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Author |
Schaffter, T. et al; Albiol, F.; Caballero, L. |
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Title |
Evaluation of Combined Artificial Intelligence and Radiologist Assessment to Interpret Screening Mammograms |
Type |
Journal Article |
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Year  |
2020 |
Publication |
JAMA Network Open |
Abbreviated Journal |
JAMA Netw. Open |
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Volume |
3 |
Issue |
3 |
Pages |
e200265 - 15pp |
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Keywords |
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Abstract |
Importance Mammography screening currently relies on subjective human interpretation. Artificial intelligence (AI) advances could be used to increase mammography screening accuracy by reducing missed cancers and false positives. Objective To evaluate whether AI can overcome human mammography interpretation limitations with a rigorous, unbiased evaluation of machine learning algorithms. Design, Setting, and Participants In this diagnostic accuracy study conducted between September 2016 and November 2017, an international, crowdsourced challenge was hosted to foster AI algorithm development focused on interpreting screening mammography. More than 1100 participants comprising 126 teams from 44 countries participated. Analysis began November 18, 2016. Main Outcomes and Measurements Algorithms used images alone (challenge 1) or combined images, previous examinations (if available), and clinical and demographic risk factor data (challenge 2) and output a score that translated to cancer yes/no within 12 months. Algorithm accuracy for breast cancer detection was evaluated using area under the curve and algorithm specificity compared with radiologists' specificity with radiologists' sensitivity set at 85.9% (United States) and 83.9% (Sweden). An ensemble method aggregating top-performing AI algorithms and radiologists' recall assessment was developed and evaluated. Results Overall, 144231 screening mammograms from 85580 US women (952 cancer positive <= 12 months from screening) were used for algorithm training and validation. A second independent validation cohort included 166578 examinations from 68008 Swedish women (780 cancer positive). The top-performing algorithm achieved an area under the curve of 0.858 (United States) and 0.903 (Sweden) and 66.2% (United States) and 81.2% (Sweden) specificity at the radiologists' sensitivity, lower than community-practice radiologists' specificity of 90.5% (United States) and 98.5% (Sweden). Combining top-performing algorithms and US radiologist assessments resulted in a higher area under the curve of 0.942 and achieved a significantly improved specificity (92.0%) at the same sensitivity. Conclusions and Relevance While no single AI algorithm outperformed radiologists, an ensemble of AI algorithms combined with radiologist assessment in a single-reader screening environment improved overall accuracy. This study underscores the potential of using machine learning methods for enhancing mammography screening interpretation. Question How do deep learning algorithms perform compared with radiologists in screening mammography interpretation? Findings In this diagnostic accuracy study using 144231 screening mammograms from 85580 women from the United States and 166578 screening mammograms from 68008 women from Sweden, no single artificial intelligence algorithm outperformed US community radiologist benchmarks; including clinical data and prior mammograms did not improve artificial intelligence performance. However, combining best-performing artificial intelligence algorithms with single-radiologist assessment demonstrated increased specificity. Meaning Integrating artificial intelligence to mammography interpretation in single-radiologist settings could yield significant performance improvements, with the potential to reduce health care system expenditures and address resource scarcity experienced in population-based screening programs. This diagnostic accuracy study evaluates whether artificial intelligence can overcome human mammography interpretation limits with a rigorous, unbiased evaluation of machine learning algorithms. |
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Address |
[Schaffter, Thomas; Hoff, Bruce; Yu, Thomas; Neto, Elias Chaibub; Friend, Stephen; Guinney, Justin] Sage Bionetworks, Computat Oncol, Seattle, WA USA, Email: gustavo@us.ibm.com |
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Amer Medical Assoc |
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English |
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ISSN |
2574-3805 |
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Notes |
WOS:000519249800002 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
4683 |
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Author |
