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Author  |
Magro Hernandez, R.M.; Muñoz-Noval, A.; Briz, J.A.; Murias, J.R.; Espinosa-Rodríguez, A.; Fraile, L.M.; Agullo-Rueda, F.; Ynsa, M.D.; Tavares de Sousa, C.; Cortes-Llanos, B.; Garcia Lopez, G.; Nacher, E.; Garcia-Tavora, V.; Mont i Geli, N.; Nerio, A.; Onecha, V.V.; Pallas, M.; Tarifeño, A.; Tengblad, O.; Manso Silvan, M.; Viñals, S. |
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Title |
Iodine-substituted hydroxyapatite nanoparticles and activation of derived ceramics for range verification in proton therapy |
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Journal Article |
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Year |
2024 |
Publication |
Journal of Materials Chemistry B |
Abbreviated Journal |
J. Mat. Chem. B |
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8pp |
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Abstract |
Osteosarcoma is a radioresistant cancer, and proton therapy is a promising radiation alternative for treating cancer with the advantage of a high dose concentration in the tumor area. In this work, we propose the use of iodine-substituted hydroxyapatite (IHAP) nanomaterials to use iodine (127I) as a proton radiation tracer, providing access to range verification studies in mineralized tissues. For this purpose, the nanomaterials were synthesized at four iodine concentrations via hydrothermal synthesis. The materials were characterized via different microstructural techniques to identify an optimal high iodine concentration and pure apatite phase nanomaterial. Finally, such pure IHAP powders were shaped and irradiated with proton beams of 6 and 10 MeV, and their activation was demonstrated through subsequent decay analysis. The materials could be integrated into phantom structures for the verification of doses and ranges of protons prior to animal testing and clinical proton therapy treatments of tumors located deep under combined soft and calcified tissues. Iodine-substituted hydroxyapatite nanomaterials were synthesised via hydrothermal process to use iodine (127I) as a proton radiation reporter with a view in hard tissue phantoms for proton therapy. |
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Address |
[Hernandez, R. Magro; Ynsa, M. D.; de Sousa, C. Tavares; Cortes-Llanos, B.; Lopez, G. Garcia; Silvan, M. Manso] Univ Autonoma Madrid, Ctr Microanal Mat, Madrid 28049, Spain |
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Publisher |
Royal Soc Chemistry |
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Language |
English |
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ISSN |
2050-750x |
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Notes |
WOS:001338555100001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
6302 |
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