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Author |
Etxebeste, A.; Barrio, J.; Bernabeu, J.; Lacasta, C.; Llosa, G.; Muñoz, E.; Ros, A.; Oliver, J.F. |
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Title |
Study of sensitivity and resolution for full ring PET prototypes based on continuous crystals and analytical modeling of the light distribution |
Type |
Journal Article |
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Year |
2019 |
Publication  |
Physics in Medicine and Biology |
Abbreviated Journal |
Phys. Med. Biol. |
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Volume |
64 |
Issue |
3 |
Pages |
035015 - 17pp |
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Keywords |
continuous crystals; NEMA NU 4-2008; positron emission tomography (PET); Monte Carlo simulations; image reconstruction; depth of interaction |
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Abstract |
Sensitivity and spatial resolution are the main parameters to maximize in the performance of a PET scanner. For this purpose, detectors consisting of a combination of continuous crystals optically coupled to segmented photodetectors have been employed. With the use of continuous crystals the sensitivity is increased with respect to the pixelated crystals. In addition, spatial resolution is no longer limited to the crystal size. The main drawback is the difficulty in determining the interaction position. In this work, we present the characterization of the performance of a full ring based on cuboid continuous crystals coupled to SiPMs. To this end, we have employed the simulations developed in a previous work for our experimental detector head. Sensitivity could be further enhanced by using tapered crystals. This enhancement is obtained by increasing the solid angle coverage, reducing the wedge-shaped gaps between contiguous detectors. The performance of the scanners based on both crystal geometries was characterized following NEMA NU 4-2008 standardized protocol in order to compare them. An average sensitivity gain over the entire axial field of view of 13.63% has been obtained with tapered geometry while similar performance of the spatial resolution has been proven with both scanners. The activity at which NECR and true peak occur is smaller and the peak value is greater for tapered crystals than for cuboid crystals. Moreover, a higher degree of homogeneity was obtained in the sensitivity map due to the tighter packing of the crystals, which reduces the gaps and results in a better recovery of homogeneous regions than for the cuboid configuration. Some of the results obtained, such as spatial resolution, depend on the interaction position estimation and may vary if other method is employed. |
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Address |
[Etxebeste, Ane; Barrio, John; Bernabeu, Jose; Lacasta, Carlos; Llosa, Gabriela; Munoz, Enrique; Ros, Ana; Oliver, Josef F.] Univ Valencia, CSIC, Inst Fis Corpuscular, Valencia, Spain, Email: ane.etxebeste@ific.uv.es |
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Iop Publishing Ltd |
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English |
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0031-9155 |
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Conference |
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Notes |
WOS:000457182500004 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
3897 |
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Author |
Muñoz, E.; Barrientos, L.; Bernabeu, J.; Borja-Lloret, M.; Llosa, G.; Ros, A.; Roser, J.; Oliver, J.F. |
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Title |
A spectral reconstruction algorithm for two-plane Compton cameras |
Type |
Journal Article |
| |
Year |
2020 |
Publication |
Physics in Medicine and Biology |
Abbreviated Journal |
Phys. Med. Biol. |
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Volume |
65 |
Issue |
2 |
Pages |
025011 - 17pp |
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Keywords |
Compton imaging; Compton camera; hadron therapy; image reconstruction |
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Abstract |
One factor limiting the current applicability extent of hadron therapy is the lack of a reliable method for real time treatment monitoring. The use of Compton imaging systems as monitors requires the correct reconstruction of the distribution of prompt gamma productions during patient irradiation. In order to extract the maximum information from all the measurable events, we implemented a spectral reconstruction method that assigns to all events a probability of being either partial or total energy depositions. The method, implemented in a list-mode maximum likelihood expectation maximization algorithm, generates a four dimensional image in the joint spatial-spectral domain, in which the voxels containing the emission positions and energies are obtained. The analytical model used for the system response function is also employed to derive an analytical expression for the sensitivity, which is calculated via Monte Carlo integration. The performance of the method is evaluated through reconstruction of various experimental and simulated sources with different spatial and energy distributions. The results show that the proposed method can recover the spectral and spatial information simultaneously, but only under the assumption of ideal measurements. The analysis of the Monte Carlo simulations has led to the identification of two important degradation sources: the mispositioning of the gamma interaction point and the missing energy recorded in the interaction. Both factors are related to the high energy transferred to the recoil electrons, which can travel far from the interaction point and even escape the detector. These effects prevent the direct application of the current method in more realistic scenarios. Nevertheless, experimental point-like sources have been accurately reconstructed and the spatial distributions and spectral emission of complex simulated phantoms can be identified. |