Archidiacono, M.; Gariazzo, S.; Giunti, C.; Hannestad, S.; Tram, T. |
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Title |
Sterile neutrino self-interactions: H-0 tension and short-baseline anomalies |
Type |
Journal Article |
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Year |
2020 |
Publication |
Journal of Cosmology and Astroparticle Physics |
Abbreviated Journal |
J. Cosmol. Astropart. Phys. |
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Volume |
12 |
Issue |
12 |
Pages |
029 - 20pp |
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Keywords |
cosmological neutrinos; cosmological parameters from CMBR; particle physics – cosmology connection; physics of the early universe |
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Abstract |
Sterile neutrinos with a mass in the eV range have been invoked as a possible explanation of a variety of short baseline (SBL) neutrino oscillation anomalies. However, if one considers neutrino oscillations between active and sterile neutrinos, such neutrinos would have been fully thermalised in the early universe, and would be therefore in strong conflict with cosmological bounds. In this study we first update cosmological bounds on the mass and energy density of eV-scale sterile neutrinos. We then perform an updated study of a previously proposed model in which the sterile neutrino couples to a new light pseudoscalar degree of freedom. Consistently with previous analyses, we find that the model provides a good fit to all cosmological data and allows the high value of H-0 measured in the local universe to be consistent with measurements of the cosmic microwave background. However, new high l polarisation data constrain the sterile neutrino mass to be less than approximately 1 eV in this scenario. Finally, we combine the cosmological bounds on the pseudoscalar model with a Bayesian inference analysis of SBL data and conclude that only a sterile mass in narrow ranges around 1 eV remains consistent with both cosmology and SBL data. |
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Address |
[Archidiacono, Maria] Univ Milan, Via G Celoria 16, I-20133 Milan, Italy, Email: maria.archidiacono@unimi.it; |
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Publisher |
Iop Publishing Ltd |
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English |
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Series Issue |
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ISSN |
1475-7516 |
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Conference |
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Notes |
WOS:000609105900015 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
4688 |
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Author |
Woolley, B.; Burt, G.; Dexter, A.C.; Peacock, R.; Millar, W.L.; Catalan Lasheras, N.; Degiovanni, A.; Grudiev, A.; Mcmonagle, G.; Syratchev, I.; Wuensch, W.; Rodriguez Castro, E.; Giner Navarro, J. |
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Title |
High-gradient behavior of a dipole-mode rf structure |
Type |
Journal Article |
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Year |
2020 |
Publication |
Physical Review Accelerators and Beams |
Abbreviated Journal |
Phys. Rev. Accel. Beams |
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Volume |
23 |
Issue |
12 |
Pages |
122002 - 11pp |
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Abstract |
A normal-conducting, X-band traveling wave structure operating in the dipole mode has been systematically high-gradient tested to gain insight into the maximum possible gradients in these types of structure. Measured structure conditioning, breakdown behavior, and achieved surface fields are reported as well as a postmortem analysis of the breakdown position and a scanning electron microscope analysis of the high-field surfaces. The results of these measurements are then compared to high-gradient results from monopole-mode cavities. Scaled to a breakdown rate of 10(-6), the cavities were found to operate at a peak electric field of 154 MV/m and a peak modified Poynting vector S-c of 5.48 MW/mm(2). The study provides important input for the further development of dipole-mode cavities for use in the Compact Linear Collider as a crab cavity and dipole-mode cavities for use in x-ray free-electron lasers as well as for studies of the fundamental processes in vacuum arcs. Of particular relevance are the unique field patterns in dipole cavities compared to monopole cavities, where the electric and magnetic fields peak in orthogonal planes, which allow the separation of the role of electric and magnetic fields in breakdown via postmortem damage observation. The azimuthal variation of breakdown crater density is measured and is fitted to sinusoidal functions. The best fit is a power law fit of exponent 6. This is significant, as it shows how breakdown probability varies over a surface area with a varying electric field after conditioning to a given peak field. |
