| Records |
| Author |
ATLAS Collaboration (Aad, G. et al); Alvarez Piqueras, D.; Cabrera Urban, S.; Castillo Gimenez, V.; Costa, M.J.; Fernandez Martinez, P.; Ferrer, A.; Fiorini, L.; Fuster, J.; Garcia, C.; Garcia Navarro, J.E.; Gonzalez de la Hoz, S.; Hernandez Jimenez, Y.; Higon-Rodriguez, E.; Irles Quiles, A.; Jimenez Pena, J.; Kaci, M.; King, M.; Lacasta, C.; Lacuesta, V.R.; Marti-Garcia, S.; Mitsou, V.A.; Pedraza Lopez, S.; Perez Garcia-Estañ, M.T.; Romero Adam, E.; Ros, E.; Salt, J.; Sanchez Martinez, V.; Soldevila, U.; Sanchez, J.; Valero, A.; Valls Ferrer, J.A.; Vos, M. |
| Title |
Measurement of the charge asymmetry in top-quark pair production in the lepton-plus-jets final state in pp collision data at root s=8 TeV with the ATLAS detector |
Type |
Journal Article |
| Year |
2016 |
Publication |
European Physical Journal C |
Abbreviated Journal |
Eur. Phys. J. C |
Volume  |
76 |
Issue |
2 |
Pages |
87 - 30pp |
| Keywords |
|
| Abstract |
This paper reports inclusive and differential measurements of the t (t) over bar charge asymmetry A(C) in 20.3 fb(-1) of root s = 8 TeV pp collisions recorded by the ATLAS experiment at the Large Hadron Collider at CERN. Three differential measurements are performed as a function of the invariant mass, transverse momentum and longitudinal boost of the t (t) over bar system. The t (t) over bar pairs are selected in the single-lepton channels (e or mu) with at least four jets, and a likelihood fit is used to reconstruct the t (t) over bar event kinematics. A Bayesian unfolding procedure is performed to infer the asymmetry at parton level from the observed data distribution. The inclusive t (t) over bar charge asymmetry is measured to be A(C) = 0.009 +/- 0.005 (stat. + syst.). The inclusive and differential measurements are compatible with the values predicted by the Standard Model. |
| Address |
[Aleksa, M.; Gonzalez, B. Alvarez; Anders, G.; Anghinolfi, F.; Armbruster, A. J.; Arnaez, O.; Avolio, G.; Baak, M. A.; Backes, M.; Backhaus, M.; Barak, L.; Beermann, T. A.; Beltramello, O.; Bianco, M.; Bogaerts, J. A.; Boveia, A.; Boyd, J.; Burckhart, H.; Campana, S.; Garrido, M. D. M. Capeans; Carli, T.; Carrillo-Montoya, G. D.; Catinaccio, A.; Cattai, A.; Cerv, M.; Chromek-Burckhart, D.; Conti, G.; Dell'Acqua, A.; Deviveiros, P. O.; Di Girolamo, A.; Di Girolamo, B.; Dittus, F.; Dobos, D.; Dudarev, A.; Duehrssen, M.; Eifert, T.; Ellis, N.; Elsing, M.; Farthouat, P.; Fassnacht, P.; Feigl, S.; Feng, E. J.; Perez, S. Fernandez; Francis, D.; Froidevaux, D.; Gadatsch, S.; Gillberg, D.; Glatzer, J.; Goossens, L.; Gorini, B.; Gray, H. M.; Hawkings, R. J.; Correia, A. M. Henriques; Hervas, L.; Hoecker, A.; Huhtinen, M.; Iengo, P.; Jaekel, M. R.; Jakobsen, S.; Jenni, P.; Klioutchnikova, T.; Krasznahorkay, A.; Lapoire, C.; Lassnig, M.; Miotto, G. Lehmann; Lenzi, B.; Lichard, P.; Macina, D.; Malyukov, S.; Mandelli, B.; Mapelli, L.; Marzin, A.; Milic, A.; Mornacchi, G.; Nairz, A. M.; Nakahama, Y.; Nessi, M.; Nicquevert, B.; Nordberg, M.; Oide, H.; Palestini, S.; Pauly, T.; Pernegger, H.; Peters, K.; Petersen, B. A.; Pommes, K.; Poppleton, A.; Poulard, G.; Poveda, J.; Prasad, S.; Rammensee, M.; Raymond, M.; Rembser, C.; Ritsch, E.; Roe, S.; Ruiz-Martinez, A.; Ruthmann, N.; Salzburger, A.; Schaefer, D.; Schlenker, S.; Schmieden, K.; Serfon, C.; Sforza, F.; Sfyrla, A.; Solans, C. A.; Spigo, G.; Stelzer, H. J.; Teischinger, F. A.; Ten Kate, H.; Tremblet, L.; Tricoli, A.; Tsarouchas, C.; Unal, G.; van Woerden, M. C.; Vandelli, W.; Voss, R.; Vuillermet, R.; Wells, P. S.; Wengler, T.; Wenig, S.; Werner, P.; Wilkens, H. G.; Wotschack, J.; Young, C. J. S.; Zwalinski, L.; ATLAS Collaboration] CERN, CH-1211 Geneva 23, Switzerland |
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Thesis |
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| Publisher |
Springer |
Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
1434-6044 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
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| Notes |
WOS:000372877800002 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
yes |
| Call Number |
IFIC @ pastor @ |
Serial |
2587 |
| Permanent link to this record |
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| Author |
