Bottoni, S. et al, Gadea, A., & Perez-Vidal, R. M. (2024). Search for the γ decay of the narrow near-threshold proton resonance in 11B. Phys. Lett. B, 855, 138851–4pp.
Abstract: The y decay of the elusive narrow, near-threshold proton resonance in 11 B was investigated at Laboratori Nazionali di Legnaro (INFN) in a particle-y coincidence experiment, using the 6 Li( 6 Li,py) fusion-evaporation reaction and the GALILEO-GALTRACE setup. No clear signature was found for a possible E1 decay to the 1/2-1, – 1 , first-excited state of 11 B, predicted by the Shell Model Embedded in the Continuum (SMEC) with a branching of 0.98+167 +167 -69 x 10-3 -3 with respect to the dominant particle-decaying modes. The statistical analysis of the y-ray spectrum provided an average upper limit of 2.37 x 10-3 -3 for this y-ray branching, with a global significance of 5 sigma. On the other hand, by imposing a global confidence level of 3 sigma, a significant excess of counts was observed for Ey y = 9300(20) keV, corresponding to a resonance energy of 11429(20) keV (namely 200(20) keV above the proton separation energy of 11 B) and a y-ray branching of 1.12(35) x10-3. -3 . This result is compatible with the SMEC calculations, potentially supporting the existence of a near-threshold proton resonance in 11 B.
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Figueroa, D. G., Pieroni, M., Ricciardone, A., & Simakachorn, P. (2024). Cosmological Background Interpretation of Pulsar Timing Array Data. Phys. Rev. Lett., 132(17), 171002–9pp.
Abstract: We discuss the interpretation of the detected signal by pulsar timing array (PTA) observations as a gravitational wave background of cosmological origin. We combine NANOGrav 15-years and EPTADR2new datasets and confront them against backgrounds from supermassive black hole binaries (SMBHBs), and cosmological signals from inflation, cosmic (super)strings, first-order phase transitions, Gaussian and non-Gaussian large scalar fluctuations, and audible axions. We find that scalar-induced, and to a lesser extent audible axion and cosmic superstring signals, provide a better fit than SMBHBs. These results depend, however, on modeling assumptions, so further data and analysis are needed to reach robust conclusions. Independently of the signal origin, the data strongly constrain the parameter space of cosmological signals, for example, setting an upper bound on primordial non-Gaussianity at PTA scales as jfnlj less than or similar to 2.34 at 95% C.L.
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Sorelli, G., Gessner, M., Treps, N., & Walschaers, M. (2024). Gaussian quantum metrology for mode-encoded parameters. New J. Phys., 26(7), 073022–23pp.
Abstract: Quantum optical metrology aims to identify ultimate sensitivity bounds for the estimation of parameters encoded into quantum states of the electromagnetic field. In many practical applications, including imaging, microscopy, and remote sensing, the parameter of interest is not only encoded in the quantum state of the field, but also in its spatio-temporal distribution, i.e. in its mode structure. In this mode-encoded parameter estimation setting, we derive an analytical expression for the quantum Fisher information valid for arbitrary multimode Gaussian fields. To illustrate the power of our approach, we apply our results to the estimation of the transverse displacement of a beam and to the temporal separation between two pulses. For these examples, we show how the estimation sensitivity can be enhanced by adding squeezing into specific modes.
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Di Gregorio, E., Staelens, M., Hosseinkhah, N., Karimpoor, M., Liburd, J., Lim, L., et al. (2024). Raman Spectroscopy Reveals Photobiomodulation-Induced α-Helix to β-Sheet Transition in Tubulins: Potential Implications for Alzheimer's and Other Neurodegenerative Diseases. Nanomaterials, 14(13), 1093–21pp.
Abstract: In small clinical studies, the application of transcranial photobiomodulation (PBM), which typically delivers low-intensity near-infrared (NIR) to treat the brain, has led to some remarkable results in the treatment of dementia and several neurodegenerative diseases. However, despite the extensive literature detailing the mechanisms of action underlying PBM outcomes, the specific mechanisms affecting neurodegenerative diseases are not entirely clear. While large clinical trials are warranted to validate these findings, evidence of the mechanisms can explain and thus provide credible support for PBM as a potential treatment for these diseases. Tubulin and its polymerized state of microtubules have been known to play important roles in the pathology of Alzheimer's and other neurodegenerative diseases. Thus, we investigated the effects of PBM on these cellular structures in the quest for insights into the underlying therapeutic mechanisms. In this study, we employed a Raman spectroscopic analysis of the amide I band of polymerized samples of tubulin exposed to pulsed low-intensity NIR radiation (810 nm, 10 Hz, 22.5 J/cm2 dose). Peaks in the Raman fingerprint region (300-1900 cm-1)-in particular, in the amide I band (1600-1700 cm-1)-were used to quantify the percentage of protein secondary structures. Under this band, hidden signals of C=O stretching, belonging to different structures, are superimposed, producing a complex signal as a result. An accurate decomposition of the amide I band is therefore required for the reliable analysis of the conformation of proteins, which we achieved through a straightforward method employing a Voigt profile. This approach was validated through secondary structure analyses of unexposed control samples, for which comparisons with other values available in the literature could be conducted. Subsequently, using this validated method, we present novel findings of statistically significant alterations in the secondary structures of polymerized NIR-exposed tubulin, characterized by a notable decrease in alpha-helix content and a concurrent increase in beta-sheets compared to the control samples. This PBM-induced alpha-helix to beta-sheet transition connects to reduced microtubule stability and the introduction of dynamism to allow for the remodeling and, consequently, refreshing of microtubule structures. This newly discovered mechanism could have implications for reducing the risks associated with brain aging, including neurodegenerative diseases like Alzheimer's disease, through the introduction of an intervention following this transition.
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Mata, R., Cros, A., Gimeno, B., & Raboso, D. (2024). Secondary electron emission yield in thick dielectric materials: a comparison between Kelvin probe and capacitive methods. J. Phys. D, 57(40), 405302–9pp.
Abstract: The recent high demand of secondary electron emission yield (SEY) measurements in dielectric materials from space industry has driven SEY laboratories to improve their facilities and measurement techniques. SEY determination by the common capacitive method, also known as pulsed method, is well accepted and has given satisfactory results in most cases. Nevertheless, the samples under study must be prepared according to the experimental limitations of the technique, i.e. they should be manufactured separated from the devices representing faithfully the surface state of the own device and be as thin as possible. A method based on the Kelvin probe (KP) is proposed here to obtain the SEY characteristics of electrically floating Platinum, Kapton and Teflon placed over dielectric spacers with thicknesses ranging from 1.6 to 12.1 mm. The results are compared with those of the capacitive method and indicate that KP SEY curves are less sensitive to spacer thickness. An explanation based on the literature is also given. In all, we have established that KP is better suited for the analysis of dielectric samples thicker than 3 mm.
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