Abstract: The AAPM TG-43 brachytherapy dosimetry formalism, introduced in 1995, has become a standard for brachytherapy dosimetry worldwide; it implicitly assumes that charged-particle equilibrium (CPE) exists for the determination of absorbed dose to water at different locations, except in the vicinity of the source capsule. Subsequent dosimetry developments, based on Monte Carlo calculations or analytical solutions of transport equations, do not rely on the CPE assumption and determine directly the dose to different tissues. At the time of relating dose to tissue and dose to water, or vice versa, it is usually assumed that the photon fluence in water and in tissues are practically identical, so that the absorbed dose in the two media can be related by their ratio of mass energy-absorption coefficients. In this work, an efficient way to correlate absorbed dose to water and absorbed dose to tissue in brachytherapy calculations at clinically relevant distances for low-energy photon emitting seeds is proposed. A correction is introduced that is based on the ratio of the water-to-tissue photon energy-fluences. State-of-the art Monte Carlo calculations are used to score photon fluence differential in energy in water and in various human tissues (muscle, adipose and bone), which in all cases include a realistic modelling of low-energy brachytherapy sources in order to benchmark the formalism proposed. The energy-fluence based corrections given in this work are able to correlate absorbed dose to tissue and absorbed dose to water with an accuracy better than 0.5% in the most critical cases (e.g. bone tissue).

Abstract: We study Born-Infeld gravity coupled to a static, non-rotating electric field in 2 + 1 dimensions and find exact analytical solutions. Two families of such solutions represent geodesically complete, and hence nonsingular, spacetimes. Another family represents a point-like charge with a singularity at the center. Despite the absence of rotation, these solutions resemble the charged, rotating BTZ solution of general relativity but with a richer structure in terms of horizons. The nonsingular character of the first two families turn out to be attached to the emergence of a wormhole structure on their innermost region. This seems to be a generic prediction of extensions of general relativity formulated in metric-affine (or Palatini) spaces, where metric and connection are regarded as independent degrees of freedom.

Abstract: Cosmological observables show a dependence with the neutrino mass, which is partially degenerate with parameters of extended models of gravity. We study and explore this degeneracy in Horndeski generalized scalar-tensor theories of gravity. Using forecasted cosmic microwave background and galaxy power spectrum datasets, we find that a single parameter in the linear regime of the effective theory dominates the correlation with the total neutrino mass. For any given mass, a particular value of this parameter approximately cancels the power suppression due to the neutrino mass at a given redshift. The extent of the cancellation of this degeneracy depends on the cosmological large-scale structure data used at different redshifts. We constrain the parameters and functions of the effective gravity theory and determine the influence of gravity on the determination of the neutrino mass from present and future surveys.

Abstract: We show that the Higgs portal interactions involving extra dark Higgs field can save generically the original Higgs inflation of the standard model (SM) from the problem of a deep non-SM vacuum in the SM Higgs potential. Specifically, we show that such interactions disconnect the top quark pole mass from inflationary observables and allow multi-dimensional parameter space to save the Higgs inflation, thanks to the additional parameters (the dark Higgs boson mass m(phi), the mixing angle a between the SM Higgs H and dark Higgs Phi, and the mixed quartic coupling) affecting RG-running of the Higgs quartic coupling. The effect of Higgs portal interactions may lead to a larger tensor-to-scalar ratio, 0.08 less than or similar to r less than or similar to 0.1, by adjusting relevant parameters in wide ranges of alpha and m(phi), some region of which can be probed at future colliders. Performing a numerical analysis we find an allowed region of parameters, matching the latest Planck data.

Abstract: We present a comprehensive review of keV-scale sterile neutrino Dark Matter, collecting views and insights from all disciplines involved – cosmology, astrophysics, nuclear, and particle physics – in each case viewed from both theoretical and experimental/observational perspectives. After reviewing the role of active neutrinos in particle physics, astrophysics, and cosmology, we focus on sterile neutrinos in the context of the Dark Matter puzzle. Here, we first review the physics motivation for sterile neutrino Dark Matter, based on challenges and tensions in purely cold Dark Matter scenarios. We then round out the discussion by critically summarizing all known constraints on sterile neutrino Dark Matter arising from astrophysical observations, laboratory experiments, and theoretical considerations. In this context, we provide a balanced discourse on the possibly positive signal from X-ray observations. Another focus of the paper concerns the construction of particle physics models, aiming to explain how sterile neutrinos of keV-scale masses could arise in concrete settings beyond the Standard Model of elementary particle physics. The paper ends with an extensive review of current and future astrophysical and laboratory searches, highlighting new ideas and their experimental challenges, as well as future perspectives for the discovery of sterile neutrinos.