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Author |
Di Gregorio, E.; Staelens, M.; Hosseinkhah, N.; Karimpoor, M.; Liburd, J.; Lim, L.; Shankar, K.; Tuszynski, J.A. |
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Title |
Raman Spectroscopy Reveals Photobiomodulation-Induced α-Helix to β-Sheet Transition in Tubulins: Potential Implications for Alzheimer's and Other Neurodegenerative Diseases |
Type |
Journal Article |
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Year |
2024 |
Publication  |
Nanomaterials |
Abbreviated Journal |
Nanomaterials |
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Volume |
14 |
Issue |
13 |
Pages |
1093 - 21pp |
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Keywords |
proteins; protein dynamics; protein structure; non-invasive therapies; low-level laser therapy; spectroscopy; amide bands; amide I; spectral decomposition |
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Abstract |
In small clinical studies, the application of transcranial photobiomodulation (PBM), which typically delivers low-intensity near-infrared (NIR) to treat the brain, has led to some remarkable results in the treatment of dementia and several neurodegenerative diseases. However, despite the extensive literature detailing the mechanisms of action underlying PBM outcomes, the specific mechanisms affecting neurodegenerative diseases are not entirely clear. While large clinical trials are warranted to validate these findings, evidence of the mechanisms can explain and thus provide credible support for PBM as a potential treatment for these diseases. Tubulin and its polymerized state of microtubules have been known to play important roles in the pathology of Alzheimer's and other neurodegenerative diseases. Thus, we investigated the effects of PBM on these cellular structures in the quest for insights into the underlying therapeutic mechanisms. In this study, we employed a Raman spectroscopic analysis of the amide I band of polymerized samples of tubulin exposed to pulsed low-intensity NIR radiation (810 nm, 10 Hz, 22.5 J/cm2 dose). Peaks in the Raman fingerprint region (300-1900 cm-1)-in particular, in the amide I band (1600-1700 cm-1)-were used to quantify the percentage of protein secondary structures. Under this band, hidden signals of C=O stretching, belonging to different structures, are superimposed, producing a complex signal as a result. An accurate decomposition of the amide I band is therefore required for the reliable analysis of the conformation of proteins, which we achieved through a straightforward method employing a Voigt profile. This approach was validated through secondary structure analyses of unexposed control samples, for which comparisons with other values available in the literature could be conducted. Subsequently, using this validated method, we present novel findings of statistically significant alterations in the secondary structures of polymerized NIR-exposed tubulin, characterized by a notable decrease in alpha-helix content and a concurrent increase in beta-sheets compared to the control samples. This PBM-induced alpha-helix to beta-sheet transition connects to reduced microtubule stability and the introduction of dynamism to allow for the remodeling and, consequently, refreshing of microtubule structures. This newly discovered mechanism could have implications for reducing the risks associated with brain aging, including neurodegenerative diseases like Alzheimer's disease, through the introduction of an intervention following this transition. |
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Address |
[Di Gregorio, Elisabetta; Staelens, Michael; Tuszynski, Jack A.] Univ Alberta, Fac Sci, Dept Phys, Edmonton, AB T6G 2E1, Canada, Email: michael.staelens@ific.uv.es |
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Mdpi |
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English |
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WOS:001269841000001 |
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no |
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yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6204 |
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Author |
Martins, A.; da Mota, A.F.; Stanford, C.; Contreras, T.; Martin-Albo, J.; Kish, A.; Escobar, C.O.; Para, A.; Guenette, R. |
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Title |
Simple strategy for the simulation of axially symmetric large-area metasurfaces |
Type |
Journal Article |
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Year |
2024 |
Publication |
Journal of the Optical Society of America B |
Abbreviated Journal |
J. Opt. Soc. Am. B |
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Volume |
41 |
Issue |
5 |
Pages |
1261-1269 |
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Abstract |