ATLAS Collaboration (Aad, G. et al); Amoros, G.; Bernabeu Verdu, J.; Cabrera Urban, S.; Castillo Gimenez, V.; Costa, M.J.; Escobar, C.; Ferrer, A.; Fuster, J.; Garcia, C.; Gonzalez de la Hoz, S.; Hernandez Jimenez, Y.; Higon-Rodriguez, E.; Irles Quiles, A.; Kaci, M.; Lacasta, C.; Lacuesta, V.R.; Marti-Garcia, S.; Miñano, M.; Mitsou, V.A.; Moles-Valls, R.; Moreno Llacer, M.; Oliver Garcia, E.; Perez Garcia-Estañ, M.T.; Ros, E.; Salt, J.; Solans, C.A.; Sanchez, J.; Torro Pastor, E.; Valladolid Gallego, E.; Valls Ferrer, J.A.; Villaplana Perez, M.; Vos, M.; Wildauer, A. |
| Title |
The ATLAS Inner Detector commissioning and calibration |
Type |
Journal Article |
| Year |
2010 |
Publication |
European Physical Journal C |
Abbreviated Journal |
Eur. Phys. J. C |
| Volume |
70 |
Issue |
3 |
Pages |
787-821 |
| Keywords |
|
| Abstract |
The ATLAS Inner Detector is a composite tracking system consisting of silicon pixels, silicon strips and straw tubes in a 2 T magnetic field. Its installation was completed in August 2008 and the detector took part in data-taking with single LHC beams and cosmic rays. The initial detector operation, hardware commissioning and in-situ calibrations are described. Tracking performance has been measured with 7.6 million cosmic-ray events, collected using a tracking trigger and reconstructed with modular pattern-recognition and fitting software. The intrinsic hit efficiency and tracking trigger efficiencies are close to 100%. Lorentz angle measurements for both electrons and holes, specific energy-loss calibration and transition radiation turn-on measurements have been performed. Different alignment techniques have been used to reconstruct the detector geometry. After the initial alignment, a transverse impact parameter resolution of 22.1 +/- 0.9 μm and a relative momentum resolution sigma (p) /p=(4.83 +/- 0.16)x10(-4) GeV(-1)xp (T) have been measured for high momentum tracks. |
| Address |
[Alam, M. S.; Ernst, J.; Mahmood, A.; Rojo, V.] SUNY Albany, Albany, NY 12222 USA, Email: atlas.secretariat@cern.ch |
| Corporate Author |
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Thesis |
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| Publisher |
Springer |
Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
1434-6044 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
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| Notes |
ISI:000285200000013 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
yes |
| Call Number |
IFIC @ pastor @ |
Serial |
250 |
| Permanent link to this record |
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| |
| Author |
Richard, J.M.; Valcarce, A.; Vijande, J. |
| Title |
Resonances in the Quark Model |
Type |
Journal Article |
| Year |
2024 |
Publication |
Few-Body Systems |
Abbreviated Journal |
Few-Body Syst. |
| Volume |
65 |
Issue |
3 |
Pages |
71 - 11pp |
| Keywords |
|
| Abstract |
A discussion is presented of the estimates of the energy and width of resonances in constituent models, with focus on the tetraquark states containing heavy quarks. |
| Address |
[Richard, Jean-Marc] Univ Claude Bernard Lyon 1, Inst Phys Infinis Lyon 2, CNRS, IN2P3, CNRS-IN2P3,4 rue Enr Fermi, F-69622 Villeurbanne, France, Email: j-m.richard@ip2i.in2p3.fr |
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Thesis |
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| Publisher |
Springer Wien |
Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
0177-7963 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
|
| Notes |
WOS:001260738300001 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
yes |
| Call Number |
IFIC @ pastor @ |
Serial |
6180 |
| Permanent link to this record |
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| |
| Author |
Mata, R.; Cros, A.; Gimeno, B.; Raboso, D. |
| Title |
Secondary electron emission yield in thick dielectric materials: a comparison between Kelvin probe and capacitive methods |
Type |
Journal Article |
| Year |
2024 |
Publication |
Journal of Physics D |
Abbreviated Journal |
J. Phys. D |
| Volume |
57 |
Issue |
40 |
Pages |
405302 - 9pp |
| Keywords |
dielectrics; secondary electron emission yield; Multipactor in space devices |
| Abstract |
