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Di Gregorio, E., Staelens, M., Hosseinkhah, N., Karimpoor, M., Liburd, J., Lim, L., et al. (2024). Raman Spectroscopy Reveals Photobiomodulation-Induced α-Helix to β-Sheet Transition in Tubulins: Potential Implications for Alzheimer's and Other Neurodegenerative Diseases. Nanomaterials, 14(13), 1093–21pp.
Abstract: In small clinical studies, the application of transcranial photobiomodulation (PBM), which typically delivers low-intensity near-infrared (NIR) to treat the brain, has led to some remarkable results in the treatment of dementia and several neurodegenerative diseases. However, despite the extensive literature detailing the mechanisms of action underlying PBM outcomes, the specific mechanisms affecting neurodegenerative diseases are not entirely clear. While large clinical trials are warranted to validate these findings, evidence of the mechanisms can explain and thus provide credible support for PBM as a potential treatment for these diseases. Tubulin and its polymerized state of microtubules have been known to play important roles in the pathology of Alzheimer's and other neurodegenerative diseases. Thus, we investigated the effects of PBM on these cellular structures in the quest for insights into the underlying therapeutic mechanisms. In this study, we employed a Raman spectroscopic analysis of the amide I band of polymerized samples of tubulin exposed to pulsed low-intensity NIR radiation (810 nm, 10 Hz, 22.5 J/cm2 dose). Peaks in the Raman fingerprint region (300-1900 cm-1)-in particular, in the amide I band (1600-1700 cm-1)-were used to quantify the percentage of protein secondary structures. Under this band, hidden signals of C=O stretching, belonging to different structures, are superimposed, producing a complex signal as a result. An accurate decomposition of the amide I band is therefore required for the reliable analysis of the conformation of proteins, which we achieved through a straightforward method employing a Voigt profile. This approach was validated through secondary structure analyses of unexposed control samples, for which comparisons with other values available in the literature could be conducted. Subsequently, using this validated method, we present novel findings of statistically significant alterations in the secondary structures of polymerized NIR-exposed tubulin, characterized by a notable decrease in alpha-helix content and a concurrent increase in beta-sheets compared to the control samples. This PBM-induced alpha-helix to beta-sheet transition connects to reduced microtubule stability and the introduction of dynamism to allow for the remodeling and, consequently, refreshing of microtubule structures. This newly discovered mechanism could have implications for reducing the risks associated with brain aging, including neurodegenerative diseases like Alzheimer's disease, through the introduction of an intervention following this transition.
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Mata, R., Cros, A., Gimeno, B., & Raboso, D. (2024). Secondary electron emission yield in thick dielectric materials: a comparison between Kelvin probe and capacitive methods. J. Phys. D, 57(40), 405302–9pp.
Abstract: The recent high demand of secondary electron emission yield (SEY) measurements in dielectric materials from space industry has driven SEY laboratories to improve their facilities and measurement techniques. SEY determination by the common capacitive method, also known as pulsed method, is well accepted and has given satisfactory results in most cases. Nevertheless, the samples under study must be prepared according to the experimental limitations of the technique, i.e. they should be manufactured separated from the devices representing faithfully the surface state of the own device and be as thin as possible. A method based on the Kelvin probe (KP) is proposed here to obtain the SEY characteristics of electrically floating Platinum, Kapton and Teflon placed over dielectric spacers with thicknesses ranging from 1.6 to 12.1 mm. The results are compared with those of the capacitive method and indicate that KP SEY curves are less sensitive to spacer thickness. An explanation based on the literature is also given. In all, we have established that KP is better suited for the analysis of dielectric samples thicker than 3 mm.
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Centelles Chulia, S., Herrero-Brocal, A., & Vicente, A. (2024). The Type-I Seesaw family. J. High Energy Phys., 07(7), 060–35pp.
Abstract: We provide a comprehensive analysis of the Type-I Seesaw family of neutrino mass models, including the conventional type-I seesaw and its low-scale variants, namely the linear and inverse seesaws. We establish that all these models essentially correspond to a particular form of the type-I seesaw in the context of explicit lepton number violation. We then focus into the more interesting scenario of spontaneous lepton number violation, systematically categorizing all inequivalent minimal models. Furthermore, we identify and flesh out specific models that feature a rich majoron phenomenology and discuss some scenarios which, despite having heavy mediators and being invisible in processes such as μ-> e gamma, predict sizable rates for decays including the majoron in the final state.
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Magalhaes, R. B., Ribeiro, G. P., Lima, H. C. D. J., Olmo, G. J., & Crispino, L. C. B. (2024). Singular space-times with bounded algebraic curvature scalars. J. Cosmol. Astropart. Phys., 05(5), 114–34pp.
Abstract: We show that the absence of unbounded algebraic curvature invariants constructed from polynomials of the Riemann tensor cannot guarantee the absence of strong singularities. As a consequence, it is not sufficient to rely solely on the analysis of such scalars to assess the regularity of a given space-time. This conclusion follows from the analysis of incomplete geodesics within the internal region of asymmetric wormholes supported by scalar matter which arise in two distinct metric-affine gravity theories. These wormholes have bounded algebraic curvature scalars everywhere, which highlights that their finiteness does not prevent the emergence of pathologies (singularities) in the geodesic structure of space-time. By analyzing the tidal forces in the internal wormhole region, we find that the angular components are unbounded along incomplete radial time-like geodesics. The strength of the singularity is determined by the evolution of Jacobi fields along such geodesics, finding that it is of strong type, as volume elements are torn apart as the singularity is approached. Lastly, and for completeness, we consider the wormhole of the quadratic Palatini theory and present an analysis of the tidal forces in the entire space-time.
Keywords: gravity; modified gravity; Wormholes
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Aguilar, A. C., Ferreira, M. N., Papavassiliou, J., & Santos, L. R. (2024). Four-gluon vertex in collinear kinematics. Eur. Phys. J. C, 84(7), 676–27pp.
Abstract: To date, the four-gluon vertex is the least explored component of the QCD Lagrangian, mainly due to the vast proliferation of Lorentz and color structures required for its description. In this work we present a nonperturbative study of this vertex, based on the one-loop dressed Schwinger-Dyson equation obtained from the 4PI effective action. A vast simplification is brought about by resorting to “collinear” kinematics, where all momenta are parallel to each other, and by appealing to the charge conjugation symmetry in order to eliminate certain color structures. Out of the fifteen form factors that comprise the transversely-projected version of this vertex, two are singled out and studied in detail; the one associated with the classical tensorial structure is moderately suppressed in the infrared regime, while the other diverges logarithmically at the origin. Quite interestingly, both form factors display the property known as “planar degeneracy” at a rather high level of accuracy. With these results we construct an effective charge that quantifies the strength of the four-gluon interaction, and compare it with other vertex-derived charges from the gauge sector of QCD.
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