Ma, Y. Z., Vijande, J., Ballester, F., Tedgren, A. C., Granero, D., Haworth, A., et al. (2017). A generic TG-186 shielded applicator for commissioning model-based dose calculation algorithms for high-dose-rate Ir-192 brachytherapy. Med. Phys., 44(11), 5961–5976.
Abstract: PurposeA joint working group was created by the American Association of Physicists in Medicine (AAPM), the European Society for Radiotherapy and Oncology (ESTRO), and the Australasian Brachytherapy Group (ABG) with the charge, among others, to develop a set of well-defined test case plans and perform calculations and comparisons with model-based dose calculation algorithms (MBDCAs). Its main goal is to facilitate a smooth transition from the AAPM Task Group No. 43 (TG-43) dose calculation formalism, widely being used in clinical practice for brachytherapy, to the one proposed by Task Group No. 186 (TG-186) for MBDCAs. To do so, in this work a hypothetical, generic high-dose rate (HDR) Ir-192 shielded applicator has been designed and benchmarked. MethodsA generic HDR Ir-192 shielded applicator was designed based on three commercially available gynecological applicators as well as a virtual cubic water phantom that can be imported into any DICOM-RT compatible treatment planning system (TPS). The absorbed dose distribution around the applicator with the TG-186 Ir-192 source located at one dwell position at its center was computed using two commercial TPSs incorporating MBDCAs (Oncentra((R)) Brachy with Advanced Collapsed-cone Engine, ACE, and BrachyVision ACUROS) and state-of-the-art Monte Carlo (MC) codes, including ALGEBRA, BrachyDose, egs_brachy, Geant4, MCNP6, and Penelope2008. TPS-based volumetric dose distributions for the previously reported source centered in water and source displaced test cases, and the new source centered in applicator test case, were analyzed here using the MCNP6 dose distribution as a reference. Volumetric dose comparisons of TPS results against results for the other MC codes were also performed. Distributions of local and global dose difference ratios are reported. ResultsThe local dose differences among MC codes are comparable to the statistical uncertainties of the reference datasets for the source centered in water and source displaced test cases and for the clinically relevant part of the unshielded volume in the source centered in applicator case. Larger local differences appear in the shielded volume or at large distances. Considering clinically relevant regions, global dose differences are smaller than the local ones. The most disadvantageous case for the MBDCAs is the one including the shielded applicator. In this case, ACUROS agrees with MC within [-4.2%, +4.2%] for the majority of voxels (95%) while presenting dose differences within [-0.12%, +0.12%] of the dose at a clinically relevant reference point. For ACE, 95% of the total volume presents differences with respect to MC in the range [-1.7%, +0.4%] of the dose at the reference point. ConclusionsThe combination of the generic source and generic shielded applicator, together with the previously developed test cases and reference datasets (available in the Brachytherapy Source Registry), lay a solid foundation in supporting uniform commissioning procedures and direct comparisons among treatment planning systems for HDR Ir-192 brachytherapy.
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Baeza-Ballesteros, J., Hernandez, P., & Romero-Lopez, F. (2022). A lattice study of pi pi scattering at large N-c. J. High Energy Phys., 06(6), 049–39pp.
Abstract: We present the first lattice study of pion-pion scattering with varying number of colors, N-c. We use lattice simulations with four degenerate quark flavors, N-f = 4, and N-c= 3 – 6. We focus on two scattering channels that do not involve vacuum diagrams. These correspond to two irreducible representations of the SU(4) flavor group: the fully symmetric one, SS, and the fully antisymmetric one, AA. The former is a repulsive channel equivalent to the isospin-2 channel of SU(2). By contrast, the latter is attractive and only exists for N-f >= 4. A representative state is (vertical bar D-s(+) pi(+)> – vertical bar D+ K+ >) /root 2. Using Lfischer's formalism, we extract the near-threshold scattering amplitude and we match our results to Chiral Perturbation Theory (ChPT) at large N-c. For this, we compute the analytical U(N-f) ChPT prediction for two-pion scattering, and use the lattice results to constrain the N-c scaling of the relevant low-energy couplings.
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ATLAS Collaboration(Abat, E. et al), Bernabeu Verdu, J., Castillo Gimenez, V., Costa, M. J., Escobar, C., Ferrer, A., et al. (2011). A layer correlation technique for pion energy calibration at the 2004 ATLAS Combined Beam Test. J. Instrum., 6, P06001–35pp.
