| Records |
| Author |
Di Gregorio, E.; Staelens, M.; Hosseinkhah, N.; Karimpoor, M.; Liburd, J.; Lim, L.; Shankar, K.; Tuszynski, J.A. |
| Title |
Raman Spectroscopy Reveals Photobiomodulation-Induced α-Helix to β-Sheet Transition in Tubulins: Potential Implications for Alzheimer's and Other Neurodegenerative Diseases |
Type |
Journal Article |
| Year |
2024 |
Publication |
Nanomaterials |
Abbreviated Journal |
Nanomaterials |
| Volume |
14 |
Issue |
13 |
Pages |
1093 - 21pp |
| Keywords |
proteins; protein dynamics; protein structure; non-invasive therapies; low-level laser therapy; spectroscopy; amide bands; amide I; spectral decomposition |
| Abstract |
In small clinical studies, the application of transcranial photobiomodulation (PBM), which typically delivers low-intensity near-infrared (NIR) to treat the brain, has led to some remarkable results in the treatment of dementia and several neurodegenerative diseases. However, despite the extensive literature detailing the mechanisms of action underlying PBM outcomes, the specific mechanisms affecting neurodegenerative diseases are not entirely clear. While large clinical trials are warranted to validate these findings, evidence of the mechanisms can explain and thus provide credible support for PBM as a potential treatment for these diseases. Tubulin and its polymerized state of microtubules have been known to play important roles in the pathology of Alzheimer's and other neurodegenerative diseases. Thus, we investigated the effects of PBM on these cellular structures in the quest for insights into the underlying therapeutic mechanisms. In this study, we employed a Raman spectroscopic analysis of the amide I band of polymerized samples of tubulin exposed to pulsed low-intensity NIR radiation (810 nm, 10 Hz, 22.5 J/cm2 dose). Peaks in the Raman fingerprint region (300-1900 cm-1)-in particular, in the amide I band (1600-1700 cm-1)-were used to quantify the percentage of protein secondary structures. Under this band, hidden signals of C=O stretching, belonging to different structures, are superimposed, producing a complex signal as a result. An accurate decomposition of the amide I band is therefore required for the reliable analysis of the conformation of proteins, which we achieved through a straightforward method employing a Voigt profile. This approach was validated through secondary structure analyses of unexposed control samples, for which comparisons with other values available in the literature could be conducted. Subsequently, using this validated method, we present novel findings of statistically significant alterations in the secondary structures of polymerized NIR-exposed tubulin, characterized by a notable decrease in alpha-helix content and a concurrent increase in beta-sheets compared to the control samples. This PBM-induced alpha-helix to beta-sheet transition connects to reduced microtubule stability and the introduction of dynamism to allow for the remodeling and, consequently, refreshing of microtubule structures. This newly discovered mechanism could have implications for reducing the risks associated with brain aging, including neurodegenerative diseases like Alzheimer's disease, through the introduction of an intervention following this transition. |
| Address |
[Di Gregorio, Elisabetta; Staelens, Michael; Tuszynski, Jack A.] Univ Alberta, Fac Sci, Dept Phys, Edmonton, AB T6G 2E1, Canada, Email: michael.staelens@ific.uv.es |
| Corporate Author |
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Thesis |
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| Publisher |
Mdpi |
Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
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ISBN |
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Medium |
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| Area |
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Expedition |
|
Conference |
|
Notes  |
WOS:001269841000001 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
yes |
| Call Number |
IFIC @ pastor @ |
Serial |
6204 |
| Permanent link to this record |
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| |
| Author |
Mata, R.; Cros, A.; Gimeno, B.; Raboso, D. |
| Title |
Secondary electron emission yield in thick dielectric materials: a comparison between Kelvin probe and capacitive methods |
Type |
Journal Article |
| Year |
2024 |
Publication |
Journal of Physics D |
Abbreviated Journal |
J. Phys. D |
| Volume |
57 |
Issue |
40 |
Pages |
405302 - 9pp |
| Keywords |
dielectrics; secondary electron emission yield; Multipactor in space devices |
| Abstract |