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Address |
[Munoz, Enrique; Barrientos, Luis; Bernabeu, Jose; Borja-Lloret, Marina; Llosa, Gabriela; Ros, Ana; Roser, Jorge; Oliver, Josep F.] Univ Valencia, CSIC, Inst Fis Corpuscular, Valencia, Spain, Email: Enrique.Munoz@ific.uv.es |
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Iop Publishing Ltd |
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English |
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ISSN |
0031-9155 |
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Expedition |
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Conference |
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Notes |
WOS:000520111400001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
4332 |
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Author |
Roser, J.; Muñoz, E.; Barrientos, L.; Barrio, J.; Bernabeu, J.; Borja-Lloret, M.; Etxebeste, A.; Llosa, G.; Ros, A.; Viegas, R.; Oliver, J.F. |
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Title |
Image reconstruction for a multi-layer Compton telescope: an analytical model for three interaction events |
Type |
Journal Article |
| |
Year |
2020 |
Publication |
Physics in Medicine and Biology |
Abbreviated Journal |
Phys. Med. Biol. |
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Volume |
65 |
Issue |
14 |
Pages |
145005 - 17pp |
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Keywords |
Compton camera; Compton imaging; hadron therapy; image reconstruction; lm-mlem; monte carlo simulations; multi-layer Compton telescope |
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Abstract |
Compton Cameras are electronically collimated photon imagers suitable for sub-MeV to few MeV gamma-ray detection. Such features are desirable to enablein vivorange verification in hadron therapy, through the detection of secondary Prompt Gammas. A major concern with this technique is the poor image quality obtained when the incoming gamma-ray energy is unknown. Compton Cameras with more than two detector planes (multi-layer Compton Cameras) have been proposed as a solution, given that these devices incorporate more signal sequences of interactions to the conventional two interaction events. In particular, three interaction events convey more spectral information as they allow inferring directly the incident gamma-ray energy. A three-layer Compton Telescope based on continuous Lanthanum (III) Bromide crystals coupled to Silicon Photomultipliers is being developed at the IRIS group of IFIC-Valencia. In a previous work we proposed a spectral reconstruction algorithm for two interaction events based on an analytical model for the formation of the signal. To fully exploit the capabilities of our prototype, we present here an extension of the model for three interaction events. Analytical expressions of the sensitivity and the System Matrix are derived and validated against Monte Carlo simulations. Implemented in a List Mode Maximum Likelihood Expectation Maximization algorithm, the proposed model allows us to obtain four-dimensional (energy and position) images by using exclusively three interaction events. We are able to recover the correct spectrum and spatial distribution of gamma-ray sources when ideal data are employed. However, the uncertainties associated to experimental measurements result in a degradation when real data from complex structures are employed. Incorrect estimation of the incident gamma-ray interaction positions, and missing deposited energy associated with escaping secondaries, have been identified as the causes of such degradation by means of a detailed Monte Carlo study. As expected, our current experimental resolution and efficiency to three interaction events prevents us from correctly recovering complex structures of radioactive sources. However, given the better spectral information conveyed by three interaction events, we expect an improvement of the image quality of conventional Compton imaging when including such events. In this regard, future development includes the incorporation of the model assessed in this work to the two interaction events model in order to allow using simultaneously two and three interaction events in the image reconstruction. |
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Address |
[Roser, J.; Munoz, E.; Barrientos, L.; Barrio, J.; Bernabeu, J.; Borja-Lloret, M.; Etxebeste, A.; Llosa, G.; Ros, A.; Viegas, R.; Oliver, J. F.] Inst Fis Corpuscular IFIC CSIC UVEG, Valencia, Spain, Email: Jorge.Roser@ific.uv.es |
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Iop Publishing Ltd |
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English |
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ISSN |
0031-9155 |
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Expedition |
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Conference |
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Notes |
WOS:000552701600001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
4481 |
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Author |
Roser, J.; Barrientos, L.; Bernabeu, J.; Borja-Lloret, M.; Muñoz, E.; Ros, A.; Viegas, R.; Llosa, G. |
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Title |
Joint image reconstruction algorithm in Compton cameras |
Type |
Journal Article |
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Year |
2022 |
Publication |
Physics in Medicine and Biology |
Abbreviated Journal |
Phys. Med. Biol. |
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Volume |
67 |
Issue |
15 |
Pages |
155009 - 15pp |
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Keywords |
Compton camera; compton imaging; hadron therapy; image reconstruction; LM-MLEM; Monte Carlo simulations; multi-layer compton telescope |
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Abstract |