Abstract: A new method for calibrating the hadron response of a segmented calorimeter is developed and successfully applied to beam test data. It is based on a principal component analysis of energy deposits in the calorimeter layers, exploiting longitudinal shower development information to improve the measured energy resolution. Corrections for invisible hadronic energy and energy lost in dead material in front of and between the calorimeters of the ATLAS experiment were calculated with simulated Geant4 Monte Carlo events and used to reconstruct the energy of pions impinging on the calorimeters during the 2004 Barrel Combined Beam Test at the CERN H8 area. For pion beams with energies between 20 GeV and 180 GeV, the particle energy is reconstructed within 3% and the energy resolution is improved by between 11% and 25% compared to the resolution at the electromagnetic scale.
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Chala, M., Delgado, A., Nardini, G., & Quiros, M. (2017). A light sneutrino rescues the light stop. J. High Energy Phys., 04(4), 097–22pp.
Abstract: Stop searches in supersymmetric frameworks with R-parity conservation usually assume the lightest neutralino to be the lightest supersymmetric particle. In this paper we consider an alternative scenario in which the left-handed tau sneutrino is lighter than neutralinos and stable at collider scales, but possibly unstable at cosmological scales. Moreover the (mostly right-handed) stop (t) over tilde is lighter than all electroweakinos, and heavier than the scalars of the third generation lepton doublet, whose charged component, (T) over tilde, is heavier than the neutral one, (v) over tilde. The remaining supersymmetric particles are decoupled from the stop phenomenology. In most of the parameter space, the relevant stop decays are only into t (T) over tildeT, t (v) over tildev and b (v) over tildeT via off-shell electroweakinos. We constrain the branching ratios of these decays by recasting the most sensitive stop searches. Due to the “double invisible” kinematics of the (t) over tilde -> t (v) over tildev process, and the low efficiency in tagging the t (T) over tildeT decay products, light stops are generically allowed. In the minimal supersymmetric standard model with similar to 100 GeV sneutrinos, stops with masses as small as similar to 350 GeV turn out to be allowed at 95% CL.
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Marco-Hernandez, R., Bau, M., Ferrari, M., Ferrari, V., Pedersen, F., & Soby, L. (2017). A Low-Noise Charge Amplifier for the ELENA Trajectory, Orbit, and Intensity Measurement System. IEEE Trans. Nucl. Sci., 64(9), 2465–2473.
Abstract: A low-noise head amplifier has been developed for the extra low energy antiproton ring beam trajectory, orbit, and intensity measurement system at CERN. This system is based on 24 double-electrode electrostatic beam position monitors installed around the ring. A head amplifier is placed close to each beam position monitor to amplify the electrode signals and generate a difference and a sum signal. These signals are sent to the digital acquisition system, about 50 m away from the ring, where they are digitized and further processed. The beam position can be measured by dividing the difference signal by the sum signal while the sum signal gives information relative to the beam intensity. The head amplifier consists of two discrete charge preamplifiers with junction field effect transistor (JFET) inputs, a sum and a difference stage, and two cable drivers. Special attention has been paid to the amplifier printed circuit board design to minimize the parasitic capacitances and inductances at the charge amplifier stages to meet the gain and noise requirements. The measurements carried out on the head amplifier showed a gain of 40.5 and 46.5 dB for the sum and difference outputs with a bandwidth from 200 Hz to 75 MHz and an input voltage noise density lower than 400 pV/v Hz. Twenty head amplifiers have been already installed in the ring and they have been used to detect the first beam signals during the first commissioning stage in November 2016.
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Peppa, V., Thomson, R. M., Enger, S. A., Fonseca, G. P., Lee, C. N., Lucero, J. N. E., et al. (2023). A MC-based anthropomorphic test case for commissioning model-based dose calculation in interstitial breast 192-Ir HDR brachytherapy. Med. Phys., 50(7), 4675–4687.
Abstract: PurposeTo provide the first clinical test case for commissioning of Ir-192 brachytherapy model-based dose calculation algorithms (MBDCAs) according to the AAPM TG-186 report workflow. Acquisition and Validation MethodsA computational patient phantom model was generated from a clinical multi-catheter Ir-192 HDR breast brachytherapy case. Regions of interest (ROIs) were contoured and digitized on the patient CT images and the model was written to a series of DICOM CT images using MATLAB. The model was imported into two commercial treatment planning systems (TPSs) currently incorporating an MBDCA. Identical treatment plans were prepared using a generic Ir-192 HDR source and the TG-43-based algorithm of each TPS. This was followed by dose to medium in medium calculations using the MBDCA option of each TPS. Monte Carlo (MC) simulation was performed in the model using three different codes and information parsed from the treatment plan exported in DICOM radiation therapy (RT) format. Results were found to agree within statistical uncertainty and the dataset with the lowest uncertainty was assigned as the reference MC dose distribution. Data Format and Usage NotesThe dataset is available online at ,. Files include the treatment plan for each TPS in DICOM RT format, reference MC dose data in RT Dose format, as well as a guide for database users and all files necessary to repeat the MC simulations. Potential ApplicationsThe dataset facilitates the commissioning of brachytherapy MBDCAs using TPS embedded tools and establishes a methodology for the development of future clinical test cases. It is also useful to non-MBDCA adopters for intercomparing MBDCAs and exploring their benefits and limitations, as well as to brachytherapy researchers in need of a dosimetric and/or a DICOM RT information parsing benchmark. Limitations include specificity in terms of radionuclide, source model, clinical scenario, and MBDCA version used for its preparation.