The recent high demand of secondary electron emission yield (SEY) measurements in dielectric materials from space industry has driven SEY laboratories to improve their facilities and measurement techniques. SEY determination by the common capacitive method, also known as pulsed method, is well accepted and has given satisfactory results in most cases. Nevertheless, the samples under study must be prepared according to the experimental limitations of the technique, i.e. they should be manufactured separated from the devices representing faithfully the surface state of the own device and be as thin as possible. A method based on the Kelvin probe (KP) is proposed here to obtain the SEY characteristics of electrically floating Platinum, Kapton and Teflon placed over dielectric spacers with thicknesses ranging from 1.6 to 12.1 mm. The results are compared with those of the capacitive method and indicate that KP SEY curves are less sensitive to spacer thickness. An explanation based on the literature is also given. In all, we have established that KP is better suited for the analysis of dielectric samples thicker than 3 mm. |
| Address |
[Mata, R.; Gimeno, B.] Ciudad Politecn Innovac, Val Space Consortium, Edificio 8G,Acceso B,Planta B, Valencia 46022, Spain, Email: rafael.mata@uv.es |
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Thesis |
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| Publisher |
IOP Publishing Ltd |
Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
0022-3727 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
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| Notes |
WOS:001269188200001 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
yes |
| Call Number |
IFIC @ pastor @ |
Serial |
6203 |
| Permanent link to this record |
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| Author |
Piriz, G.H.; Gonzalez-Sprinberg, G.A.; Ballester, F.; Vijande, J. |
| Title |
Dosimetry of Large Field Valencia applicators for Cobalt-60-based brachytherapy |
Type |
Journal Article |
| Year |
2024 |
Publication |
Medical Physics |
Abbreviated Journal |
Med. Phys. |
| Volume |
51 |
Issue |
|
Pages |
5094-5098 |
| Keywords |
dosimetry; Monte Carlo; skin brachytherapy; Valencia applicators |
| Abstract |
BackgroundNon-melanoma skin cancer is one of the most common types of cancer and one of the main approaches is brachytherapy. For small lesions, the treatment of this cancer with brachytherapy can be done with two commercial applicators, one of these is the Large Field Valencia Applicators (LFVA).PurposeThe aim of this study is to test the capabilities of the LFVA to use clinically 60Co sources instead of the 192Ir ones. This study was designed for the same dwell positions and weights for both sources.MethodsThe Penelope Monte Carlo code was used to evaluate dose distribution in a water phantom when a 60Co source is considered. The LFVA design and the optimized dwell weights reported for the case of 192Ir are maintained with the only exception of the dwell weight of the central position, that was increased. 2D dose distributions, field flatness, symmetry and the leakage dose distribution around the applicator were calculated.ResultsWhen comparing the dose distributions of both sources, field flatness and symmetry remain unchanged. The only evident difference is an increase of the penumbra regions for all depths when using the 60Co source. Regarding leakage, the maximum dose within the air volume surrounding the applicator is in the order of 20% of the prescription dose for the 60Co source, but it decreases to less than 5% at about 1 cm distance.ConclusionsFlatness and symmetry remains unaltered as compared with 192Ir sources, while an increase in leakage has been observed. This proves the feasibility of using the LFVA in a larger range of clinical applications. |
| Address |
[Piriz, Gustavo H.; Gonzalez-Sprinberg, Gabriel A.] Univ Republica, Fac Sci, Med Phys Unit, Montevideo, Uruguay, Email: ghpiriz@gmail.com |
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Thesis |
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| Publisher |
Wiley |
Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
0094-2405 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
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| Notes |
WOS:001187737100001 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
yes |
| Call Number |
IFIC @ pastor @ |
Serial |
6011 |
| Permanent link to this record |
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| |
| Author |
Martins, A.; da Mota, A.F.; Stanford, C.; Contreras, T.; Martin-Albo, J.; Kish, A.; Escobar, C.O.; Para, A.; Guenette, R. |
| Title |
Simple strategy for the simulation of axially symmetric large-area metasurfaces |
Type |
Journal Article |
| Year |
2024 |
Publication |
Journal of the Optical Society of America B |
Abbreviated Journal |
J. Opt. Soc. Am. B |
| Volume |
41 |
Issue |
5 |
Pages |
1261-1269 |
| Keywords |
|