The recent high demand of secondary electron emission yield (SEY) measurements in dielectric materials from space industry has driven SEY laboratories to improve their facilities and measurement techniques. SEY determination by the common capacitive method, also known as pulsed method, is well accepted and has given satisfactory results in most cases. Nevertheless, the samples under study must be prepared according to the experimental limitations of the technique, i.e. they should be manufactured separated from the devices representing faithfully the surface state of the own device and be as thin as possible. A method based on the Kelvin probe (KP) is proposed here to obtain the SEY characteristics of electrically floating Platinum, Kapton and Teflon placed over dielectric spacers with thicknesses ranging from 1.6 to 12.1 mm. The results are compared with those of the capacitive method and indicate that KP SEY curves are less sensitive to spacer thickness. An explanation based on the literature is also given. In all, we have established that KP is better suited for the analysis of dielectric samples thicker than 3 mm. |
| Address |
[Mata, R.; Gimeno, B.] Ciudad Politecn Innovac, Val Space Consortium, Edificio 8G,Acceso B,Planta B, Valencia 46022, Spain, Email: rafael.mata@uv.es |
| Corporate Author |
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Thesis |
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| Publisher |
IOP Publishing Ltd |
Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
0022-3727 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
|
| Notes |
WOS:001269188200001 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
yes |
| Call Number |
IFIC @ pastor @ |
Serial |
6203 |
| Permanent link to this record |
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| |
| Author |
Figueroa, D.G.; Pieroni, M.; Ricciardone, A.; Simakachorn, P. |
| Title |
Cosmological Background Interpretation of Pulsar Timing Array Data |
Type |
Journal Article |
| Year |
2024 |
Publication |
Physical Review Letters |
Abbreviated Journal |
Phys. Rev. Lett. |
| Volume |
132 |
Issue |
17 |
Pages |
171002 - 9pp |
| Keywords |
|
| Abstract |
We discuss the interpretation of the detected signal by pulsar timing array (PTA) observations as a gravitational wave background of cosmological origin. We combine NANOGrav 15-years and EPTADR2new datasets and confront them against backgrounds from supermassive black hole binaries (SMBHBs), and cosmological signals from inflation, cosmic (super)strings, first-order phase transitions, Gaussian and non-Gaussian large scalar fluctuations, and audible axions. We find that scalar-induced, and to a lesser extent audible axion and cosmic superstring signals, provide a better fit than SMBHBs. These results depend, however, on modeling assumptions, so further data and analysis are needed to reach robust conclusions. Independently of the signal origin, the data strongly constrain the parameter space of cosmological signals, for example, setting an upper bound on primordial non-Gaussianity at PTA scales as jfraj less than or similar to 2.34 at 95% C.L. |
| Address |
[Figueroa, Daniel G.; Simakachorn, Peera] CSIC, Inst Fis Corpuscular, Valencia 46980, Spain |
| Corporate Author |
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Thesis |
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| Publisher |
Amer Physical Soc |
Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
0031-9007 |
ISBN |
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Medium |
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| Area |
|
Expedition |
|
Conference |
|
| Notes |
WOS:001266039300006 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
yes |
| Call Number |
IFIC @ pastor @ |
Serial |
6188 |
| Permanent link to this record |
| |
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| |
| Author |
Magalhaes, R.B.; Ribeiro, G.P.; Lima, H.C.D.J.; Olmo, G.J.; Crispino, L.C.B. |
| Title |
Singular space-times with bounded algebraic curvature scalars |
Type |
Journal Article |
| Year |
2024 |
Publication |
Journal of Cosmology and Astroparticle Physics |
Abbreviated Journal |
J. Cosmol. Astropart. Phys. |
| Volume |
05 |
Issue |
5 |
Pages |
114 - 34pp |
| Keywords |
gravity; modified gravity; Wormholes |
| Abstract |
We show that the absence of unbounded algebraic curvature invariants constructed from polynomials of the Riemann tensor cannot guarantee the absence of strong singularities. As a consequence, it is not sufficient to rely solely on the analysis of such scalars to assess the regularity of a given space-time. This conclusion follows from the analysis of incomplete geodesics within the internal region of asymmetric wormholes supported by scalar matter which arise in two distinct metric-affine gravity theories. These wormholes have bounded algebraic curvature scalars everywhere, which highlights that their finiteness does not prevent the emergence of pathologies (singularities) in the geodesic structure of space-time. By analyzing the tidal forces in the internal wormhole region, we find that the angular components are unbounded along incomplete radial time-like geodesics. The strength of the singularity is determined by the evolution of Jacobi fields along such geodesics, finding that it is of strong type, as volume elements are torn apart as the singularity is approached. Lastly, and for completeness, we consider the wormhole of the quadratic Palatini theory and present an analysis of the tidal forces in the entire space-time. |
