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Author |
Di Gregorio, E.; Staelens, M.; Hosseinkhah, N.; Karimpoor, M.; Liburd, J.; Lim, L.; Shankar, K.; Tuszynski, J.A. |
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Title |
Raman Spectroscopy Reveals Photobiomodulation-Induced α-Helix to β-Sheet Transition in Tubulins: Potential Implications for Alzheimer's and Other Neurodegenerative Diseases |
Type |
Journal Article |
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Year |
2024 |
Publication |
Nanomaterials |
Abbreviated Journal |
Nanomaterials |
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Volume |
14 |
Issue |
13 |
Pages |
1093 - 21pp |
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Keywords |
proteins; protein dynamics; protein structure; non-invasive therapies; low-level laser therapy; spectroscopy; amide bands; amide I; spectral decomposition |
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Abstract |
In small clinical studies, the application of transcranial photobiomodulation (PBM), which typically delivers low-intensity near-infrared (NIR) to treat the brain, has led to some remarkable results in the treatment of dementia and several neurodegenerative diseases. However, despite the extensive literature detailing the mechanisms of action underlying PBM outcomes, the specific mechanisms affecting neurodegenerative diseases are not entirely clear. While large clinical trials are warranted to validate these findings, evidence of the mechanisms can explain and thus provide credible support for PBM as a potential treatment for these diseases. Tubulin and its polymerized state of microtubules have been known to play important roles in the pathology of Alzheimer's and other neurodegenerative diseases. Thus, we investigated the effects of PBM on these cellular structures in the quest for insights into the underlying therapeutic mechanisms. In this study, we employed a Raman spectroscopic analysis of the amide I band of polymerized samples of tubulin exposed to pulsed low-intensity NIR radiation (810 nm, 10 Hz, 22.5 J/cm2 dose). Peaks in the Raman fingerprint region (300-1900 cm-1)-in particular, in the amide I band (1600-1700 cm-1)-were used to quantify the percentage of protein secondary structures. Under this band, hidden signals of C=O stretching, belonging to different structures, are superimposed, producing a complex signal as a result. An accurate decomposition of the amide I band is therefore required for the reliable analysis of the conformation of proteins, which we achieved through a straightforward method employing a Voigt profile. This approach was validated through secondary structure analyses of unexposed control samples, for which comparisons with other values available in the literature could be conducted. Subsequently, using this validated method, we present novel findings of statistically significant alterations in the secondary structures of polymerized NIR-exposed tubulin, characterized by a notable decrease in alpha-helix content and a concurrent increase in beta-sheets compared to the control samples. This PBM-induced alpha-helix to beta-sheet transition connects to reduced microtubule stability and the introduction of dynamism to allow for the remodeling and, consequently, refreshing of microtubule structures. This newly discovered mechanism could have implications for reducing the risks associated with brain aging, including neurodegenerative diseases like Alzheimer's disease, through the introduction of an intervention following this transition. |
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Address |
[Di Gregorio, Elisabetta; Staelens, Michael; Tuszynski, Jack A.] Univ Alberta, Fac Sci, Dept Phys, Edmonton, AB T6G 2E1, Canada, Email: michael.staelens@ific.uv.es |
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Mdpi |
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English |
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WOS:001269841000001 |
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no |
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yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6204 |
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Author |
Mata, R.; Cros, A.; Gimeno, B.; Raboso, D. |
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Title |
Secondary electron emission yield in thick dielectric materials: a comparison between Kelvin probe and capacitive methods |
Type |
Journal Article |
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Year |
2024 |
Publication |
Journal of Physics D |
Abbreviated Journal |
J. Phys. D |
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Volume |
57 |
Issue |
40 |
Pages |
405302 - 9pp |
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Keywords |
dielectrics; secondary electron emission yield; Multipactor in space devices |
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Abstract |
The recent high demand of secondary electron emission yield (SEY) measurements in dielectric materials from space industry has driven SEY laboratories to improve their facilities and measurement techniques. SEY determination by the common capacitive method, also known as pulsed method, is well accepted and has given satisfactory results in most cases. Nevertheless, the samples under study must be prepared according to the experimental limitations of the technique, i.e. they should be manufactured separated from the devices representing faithfully the surface state of the own device and be as thin as possible. A method based on the Kelvin probe (KP) is proposed here to obtain the SEY characteristics of electrically floating Platinum, Kapton and Teflon placed over dielectric spacers with thicknesses ranging from 1.6 to 12.1 mm. The results are compared with those of the capacitive method and indicate that KP SEY curves are less sensitive to spacer thickness. An explanation based on the literature is also given. In all, we have established that KP is better suited for the analysis of dielectric samples thicker than 3 mm. |