Objective. To demonstrate the benefits of using an joint image reconstruction algorithm based on the List Mode Maximum Likelihood Expectation Maximization that combines events measured in different channels of information of a Compton camera. Approach. Both simulations and experimental data are employed to show the algorithm performance. Main results. The obtained joint images present improved image quality and yield better estimates of displacements of high-energy gamma-ray emitting sources. The algorithm also provides images that are more stable than any individual channel against the noisy convergence that characterizes Maximum Likelihood based algorithms. Significance. The joint reconstruction algorithm can improve the quality and robustness of Compton camera images. It also has high versatility, as it can be easily adapted to any Compton camera geometry. It is thus expected to represent an important step in the optimization of Compton camera imaging. |
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Address |
[Roser, J.; Barrientos, L.; Bernabeu, J.; Borja-Lloret, M.; Munoz, E.; Ros, A.; Viegas, R.; Llosa, G.] CSIC UV, Inst Fis Corpuscular IFIC, Valencia, Spain, Email: Jorge.Roser@ific.uv.es |
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Publisher |
IOP Publishing Ltd |
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English |
Summary Language |
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ISSN |
0031-9155 |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:000827830200001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
5298 |
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Author |
Borja-Lloret, M.; Barrientos, L.; Bernabeu, J.; Lacasta, C.; Muñoz, E.; Ros, A.; Roser, J.; Viegas, R.; Llosa, G. |
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Title |
Influence of the background in Compton camera images for proton therapy treatment monitoring |
Type |
Journal Article |
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Year |
2023 |
Publication |
Physics in Medicine and Biology |
Abbreviated Journal |
Phys. Med. Biol. |
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Volume |
68 |
Issue |
14 |
Pages |
144001 - 16pp |
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Keywords |
Compton imaging; Compton camera; proton therapy; treatment monitoring; Monte Carlo simulation; image reconstruction; background |
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Abstract |
Objective. Background events are one of the most relevant contributions to image degradation in Compton camera imaging for hadron therapy treatment monitoring. A study of the background and its contribution to image degradation is important to define future strategies to reduce the background in the system. Approach. In this simulation study, the percentage of different kinds of events and their contribution to the reconstructed image in a two-layer Compton camera have been evaluated. To this end, GATE v8.2 simulations of a proton beam impinging on a PMMA phantom have been carried out, for different proton beam energies and at different beam intensities. Main results. For a simulated Compton camera made of Lanthanum (III) Bromide monolithic crystals, coincidences caused by neutrons arriving from the phantom are the most common type of background produced by secondary radiations in the Compton camera, causing between 13% and 33% of the detected coincidences, depending on the beam energy. Results also show that random coincidences are a significant cause of image degradation at high beam intensities, and their influence in the reconstructed images is studied for values of the time coincidence windows from 500 ps to 100 ns. Significance. Results indicate the timing capabilities required to retrieve the fall-off position with good precision. Still, the noise observed in the image when no randoms are considered make us consider further background rejection methods. |
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Address |
[Borja-Lloret, M.; Barrientos, L.; Bernabeu, J.; Lacasta, C.; Munoz, E.; Ros, A.; Roser, J.; Viegas, R.; Llosa, G.] Inst Fis Corpuscular IFIC, CSIC UV, Valencia, Spain, Email: Marina.Borja@csic.es |
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Corporate Author |
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Publisher |
IOP Publishing Ltd |
Place of Publication |
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English |
Summary Language |
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Series Editor |
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Series Volume |
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ISSN |
0031-9155 |
ISBN |
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Expedition |
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Conference |
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Notes |
WOS:001022671300001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
5571 |
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Author |
Bernabeu, J.; Mavromatos, N.E.; Villanueva-Perez, P. |
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Title |
Consistent probabilistic description of the neutral Kaon system |
Type |
Journal Article |
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Year |
2013 |
Publication |
Physics Letters B |
Abbreviated Journal |
Phys. Lett. B |
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Volume |
724 |
Issue |
4-5 |
Pages |
269-273 |
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Keywords |
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Abstract |