| Address |
[Magalhaes, Renan B.; Ribeiro, Gabriel P.; Lima Jr, Haroldo C. D.; Crispino, Luis C. B.] Univ Fed Para, Programa Posgrad Fis, BR-66075110 Belem, Para, Brazil, Email: renan.magalhaes@icen.ufpa.br; |
| Corporate Author |
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Thesis |
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| Publisher |
IOP Publishing Ltd |
Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
|
Edition |
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| ISSN |
1475-7516 |
ISBN |
|
Medium |
|
| Area |
|
Expedition |
|
Conference |
|
| Notes |
WOS:001265908300012 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
yes |
| Call Number |
IFIC @ pastor @ |
Serial |
6200 |
| Permanent link to this record |
| |
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| |
| Author |
Aguilar, A.C.; Ferreira, M.N.; Papavassiliou, J.; Santos, L.R. |
| Title |
Four-gluon vertex in collinear kinematics |
Type |
Journal Article |
| Year |
2024 |
Publication |
European Physical Journal C |
Abbreviated Journal |
Eur. Phys. J. C |
| Volume |
84 |
Issue |
7 |
Pages |
676 - 27pp |
| Keywords |
|
| Abstract |
To date, the four-gluon vertex is the least explored component of the QCD Lagrangian, mainly due to the vast proliferation of Lorentz and color structures required for its description. In this work we present a nonperturbative study of this vertex, based on the one-loop dressed Schwinger-Dyson equation obtained from the 4PI effective action. A vast simplification is brought about by resorting to “collinear” kinematics, where all momenta are parallel to each other, and by appealing to the charge conjugation symmetry in order to eliminate certain color structures. Out of the fifteen form factors that comprise the transversely-projected version of this vertex, two are singled out and studied in detail; the one associated with the classical tensorial structure is moderately suppressed in the infrared regime, while the other diverges logarithmically at the origin. Quite interestingly, both form factors display the property known as “planar degeneracy” at a rather high level of accuracy. With these results we construct an effective charge that quantifies the strength of the four-gluon interaction, and compare it with other vertex-derived charges from the gauge sector of QCD. |
| Address |
[Aguilar, A. C.; Santos, L. R.] Univ Campinas UNICAMP, Inst Phys Gleb Wataghin, BR-13083859 Campinas, SP, Brazil, Email: aguilar@ifi.unicamp.br |
| Corporate Author |
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Thesis |
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| Publisher |
Springer |
Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
1434-6044 |
ISBN |
|
Medium |
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| Area |
|
Expedition |
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Conference |
|
| Notes |
WOS:001264786100001 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
yes |
| Call Number |
IFIC @ pastor @ |
Serial |
6199 |
| Permanent link to this record |
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| |
| Author |
Centelles Chulia, S.; Herrero-Brocal, A.; Vicente, A. |
| Title |
The Type-I Seesaw family |
Type |
Journal Article |
| Year |
2024 |
Publication |
Journal of High Energy Physics |
Abbreviated Journal |
J. High Energy Phys. |
| Volume |
07 |
Issue |
7 |
Pages |
060 - 35pp |
| Keywords |
Lepton Flavour Violation (charged); New Light Particles; Non-Standard Neutrino Properties; Specific BSM Phenomenology |
| Abstract |
We provide a comprehensive analysis of the Type-I Seesaw family of neutrino mass models, including the conventional type-I seesaw and its low-scale variants, namely the linear and inverse seesaws. We establish that all these models essentially correspond to a particular form of the type-I seesaw in the context of explicit lepton number violation. We then focus into the more interesting scenario of spontaneous lepton number violation, systematically categorizing all inequivalent minimal models. Furthermore, we identify and flesh out specific models that feature a rich majoron phenomenology and discuss some scenarios which, despite having heavy mediators and being invisible in processes such as μ-> e gamma, predict sizable rates for decays including the majoron in the final state. |
| Address |
[Centelles Chulia, Salvador] Max Planck Inst Kernphys, Saupfercheckweg 1, D-69117 Heidelberg, Germany, Email: chulia@mpi-hd.mpg.de; |
| Corporate Author |
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Thesis |