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Address |
[Mata, R.; Gimeno, B.] Ciudad Politecn Innovac, Val Space Consortium, Edificio 8G,Acceso B,Planta B, Valencia 46022, Spain, Email: rafael.mata@uv.es |
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IOP Publishing Ltd |
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English |
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0022-3727 |
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Notes |
WOS:001269188200001 |
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no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6203 |
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Author |
Centelles Chulia, S.; Herrero-Brocal, A.; Vicente, A. |
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Title |
The Type-I Seesaw family |
Type |
Journal Article |
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Year |
2024 |
Publication |
Journal of High Energy Physics |
Abbreviated Journal |
J. High Energy Phys. |
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Volume |
07 |
Issue |
7 |
Pages |
060 - 35pp |
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Keywords |
Lepton Flavour Violation (charged); New Light Particles; Non-Standard Neutrino Properties; Specific BSM Phenomenology |
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Abstract |
We provide a comprehensive analysis of the Type-I Seesaw family of neutrino mass models, including the conventional type-I seesaw and its low-scale variants, namely the linear and inverse seesaws. We establish that all these models essentially correspond to a particular form of the type-I seesaw in the context of explicit lepton number violation. We then focus into the more interesting scenario of spontaneous lepton number violation, systematically categorizing all inequivalent minimal models. Furthermore, we identify and flesh out specific models that feature a rich majoron phenomenology and discuss some scenarios which, despite having heavy mediators and being invisible in processes such as μ-> e gamma, predict sizable rates for decays including the majoron in the final state. |
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Address |
[Centelles Chulia, Salvador] Max Planck Inst Kernphys, Saupfercheckweg 1, D-69117 Heidelberg, Germany, Email: chulia@mpi-hd.mpg.de; |
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Springer |
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English |
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ISSN |
1029-8479 |
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Notes |
WOS:001264784900001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6201 |
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Author |
Bas i Beneito, A.; Gargalionis, J.; Herrero-Garcia, J.; Santamaria, A.; Schmidt, M.A. |
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Title |
An EFT approach to baryon number violation: lower limits on the new physics scale and correlations between nucleon decay modes |
Type |
Journal Article |
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Year |
2024 |
Publication |
Journal of High Energy Physics |
Abbreviated Journal |
J. High Energy Phys. |
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Volume |
07 |
Issue |
7 |
Pages |
004 - 37pp |
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Keywords |
Baryon/Lepton Number Violation; SMEFT; Specific BSM Phenomenology |
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Abstract |
Baryon number is an accidental symmetry of the Standard Model at the Lagrangian level. Its violation is arguably one of the most compelling phenomena predicted by physics beyond the Standard Model. Furthermore, there is a large experimental effort to search for it including the Hyper-K, DUNE, JUNO, and THEIA experiments. Therefore, an agnostic, model-independent, analysis of baryon number violation using the power of Effective Field Theory is very timely. In particular, in this work we study the contribution of dimension six and seven effective operators to |triangle(B – L)| = 0, 2 nucleon decays taking into account the effects of Renormalisation Group Evolution. We obtain lower limits on the energy scale of each operator and study the correlations between different decay modes. We find that for some operators the effect of running is very significant. |
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Address |
[Bas i Beneito, Arnau; Gargalionis, John; Herrero-Garcia, Juan; Santamaria, Arcadi] Univ Valencia, Dept Fis Teor, Burjassot 46100, Spain, Email: arnau.bas@ific.uv.es; |
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Springer |
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English |
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Abbreviated Series Title |
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Series Volume |
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ISSN |
1029-8479 |
ISBN |
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Conference |
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Notes |
WOS:001262559200004 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6181 |
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Author |
Forconi, M.; Giare, W.; Mena, O.; Ruchika; Di Valentino, E.; Melchiorri, A.; Nunes, R.C. |