| Abstract |
Metalenses are composed of nanostructures for focusing light and have been widely explored in many exciting applications. However, their expanding dimensions pose simulation challenges. We propose a method to simulate metalenses in a timely manner using vectorial wave and ray tracing models. We sample the metalens's radial phase gradient and locally approximate the phase profile by a linear phase response. Each sampling point is modeled as a binary blazed grating, employing the chosen nanostructure, to build a transfer function set. The metalens transmission or reflection is then obtained by applying the corresponding transfer function to the incoming field on the regions surrounding each sampling point. Fourier optics is used to calculate the scattered fields under arbitrary illumination for the vectorial wave method, and a Monte Carlo algorithm is used in the ray tracing formalism. We validated our method against finite -difference time domain simulations at 632 nm, and we were able to simulate metalenses larger than 3000 wavelengths in diameter on a personal computer. |
| Address |
[Martins, Augusto; Guenette, Roxanne] Univ Manchester, Dept Phys, Manchester M13 9PL, England, Email: augusto.martins@york.ac.uk |
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Thesis |
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| Publisher |
Optica Publishing Group |
Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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Series Title |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
0740-3224 |
ISBN |
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Medium |
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Expedition |
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Conference |
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| Notes |
WOS:001237140900001 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
yes |
| Call Number |
IFIC @ pastor @ |
Serial |
6140 |
| Permanent link to this record |
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| Author |
Sorelli, G.; Gessner, M.; Treps, N.; Walschaers, M. |
| Title |
Gaussian quantum metrology for mode-encoded parameters |
Type |
Journal Article |
| Year |
2024 |
Publication |
New Journal of Physics |
Abbreviated Journal |
New J. Phys. |
| Volume |
26 |
Issue |
7 |
Pages |
073022 - 23pp |
| Keywords |
quantum metrology; multimode quantum optics; Gaussian states |
| Abstract |
Quantum optical metrology aims to identify ultimate sensitivity bounds for the estimation of parameters encoded into quantum states of the electromagnetic field. In many practical applications, including imaging, microscopy, and remote sensing, the parameter of interest is not only encoded in the quantum state of the field, but also in its spatio-temporal distribution, i.e. in its mode structure. In this mode-encoded parameter estimation setting, we derive an analytical expression for the quantum Fisher information valid for arbitrary multimode Gaussian fields. To illustrate the power of our approach, we apply our results to the estimation of the transverse displacement of a beam and to the temporal separation between two pulses. For these examples, we show how the estimation sensitivity can be enhanced by adding squeezing into specific modes. |
| Address |
[Sorelli, Giacomo; Treps, Nicolas; Walschaers, Mattia] Sorbonne Univ, ENS Univ PSL, CNRS, Lab Kastler Brossel,Coll France, 4 Pl Jussieu, F-75252 Paris, France, Email: giacomo.sorelli@iosb-extern.fraunhofer.de |
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Thesis |
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| Publisher |
IOP Publishing Ltd |
Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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Series Title |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
1367-2630 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
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| Notes |
WOS:001270966100001 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
yes |
| Call Number |
IFIC @ pastor @ |
Serial |
6209 |
| Permanent link to this record |
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| Author |
CALICE Collaboration (Lai, S. et al); Irles, A. |
| Title |
Software compensation for highly granular calorimeters using machine learning |
Type |
Journal Article |
| Year |
2024 |
Publication |
Journal of Instrumentation |
Abbreviated Journal |
J. Instrum. |
| Volume |