The neutral Kaon system has both CF violation in the mass matrix and a non-vanishing lifetime difference in the width matrix. This leads to an effective Hamiltonian which is not a normal operator, with incompatible (non-commuting) masses and widths. In the Weisskopf-Wigner Approach (WWA), by diagonalizing the entire Hamiltonian, the unphysical non-orthogonal “stationary” states K-L,K-S are obtained. These states have complex eigenvalues whose real (imaginary) part does not coincide with the eigenvalues of the mass (width). matrix. In this work we describe the system as an open Lindblad-type quantum mechanical system due to Kaon decays. This approach, in terms of density matrices for initial and final states, provides a consistent probabilistic description, avoiding the standard problems because the width matrix becomes a composite operator not included in the Hamiltonian. We consider the dominant decay channel to two pions, so that one of the Kaon states with definite lifetime becomes stable. This new approach provides results for the time dependent decay rates in agreement with those of the WWA. |
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Address |
[Bernabeu, J.; Villanueva-Perez, P.] Univ Valencia, Dept Theoret Phys, E-46100 Valencia, Spain, Email: pablo.villanueva@uv.es |
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Publisher |
Elsevier Science Bv |
Place of Publication |
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English |
Summary Language |
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Original Title |
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Series Editor |
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Abbreviated Series Title |
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Series Volume |
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Edition |
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ISSN |
0370-2693 |
ISBN |
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Conference |
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Notes |
WOS:000322358500011 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
1526 |
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Author |
Bernabeu, J.; Botella, F.J.; Nebot, M. |
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Title |
Novel T-Violation observable open to any pair of decay channels at meson factories |
Type |
Journal Article |
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Year |
2014 |
Publication |
Physics Letters B |
Abbreviated Journal |
Phys. Lett. B |
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Volume |
728 |
Issue |
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Pages |
95-98 |
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Keywords |
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Abstract |
Quantum entanglement between the two neutral mesons produced in meson factories has allowed the first indisputable direct observation of Time Reversal Violation in the time evolution of the neutral meson between the two decays. The exceptional meson transitions are directly connected to semileptonic and CP eigenstate decay channels. The possibility of extending the observable asymmetries to more decay channels confronts the problem of the “orthogonality condition”, which can be stated with this tonguetwister: Given a decay channel f, which is the decay channel f' such that the meson state not decaying to f is orthogonal to the meson state not decaying to f? In this Letter we propose an alternative T-Violation asymmetry at meson factories which allows its opening to any pair of decay channels. Instead of searching which is the pair of decay channels associated to the T-reverse meson transition, we build an asymmetry which tags the initial states of both the Reference and the T-reverse meson transitions. This observable filters the appropriate final states by means of two measurable survival probabilities. We discuss the methodology to be followed in the analysis of the new observable and the results expected in specific examples. |
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Address |
[Nebot, Miguel] Univ Valencia, Dept Fis Teor, CSIC, E-46100 Burjassot, Spain, Email: Jose.Bernabeu@uv.es; |
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Elsevier Science Bv |
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English |
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ISSN |
0370-2693 |
ISBN |
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Conference |
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Notes |
WOS:000330556000017 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
1705 |
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Author |
MoEDAL Collaboration (Acharya, B. et al); Bernabeu, J.; Garcia, C.; Mamuzic, J.; Mitsou, V.A.; Ruiz de Austri, R.; Santra, A.; Vento, V.; Vives, O. |
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Title |
Search for magnetic monopoles with the MoEDAL forward trapping detector in 2.11 fb(-1) of 13 TeV proton-proton collisions at the LHC |
Type |
Journal Article |
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Year |
2018 |
Publication |
Physics Letters B |
Abbreviated Journal |
Phys. Lett. B |
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Volume |
782 |
Issue |
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Pages |
510-516 |
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Keywords |
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Abstract |
We update our previous search for trapped magnetic monopoles in LHC Run 2 using nearly six times more integrated luminosity and including additional models for the interpretation of the data. The MoEDAL forward trapping detector, comprising 222 kg of aluminium samples, was exposed to 2.11 fb(-1) of 13 TeV proton-proton collisions near the LHCb interaction point and analysed by searching for induced persistent currents after passage through a superconducting magnetometer. Magnetic charges equal to the Dirac charge or above are excluded in all samples. The results are interpreted in Drell-Yan production models for monopoles with spins 0, 1/2 and 1: in addition to standard point-like couplings, we also consider couplings with momentum-dependent form factors. The search provides the best current laboratory constraints for monopoles with magnetic charges ranging from two to five times the Dirac charge. |
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Address |