Metalenses are composed of nanostructures for focusing light and have been widely explored in many exciting applications. However, their expanding dimensions pose simulation challenges. We propose a method to simulate metalenses in a timely manner using vectorial wave and ray tracing models. We sample the metalens's radial phase gradient and locally approximate the phase profile by a linear phase response. Each sampling point is modeled as a binary blazed grating, employing the chosen nanostructure, to build a transfer function set. The metalens transmission or reflection is then obtained by applying the corresponding transfer function to the incoming field on the regions surrounding each sampling point. Fourier optics is used to calculate the scattered fields under arbitrary illumination for the vectorial wave method, and a Monte Carlo algorithm is used in the ray tracing formalism. We validated our method against finite -difference time domain simulations at 632 nm, and we were able to simulate metalenses larger than 3000 wavelengths in diameter on a personal computer. |
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Address |
[Martins, Augusto; Guenette, Roxanne] Univ Manchester, Dept Phys, Manchester M13 9PL, England, Email: augusto.martins@york.ac.uk |
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Optica Publishing Group |
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English |
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ISSN |
0740-3224 |
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Notes |
WOS:001237140900001 |
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no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6140 |
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Author |
Mata, R.; Cros, A.; Gimeno, B.; Raboso, D. |
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Title |
Secondary electron emission yield in thick dielectric materials: a comparison between Kelvin probe and capacitive methods |
Type |
Journal Article |
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Year |
2024 |
Publication |
Journal of Physics D |
Abbreviated Journal |
J. Phys. D |
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Volume |
57 |
Issue |
40 |
Pages |
405302 - 9pp |
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Keywords |
dielectrics; secondary electron emission yield; Multipactor in space devices |
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Abstract |
The recent high demand of secondary electron emission yield (SEY) measurements in dielectric materials from space industry has driven SEY laboratories to improve their facilities and measurement techniques. SEY determination by the common capacitive method, also known as pulsed method, is well accepted and has given satisfactory results in most cases. Nevertheless, the samples under study must be prepared according to the experimental limitations of the technique, i.e. they should be manufactured separated from the devices representing faithfully the surface state of the own device and be as thin as possible. A method based on the Kelvin probe (KP) is proposed here to obtain the SEY characteristics of electrically floating Platinum, Kapton and Teflon placed over dielectric spacers with thicknesses ranging from 1.6 to 12.1 mm. The results are compared with those of the capacitive method and indicate that KP SEY curves are less sensitive to spacer thickness. An explanation based on the literature is also given. In all, we have established that KP is better suited for the analysis of dielectric samples thicker than 3 mm. |
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Address |
[Mata, R.; Gimeno, B.] Ciudad Politecn Innovac, Val Space Consortium, Edificio 8G,Acceso B,Planta B, Valencia 46022, Spain, Email: rafael.mata@uv.es |
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Publisher |
IOP Publishing Ltd |
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English |
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ISSN |
0022-3727 |
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Notes |
WOS:001269188200001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6203 |
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Author |
CALICE Collaboration (Lai, S. et al); Irles, A. |
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Title |
Software compensation for highly granular calorimeters using machine learning |
Type |
Journal Article |
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Year |
2024 |
Publication |
Journal of Instrumentation |
Abbreviated Journal |
J. Instrum. |
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Volume |
19 |
Issue |
4 |
Pages |
P04037 - 28pp |
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Keywords |
Large detector-systems performance; Pattern recognition; cluster finding; calibration and fitting methods; Performance of High Energy Physics Detectors |
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Abstract |
A neural network for software compensation was developed for the highly granular CALICE Analogue Hadronic Calorimeter (AHCAL). The neural network uses spatial and temporal event information from the AHCAL and energy information, which is expected to improve sensitivity to shower development and the neutron fraction of the hadron shower. The neural network method produced a depth-dependent energy weighting and a time-dependent threshold for enhancing energy deposits consistent with the timescale of evaporation neutrons. Additionally, it was observed to learn an energy-weighting indicative of longitudinal leakage correction. In addition, the method produced a linear detector response and outperformed a published control method regarding resolution for every particle energy studied. |