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Title |
A double take on early and interacting dark energy from JWST |
Type |
Journal Article |
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Year |
2024 |
Publication |
Journal of Cosmology and Astroparticle Physics |
Abbreviated Journal |
J. Cosmol. Astropart. Phys. |
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Volume |
05 |
Issue |
5 |
Pages |
097 - 37pp |
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Keywords |
high redshift galaxies; dark energy theory; physics of the early universe |
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Abstract |
The very first light captured by the James Webb Space Telescope (JWST) revealed a population of galaxies at very high redshifts more massive than expected in the canonical Lambda CDM model of structure formation. Barring, among others, a systematic origin of the issue, in this paper, we test alternative cosmological perturbation histories. We argue that models with a larger matter component ohm m and/or a larger scalar spectral index n s can substantially improve the fit to JWST measurements. In this regard, phenomenological extensions related to the dark energy sector of the theory are appealing alternatives, with Early Dark Energy emerging as an excellent candidate to explain (at least in part) the unexpected JWST preference for larger stellar mass densities. Conversely, Interacting Dark Energy models, despite producing higher values of matter clustering parameters such as sigma 8 , are generally disfavored by JWST measurements. This is due to the energy -momentum flow from the dark matter to the dark energy sector, implying a smaller matter energy density. Upcoming observations may either strengthen the evidence or falsify some of these appealing phenomenological alternatives to the simplest Lambda CDM picture. |
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Address |
[Forconi, Matteo; Melchiorri, Alessandro] Univ Roma La Sapienza, Phys Dept, Ple Aldo Moro 2, I-00185 Rome, Italy, Email: matteo.forconi@roma1.infn.it; |
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IOP Publishing Ltd |
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Language |
English |
Summary Language |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
1475-7516 |
ISBN |
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Conference |
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Notes |
WOS:001259284100005 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6179 |
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Author |
Belchior, F.M.; Maluf, R. |
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Title |
Duality between the Maxwell-Chern-Simons and self-dual models in very special relativity |
Type |
Journal Article |
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Year |
2024 |
Publication |
Physics Letters B |
Abbreviated Journal |
Phys. Lett. B |
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Volume |
855 |
Issue |
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Pages |
138794 - 7pp |
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Keywords |
Duality; Very special relativity; Maxwell-Chern-Simons theory |
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Abstract |
This work investigates the classical and quantum duality between the SIM (1)-Maxwell-Chern-Simons (MCS) model and its self -dual counterpart. Initially, we focus on free -field cases to establish equivalence through two distinct approaches: comparing the equations of motion and utilizing the master Lagrangian method. In both instances, the classical correspondence between the self -dual and MCS dual fields undergoes modifications due to very special relativity (VSR). Specifically, the duality is established when the associated VSR-mass parameters are identical, and the dual field is introduced through a non -local VSR correction. Furthermore, we analyze the duality when the self -dual model is minimally coupled to fermions. As a result, we demonstrate that Thirring-like interactions, corrected for non -local VSR contributions, are included in the MCS model. Additionally, we establish the quantum equivalence of the models by performing a functional integration of the fields and comparing the resulting effective Lagrangians. |
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Address |
[Belchior, Fernando M.; Maluf, Roberto, V] Univ Fed Ceara UFC, Dept Fis, Campus Pici,CP 6030, BR-60455760 Fortaleza, CE, Brazil, Email: belchior@fisica.ufc.br |
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Publisher |
Elsevier |
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English |
Summary Language |
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Series Editor |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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ISSN |
0370-2693 |
ISBN |
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Conference |
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Notes |
WOS:001259074700001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6174 |
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Author |
Babak, S.; Caprini, C.; Figueroa, D.G.; Karnesis, N.; Marcoccia, P.; Nardini, G.; Pieroni, M.; Ricciardone, A.; Sesanah, A.; Torradol, J. |
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Title |
Stochastic gravitational wave background from stellar origin binary black holes in LISA |
Type |
Journal Article |
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Year |
2023 |
Publication |
Journal of Cosmology and Astroparticle Physics |
Abbreviated Journal |
J. Cosmol. Astropart. Phys. |