[Acharya, B.; Alexandre, J.; Baines, S.; Ellis, J. R.; Fairbairn, M.; Mavromatos, N. E.; Sakellariadou, M.; Sarkar, S.] Kings Coll London, Dept Phys, Theoret Particle & Phys Cosmol Grp, London, England, Email: philippe.mermod@cern.ch |
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Publisher |
Elsevier Science Bv |
Place of Publication |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
0370-2693 |
ISBN |
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Medium |
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Area |
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Conference |
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Notes |
WOS:000438486900076 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
3664 |
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Author |
KLOE-2 Collaboration (Babusci, D. et al); Bernabeu, J. |
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Title |
Direct tests of T, CP, CPT symmetries in transitions of neutral K mesons with the KLOE experiment |
Type |
Journal Article |
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Year |
2023 |
Publication |
Physics Letters B |
Abbreviated Journal |
Phys. Lett. B |
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Volume |
845 |
Issue |
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Pages |
138164 - 11pp |
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Keywords |
Discrete and finite symmetries; Kaon physics; CP violation |
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Abstract |
Tests of the T, CP and CPT symmetries in the neutral kaon system are performed by the direct comparison of the probabilities of a kaon transition process to its symmetry-conjugate. The exchange of in and out states required for a genuine test involving an antiunitary transformation implied by time-reversal is implemented exploiting the entanglement of K0K0 pairs produced at a 0 -factory.A data sample collected by the KLOE experiment at DAONE corresponding to an integrated luminosity of about 1.7 fb-1 is analysed to study the At distributions of the 0 -> KSKL -> pi+pi- pi +/- e -/+ v and 0 -> KSKL -> pi +/- e -/+ v3 pi 0 processes, with At the difference of the kaon decay times. A comparison of the measured At distributions in the asymptotic region At ⠅ iS allows to test for the first time T and CPT symmetries in kaon transitions with a precision of few percent, and to observe CP violation with this novel method. |
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Address |
[Mandaglio, G.] INFN, Sez Catania, Catania, Italy, Email: eryk.czerwinski@uj.edu.pl |
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Publisher |
Elsevier |
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English |
Summary Language |
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Series Volume |
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Edition |
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ISSN |
0370-2693 |
ISBN |
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Area |
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Conference |
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Notes |
WOS:001080223500001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
5704 |
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Author |
Bernabeu, J.; Martinez-Vidal, F. |
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Title |
Colloquium: Time-reversal violation with quantum-entangled B mesons |
Type |
Journal Article |
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Year |
2015 |
Publication |
Reviews of Modern Physics |
Abbreviated Journal |
Rev. Mod. Phys. |
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Volume |
87 |
Issue |
1 |
Pages |
165-182 |
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Keywords |
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Abstract |
Symmetry transformations have been proven a bedrock tool for understanding the nature of particle interactions, formulating, and testing fundamental theories. Based on the up to now unbroken CPT symmetry, the violation of the CP symmetry between matter and antimatter by weak interactions, discovered in the decay of kaons in 1964 and observed more recently in 2001 in B mesons, strongly suggests that the behavior of these particles under weak interactions must also be asymmetric under time reversal T. However, until recent years there has not been a direct detection of the expected time-reversal violation in the time evolution of any system. This Colloquium examines the field of time-reversal symmetry breaking in the fundamental laws of physics. For transitions, its observation requires an asymmetry with exchange of initial and final states. A discussion is given of the conceptual basis for such an exchange with unstable particles, using the quantum properties of Einstein-Podolsky-Rosen entanglement available at B meson factories combined with the decay as a filtering measurement. The method allows a clear-cut separation of different transitions between flavor and CP eigenstates in the decay of neutral B mesons. These ideas have been implemented for the experiment by the BABAR Collaboration at SLAC's B factory. The results, presented in 2012, prove beyond any doubt the violation of time-reversal invariance in the time evolution between these two states of the neutral B meson. |
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Address |
[Bernabeu, J.; Martinez-Vidal, F.] Univ Valencia, CSIC, IFIC, E-46071 Valencia, Spain, Email: Jose.Bernabeu@uv.es; |
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Publisher |
Amer Physical Soc |
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Language |
English |
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ISSN |
0034-6861 |
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Notes |
WOS:000352076500001 |
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no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
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2179 |
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