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Address |
[Lai, S.; Utehs, J.; Wilhahn, A.] Georg August Univ Gottingen, Phys Inst 2, Friedrich Hund Pl 1, D-37077 Gottingen, Germany, Email: jack.rolph@desy.de |
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IOP Publishing Ltd |
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English |
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ISSN |
1748-0221 |
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Notes |
WOS:001230094600001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6128 |
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Author |
Bas i Beneito, A.; Gargalionis, J.; Herrero-Garcia, J.; Santamaria, A.; Schmidt, M.A. |
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Title |
An EFT approach to baryon number violation: lower limits on the new physics scale and correlations between nucleon decay modes |
Type |
Journal Article |
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Year |
2024 |
Publication |
Journal of High Energy Physics |
Abbreviated Journal |
J. High Energy Phys. |
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Volume |
07 |
Issue |
7 |
Pages |
004 - 37pp |
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Keywords |
Baryon/Lepton Number Violation; SMEFT; Specific BSM Phenomenology |
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Abstract |
Baryon number is an accidental symmetry of the Standard Model at the Lagrangian level. Its violation is arguably one of the most compelling phenomena predicted by physics beyond the Standard Model. Furthermore, there is a large experimental effort to search for it including the Hyper-K, DUNE, JUNO, and THEIA experiments. Therefore, an agnostic, model-independent, analysis of baryon number violation using the power of Effective Field Theory is very timely. In particular, in this work we study the contribution of dimension six and seven effective operators to |triangle(B – L)| = 0, 2 nucleon decays taking into account the effects of Renormalisation Group Evolution. We obtain lower limits on the energy scale of each operator and study the correlations between different decay modes. We find that for some operators the effect of running is very significant. |
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Address |
[Bas i Beneito, Arnau; Gargalionis, John; Herrero-Garcia, Juan; Santamaria, Arcadi] Univ Valencia, Dept Fis Teor, Burjassot 46100, Spain, Email: arnau.bas@ific.uv.es; |
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Springer |
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English |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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ISSN |
1029-8479 |
ISBN |
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Expedition |
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Conference |
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Notes |
WOS:001262559200004 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6181 |
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Author |
Di Bari, P.; King, S.F.; Hossain Rahat, M. |
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Title |
Gravitational waves from phase transitions and cosmic strings in neutrino mass models with multiple majorons |
Type |
Journal Article |
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Year |
2024 |
Publication |
Journal of High Energy Physics |
Abbreviated Journal |
J. High Energy Phys. |
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Volume |
05 |
Issue |
5 |
Pages |
068 - 31pp |
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Keywords |
Cosmology of Theories BSM; Early Universe Particle Physics; Phase Transitions in the Early Universe |
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Abstract |
We explore the origin of Majorana masses within the majoron model and how this can lead to the generation of a distinguishable primordial stochastic background of gravitational waves. We first show how in the simplest majoron model only a contribution from cosmic string can be within the reach of planned experiments. We then consider extensions containing multiple complex scalars, demonstrating how in this case a spectrum comprising contributions from both a strong first order phase transition and cosmic strings can naturally emerge. We show that the interplay between multiple scalar fields can amplify the phase transition signal, potentially leading to double peaks over the wideband sloped spectrum from cosmic strings. We also underscore the possibility of observing such a gravitational wave background to provide insights into the reheating temperature of the universe. We conclude highlighting how the model can be naturally combined with scenarios addressing the origin of matter of the universe, where baryogenesis occurs via leptogenesis and a right-handed neutrino plays the role of dark matter. |
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Address |
[Di Bari, Pasquale; King, Stephen F.; Rahat, Moinul Hossain] Univ Southampton, Sch Phys & Astron, Southampton SO17 1BJ, England, Email: P.Di-Bari@soton.ac.uk; |
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Publisher |
Springer |
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English |
