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Hueso-Gonzalez, F., Casaña Copado, J. V., Fernandez Prieto, A., Gallas Torreira, A., Lemos Cid, E., Ros Garcia, A., et al. (2022). A dead-time-free data acquisition system for prompt gamma-ray measurements during proton therapy treatments. Nucl. Instrum. Methods Phys. Res. A, 1033, 166701–9pp.
Abstract: In cancer patients undergoing proton therapy, a very intense secondary radiation is produced during the treatment, which lasts around one minute. About one billion prompt gamma-rays are emitted per second, and their detection with fast scintillation detectors is useful for monitoring a correct beam delivery. To cope with the expected count rate and pile-up, as well as the scarce statistics due to the short treatment duration, we developed an eidetic data acquisition system capable of continuously digitizing the detector signal with a high sampling rate and without any dead time. By streaming the fully unprocessed waveforms to the computer, complex pile-up decomposition algorithms can be applied and optimized offline. We describe the data acquisition architecture and the multiple experimental tests designed to verify the sustained data throughput speed and the absence of dead time. While the system is tailored for the proton therapy environment, the methodology can be deployed in any other field requiring the recording of raw waveforms at high sampling rates with zero dead time.
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Valdes-Cortez, C., Niatsetski, Y., Perez-Calatayud, J., Ballester, F., & Vijande, J. (2022). A Monte Carlo study of the relative biological effectiveness in surface brachytherapy. Med. Phys., 49, 5576–5588.
Abstract: Purpose This work aims to simulate clustered DNA damage from ionizing radiation and estimate the relative biological effectiveness (RBE) for radionuclide (rBT)- and electronic (eBT)-based surface brachytherapy through a hybrid Monte Carlo (MC) approach, using realistic models of the sources and applicators. Methods Damage from ionizing radiation has been studied using the Monte Carlo Damage Simulation algorithm using as input the primary electron fluence simulated using a state-of-the-art MC code, PENELOPE-2018. Two Ir-192 rBT applicators, Valencia and Leipzig, one Co-60 source with a Freiburg Flap applicator (reference source), and two eBT systems, Esteya and INTRABEAM, have been included in this study implementing full realizations of their geometries as disclosed by the manufacturer. The role played by filtration and tube kilovoltage has also been addressed. Results For rBT, an RBE value of about 1.01 has been found for the applicators and phantoms considered. In the case of eBT, RBE values for the Esteya system show an almost constant RBE value of about 1.06 for all depths and materials. For INTRABEAM, variations in the range of 1.12-1.06 are reported depending on phantom composition and depth. Modifications in the Esteya system, filtration, and tube kilovoltage give rise to variations in the same range. Conclusions Current clinical practice does not incorporate biological effects in surface brachytherapy. Therefore, the same absorbed dose is administered to the patients independently on the particularities of the rBT or eBT system considered. The almost constant RBE values reported for rBT support that assumption regardless of the details of the patient geometry, the presence of a flattening filter in the applicator design, or even significant modifications in the photon energy spectra above 300 keV. That is not the case for eBT, where a clear dependence on the eBT system and the characteristics of the patient geometry are reported. A complete study specific for each eBT system, including detailed applicator characteristics (size, shape, filtering, among others) and common anatomical locations, should be performed before adopting an existing RBE value.
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ATLAS Collaboration(Aad, G. et al), Alvarez Piqueras, D., Barranco Navarro, L., Cabrera Urban, S., Castillo Gimenez, V., Cerda Alberich, L., et al. (2016). A search for an excited muon decaying to a muon and two jets in pp collisions at root s=8 TeV with the ATLAS detector. New J. Phys., 18, 073021–21pp.
Abstract: Anew search signature for excited leptons is explored. Excited muons are sought in the channel pp -> μmu* -> μμjet jet, assuming both the production and decay occur via a contact interaction. The analysis is based on 20.3 fb(-1) of pp collision data at a centre-of-mass energy of root s = 8 TeV taken with the ATLAS detector at the large hadron collider. No evidence of excited muons is found, and limits are set at the 95% confidence level on the cross section times branching ratio as a function of the excited-muon mass m(mu)*. For m(mu)* between 1.3 and 3.0 TeV, the upper limit on sigma B(mu* -> μq (q) over bar) is between 0.6 and 1 fb. Limits on sB are converted to lower bounds on the compositeness scale Lambda. In the limiting case Lambda = m(mu)*, excited muons with a mass below 2.8 TeV are excluded. With the same model assumptions, these limits at larger mu* masses improve upon previous limits from traditional searches based on the gauge-mediated decay mu* -> μgamma.
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NEXT Collaboration(Cebrian, S. et al), Alvarez, V., Carcel, S., Cervera-Villanueva, A., Diaz, J., Ferrario, P., et al. (2015). Accurate gamma and MeV-electron track reconstruction with an ultra-low diffusion Xenon/TMA TPC at 10 atm. Nucl. Instrum. Methods Phys. Res. A, 804, 8–24.
Abstract: We report the performance of a 10 atm Xenon/trimethylamine time projection chamber (TPC) for the detection of X-rays (30 keV) and gamma-rays (0.511-1.275 MeV) in conjunction with the accurate tracking of the associated electrons. When operated at such a high pressure and in similar to 1%-admixtures, trimethylamine (TMA) endows Xenon with an extremely low electron diffusion (1.3 +/- 0.13 mm-sigma (longitudinal), 0.95 +/- 0.20 mm-sigma (transverse) along 1 m drift) besides forming a convenient Penning-Fluorescent' mixture. The TPC, that houses 1.1 kg of gas in its fiducial volume, operated continuously for 100 live-days in charge amplification mode. The readout was performed through the recently introduced microbulk Micromegas technology and the AFTER chip, providing a 3D voxelization of 8 mm x 8 mm x 1.2 mm for approximately 10 cm/MeV-long electron tracks. Resolution in energy (epsilon) at full width half maximum (R) inside the fiducial volume ranged from R = 14.6% (30 keV) to R = 4.6% (1.275 MeV). This work was developed as part of the R&D program of the NEXT collaboration for future detector upgrades in the search of the neutrino-less double beta decay (beta beta 0 nu) in Xe-136, specifically those based on novel gas mixtures. Therefore we ultimately focus on the calorimetric and topological properties of the reconstructed MeV-electron tracks. In particular, the obtained energy resolution has been decomposed in its various contributions and improvements towards achieving the R =1.4%root MeV/epsilon levels obtained in small sensors are discussed.
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Morisi, S., & Peinado, E. (2011). Admixture of quasi-Dirac and Majorana neutrinos with tri-bimaximal mixing. Phys. Lett. B, 701(4), 451–457.
Abstract: We propose a realization of the so-called bimodal/schizophrenic model proposed recently. We assume 54, the permutation group of four objects as flavor symmetry giving tri-bimaximal lepton mixing at leading order. In these models the second massive neutrino state is assumed quasi-Dirac and the remaining neutrinos are Majorana states. In the case of inverse mass hierarchy, the lower bound on the neutrinoless double beta decay parameter m(ee) is about two times that of the usual lower bound, within the range of sensitivity of the next generation of experiments.
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