Abstract: The introduction of model-based dose calculation algorithms (MBDCAs) in brachytherapy provides an opportunity for a more accurate dose calculation and opens the possibility for novel, innovative treatment modalities. The joint AAPM, ESTRO, and ABG Task Group 186 (TG-186) report provided guidance to early adopters. However, the commissioning aspect of these algorithms was described only in general terms with no quantitative goals. This report, from the Working Group on Model-Based Dose Calculation Algorithms in Brachytherapy, introduced a field-tested approach to MBDCA commissioning. It is based on a set of well-characterized test cases for which reference Monte Carlo (MC) and vendor-specific MBDCA dose distributions are available in a Digital Imaging and Communications in Medicine-Radiotherapy (DICOM-RT) format to the clinical users. The key elements of the TG-186 commissioning workflow are now described in detail, and quantitative goals are provided. This approach leverages the well-known Brachytherapy Source Registry jointly managed by the AAPM and the Imaging and Radiation Oncology Core (IROC) Houston Quality Assurance Center (with associated links at ESTRO) to provide open access to test cases as well as step-by-step user guides. While the current report is limited to the two most widely commercially available MBDCAs and only for Ir-192-based afterloading brachytherapy at this time, this report establishes a general framework that can easily be extended to other brachytherapy MBDCAs and brachytherapy sources. The AAPM, ESTRO, ABG, and ABS recommend that clinical medical physicists implement the workflow presented in this report to validate both the basic and the advanced dose calculation features of their commercial MBDCAs. Recommendations are also given to vendors to integrate advanced analysis tools into their brachytherapy treatment planning system to facilitate extensive dose comparisons. The use of the test cases for research and educational purposes is further encouraged.

Abstract: The 2 nu-mediated force has a range of microns, well beyond the atomic scale. The effective potential is built from the t-channel absorptive part of the scattering amplitude and depends on neutrino properties on shell. We demonstrate that neutral aggregate matter has a weak charge and calculate the matrix of six coherent charges for its interaction with definite-mass neutrinos. Near the range of the potential the neutrino pair is nonrelativistic, leading to observable absolute mass and Dirac/Majorana distinction via different r-dependence and violation of the weak equivalence principle.

Abstract: Time of flight delay in the supernova neutrino signal offers a unique tool to set model-independent constraints on the absolute neutrino mass. The presence of a sharp time structure during a first emission phase, the so-called neutronization burst in the electron neutrino flavor time distribution, makes this channel a very powerful one. Large liquid argon underground detectors will provide precision measurements of the time dependence of the electron neutrino fluxes. We derive here a new v mass sensitivity attainable at the future DUNE far detector from a future supernova collapse in our galactic neighborhood, finding a sub-eV reach under favorable scenarios. These values are competitive with those expected for laboratory direct neutrino mass searches.

Abstract: Geodesic completeness is typically regarded as a basic criterion to determine whether a given spacetime is regular or singular. However, the principle of general covariance does not privilege any family of observers over the others and, therefore, observers with arbitrary motions should be able to provide a complete physical description of the world. This suggests that in a regular spacetime, all physically acceptable observers should have complete paths. In this work we explore this idea by studying the motion of accelerated observers in spherically symmetric spacetimes and illustrate it by considering two geodesically complete black hole spacetimes recently described in the literature. We show that for bound and locally unbound accelerations, the paths of accelerated test particles are complete, providing further support to the regularity of such spacetimes.

Abstract: The framed Standard Model (FSM) predicts a 0(+) boson with mass around 20 MeV in the “hidden sector,” which mixes at tree level with the standard Higgs hW and hence acquires small couplings to quarks and leptons which can be calculated in the FSM apart from the mixing parameter rho Uh. The exchange of this mixed state U will contribute to g – 2 and to the Lamb shift. By adjusting rho Uh alone, it is found that the FSM can satisfy all present experimental bounds on the g – 2 and Lamb shift anomalies for μand e, and for the latter for both hydrogen and deuterium. The FSM predicts also a 1(-) boson in the “hidden sector” with a mass of 17 MeV, that is, right on top of the Atomki anomaly X. This mixes with the photon at 1-loop level and couples thereby like a dark photon to quarks and leptons. It is however a compound state and is thought likely to possess additional compound couplings to hadrons. By adjusting the mixing parameter and the X's compound coupling to nucleons, the FSM can reproduce the production rate of the X in beryllium decay as well as satisfy all the bounds on X listed so far in the literature. The above two results are consistent in that the U, being 0(+), does not contribute to the Atomki anomaly if parity and angular momentum are conserved, while X, though contributing to g – 2 and Lamb shift, has smaller couplings than U and can, at first instance, be neglected there. Thus, despite the tentative nature of the three anomalies in experiment on the one hand and of the FSM as theory on the other, the accommodation of the former in the latter has strengthened the credibility of both. Indeed, if this FSM interpretation were correct, it would change the whole aspect of the anomalies from just curiosities to windows into a vast hitherto hidden sector comprising at least in part the dark matter which makes up the bulk of our universe.