Summary Language |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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ISSN |
1029-8479 |
ISBN |
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Conference |
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Notes |
WOS:001256020200004 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6182 |
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Author |
ATLAS Collaboration (Aad, G. et al); Aikot, A.; Amos, K.R.; Aparisi Pozo, J.A.; Bailey, A.J.; Bouchhar, N.; Cabrera Urban, S.; Cantero, J.; Cardillo, F.; Castillo Gimenez, V.; Chitishvili, M.; Costa, M.J.; Didenko, M.; Escobar, C.; Fiorini, L.; Fuster, J.; Garcia, C.; Garcia Navarro, J.E.; Gomez Delegido, A.J.; Gonzalez de la Hoz, S.; Gonzalvo Rodriguez, G.R.; Guerrero Rojas, J.G.R.; Lacasta, C.; Marti-Garcia, S.; Martinez Agullo, P.; Miralles Lopez, M.; Mitsou, V.A.; Monsonis Romero, L.; Moreno Llacer, M.; Munoz Perez, D.; Navarro-Gonzalez, J.; Poveda, J.; Prades Ibañez, A.; Rubio Jimenez, A.; Ruiz-Martinez, A.; Sabatini, P.; Saibel, A.; Salt, J.; Sanchez Sebastian, V.; Sayago Galvan, I.; Senthilkumar, V.; Soldevila, U.; Sanchez, J.; Torro Pastor, E.; Valero, A.; Valiente Moreno, E.; Valls Ferrer, J.A.; Varriale, L.; Villaplana Perez, M.; Vos, M. |
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Title |
A search for R-parity-violating supersymmetry in final states containing many jets in pp collisions at √s=13 TeV with the ATLAS detector |
Type |
Journal Article |
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Year |
2024 |
Publication |
Journal of High Energy Physics |
Abbreviated Journal |
J. High Energy Phys. |
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Volume |
05 |
Issue |
5 |
Pages |
003 - 46pp |
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Keywords |
Supersymmetry; Hadron-Hadron Scattering; Jets; Beyond Standard Model |
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Abstract |
A search for R-parity-violating supersymmetry in final states with high jet multiplicity is presented. The search uses 140 fb(-1) of proton-proton collision data at root s = 13 TeV collected by the ATLAS experiment during Run 2 of the Large Hadron Collider. The results are interpreted in the context of R-parity-violating supersymmetry models that feature prompt gluino-pair production decaying directly to three jets each or decaying to two jets and a neutralino which subsequently decays promptly to three jets. No significant excess over the Standard Model expectation is observed and exclusion limits at the 95% confidence level are extracted. Gluinos with masses up to 1800 GeV are excluded when decaying directly to three jets. In the cascade scenario, gluinos with masses up to 2340 GeV are excluded for a neutralino with mass up to 1250 GeV. |
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Address |
[Filmer, E. K.; Grant, C. M.; Jackson, P.; Kong, A. X. Y.; Pandya, H. D.; Potti, H.; Ruggeri, T. A.; Ting, E. X. L.; White, M. J.] Univ Adelaide, Dept Phys, Adelaide, SA, Australia |
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Publisher |
Springer |
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English |
Summary Language |
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Series Editor |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
1029-8479 |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:001261438700001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6207 |
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Author |
NA64 Collaboration (Andreev, Y.M. et al); Molina Bueno, L.; Tuzi, M. |
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Title |
First constraints on the Lμ – Lτ explanation of the muon g-2 anomaly from NA64-e at CERN |
Type |
Journal Article |
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Year |
2024 |
Publication |
Journal of High Energy Physics |
Abbreviated Journal |
J. High Energy Phys. |
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Volume |
07 |
Issue |
7 |
Pages |
212 - 15pp |
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Keywords |
Beyond Standard Model; Fixed Target Experiments; Dark Matter |
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Abstract |
The inclusion of an additional U(1) gauge L-mu – L-tau symmetry would release the tension between the measured and the predicted value of the anomalous muon magnetic moment: this paradigm assumes the existence of a new, light Z ' vector boson, with dominant coupling to μand tau leptons and interacting with electrons via a loop mechanism. The L-mu – L-tau model can also explain the Dark Matter relic abundance, by assuming that the Z ' boson acts as a “portal” to a new Dark Sector of particles in Nature, not charged under known interactions. In this work we present the results of the Z ' search performed by the NA64-e experiment at CERN SPS, that collected similar to 9 x 10(11) 100 GeV electrons impinging on an active thick target. Despite the suppressed Z ' production yield with an electron beam, NA64-e provides the first accelerator-based results excluding the g – 2 preferred band of the Z ' parameter space in the 1 keV < m(Z ') less than or similar to 2 MeV range, in complementarity with the limits recently obtained by the NA64-mu experiment with a muon beam. |
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Address |
