Abstract: In small clinical studies, the application of transcranial photobiomodulation (PBM), which typically delivers low-intensity near-infrared (NIR) to treat the brain, has led to some remarkable results in the treatment of dementia and several neurodegenerative diseases. However, despite the extensive literature detailing the mechanisms of action underlying PBM outcomes, the specific mechanisms affecting neurodegenerative diseases are not entirely clear. While large clinical trials are warranted to validate these findings, evidence of the mechanisms can explain and thus provide credible support for PBM as a potential treatment for these diseases. Tubulin and its polymerized state of microtubules have been known to play important roles in the pathology of Alzheimer's and other neurodegenerative diseases. Thus, we investigated the effects of PBM on these cellular structures in the quest for insights into the underlying therapeutic mechanisms. In this study, we employed a Raman spectroscopic analysis of the amide I band of polymerized samples of tubulin exposed to pulsed low-intensity NIR radiation (810 nm, 10 Hz, 22.5 J/cm2 dose). Peaks in the Raman fingerprint region (300-1900 cm-1)-in particular, in the amide I band (1600-1700 cm-1)-were used to quantify the percentage of protein secondary structures. Under this band, hidden signals of C=O stretching, belonging to different structures, are superimposed, producing a complex signal as a result. An accurate decomposition of the amide I band is therefore required for the reliable analysis of the conformation of proteins, which we achieved through a straightforward method employing a Voigt profile. This approach was validated through secondary structure analyses of unexposed control samples, for which comparisons with other values available in the literature could be conducted. Subsequently, using this validated method, we present novel findings of statistically significant alterations in the secondary structures of polymerized NIR-exposed tubulin, characterized by a notable decrease in alpha-helix content and a concurrent increase in beta-sheets compared to the control samples. This PBM-induced alpha-helix to beta-sheet transition connects to reduced microtubule stability and the introduction of dynamism to allow for the remodeling and, consequently, refreshing of microtubule structures. This newly discovered mechanism could have implications for reducing the risks associated with brain aging, including neurodegenerative diseases like Alzheimer's disease, through the introduction of an intervention following this transition.

Abstract: The branching fraction B(B-0 -> D*(-)tau(+)nu(tau)) is measured relative to that of the normalization mode B-0 -> D*(-) pi(+)pi(-)pi(+) using hadronic tau(+) -> pi(+)pi(-)pi(+) (pi(0))(nu) over bar (tau) decays in proton-proton collision data at a center-of-mass energy of 13 TeV collected by the LHCb experiment, corresponding to an integrated luminosity of 2 fb(-1). The measured ratio is B(B-0 -> D*(-)tau(+)nu(tau))/B(B-0 -> D*(-) pi(+)pi(-)pi(+)) = 1.70 +/- 0.10(-0.10)(+0.11), where the first uncertainty is statistical and the second is related to systematic effects. Using established branching fractions for the B-0 -> D*(-) pi(+)pi(-)pi(+) and B-0 -> D*(-)mu(+)nu(mu) modes, the lepton universality test R(D*(-)) = B(B-0 -> D*(-)tau(+)nu(tau))/B(B-0 -> D*(-)mu(+)nu(mu)) is calculated, R(D*(-)) = 0.247 +/- 0.015 +/- 0.015 +/- 0.012, where the third uncertainty is due to the uncertainties on the external branching fractions. This result is consistent with the Standard Model prediction and with previous measurements.

Abstract: We show that the absence of unbounded algebraic curvature invariants constructed from polynomials of the Riemann tensor cannot guarantee the absence of strong singularities. As a consequence, it is not sufficient to rely solely on the analysis of such scalars to assess the regularity of a given space-time. This conclusion follows from the analysis of incomplete geodesics within the internal region of asymmetric wormholes supported by scalar matter which arise in two distinct metric-affine gravity theories. These wormholes have bounded algebraic curvature scalars everywhere, which highlights that their finiteness does not prevent the emergence of pathologies (singularities) in the geodesic structure of space-time. By analyzing the tidal forces in the internal wormhole region, we find that the angular components are unbounded along incomplete radial time-like geodesics. The strength of the singularity is determined by the evolution of Jacobi fields along such geodesics, finding that it is of strong type, as volume elements are torn apart as the singularity is approached. Lastly, and for completeness, we consider the wormhole of the quadratic Palatini theory and present an analysis of the tidal forces in the entire space-time.

Abstract: A search for K-S(L)(0) -> mu(+) mu(-) mu(+) mu(-) decays is performed using proton-proton collision data collected by the LHCb experiment at a center-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 5.1 fb(-1). No evidence for signal is found. The 90% confidence level upper limits are the first set for both decays and are B(K-S(0)) -> mu(+) mu(-) mu(+) mu(-)) < 5.1 x 10(-12) and B(K-L(0))-> mu(+) mu(-) mu(+) mu(-)) < 2.3 x 10(-9).

Abstract: This Letter presents the measurement of the fiducial and differential cross-sections of the electroweak production of a Z gamma pair in association with two jets. The analysis uses 140 fb(-1)of LHC proton-proton collision data taken at root s=13 TeV recorded by the ATLAS detector during the years 2015-2018. Events with a Zboson candidate decaying into either an e(+) e(-) or mu(+) mu(-) pair, a photon and two jets are selected. The electroweak component is extracted by requiring a large dijet invariant mass and by using the information about the centrality of the system and is measured with an observed and expected significance well above five standard deviations. The fiducial pp -> Z gamma jj cross-section for the electroweak production is measured to be 3.6 +/- 0.5fb. The total fiducial cross-section that also includes contributions where the jets arise from strong interactions is measured to be 16.8(-1.8)(+2.0) fb. The results are consistent with the Standard Model predictions. Differential cross-sections are also measured using the same events and are compared with parton-shower Monte Carlo simulations. Good agreement is observed between data and predictions.