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Volume |
08 |
Issue |
8 |
Pages |
034 - 40pp |
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Keywords |
gravitational waves; experiments; sources |
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Abstract |
We use the latest constraints on the population of stellar origin binary black holes (SOBBH) from LIGO/Virgo/KAGRA (LVK) observations, to estimate the stochastic gravi-tational wave background (SGWB) they generate in the frequency band of LISA. In order to account for the faint and distant binaries, which contribute the most to the SGWB, we extend the merger rate at high redshift assuming that it tracks the star formation rate. We adopt different methods to compute the SGWB signal: we perform an analytical evaluation, we use Monte Carlo sums over the SOBBH population realisations, and we account for the role of the detector by simulating LISA data and iteratively removing the resolvable signals until only the confusion noise is left. The last method allows the extraction of both the expected SGWB and the number of resolvable SOBBHs. Since the latter are few for signal-to-noise ratio thresholds larger than five, we confirm that the spectral shape of the SGWB in the LISA band agrees with the analytical prediction of a single power law. We infer the probability dis-tribution of the SGWB amplitude from the LVK GWTC-3 posterior of the binary population model: at the reference frequency of 0.003 Hz it has an interquartile range of h(2 Omega)GW(f = 3 x 10(-3) Hz) is an element of [5.65, 11.5] x 10(-13), in agreement with most previous estimates. We then perform a MC analysis to assess LISA's capability to detect and characterise this signal. Ac-counting for both the instrumental noise and the galactic binaries foreground, with four years of data, LISA will be able to detect the SOBBH SGWB with percent accuracy, narrowing down the uncertainty on the amplitude by one order of magnitude with respect to the range of possible amplitudes inferred from the population model. A measurement of this signal by LISA will help to break the degeneracy among some of the population parameters, and pro-vide interesting constraints, in particular on the redshift evolution of the SOBBH merger rate. |
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Address |
[Torradol, Jesus] Univ Paris, CNRS, Astroparticule & Cosmol, F-75013 Paris, France, Email: stas@apc.in2p3.fr; |
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Publisher |
IOP Publishing Ltd |
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English |
Summary Language |
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Series Editor |
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Abbreviated Series Title |
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Series Volume |
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Edition |
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ISSN |
1475-7516 |
ISBN |
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Conference |
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Notes |
WOS:001258137500008 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6177 |
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Author |
Amarilo, K.M.; Ferreira Filho, M.B.; Araujo Filho, A.A.; Reis, J.A.A.S. |
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Title |
Gravitational waves effects in a Lorentz-violating scenario |
Type |
Journal Article |
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Year |
2024 |
Publication |
Physics Letters B |
Abbreviated Journal |
Phys. Lett. B |
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Volume |
855 |
Issue |
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Pages |
138785 - 7pp |
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Keywords |
Gravitational waves; Lorentz symmetry breaking; Polarization states; Quadrupole term |
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Abstract |
This paper focuses on how the production and polarization of gravitational waves are affected by spontaneous Lorentz symmetry breaking, which is driven by a self-interacting vector field. Specifically, we examine the impact of a smooth quadratic potential and a non-minimal coupling, discussing the constraints and causality features of the linearized Einstein equation. To analyze the polarization states of a plane wave, we consider a fixed vacuum expectation value (VEV) of the vector field. Remarkably, we verify that a space-like background vector field modifies the polarization plane and introduces a longitudinal degree of freedom. In order to investigate the Lorentz violation effect on the quadrupole formula, we use the modified Green function. Finally, we show that the space-like component of the background field leads to a third-order time derivative of the quadrupole moment, and the bounds for the Lorentz-breaking coefficients are estimated as well. |
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Address |
[Amarilo, K. M.; Ferreira Filho, M. B.] Univ Estado Rio de Janeiro, Dep Fis Nucl & Altas Energias, Inst Fis, Rua Sao Francisco Xavier 524, BR-20559900 Rio De Janeiro, RJ, Brazil, Email: kevin.amarilo@cern.ch; |
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Publisher |
Elsevier |
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English |
Summary Language |
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Abbreviated Series Title |
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ISSN |
0370-2693 |
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Notes |
WOS:001257664300001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6168 |
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Author |