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Address |
[Woolley, B.; Burt, G.; Dexter, A. C.; Peacock, R.; Millar, W. L.] Univ Lancaster, Lancaster LA1 4YW, England |
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Amer Physical Soc |
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English |
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Series Issue |
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Edition |
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ISSN |
2469-9888 |
ISBN |
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Expedition |
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Conference |
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Notes |
WOS:000614886300002 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
4696 |
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Author |
Antusch, S.; Figueroa, D.G.; Marschall, K.; Torrenti, F. |
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Title |
Energy distribution and equation of state of the early Universe: Matching the end of inflation and the onset of radiation domination |
Type |
Journal Article |
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Year |
2020 |
Publication |
Physics Letters B |
Abbreviated Journal |
Phys. Lett. B |
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Volume |
811 |
Issue |
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Pages |
135888 - 7pp |
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Keywords |
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Abstract |
We study the energy distribution and equation of state of the universe between the end of inflation and the onset of radiation domination (RD), considering observationally consistent single-field inflationary scenarios, with a potential 'flattening' at large field values, and a monomial shape V(phi) proportional to vertical bar phi vertical bar(p) around the origin. As a proxy for (p)reheating, we include a quadratic interaction g(2)phi X-2(2) between the inflaton phi and a light scalar 'daughter' field X, with g(2) > 0. We capture the non-perturbative and non-linear nature of the system dynamics with lattice simulations, obtaining that: i) the final energy transferred to X depends only on p, not on g(2); ii) the final transfer of energy is always negligible for 2 <= p < 4, and of order similar to 50% for p >= 4; iii) the system goes at late times to matter-domination for p = 2, and always to RD for p > 2. In the latter case we calculate the number of e-folds until RD, significantly reducing the uncertainty in the inflationary observables Tl-s and r. |
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Address |
[Antusch, Stefan; Marschall, Kenneth; Torrenti, Francisco] Univ Basel, Dept Phys, Klingelbergstr 82, CH-4056 Basel, Switzerland, Email: f.torrenti@unibas.ch |
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Elsevier |
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English |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
0370-2693 |
ISBN |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:000612225400040 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
4699 |
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Author |
AGATA Collaboration (Avigo, R. et al); Domingo-Pardo, C.; Gadea, A.; Gonzalez, V. |
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Title |
Low-lying electric dipole gamma-continuum for the unstable Fe-62(,)64 nuclei: Strength evolution with neutron number |
Type |
Journal Article |
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Year |
2020 |
Publication |
Physics Letters B |
Abbreviated Journal |
Phys. Lett. B |
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Volume |
811 |
Issue |
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Pages |
135951 - 6pp |
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Keywords |
Fe-64; Fe-62; Nuclear structure; Dipole excitation around neutron threshold |
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Abstract |
The gamma-ray emission from the nuclei Fe-62,Fe-64 following Coulomb excitation at bombarding energy of 400-440 AMeV was measured with special focus on E1 transitions in the energy region 4-8 MeV. The unstable neutron-rich nuclei Fe-62,Fe-64 were produced at the FAIR-GSI laboratories and selected with the FRS spectrometer. The gamma decay was detected with AGATA. From the measured gamma-ray spectra the summed E1 strength is extracted and compared to microscopic quasi-particle phonon model calculations. The trend of the E1 strength with increasing neutron number is found to be fairly well reproduced with calculations that assume a rather complex structure of the 1(-) states (three-phonon states) inducing a strong fragmentation of the E1 nuclear response below the neutron binding energy. |
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Address |