[Antonov, A.; Bisio, P.; Celentano, A.; Marini, A.; Marsicano, L.] INFN Sez Genova, I-16147 Genoa, Italy, Email: luca.marsicano@ge.infn.it |
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Publisher |
Springer |
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English |
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1029-8479 |
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Notes |
WOS:001276265700010 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6218 |
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Author |
LHCb Collaboration (Aaij, R. et al); Jaimes Elles, S.J.; Jashal, B.K.; Martinez-Vidal, F.; Oyanguren, A.; Rebollo De Miguel, M.; Sanderswood, I.; Zhuo, J. |
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Title |
Search for CP violation in the phase space of D0 → KS0 K± π∓ decays with the energy test |
Type |
Journal Article |
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Year |
2024 |
Publication |
Journal of High Energy Physics |
Abbreviated Journal |
J. High Energy Phys. |
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Volume |
03 |
Issue |
3 |
Pages |
107 - 20pp |
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Keywords |
Charm Physics; CP Violation; Hadron-Hadron Scattering |
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Abstract |
A search for CP violation in D-0 -> (KSK+)-K-0 pi(-) and D-0 -> (KSK-)-K-0 pi(+) decays is reported. The search is performed using an unbinned model-independent method known as the energy test that probes local CP violation in the phase space of the decays. The data analysed correspond to an integrated luminosity of 5.4 fb(-1) collected in proton-proton collisions by the LHCb experiment at a centre-of-mass energy of root s = 13TeV, amounting to approximately 950 thousand and 620 thousand signal candidates for the D-0 -> (KSK-)-K-0 pi(+) and D-0 -> (KSK+)-K-0 pi(-) modes, respectively. The method is validated using D-0 -> K-pi(+)pi(-)pi(+) and D-0 -> K-S(0)pi(+)pi(-) decays, where CP-violating effects are expected to be negligible, and using background-enhanced regions of the signal decays. The results are consistent with CP symmetry in both the D-0 -> (KSK-)-K-0 pi(+) and the D-0 -> (KSK+)-K-0 pi(-) decays, with p-values for the hypothesis of no CP violation of 70% and 66%, respectively. |
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Address |
[Egede, U.; Fujii, Y.; Hadavizadeh, T.; Henderson, R. D. L.; Lane, J. J.; Monk, M.; Singla, M.; Song, R.; Walton, E. J.; Ward, J. A.] Monash Univ, Sch Phys & Astron, Melbourne, Vic, Australia, Email: gianluca.zunica@epfl.ch |
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Springer |
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English |
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1029-8479 |
ISBN |
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Expedition |
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Conference |
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Notes |
WOS:001190072500001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6124 |
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Author |
De Romeri, V.; Papoulias, D.K.; Ternes, C.A. |
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Title |
Light vector mediators at direct detection experiments |
Type |
Journal Article |
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Year |
2024 |
Publication |
Journal of High Energy Physics |
Abbreviated Journal |
J. High Energy Phys. |
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Volume |
05 |
Issue |
5 |
Pages |
165 - 22pp |
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Keywords |
New Gauge Interactions; New Light Particles; Specific BSM Phenomenology |
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Abstract |
Solar neutrinos induce elastic neutrino-electron scattering in dark matter direct detection experiments, resulting in detectable event rates at current facilities. We analyze recent data from the XENONnT, LUX-ZEPLIN, and PandaX-4T experiments and we derive stringent constraints on several U(1) ' extensions of the Standard Model, accommodating new neutrino-electron interactions. We provide bounds on the relevant coupling and mass of light vector mediators for a variety of models, including the anomaly-free B – L model, lepton flavor-dependent interactions like L alpha – L beta , B – 2L e – L mu,tau , B – 3L alpha , and B + 2L μ+ 2L tau models. We compare our results with other limits obtained in the literature from both terrestrial and astrophysical experiments. Finally, we present forecasts for improving current bounds with a future experiment like DARWIN. |
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Address |
[De Romeri, Valentina] Univ Valencia, Inst Fis Corpuscular, CSIC, Parc Cient UV C Catedrat Jose Beltran 2, E-46980 Paterna, Valencia, Spain, Email: deromeri@ific.uv.es; |
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Publisher |
Springer |
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English |
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ISSN |
1029-8479 |
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Notes |
WOS:001224185000004 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6132 |
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