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Author |
Peppa, V.; Thomson, R.M.; Enger, S.A.; Fonseca, G.P.; Lee, C.N.; Lucero, J.N.E.; Mourtada, F.; Siebert, F.A.; Vijande, J.; Papagiannis, P. |
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Title  |
A MC-based anthropomorphic test case for commissioning model-based dose calculation in interstitial breast 192-Ir HDR brachytherapy |
Type |
Journal Article |
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Year |
2023 |
Publication |
Medical Physics |
Abbreviated Journal |
Med. Phys. |
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Volume |
50 |
Issue |
7 |
Pages |
4675-4687 |
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Keywords |
anthropomorphic phantom; commissioning; HDR brachytherapy; model based dose calculation algorithms; Monte Carlo |
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Abstract |
PurposeTo provide the first clinical test case for commissioning of Ir-192 brachytherapy model-based dose calculation algorithms (MBDCAs) according to the AAPM TG-186 report workflow. Acquisition and Validation MethodsA computational patient phantom model was generated from a clinical multi-catheter Ir-192 HDR breast brachytherapy case. Regions of interest (ROIs) were contoured and digitized on the patient CT images and the model was written to a series of DICOM CT images using MATLAB. The model was imported into two commercial treatment planning systems (TPSs) currently incorporating an MBDCA. Identical treatment plans were prepared using a generic Ir-192 HDR source and the TG-43-based algorithm of each TPS. This was followed by dose to medium in medium calculations using the MBDCA option of each TPS. Monte Carlo (MC) simulation was performed in the model using three different codes and information parsed from the treatment plan exported in DICOM radiation therapy (RT) format. Results were found to agree within statistical uncertainty and the dataset with the lowest uncertainty was assigned as the reference MC dose distribution. Data Format and Usage NotesThe dataset is available online at ,. Files include the treatment plan for each TPS in DICOM RT format, reference MC dose data in RT Dose format, as well as a guide for database users and all files necessary to repeat the MC simulations. Potential ApplicationsThe dataset facilitates the commissioning of brachytherapy MBDCAs using TPS embedded tools and establishes a methodology for the development of future clinical test cases. It is also useful to non-MBDCA adopters for intercomparing MBDCAs and exploring their benefits and limitations, as well as to brachytherapy researchers in need of a dosimetric and/or a DICOM RT information parsing benchmark. Limitations include specificity in terms of radionuclide, source model, clinical scenario, and MBDCA version used for its preparation. |
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Address |
[Peppa, Vasiliki; Papagiannis, Panagiotis] Natl & Kapodistrian Univ Athens, Med Sch, Med Phys Lab, Athens, Greece, Email: ppapagi@med.uoa.gr |
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Wiley |
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English |
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0094-2405 |
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WOS:000989616100001 |
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no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
5529 |
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Author |
Arganda, E.; Marcano, X.; Martin Lozano, V.; Medina, A.D.; Perez, A.D.; Szewc, M.; Szynkman, A. |
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Title |
A method for approximating optimal statistical significances with machine-learned likelihoods |
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Journal Article |
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Year |
2022 |
Publication |
European Physical Journal C |
Abbreviated Journal |
Eur. Phys. J. C |
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Volume |
82 |
Issue |
11 |
Pages |
993 - 14pp |
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Abstract |
Machine-learning techniques have become fundamental in high-energy physics and, for new physics searches, it is crucial to know their performance in terms of experimental sensitivity, understood as the statistical significance of the signal-plus-background hypothesis over the background-only one. We present here a simple method that combines the power of current machine-learning techniques to face high-dimensional data with the likelihood-based inference tests used in traditional analyses, which allows us to estimate the sensitivity for both discovery and exclusion limits through a single parameter of interest, the signal strength. Based on supervised learning techniques, it can perform well also with high-dimensional data, when traditional techniques cannot. We apply the method to a toy model first, so we can explore its potential, and then to a LHC study of new physics particles in dijet final states. Considering as the optimal statistical significance the one we would obtain if the true generative functions were known, we show that our method provides a better approximation than the usual naive counting experimental results. |
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[Arganda, Ernesto; Marcano, Xabier] Inst Fis Teor UAM CSIC, C Nicolas Cabrera 13-15,Campus Cantoblanco, Madrid 28049, Spain, Email: ernesto.arganda@csic.es; |
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Springer |
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1434-6044 |
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WOS:000879175000003 |
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no |
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yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
5404 |
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Author |
Contreras, T.; Martins, A.; Stanford, C.; Escobar, C.O.; Guenette, R.; Stancari, M.; Martin-Albo, J.; Lawrence-Sanderson, B.; Para, A.; Kish, A.; Kellerer, F. |
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Title |
A method to characterize metalenses for light collection applications |
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Journal Article |
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Year |
2023 |
Publication |
Journal of Instrumentation |
Abbreviated Journal |
J. Instrum. |
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18 |
Issue |
9 |
Pages |
T09004 - 11pp |
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Abstract |