[Avigo, R.; Wieland, O.; Bracco, A.; Camera, F.; Benzoni, G.; Blasi, N.; Bottoni, S.; Brambilla, S.; Crespi, F. C. L.; Leoni, S.; Million, B.; Morales, A., I; Pullia, A.; Riboldi, S.] Ist Nazl Fis Nucl, Sez Milano, I-20133 Milan, Italy, Email: oliver.wieland@mi.infn.it |
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Elsevier |
Place of Publication |
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English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
0370-2693 |
ISBN |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:000612225400080 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
4700 |
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Author |
Molina, R.; Oset, E. |
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Title |
Molecular picture for the X-0(2866) as a D*(K)over-bar* J(P)=0(+) state and related 1(+), 2(+) states |
Type |
Journal Article |
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Year |
2020 |
Publication |
Physics Letters B |
Abbreviated Journal |
Phys. Lett. B |
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Volume |
811 |
Issue |
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Pages |
135870 - 7pp |
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Keywords |
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Abstract |
We recall the predictions made ten years ago about a bound state of J(P) = 0(+) in I = 0 of the D*(K) over bar* system, which is manifestly exotic, and we associate it to the X-0(2866) state reported in the recent LHCb experiment. Fine tuning the parameters to reproduce exactly the mass and width of the X-0(2866) state, we report two more states stemming from the same interaction, one with 1(+) and the other with 2(+). For reasons of parity, the 1(+) state cannot be observed in D (K) over bar decay, and we suggest to observe it in the D*(K) over bar spectrum. On the other hand, the 2(+) state can be observed in D (K) over bar decay but the present experiment has too small statistics in the region of its mass to make any claim. We note that measurements of the D*(K) over bar spectrum and of the D (K) over bar with more statistics should bring important information concerning the nature of the X-0(2866) and related ones that could be observed. |
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Address |
[Molina, R.; Oset, E.] Ctr Mixto Univ Valencia CSIC, Dept Fis Teor, Inst Invest Paterna, Aptdo 22085, Valencia 46071, Spain, Email: Raquel.Molina@ific.uv.es; |
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Elsevier |
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English |
Summary Language |
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ISSN |
0370-2693 |
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Notes |
WOS:000612225400022 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
4701 |
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Author |
ATLAS Collaboration (Aad, G. et al); Aparisi Pozo, J.A.; Bailey, A.J.; Cabrera Urban, S.; Castillo, F.L.; Castillo Gimenez, V.; Costa, M.J.; Escobar, C.; Estrada Pastor, O.; Ferrer, A.; Fiorini, L.; Fullana Torregrosa, E.; Fuster, J.; Garcia, C.; Garcia Navarro, J.E.; Gonzalez de la Hoz, S.; Gonzalvo Rodriguez, G.R.; Guerrero Rojas, J.G.R.; Higon-Rodriguez, E.; Lacasta, C.; Lozano Bahilo, J.J.; Madaffari, D.; Mamuzic, J.; Marti-Garcia, S.; Martinez Agullo, P.; Mitsou, V.A.; Moreno Llacer, M.; Poveda, J.; Rodriguez Bosca, S.; Ruiz-Martinez, A.; Salt, J.; Santra, A.; Sayago Galvan, I.; Soldevila, U.; Sanchez, J.; Valero, A.; Valls Ferrer, J.A.; Vos, M. |
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Title |
Measurements of the Higgs boson inclusive and differential fiducial cross sections in the 4l decay channel at root s=13 TeV |
Type |
Journal Article |
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Year |
2020 |
Publication |
European Physical Journal C |
Abbreviated Journal |
Eur. Phys. J. C |
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Volume |
80 |
Issue |
10 |
Pages |
942 - 67pp |
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Keywords |
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Abstract |
Inclusive and differential fiducial cross sections of the Higgs boson are measured in the H -> ZZ* -> 4l (l = e, mu) decay channel. The results are based on proton-proton collision data produced at the Large Hadron Collider at a centre-of-mass energy of 13 TeV and recorded by the ATLAS detector from 2015 to 2018, equivalent to an integrated luminosity of 139 fb(-1). The inclusive fiducial cross section for the H -> ZZ* -> 4l process is measured to be sigma(fid) = 3.28 +/- 0.32 fb, in agreement with the StandardModel prediction of sigma(fid,SM) = 3.41 +/- 0.18 fb. Differential fiducial cross sections are measured for a variety of observables which are sensitive to the production and decay of the Higgs boson. Allmeasurements are in agreement with the Standard Model predictions. The results are used to constrain anomalous Higgs boson interactions with StandardModel particles. |