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LHCb Collaboration(Aaij, R. et al), Garcia Martin, L. M., Henry, L., Martinez-Vidal, F., Oyanguren, A., Remon Alepuz, C., et al. (2018). A measurement of the CP asymmetry difference between Lambda(+)(C) -> pK(-)K(+) and p pi(-)pi(+) decays. J. High Energy Phys., 03(3), 182–21pp.
Abstract: The difference between the CP asymmetries in the decays Lambda(+)(C) -> pK(-)K(+) and Lambda(+)(C) -> p pi(-)pi(+) is presented. Proton-proton collision data taken at centre-of-mass energies of 7 and 8 TeV collected by the LHCb detector in 2011 and 2012 are used, corresponding to an integrated luminosity of 3 fb(-1). The Lambda(+)(C) candidates are reconstructed as part of the Lambda(0)(b) -> Lambda(+)(c)mu X- decay chain. In order to maximize the cancellation of production and detection asymmetries in the difference, the final-state kinematic distributions of the two samples are aligned by applying phase-space-dependent weights to the Lambda(+)(C) -> pK(-)K(+) sample. This alters the definition of the integrated CP asymmetry to A(CP)(wgt)(p pi(-)pi(+)). Both samples are corrected for reconstruction and selection efficiencies across the five-dimensional Lambda(+)(C) decay phase space. The difference in CP asymmetries is found to be Delta A(CP)(wgt) = A(CP)(pK(-)K(+)) – A(CP)(wgt)(p pi(-)pi(+)) = (0.30 +/- 0.91 +/- 0.61) %, where the first uncertainty is statistical and the second is systematic.
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Arganda, E., Marcano, X., Martin Lozano, V., Medina, A. D., Perez, A. D., Szewc, M., et al. (2022). A method for approximating optimal statistical significances with machine-learned likelihoods. Eur. Phys. J. C, 82(11), 993–14pp.
Abstract: Machine-learning techniques have become fundamental in high-energy physics and, for new physics searches, it is crucial to know their performance in terms of experimental sensitivity, understood as the statistical significance of the signal-plus-background hypothesis over the background-only one. We present here a simple method that combines the power of current machine-learning techniques to face high-dimensional data with the likelihood-based inference tests used in traditional analyses, which allows us to estimate the sensitivity for both discovery and exclusion limits through a single parameter of interest, the signal strength. Based on supervised learning techniques, it can perform well also with high-dimensional data, when traditional techniques cannot. We apply the method to a toy model first, so we can explore its potential, and then to a LHC study of new physics particles in dijet final states. Considering as the optimal statistical significance the one we would obtain if the true generative functions were known, we show that our method provides a better approximation than the usual naive counting experimental results.
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ANTARES Collaboration(Aguilar, J. A. et al), Bigongiari, C., Dornic, D., Emanuele, U., Gomez-Gonzalez, J. P., Hernandez-Rey, J. J., et al. (2012). A method for detection of muon induced electromagnetic showers with the ANTARES detector. Nucl. Instrum. Methods Phys. Res. A, 675, 56–62.
Abstract: The primary aim of ANTARES is neutrino astronomy with upward going muons created in charged current muon neutrino interactions in the detector and its surroundings. Downward going muons are background for neutrino searches. These muons are the decay products of cosmic-ray collisions in the Earth's atmosphere far above the detector. This paper presents a method to identify and count electromagnetic showers induced along atmospheric muon tracks with the ANTARES detector. The method is applied to both cosmic muon data and simulations and its applicability to the reconstruction of muon event energies is demonstrated.
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Contreras, T., Martins, A., Stanford, C., Escobar, C. O., Guenette, R., Stancari, M., et al. (2023). A method to characterize metalenses for light collection applications. J. Instrum., 18(9), T09004–11pp.
Abstract: Metalenses and metasurfaces are promising emerging technologies that could improve light collection in light collection detectors, concentrating light on small area photodetectors such as silicon photomultipliers. Here we present a detailed method to characterize metalenses to assess their efficiency at concentrating monochromatic light coming from a wide range of incidence angles, not taking into account their imaging quality.
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