Metalenses and metasurfaces are promising emerging technologies that could improve light collection in light collection detectors, concentrating light on small area photodetectors such as silicon photomultipliers. Here we present a detailed method to characterize metalenses to assess their efficiency at concentrating monochromatic light coming from a wide range of incidence angles, not taking into account their imaging quality. |
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no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6086 |
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Author |
LHCb Collaboration (Aaij, R. et al); Jaimes Elles, S.J.; Jashal, B.K.; Martinez-Vidal, F.; Oyanguren, A.; Rebollo De Miguel, M.; Sanderswood, I.; Zhuo, J. |
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Title |
A model-independent measurement of the CKM angle γ in partially reconstructed B±→D∗h± decays with D→K0Sh+h-(h=π,K) |
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Journal Article |
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Year |
2024 |
Publication |
Journal of High Energy Physics |
Abbreviated Journal |
J. High Energy Phys. |
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Volume |
02 |
Issue |
2 |
Pages |
118 - 30pp |
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Keywords |
B Physics; CKM Angle Gamma; CP Violation; Hadron-Hadron Scattering |
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Abstract |
A measurement of CP-violating observables in B-+/-->(DK +/-)-K-& lowast; and B-+/--> D-& lowast;pi(+/-) decays is made where the photon or neutral pion from the D-& lowast;-> D gamma or D-& lowast;-> D pi(0) decay is not reconstructed. The D meson is reconstructed in the self-conjugate decay modes, D -> K-S(0)pi(+)pi(-) or D ->(KSK+K-)-K-0. The distribution of signal yields in the D decay phase space is analysed in a model-independent way. The measurement uses a data sample collected in proton-proton collisions at centre-of-mass energies of 7, 8, and 13 TeV, corresponding to a total integrated luminosity of approximately 9 fb(-1). The B-+/-->(DK +/-)-K-& lowast; and B-+/--> D-& lowast;pi(+/-) CP-violating observables are interpreted in terms of hadronic parameters and the CKM angle gamma, resulting in a measurement of gamma=(92(-17)(+21))degrees. The total uncertainty includes the statistical and systematic uncertainties, and the uncertainty due to external strong-phase inputs. |
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Address |
[Egede, U.; Fujii, Y.; Hadavizadeh, T.; Henderson, R. D. L.; Lane, J. J.; Monk, M.; Song, R.; Walton, E. J.; Ward, J. A.] Monash Univ, Sch Phys & Astron, Melbourne, Vic, Australia, Email: seophine.stanislaus@cern.ch |
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Springer |
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English |
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1029-8479 |
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Notes |
WOS:001183129400001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6106 |
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Author |
Valdes-Cortez, C.; Niatsetski, Y.; Perez-Calatayud, J.; Ballester, F.; Vijande, J. |
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Title |
A Monte Carlo study of the relative biological effectiveness in surface brachytherapy |
Type |
Journal Article |
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Year |
2022 |
Publication |
Medical Physics |
Abbreviated Journal |
Med. Phys. |
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Volume |
49 |
Issue |
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Pages |
5576-5588 |
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Keywords |
Monte Carlo; relative biological effectiveness; surface HDR brachytherapy |
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Abstract |
Purpose This work aims to simulate clustered DNA damage from ionizing radiation and estimate the relative biological effectiveness (RBE) for radionuclide (rBT)- and electronic (eBT)-based surface brachytherapy through a hybrid Monte Carlo (MC) approach, using realistic models of the sources and applicators. Methods Damage from ionizing radiation has been studied using the Monte Carlo Damage Simulation algorithm using as input the primary electron fluence simulated using a state-of-the-art MC code, PENELOPE-2018. Two Ir-192 rBT applicators, Valencia and Leipzig, one Co-60 source with a Freiburg Flap applicator (reference source), and two eBT systems, Esteya and INTRABEAM, have been included in this study implementing full realizations of their geometries as disclosed by the manufacturer. The role played by filtration and tube kilovoltage has also been addressed. Results For rBT, an RBE value of about 1.01 has been found for the applicators and phantoms considered. In the case of eBT, RBE values for the Esteya system show an almost constant RBE value of about 1.06 for all depths and materials. For INTRABEAM, variations in the range of 1.12-1.06 are reported depending on phantom composition and depth. Modifications in the Esteya system, filtration, and tube kilovoltage give rise to variations in the same range. Conclusions Current clinical practice does not incorporate biological effects in surface brachytherapy. Therefore, the same absorbed dose is administered to the patients independently on the particularities of the rBT or eBT system considered. The almost constant RBE values reported for rBT support that assumption regardless of the details of the patient geometry, the presence of a flattening filter in the applicator design, or even significant modifications in the photon energy spectra above 300 keV. That is not the case for eBT, where a clear dependence on the eBT system and the characteristics of the patient geometry are reported. A complete study specific for each eBT system, including detailed applicator characteristics (size, shape, filtering, among others) and common anatomical locations, should be performed before adopting an existing RBE value. |
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[Valdes-Cortez, Christian] Hosp Reg Antofagasta, Nucl Med Dept, Antofagasta, Chile, Email: cvalcort@gmail.com |
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Publisher |
Wiley |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Abbreviated Series Title |
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ISSN |
0094-2405 |
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Notes |
WOS:000811709400001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
5262 |
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