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Address |
[Banerjee, S.; Dang, N. P.; Duvnjak, D.; Jackson, P.; Oliver, J. L.; Petridis, A.; Qureshi, A.; Sharma, A. S.; White, M. J.] Univ Adelaide, Dept Phys, Adelaide, SA, Australia |
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Springer |
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English |
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Edition |
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ISSN |
1434-6044 |
ISBN |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:000615187600004 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
4702 |
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Author |
ATLAS Collaboration (Aad, G. et al); Aparisi Pozo, J.A.; Bailey, A.J.; Cabrera Urban, S.; Castillo, F.L.; Castillo Gimenez, V.; Costa, M.J.; Escobar, C.; Estrada Pastor, O.; Ferrer, A.; Fiorini, L.; Fullana Torregrosa, E.; Fuster, J.; Garcia, C.; Garcia Navarro, J.E.; Gonzalez de la Hoz, S.; Gonzalvo Rodriguez, G.R.; Guerrero Rojas, J.G.R.; Higon-Rodriguez, E.; Lacasta, C.; Lozano Bahilo, J.J.; Madaffari, D.; Mamuzic, J.; Marti-Garcia, S.; Martinez Agullo, P.; Mitsou, V.A.; Moreno Llacer, M.; Poveda, J.; Rodriguez Bosca, S.; Ruiz-Martinez, A.; Salt, J.; Santra, A.; Sayago Galvan, I.; Soldevila, U.; Sanchez, J.; Valero, A.; Valls Ferrer, J.A.; Vos, M. |
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Title |
Search for a scalar partner of the top quark in the all-hadronic t(t)over-bar plus missing transverse momentum final state at root s=13 TeV with the ATLAS detector |
Type |
Journal Article |
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Year |
2020 |
Publication |
European Physical Journal C |
Abbreviated Journal |
Eur. Phys. J. C |
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Volume |
80 |
Issue |
8 |
Pages |
737 - 44pp |
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Keywords |
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Abstract |
A search for direct pair production of scalar partners of the top quark (top squarks or scalar third-generation up-type leptoquarks) in the all-hadronic t (t) over bar plus missing transverse momentum final state is presented. The analysis of 139 fb(-1) of root s = 13 TeV proton-proton collision data collected using the ATLAS detector at the LHC yields no significant excess over the Standard Model background expectation. To interpret the results, a supersymmetric model is used where the top squark decays via (t) over tilde -> t(*) (chi) over tilde (0)(1), with t(*) denoting an on-shell (off-shell) top quark and (chi) over tilde (0)(1) the lightest neutralino. Three specific event selections are optimised for the following scenarios. In the scenario where m((t) over tilde) > m(t) + m((chi) over tilde 10), top squark masses are excluded in the range 400-1250 GeV for (chi) over tilde (0)(1) masses below 200 GeV at 95% confidence level. In the situation where m((t) over tilde) similar to m(t) + m((chi) over tilde 10), top squarkmasses in the range 300-630 GeV are excluded, while in the case where m((t) over tilde) < m(W) + m(b) + m(<(chi)over tilde>10) (with m((t) over tilde) – m((chi) over tilde 10) >= 5 GeV), considered for the first time in an ATLAS all-hadronic search, top squark masses in the range 300-660 GeV are excluded. Limits are also set for scalar third-generation up-type leptoquarks, excluding leptoquarks with masses below 1240 GeV when considering only leptoquark decays into a top quark and a neutrino. |
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Address |
[Banerjee, S.; Dang, N. P.; Duvnjak, D.; Jackson, P.; Oliver, J. L.; Petridis, A.; Qureshi, A.; Sharma, A. S.; White, M. J.] Univ Adelaide, Dept Phys, Adelaide, SA, Australia |
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Springer |
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English |
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Series Issue |
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ISSN |
1434-6044 |
ISBN |
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Area |
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Conference |
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Notes |
WOS:000615182800002 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
4705 |
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Author |
Moretti, F.; Bombacigno, F.; Montani, G. |
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Title |
Gravitational Landau damping for massive scalar modes |
Type |
Journal Article |
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Year |
2020 |
Publication |
European Physical Journal C |
Abbreviated Journal |
Eur. Phys. J. C |
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Volume |
80 |
Issue |
12 |
Pages |
1203 - 9pp |