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| Publisher |
Springer |
Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
1029-8479 |
ISBN |
|
Medium |
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| Area |
|
Expedition |
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Conference |
|
| Notes |
WOS:001264784900001 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
yes |
| Call Number |
IFIC @ pastor @ |
Serial |
6201 |
| Permanent link to this record |
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| |
| Author |
Bas i Beneito, A.; Gargalionis, J.; Herrero-Garcia, J.; Santamaria, A.; Schmidt, M.A. |
| Title |
An EFT approach to baryon number violation: lower limits on the new physics scale and correlations between nucleon decay modes |
Type |
Journal Article |
| Year |
2024 |
Publication |
Journal of High Energy Physics |
Abbreviated Journal |
J. High Energy Phys. |
| Volume |
07 |
Issue |
7 |
Pages |
004 - 37pp |
| Keywords |
Baryon/Lepton Number Violation; SMEFT; Specific BSM Phenomenology |
| Abstract |
Baryon number is an accidental symmetry of the Standard Model at the Lagrangian level. Its violation is arguably one of the most compelling phenomena predicted by physics beyond the Standard Model. Furthermore, there is a large experimental effort to search for it including the Hyper-K, DUNE, JUNO, and THEIA experiments. Therefore, an agnostic, model-independent, analysis of baryon number violation using the power of Effective Field Theory is very timely. In particular, in this work we study the contribution of dimension six and seven effective operators to |triangle(B – L)| = 0, 2 nucleon decays taking into account the effects of Renormalisation Group Evolution. We obtain lower limits on the energy scale of each operator and study the correlations between different decay modes. We find that for some operators the effect of running is very significant. |
| Address |
[Bas i Beneito, Arnau; Gargalionis, John; Herrero-Garcia, Juan; Santamaria, Arcadi] Univ Valencia, Dept Fis Teor, Burjassot 46100, Spain, Email: arnau.bas@ific.uv.es; |
| Corporate Author |
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Thesis |
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| Publisher |
Springer |
Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
1029-8479 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
|
| Notes |
WOS:001262559200004 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
yes |
| Call Number |
IFIC @ pastor @ |
Serial |
6181 |
| Permanent link to this record |
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| Author |
Agius, D.; Essig, R.; Gaggero, D.; Scarcella, F.; Suczewski, G.; Valli, M. |
| Title |
Feedback in the dark: a critical examination of CMB bounds on primordial black holes |
Type |
Journal Article |
| Year |
2024 |
Publication |
Journal of Cosmology and Astroparticle Physics |
Abbreviated Journal |
J. Cosmol. Astropart. Phys. |
| Volume |
07 |
Issue |
7 |
Pages |
003 - 36pp |
| Keywords |
accretion; cosmological parameters from CMBR; dark matter theory; primordial black holes |
| Abstract |
If present in the early universe, primordial black holes (PBHs) would have accreted matter and emitted high-energy photons, altering the statistical properties of the Cosmic Microwave Background (CMB). This mechanism has been used to constrain the fraction of dark matter that is in the form of PBHs to be much smaller than unity for PBH masses well above one solar mass. Moreover, the presence of dense dark matter mini -halos around the PBHs has been used to set even more stringent constraints, as these would boost the accretion rates. In this work, we critically revisit CMB constraints on PBHs taking into account the role of the local ionization of the gas around them. We discuss how the local increase in temperature around PBHs can prevent the dark matter mini -halos from strongly enhancing the accretion process, in some cases significantly weakening previously derived CMB constraints. We explore in detail the key ingredients of the CMB bound and derive a conservative limit on the cosmological abundance of massive PBHs. |
| Address |
[Agius, Dominic] Univ Valencia, CSIC, Inst Fis Corpuscular, C Catedrat Jose Beltran 2, E-46980 Paterna, Spain, Email: dominic.agius@ific.uv.es; |
| Corporate Author |
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Thesis |
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| Publisher |
IOP Publishing Ltd |
Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
1475-7516 |
ISBN |
|
Medium |
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| Area |
|
Expedition |
|
Conference |
|
| Notes |
WOS:001262242300001 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
yes |
| Call Number |
IFIC @ pastor @ |
Serial |
6187 |
| Permanent link to this record |
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| |
| Author |
Ardu, M.; Davidson, S.; Lavignac, S. |
