Abstract: We present a search for magnetic monopoles and high-electric-charge objects using LHC Run 2 root s = 13TeV proton-proton collisions recorded by the ATLAS detector. A total integrated luminosity of 138 fb(-1) was collected by a specialized trigger. No highly ionizing particle candidate was observed. Considering the Drell-Yan and photon-fusion pair production mechanisms as benchmark models, cross-section upper limits are presented for spin-0 and spin-1/2 magnetic monopoles of magnetic charge 1g(D) and 2g(D) and for high-electric-charge objects of electric charge 20 <= vertical bar z vertical bar <= 100, for masses between 200 GeV and 4000 GeV. The search improves by approximately a factor of three the previous cross-section limits on the Drell-Yan production of magnetic monopoles and high-electric charge objects. Also, the first ATLAS limits on the photon-fusion pair production mechanism of magnetic monopoles and high-electric-charge objects are obtained.

Abstract: A search for K-S(L)(0) -> mu(+) mu(-) mu(+) mu(-) decays is performed using proton-proton collision data collected by the LHCb experiment at a center-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 5.1 fb(-1). No evidence for signal is found. The 90% confidence level upper limits are the first set for both decays and are B(K-S(0)) -> mu(+) mu(-) mu(+) mu(-)) < 5.1 x 10(-12) and B(K-L(0))-> mu(+) mu(-) mu(+) mu(-)) < 2.3 x 10(-9).

Abstract: A discussion is presented of the estimates of the energy and width of resonances in constituent models, with focus on the tetraquark states containing heavy quarks.

Abstract: In small clinical studies, the application of transcranial photobiomodulation (PBM), which typically delivers low-intensity near-infrared (NIR) to treat the brain, has led to some remarkable results in the treatment of dementia and several neurodegenerative diseases. However, despite the extensive literature detailing the mechanisms of action underlying PBM outcomes, the specific mechanisms affecting neurodegenerative diseases are not entirely clear. While large clinical trials are warranted to validate these findings, evidence of the mechanisms can explain and thus provide credible support for PBM as a potential treatment for these diseases. Tubulin and its polymerized state of microtubules have been known to play important roles in the pathology of Alzheimer's and other neurodegenerative diseases. Thus, we investigated the effects of PBM on these cellular structures in the quest for insights into the underlying therapeutic mechanisms. In this study, we employed a Raman spectroscopic analysis of the amide I band of polymerized samples of tubulin exposed to pulsed low-intensity NIR radiation (810 nm, 10 Hz, 22.5 J/cm2 dose). Peaks in the Raman fingerprint region (300-1900 cm-1)-in particular, in the amide I band (1600-1700 cm-1)-were used to quantify the percentage of protein secondary structures. Under this band, hidden signals of C=O stretching, belonging to different structures, are superimposed, producing a complex signal as a result. An accurate decomposition of the amide I band is therefore required for the reliable analysis of the conformation of proteins, which we achieved through a straightforward method employing a Voigt profile. This approach was validated through secondary structure analyses of unexposed control samples, for which comparisons with other values available in the literature could be conducted. Subsequently, using this validated method, we present novel findings of statistically significant alterations in the secondary structures of polymerized NIR-exposed tubulin, characterized by a notable decrease in alpha-helix content and a concurrent increase in beta-sheets compared to the control samples. This PBM-induced alpha-helix to beta-sheet transition connects to reduced microtubule stability and the introduction of dynamism to allow for the remodeling and, consequently, refreshing of microtubule structures. This newly discovered mechanism could have implications for reducing the risks associated with brain aging, including neurodegenerative diseases like Alzheimer's disease, through the introduction of an intervention following this transition.

Abstract: The recent observation of coherent elastic neutrino-nucleus scattering (CEvNS) with neutrinos from pion decay at rest (N-DAR) sources by the COHERENT Collaboration has raised interest in this process in the search for new physics. Unfortunately, current uncertainties in the determination of nuclear parameters relevant to those processes can hide new physics effects. This is not the case for processes involving lower-energy neutrino sources such as nuclear reactors. Note, however, that a CEvNS measurement with reactor neutrinos depends largely on a (still-missing) precise determination of the quenching factor at very low energies, making its observation more challenging. In the upcoming years, once this signal is confirmed, a combined analysis of N-DAR and reactor CEvNS experiments will be very useful to probe particle and nuclear physics, with a reduced dependence on nuclear uncertainties. In this work, we explore this idea by simultaneously testing the sensitivity of current and future CEvNS experiments to neutrino nonstandard interactions (NSIs) and the neutron root mean square (rms) radius, considering different neutrino sources as well as several detection materials. We show how the interplay between future reactor and accelerator CEvNS experiments can help to get robust constraints on the neutron rms and to break degeneracies between the NSI parameters. Our forecast could be used as a guide to optimize the experimental sensitivity to the parameters under study.