Abstract: Recent experiments show that the top-right corner element (U-e3) of the PMNS matrix is small but nonzero, and suggest further via unitarity that it is smaller than the bottom-left corner element (U-tau 1). Here, it is shown that if to the assumption of a universal rank-one mass matrix, long favoured by phenomenologists, one adds that this matrix rotates with scale, then it follows that A) by inputting the mass ratios m(c)/m(t), m(s)/m(b), m(mu)/m(tau), and m(2)/m(3), i) the corner elements are small but nonzero, ii) V-ub < V-td, U-e3 < U-tau 1, iii) estimates result for the ratios V-ub/V-td and U-e3/U-tau 1, and B) by inputting further the experimental values of V-us, V-tb and U-e2, U-mu 3, iv) estimates result for the values of the corner elements themselves. All the inequalities and estimates obtained are consistent with present data within expectation for the approximations made.

Abstract: Here we review the current status of global fits to neutrino oscillation data within the three-flavour framework. In our analysis we include the most recent data from solar and atmospheric neutrino experiments as well as the latest results from the long-baseline accelerator neutrino experiments and the recent measurements of reactor neutrino disappearance reported by Double Chooz, Daya Bay and RENO. We present updated determinations for the two neutrino mass splittings and the three mixing angles responsible for neutrino oscillations that, for the first time, have all been measured with 1 sigma accuracies ranging from 3 to 15%. A weak sensitivity for the CP violating phase is also reported from the global analysis.

Abstract: The DEPFET collaboration develops highly granular, ultra-transparent active pixel detectors for high-performance vertex reconstruction at future collider experiments. The characterization of detector prototypes has proven that the key principle, the integration of a first amplification stage in a detector-grade sensor material, can provide a comfortable signal to noise ratio of over 40 for a sensor thickness of 50-75 μm. ASICs have been designed and produced to operate a DEPFET pixel detector with the required read-out speed. A complete detector concept is being developed, including solutions for mechanical support, cooling, and services. In this paper, the status of the DEPFET R & D project is reviewed in the light of the requirements of the vertex detector at a future linear e(+)e(-) collider.

Abstract: Hadron therapy exploits the properties of ion beams to treat tumors by maximizing the dose released to the target and sparing healthy tissue. With hadron beams, the dose distribution shows a relatively low entrance dose which rises sharply at the end of the range, providing the characteristic Bragg peak that drops quickly thereafter. It is of critical importance in order not to damage surrounding healthy tissues and/or avoid targeting underdosage to know where the delivered dose profile ends-the location of the Bragg peak. During hadron therapy, short-lived beta(+)-emitters are produced along the beam path, their distribution being correlated with the delivered dose. Following positron annihilation, two photons are emitted, which can be detected using a positron emission tomography (PET) scanner. The low yield of emitters, their short half-life, and the wash out from the target region make the use of PET, even only a few minutes after hadron irradiation, a challenging application. In-beam PET represents a potential candidate to estimate the distribution of beta(+)-emitters during or immediately after irradiation, at the cost of truncation effects and degraded image quality due to the partial rings required of the PET scanner. Time-of-flight (ToF) information can potentially be used to compensate for truncation effects and to enhance image contrast. However, the highly demanding timing performance required in ToF-PET makes this option costly. Alternatively, the use of maximum-a-posteriori-expectation-maximization (MAP-EM), including total variation (TV) in the cost function, produces images with low noise, while preserving spatial resolution. In this paper, we compare data reconstructed with maximum-likelihood-expectation-maximization (ML-EM) and MAP-EM using TV as prior, and the impact of including ToF information, from data acquired with a complete and a partial-ring PET scanner, of simulated hadron beams interacting with a polymethyl methacrylate (PMMA) target. The results show that MAP-EM, in the absence of ToF information, produces lower noise images and more similar data compared to the simulated beta(+) distributions than ML-EM with ToF information in the order of 200-600 ps. The investigation is extended to the combination of MAP-EM and ToF information to study the limit of performance using both approaches.

Abstract: In this work, the development and characterization of a multiple synchronous registers interface communicating with a high-speed serial link and using the Aurora protocol is presented. A detailed description of the developing process and the characterization methods and hardware test benches are also included. This interface will implement the slow control buses of the digitizer cards for the second generation of electronics for the Advanced GAmma Tracking Array (AGATA).