19 |
Issue |
4 |
Pages |
P04037 - 28pp |
| Keywords |
Large detector-systems performance; Pattern recognition; cluster finding; calibration and fitting methods; Performance of High Energy Physics Detectors |
| Abstract |
A neural network for software compensation was developed for the highly granular CALICE Analogue Hadronic Calorimeter (AHCAL). The neural network uses spatial and temporal event information from the AHCAL and energy information, which is expected to improve sensitivity to shower development and the neutron fraction of the hadron shower. The neural network method produced a depth-dependent energy weighting and a time-dependent threshold for enhancing energy deposits consistent with the timescale of evaporation neutrons. Additionally, it was observed to learn an energy-weighting indicative of longitudinal leakage correction. In addition, the method produced a linear detector response and outperformed a published control method regarding resolution for every particle energy studied. |
| Address |
[Lai, S.; Utehs, J.; Wilhahn, A.] Georg August Univ Gottingen, Phys Inst 2, Friedrich Hund Pl 1, D-37077 Gottingen, Germany, Email: jack.rolph@desy.de |
| Corporate Author |
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Thesis |
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| Publisher |
IOP Publishing Ltd |
Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
1748-0221 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
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| Notes |
WOS:001230094600001 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
yes |
| Call Number |
IFIC @ pastor @ |
Serial |
6128 |
| Permanent link to this record |
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| Author |
Di Gregorio, E.; Staelens, M.; Hosseinkhah, N.; Karimpoor, M.; Liburd, J.; Lim, L.; Shankar, K.; Tuszynski, J.A. |
| Title |
Raman Spectroscopy Reveals Photobiomodulation-Induced α-Helix to β-Sheet Transition in Tubulins: Potential Implications for Alzheimer's and Other Neurodegenerative Diseases |
Type |
Journal Article |
| Year |
2024 |
Publication |
Nanomaterials |
Abbreviated Journal |
Nanomaterials |
| Volume |
14 |
Issue |
13 |
Pages |
1093 - 21pp |
| Keywords |
proteins; protein dynamics; protein structure; non-invasive therapies; low-level laser therapy; spectroscopy; amide bands; amide I; spectral decomposition |
| Abstract |
In small clinical studies, the application of transcranial photobiomodulation (PBM), which typically delivers low-intensity near-infrared (NIR) to treat the brain, has led to some remarkable results in the treatment of dementia and several neurodegenerative diseases. However, despite the extensive literature detailing the mechanisms of action underlying PBM outcomes, the specific mechanisms affecting neurodegenerative diseases are not entirely clear. While large clinical trials are warranted to validate these findings, evidence of the mechanisms can explain and thus provide credible support for PBM as a potential treatment for these diseases. Tubulin and its polymerized state of microtubules have been known to play important roles in the pathology of Alzheimer's and other neurodegenerative diseases. Thus, we investigated the effects of PBM on these cellular structures in the quest for insights into the underlying therapeutic mechanisms. In this study, we employed a Raman spectroscopic analysis of the amide I band of polymerized samples of tubulin exposed to pulsed low-intensity NIR radiation (810 nm, 10 Hz, 22.5 J/cm2 dose). Peaks in the Raman fingerprint region (300-1900 cm-1)-in particular, in the amide I band (1600-1700 cm-1)-were used to quantify the percentage of protein secondary structures. Under this band, hidden signals of C=O stretching, belonging to different structures, are superimposed, producing a complex signal as a result. An accurate decomposition of the amide I band is therefore required for the reliable analysis of the conformation of proteins, which we achieved through a straightforward method employing a Voigt profile. This approach was validated through secondary structure analyses of unexposed control samples, for which comparisons with other values available in the literature could be conducted. Subsequently, using this validated method, we present novel findings of statistically significant alterations in the secondary structures of polymerized NIR-exposed tubulin, characterized by a notable decrease in alpha-helix content and a concurrent increase in beta-sheets compared to the control samples. This PBM-induced alpha-helix to beta-sheet transition connects to reduced microtubule stability and the introduction of dynamism to allow for the remodeling and, consequently, refreshing of microtubule structures. This newly discovered mechanism could have implications for reducing the risks associated with brain aging, including neurodegenerative diseases like Alzheimer's disease, through the introduction of an intervention following this transition. |