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Keywords |
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Abstract |
We establish the possibility of Landau damping for gravitational scalar waves which propagate in a non-collisional gas of particles. In particular, under the hypothesis of homogeneity and isotropy, we describe the medium at the equilibrium with a Juttner-Maxwell distribution, and we analytically determine the damping rate from the Vlasov equation. We find that damping occurs only if the phase velocity of the wave is subluminal throughout the propagation within the medium. Finally, we investigate relativistic media in cosmological settings by adopting numerical techniques. |
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Address |
[Moretti, Fabio; Montani, Giovanni] Sapienza Univ Rome, Phys Dept, Ple Aldo Moro 5, I-00185 Rome, Italy, Email: fabio.moretti@uniroma1.it; |
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Springer |
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English |
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1434-6044 |
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WOS:000615196900004 |
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no |
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yes |
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yes |
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IFIC @ pastor @ |
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4707 |
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Author |
Valdes-Cortez, C.; Ballester, F.; Vijande, J.; Gimenez, V.; Gimenez-Alventosa, V.; Perez-Calatayud, J.; Niatsetski, Y.; Andreo, P. |
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Title |
Depth-dose measurement corrections for the surface electronic brachytherapy beams of an Esteya(R) unit: a Monte Carlo study |
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Journal Article |
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2020 |
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Physics in Medicine and Biology |
Abbreviated Journal |
Phys. Med. Biol. |
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65 |
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24 |
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245026 - 12pp |
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Keywords |
electronic brachytherapy; eBT; dosimetry; ionization chamber; Monte Carlo |
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Abstract |
Three different correction factors for measurements with the parallel-plate ionization chamber PTW T34013 on the Esteya electronic brachytherapy unit have been investigated. This chamber type is recommended by AAPM TG-253 for depth-dose measurements in the 69.5 kV x-ray beam generated by the Esteya unit. Monte Carlo simulations using the PENELOPE-2018 system were performed to determine the absorbed dose deposited in water and in the chamber sensitive volume at different depths with a Type A uncertainty smaller than 0.1%. Chamber-to-chamber differences have been explored performing measurements using three different chambers. The range of conical applicators available, from 10 to 30 mm in diameter, has been explored. Using a depth-independent global chamber perturbation correction factor without a shift of the effective point of measurement yielded differences between the absorbed dose to water and the corrected absorbed dose in the sensitive volume of the chamber of up to 1% and 0.6% for the 10 mm and 30 mm applicators, respectively. Calculations using a depth-dependent perturbation factor, including or excluding a shift of the effective point of measurement, resulted in depth-dose differences of about +/- 0.5% or less for both applicators. The smallest depth-dose differences were obtained when a shift of the effective point of measurement was implemented, being displaced 0.4 mm towards the center of the sensitive volume of the chamber. The correction factors were obtained with combined uncertainties of 0.4% (k = 2). Uncertainties due to chamber-to-chamber differences are found to be lower than 2%. The results emphasize the relevance of carrying out detailed Monte Carlo studies for each electronic brachytherapy device and ionization chamber used for its dosimetry. |
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[Valdes-Cortez, Christian; Ballester, Facundo; Vijande, Javier] Univ Valencia UV, Dept Fis Atom Mol & Nucl, Burjassot, Spain, Email: cvalcort@gmail.com |
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Iop Publishing Ltd |
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English |
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0031-9155 |
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Notes |
WOS:000618031500001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
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4708 |
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