as proton-CT scanner. The results show that the scanner can produce medium-high quality images, with spatial resolution better than 2 mm in radiography, below 3 mm in tomography and resolving power in the RSP comparable to other state-of-the-art pCT scanners. |
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Address |
[Nacher, E.] Univ Valencia, CSIC, Inst Fis Corpuscular, Valencia 46980, Spain, Email: enrique.nacher@csic.es |
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Publisher |
Springer Heidelberg |
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English |
Summary Language |
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ISSN |
2190-5444 |
ISBN |
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Notes |
WOS:001218502700005 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6123 |
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Author |
Chen, M.C.; Li, X.Q.; Liu, X.G.; Medina, O.; Ratz, M. |
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Title |
Modular invariant holomorphic observables |
Type |
Journal Article |
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Year |
2024 |
Publication |
Physics Letters B |
Abbreviated Journal |
Phys. Lett. B |
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Volume |
852 |
Issue |
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Pages |
138600 - 13pp |
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Abstract |
In modular invariant models of flavor, observables must be modular invariant. The observables discussed so far in the literature are functions of the modulus tau and its conjugate, (tau) over bar. We point out that certain combinations of observables depend only on tau , i.e. are meromorphic, and in some cases even holomorphic functions of tau. These functions, which we dub “invariants” in this Letter, are highly constrained, renormalization group invariant, and allow us to derive many of the models' features without the need for extensive parameter scans. We illustrate the robustness of these invariants in two existing models in the literature based on modular symmetries, Gamma(3) and Gamma(5). We find that, in some cases, the invariants give rise to robust relations among physical observables that are independent of tau. Furthermore, there are instances where additional symmetries exist among the invariants. These symmetries are relevant phenomenologically and may provide a dynamical way to realize symmetries of mass matrices. |
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Address |
[Chen, Mu-Chun; Li, Xueqi; Liu, Xiang-Gan; Ratz, Michael] Univ Calif Irvine, Dept Phys & Astron, Irvine, CA 92697 USA, Email: muchunc@uci.edu; |
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Elsevier |
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English |
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ISSN |
0370-2693 |
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Notes |
WOS:001221253800001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6125 |
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Author |
Ferrer-Sanchez, A.; Martin-Guerrero, J.; Ruiz de Austri, R.; Torres-Forne, A.; Font, J.A. |
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Title |
Gradient-annihilated PINNs for solving Riemann problems: Application to relativistic hydrodynamics |
Type |
Journal Article |
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Year |
2024 |
Publication |
Computer Methods in Applied Mechanics and Engineering |
Abbreviated Journal |
Comput. Meth. Appl. Mech. Eng. |
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Volume |
424 |
Issue |
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Pages |
116906 - 18pp |
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Keywords |
Riemann problem; Euler equations; Machine learning; Neural networks; Relativistic hydrodynamics |
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Abstract |
We present a novel methodology based on Physics-Informed Neural Networks (PINNs) for solving systems of partial differential equations admitting discontinuous solutions. Our method, called Gradient-Annihilated PINNs (GA-PINNs), introduces a modified loss function that forces the model to partially ignore high-gradients in the physical variables, achieved by introducing a suitable weighting function. The method relies on a set of hyperparameters that control how gradients are treated in the physical loss. The performance of our methodology is demonstrated by solving Riemann problems in special relativistic hydrodynamics, extending earlier studies with PINNs in the context of the classical Euler equations. The solutions obtained with the GA-PINN model correctly describe the propagation speeds of discontinuities and sharply capture the associated jumps. We use the relative l(2) error to compare our results with the exact solution of special relativistic Riemann problems, used as the reference ''ground truth'', and with the corresponding error obtained with a second-order, central, shock-capturing scheme. In all problems investigated, the accuracy reached by the GA-PINN model is comparable to that obtained with a shock-capturing scheme, achieving a performance superior to that of the baseline PINN algorithm in general. An additional benefit worth stressing is that our PINN-based approach sidesteps the costly recovery of the primitive variables from the state vector of conserved variables, a well-known drawback of grid-based solutions of the relativistic hydrodynamics equations. Due to its inherent generality and its ability to handle steep gradients, the GA-PINN methodology discussed in this paper could be a valuable tool to model relativistic flows in astrophysics and particle physics, characterized by the prevalence of discontinuous solutions. |
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Address |
[Ferrer-Sanchez, Antonio; Martin-Guerrero, JoseD.] ETSE UV, Elect Engn Dept, IDAL, Avgda Univ S-N, Valencia 46100, Spain, Email: Antonio.Ferrer-Sanchez@uv.es |
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Elsevier Science Sa |
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English |
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Series Issue |
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Edition |
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ISSN |
0045-7825 |
ISBN |
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Area |
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Expedition |
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Notes |
WOS:001221797400001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
6126 |
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Author |
LHCb Collaboration (Aaij, R. et al); Jaimes Elles, S.J.; Jashal, B.K.; Martinez-Vidal, F.; Oyanguren, A.; Rebollo De Miguel, M.; Sanderswood, I., Zhuo, J. |
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Title |
Amplitude Analysis of the B0 -> K*0 μ+μ- Decay |
Type |
Journal Article |
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Year |
2024 |
Publication |
Physical Review Letters |
Abbreviated Journal |
Phys. Rev. Lett. |
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Volume |
132 |
Issue |
13 |
Pages |
131801 - 13pp |
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Abstract |
An amplitude analysis of the B-0 -> K*(0) mu(+)mu(-) decay is presented using a dataset corresponding to an integrated luminosity of 4.7 fb(-1) of pp collision data collected with the LHCb experiment. For the first time, the coefficients associated to short-distance physics effects, sensitive to processes beyond the standard model, are extracted directly from the data through a q(2)-unbinned amplitude analysis, where q(2) is the mu(+)mu(-) invariant mass squared. Long-distance contributions, which originate from nonfactorizable QCD processes, are systematically investigated, and the most accurate assessment to date of their impact on the physical observables is obtained. The pattern of measured corrections to the short-distance couplings is found to be consistent with previous analyses of b- to s-quark transitions, with the largest discrepancy from the standard model predictions found to be at the level of 1.8 standard deviations. The global significance of the observed differences in the decay is 1.4 standard deviations. |
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Address |
[Dettori, F.; Fujii, Y.; Hadavizadeh, T.; Lane, J. J.; Litvinov, R.; Manca, G.; Saitta, B.; Ward, J. A.] Monash Univ, Sch Phys & Astron, Melbourne, Australia |
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Publisher |
Amer Physical Soc |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Edition |
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ISSN |
0031-9007 |
ISBN |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:001201992300011 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6127 |
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| Permanent link to this record |