| Address |
[Di Gregorio, Elisabetta; Staelens, Michael; Tuszynski, Jack A.] Univ Alberta, Fac Sci, Dept Phys, Edmonton, AB T6G 2E1, Canada, Email: michael.staelens@ific.uv.es |
| Corporate Author |
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Thesis |
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| Publisher |
Mdpi |
Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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Series Title |
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Series Issue |
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Edition |
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ISBN |
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Medium |
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Expedition |
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Conference |
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| Notes |
WOS:001269841000001 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
yes |
| Call Number |
IFIC @ pastor @ |
Serial |
6204 |
| Permanent link to this record |
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| Author |
Penas, J.; Alejo, A.; Bembibre, A.; Apiñaniz, J.I.; Garcia-Garcia, E.; Guerrero, C.; Henares, J.L.; Hernandez-Palmero, I.; Mendez, C.; Millan-Callado, M.A.; Puyuelo-Valdes, P.; Seimetz, M.; Benlliure, J. |
| Title |
Production of carbon-11 for PET preclinical imaging using a high-repetition rate laser-driven proton source |
Type |
Journal Article |
| Year |
2024 |
Publication |
Scientific Reports |
Abbreviated Journal |
Sci Rep |
| Volume |
14 |
Issue |
1 |
Pages |
11448 - 12pp |
| Keywords |
|
| Abstract |
Most advanced medical imaging techniques, such as positron-emission tomography (PET), require tracers that are produced in conventional particle accelerators. This paper focuses on the evaluation of a potential alternative technology based on laser-driven ion acceleration for the production of radioisotopes for PET imaging. We report for the first time the use of a high-repetition rate, ultra-intense laser system for the production of carbon-11 in multi-shot operation. Proton bunches with energies up to 10-14 MeV were systematically accelerated in long series at pulse rates between 0.1 and 1 Hz using a PW-class laser. These protons were used to activate a boron target via the 11 \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$<^>{11}$$\end{document} B(p,n) 11 \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$<^>{11}$$\end{document} C nuclear reaction. A peak activity of 234 kBq was obtained in multi-shot operation with laser pulses with an energy of 25 J. Significant carbon-11 production was also achieved for lower pulse energies. The experimental carbon-11 activities measured in this work are comparable to the levels required for preclinical PET, which would be feasible by operating at the repetition rate of current state-of-the-art technology (10 Hz). The scalability of next-generation laser-driven accelerators in terms of this parameter for sustained operation over time could increase these overall levels into the clinical PET range. |
| Address |
[Penas, Juan; Alejo, Aaron; Bembibre, Adrian; Benlliure, Jose] Univ Santiago de Compostela, Inst Galego Fis Altas Enerxias IGFAE, Santiago De Compostela 15782, Spain, Email: j.benlliure@usc.es |
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Nature Portfolio |
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English |
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2045-2322 |
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WOS:001228252900017 |
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no |
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yes |
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no |
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IFIC @ pastor @ |
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6143 |
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