Abstract: A scheme is proposed for hardware estimation of the location of zero crossings of sampled signals with subsample resolution for timing applications, which consists of interpolating the signal with a cubic spline near the zero crossing and then finding the root of the resulting polynomial. An iterative algorithm based on the bisection method is presented that obtains one bit of the result per step and admits an efficient digital implementation using fixed-point representation. In particular, the root estimation iteration involves only two additions, and the initial values can be obtained from finite impulse response (FIR) filters with certain symmetry properties. It is shown that this allows online real-time estimation of timestamps in free-running sampling detector systems with improved accuracy with respect to the more common linear interpolation. The method is evaluated with simulations using ideal and real timing signals, and estimates are given for the resource usage and speed of its implementation.

Abstract: Purpose This work aims to simulate clustered DNA damage from ionizing radiation and estimate the relative biological effectiveness (RBE) for radionuclide (rBT)- and electronic (eBT)-based surface brachytherapy through a hybrid Monte Carlo (MC) approach, using realistic models of the sources and applicators. Methods Damage from ionizing radiation has been studied using the Monte Carlo Damage Simulation algorithm using as input the primary electron fluence simulated using a state-of-the-art MC code, PENELOPE-2018. Two Ir-192 rBT applicators, Valencia and Leipzig, one Co-60 source with a Freiburg Flap applicator (reference source), and two eBT systems, Esteya and INTRABEAM, have been included in this study implementing full realizations of their geometries as disclosed by the manufacturer. The role played by filtration and tube kilovoltage has also been addressed. Results For rBT, an RBE value of about 1.01 has been found for the applicators and phantoms considered. In the case of eBT, RBE values for the Esteya system show an almost constant RBE value of about 1.06 for all depths and materials. For INTRABEAM, variations in the range of 1.12-1.06 are reported depending on phantom composition and depth. Modifications in the Esteya system, filtration, and tube kilovoltage give rise to variations in the same range. Conclusions Current clinical practice does not incorporate biological effects in surface brachytherapy. Therefore, the same absorbed dose is administered to the patients independently on the particularities of the rBT or eBT system considered. The almost constant RBE values reported for rBT support that assumption regardless of the details of the patient geometry, the presence of a flattening filter in the applicator design, or even significant modifications in the photon energy spectra above 300 keV. That is not the case for eBT, where a clear dependence on the eBT system and the characteristics of the patient geometry are reported. A complete study specific for each eBT system, including detailed applicator characteristics (size, shape, filtering, among others) and common anatomical locations, should be performed before adopting an existing RBE value.

Abstract: Asymmetric tri-bi-maximal mixing is a recently proposed, grand unified theory (GUT) based, flavor mixing scheme. In it, the charged lepton mixing is fixed by the GUT connection to down-type quarks and a T-13 flavor symmetry, while neutrino mixing is assumed to be tri-bi-maximal (TBM) with one additional free phase. Here we show that this additional free phase can be fixed by the residual flavor and CP symmetries of the effective neutrino mass matrix. We discuss how those residual symmetries can be unified with T-13 and identify the smallest possible unified flavor symmetries, namely (Z(13)xZ(13))(sic)D-12 and (Z(13)xZ(13))(sic)S-4. Sharp predictions are obtained for lepton mixing angles, CP violating phases and neutrinoless double beta decay.

Abstract: With the historic discovery of the Higgs boson our picutre of particle physics would have been complete were it nor for the neutrino sector and cosmology. I briefly discuss the role of neutrino masses and mixing upon gauge coupling unification, electroweak breaking and the flavor sector. Time is ripe for new discoveries such as leptonic CP violation, charged lepton flavor violation and neutrinoless double beta decay. Neutrinos could also play a role is elucidating the nature of dark matter and cosmic inflation.

Abstract: After some short introductory remarks on particular issues on the vector mesons in nuclei, in this paper, we present a short review of recent developments concerning the interaction of vector mesons with baryons and with nuclei from a modern perspective using the local hidden gauge formalism for the interaction of vector mesons. We present results for the vector-baryon interaction and in particular for the resonances which appear as composite states, dynamically generated from the interaction of vector mesons with baryons, taking also the mixing of these states with pseudoscalars and baryons into account. We then venture into the charm sector, reporting on hidden charm baryon states around 4400 MeV, generated from the interaction of vector mesons and baryons with charm, which have a strong repercussion on the properties of the J/Psi N interaction. We also address the interaction of K* with nuclei and make suggestions to measure the predicted huge width in the medium by means of transparency ratio. The formalism is extended to study the phenomenon of J/psi suppression in nuclei via J/psi photo-production reactions.