ATLAS Collaboration (Aad, G. et al); Aikot, A.; Amos, K.R.; Aparisi Pozo, J.A.; Bailey, A.J.; Bouchhar, N.; Cabrera Urban, S.; Cantero, J.; Cardillo, F.; Castillo Gimenez, V.; Chitishvili, M.; Costa, M.J.; Didenko, M.; Escobar, C.; Fiorini, L.; Fullana Torregrosa, E.; Fuster, J.; Garcia, C.; Garcia Navarro, J.E.; Gomez Delegido, A.J.; Gonzalez de la Hoz, S.; Gonzalvo Rodriguez, G.R.; Guerrero Rojas, J.G.R.; Lacasta, C.; Marti-Garcia, S.; Martinez Agullo, P.; Miralles Lopez, M.; Mitsou, V.A.; Monsonis Romero, L.; Moreno Llacer, M.; Munoz Perez, D.; Navarro-Gonzalez, J.; Poveda, J.; Prades Ibañez, A.; Rubio Jimenez, A.; Ruiz-Martinez, A.; Sabatini, P.; Salt, J.; Sanchez Sebastian, V.; Sayago Galvan, I.; Senthilkumar, V.; Soldevila, U.; Sanchez, J.; Torro Pastor, E.; Valero, A.; Valiente Moreno, E.; Valls Ferrer, J.A.; Varriale, L.; Villaplana Perez, M.; Vos, M. |
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Title |
Search for lepton-flavour violation in high-mass dilepton final states using 139 fb-1 of pp collisions at √s=13 TeV with the ATLAS detector |
Type |
Journal Article |
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Year |
2023 |
Publication |
Journal of High Energy Physics |
Abbreviated Journal |
J. High Energy Phys. |
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Volume |
10 |
Issue |
10 |
Pages |
082 - 50pp |
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Keywords |
Beyond Standard Model; Exotics; Flavour Physics; Hadron-Hadron Scattering |
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Abstract |
A search is performed for a heavy particle decaying into different-flavour, dilepton final states, using 139 fb(-1) of proton-proton collision data at root s = 13TeV collected in 2015-2018 by the ATLAS detector at the Large Hadron Collider. Final states with electrons, muons and hadronically decaying tau leptons are considered (e mu, e tau or μtau). No significant excess over the Standard Model predictions is observed. Upper limits on the production cross-section are set as a function of the mass of a Z' boson, a supersymmetric tau-sneutrino, and a quantum black-hole. The observed 95% CL lower mass limits obtained on a typical benchmark model Z' boson are 5.0TeV (e mu), 4.0TeV (e tau), and 3.9TeV (mu tau), respectively. |
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Address |
[Filmer, E. K.; Grant, C. M.; Jackson, P.; Kong, A. X. Y.; Pandya, H. D.; Potti, H.; Ruggeri, T. A.; Ting, E. X. L.; White, M. J.] Univ Adelaide, Dept Phys, Adelaide, SA, Australia |
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Springer |
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English |
Summary Language |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
1029-8479 |
ISBN |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:001257391700001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6192 |
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| Permanent link to this record |
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Author |
Gargalionis, J.; Herrero-Garcia, J.; Schmidt, M.A. |
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Title |
Model-independent estimates for loop-induced baryon-number-violating nucleon decays |
Type |
Journal Article |
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Year |
2024 |
Publication |
Journal of High Energy Physics |
Abbreviated Journal |
J. High Energy Phys. |
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Volume |
06 |
Issue |
6 |
Pages |
182 - 52pp |
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Keywords |
Baryon/Lepton Number Violation; SMEFT |
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Abstract |
Baryon number is an accidental symmetry of the Standard Model (SM) Lagrangian that so far has been measured to be exactly preserved, although it is expected to be violated at higher energies. In this work we compute order-of-magnitude estimates for the matching contributions of generic ultraviolet models to effective operators that generate nucleon decay processes. This is done in a systematic and automated way using operators constructed from SM fields up to dimension nine and working in a framework that has proved useful in the study of lepton-number violation. For each of the operators we derive estimates for the rates of different nucleon-decay channels. These allow us to establish model-independent lower bounds on the underlying new-physics scale and identify potential correlations between the various decay modes. The results are most relevant for families of models that generate the considered operator. This analysis is especially timely given the expected future sensitivities in numerous experiments such as Hyper-K, DUNE, JUNO and THEIA. |
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Address |
[Gargalionis, John; Herrero-Garcia, Juan] Univ Valencia, Dept Fis Teor, Burjassot 46100, Spain, Email: john.gargalionis@ific.uv.es; |
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Publisher |
Springer |
Place of Publication |
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Language |
English |
Summary Language |
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Original Title |
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Series Title |
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Series Volume |
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Edition |
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ISSN |
1029-8479 |
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Notes |
WOS:001257098800002 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6166 |
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