| Title |
Constraining new physics models from μ → e observables in bottom-up EFT |
Type |
Journal Article |
| Year |
2024 |
Publication |
European Physical Journal C |
Abbreviated Journal |
Eur. Phys. J. C |
| Volume |
84 |
Issue |
5 |
Pages |
458 - 36pp |
| Keywords |
|
| Abstract |
Upcoming experiments will improve the sensitivity to μ-> e processes by several orders of magnitude, and could observe lepton flavour-changing contact interactions for the first time. In this paper, we investigate what could be learned about New Physics from the measurements of these μ-> e observables, using a bottom-up effective field theory (EFT) approach and focusing on three popular models with new particles around the TeV scale (the type II seesaw, the inverse seesaw and a scalar leptoquark). We showed in a previous publication that μ-> e observables have the ability to rule out these models because none can fill the whole experimentally accessible parameter space. In this work we give more details on our EFT formalism and present more complete results. We discuss the impact of some observables complementary to μ-> e transitions (such as the neutrino mass scale and ordering, and LFV tau decays) and draw attention to the interesting appearance of Jarlskog-like invariants in our expressions for the low-energy Wilson coefficients. |
| Address |
[Ardu, Marco] Univ Valencia, Dept Fis Teor, Dr Moliner 50, Burjassot 46100, Spain, Email: marco.ardu@ific.uv.es; |
| Corporate Author |
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Thesis |
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| Publisher |
Springer |
Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
1434-6044 |
ISBN |
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Medium |
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| Area |
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Expedition |
|
Conference |
|
| Notes |
WOS:001262129500004 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
yes |
| Call Number |
IFIC @ pastor @ |
Serial |
6184 |
| Permanent link to this record |
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| Author |
ATLAS Collaboration (Aad, G. et al); Aikot, A.; Amos, K.R.; Bouchhar, N.; Cabrera Urban, S.; Cantero, J.; Castillo Gimenez, V.; Chitishvili, M.; Costa, M.J.; Curcio, F.; Didenko, M.; Escobar, C.; Fiorini, L.; Fuster, J.; Garcia, C.; Garcia Navarro, J.E.; Gomez Delegido, A.J.; Gonzalez de la Hoz, S.; Guerrero Rojas, J.G.R.; Lacasta, C.; Marti-Garcia, S.; Martinez Agullo, P.; Miralles Lopez, M.; Melini, D.; Mitsou, V.A.; Monsonis Romero, L.; Moreno Llacer, M.; Munoz Perez, D.; Navarro-Gonzalez, J.; Poveda, J.; Prades Ibañez, A.; Rubio Jimenez, A.; Ruiz-Martinez, A.; Sabatini, P.; Saibel, A.; Salt, J.; Sanchez Sebastian, V.; Sayago Galvan, I.; Senthilkumar, V.; Soldevila, U.; Sanchez, J.; Torro Pastor, E.; Valero, A.; Valiente Moreno, E.; Valls Ferrer, J.A.; Varriale, L.; Villaplana Perez, M.; Vos, M.; Zakareishvili, T. |
| Title |
Measurement of vector boson production cross sections and their ratios using pp collisions at √s=13.6 TeV with the ATLAS detector |
Type |
Journal Article |
| Year |
2024 |
Publication |
Physics Letters B |
Abbreviated Journal |
Phys. Lett. B |
| Volume |
854 |
Issue |
|
Pages |
138725 - 27pp |
| Keywords |
|
| Abstract |
Fiducial and total W+ and Z boson cross sections, their ratios and the ratio of top-antitop-quark pair and.. -boson fiducial cross sections are measured in proton-proton collisions at a centre-of-mass energy of root s = 13.6 TeV, corresponding to an integrated luminosity of 29 fb(-1) of data collected in 2022 by the ATLAS experiment at the Large Hadron Collider. The measured fiducial cross-section values for W+ -> l(+) v, W- -> l(-) v- <overline>, and Z -> l(+)l(-) (l =e or mu) boson productions are 4250 +/- 150 pb, 3310 +/- 120 pb, and 744 +/- 20 pb, respectively, where the uncertainty is the total uncertainty, including that arising from the luminosity of about 2.2%. The measurements are in agreement with Standard-Model predictions calculated at next-to-next-to-leading-order in alpha(s) ,next-to-nextto-leading logarithmic accuracy and next-to-leading-order electroweak accuracy. |
| Address |
[Filmer, E. K.; Grant, C. M.; Jackson, P.; Kong, A. X. Y.; Pandya, H. D.; Ruggeri, T. A.; Saha, S.; Ting, E. X. L.; White, M. J.] Univ Adelaide, Dept Phys, Adelaide, SA, Australia |
| Corporate Author |
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Thesis |
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| Publisher |
Elsevier |
Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
0370-2693 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
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| Notes |
WOS:001261443900001 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
yes |
| Call Number |
IFIC @ pastor @ |
Serial |
6190 |
| Permanent link to this record |
