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Author |
Di Gregorio, E.; Staelens, M.; Hosseinkhah, N.; Karimpoor, M.; Liburd, J.; Lim, L.; Shankar, K.; Tuszynski, J.A. |
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Title |
Raman Spectroscopy Reveals Photobiomodulation-Induced α-Helix to β-Sheet Transition in Tubulins: Potential Implications for Alzheimer's and Other Neurodegenerative Diseases |
Type |
Journal Article |
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Year |
2024 |
Publication |
Nanomaterials |
Abbreviated Journal |
Nanomaterials |
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Volume |
14 |
Issue |
13 |
Pages |
1093 - 21pp |
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Keywords |
proteins; protein dynamics; protein structure; non-invasive therapies; low-level laser therapy; spectroscopy; amide bands; amide I; spectral decomposition |
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Abstract |
In small clinical studies, the application of transcranial photobiomodulation (PBM), which typically delivers low-intensity near-infrared (NIR) to treat the brain, has led to some remarkable results in the treatment of dementia and several neurodegenerative diseases. However, despite the extensive literature detailing the mechanisms of action underlying PBM outcomes, the specific mechanisms affecting neurodegenerative diseases are not entirely clear. While large clinical trials are warranted to validate these findings, evidence of the mechanisms can explain and thus provide credible support for PBM as a potential treatment for these diseases. Tubulin and its polymerized state of microtubules have been known to play important roles in the pathology of Alzheimer's and other neurodegenerative diseases. Thus, we investigated the effects of PBM on these cellular structures in the quest for insights into the underlying therapeutic mechanisms. In this study, we employed a Raman spectroscopic analysis of the amide I band of polymerized samples of tubulin exposed to pulsed low-intensity NIR radiation (810 nm, 10 Hz, 22.5 J/cm2 dose). Peaks in the Raman fingerprint region (300-1900 cm-1)-in particular, in the amide I band (1600-1700 cm-1)-were used to quantify the percentage of protein secondary structures. Under this band, hidden signals of C=O stretching, belonging to different structures, are superimposed, producing a complex signal as a result. An accurate decomposition of the amide I band is therefore required for the reliable analysis of the conformation of proteins, which we achieved through a straightforward method employing a Voigt profile. This approach was validated through secondary structure analyses of unexposed control samples, for which comparisons with other values available in the literature could be conducted. Subsequently, using this validated method, we present novel findings of statistically significant alterations in the secondary structures of polymerized NIR-exposed tubulin, characterized by a notable decrease in alpha-helix content and a concurrent increase in beta-sheets compared to the control samples. This PBM-induced alpha-helix to beta-sheet transition connects to reduced microtubule stability and the introduction of dynamism to allow for the remodeling and, consequently, refreshing of microtubule structures. This newly discovered mechanism could have implications for reducing the risks associated with brain aging, including neurodegenerative diseases like Alzheimer's disease, through the introduction of an intervention following this transition. |
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Address |
[Di Gregorio, Elisabetta; Staelens, Michael; Tuszynski, Jack A.] Univ Alberta, Fac Sci, Dept Phys, Edmonton, AB T6G 2E1, Canada, Email: michael.staelens@ific.uv.es |
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Mdpi |
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WOS:001269841000001 |
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no |
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yes |
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yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6204 |
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Author |
Mata, R.; Cros, A.; Gimeno, B.; Raboso, D. |
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Title |
Secondary electron emission yield in thick dielectric materials: a comparison between Kelvin probe and capacitive methods |
Type |
Journal Article |
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Year |
2024 |
Publication |
Journal of Physics D |
Abbreviated Journal |
J. Phys. D |
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Volume |
57 |
Issue |
40 |
Pages |
405302 - 9pp |
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Keywords |
dielectrics; secondary electron emission yield; Multipactor in space devices |
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Abstract |
The recent high demand of secondary electron emission yield (SEY) measurements in dielectric materials from space industry has driven SEY laboratories to improve their facilities and measurement techniques. SEY determination by the common capacitive method, also known as pulsed method, is well accepted and has given satisfactory results in most cases. Nevertheless, the samples under study must be prepared according to the experimental limitations of the technique, i.e. they should be manufactured separated from the devices representing faithfully the surface state of the own device and be as thin as possible. A method based on the Kelvin probe (KP) is proposed here to obtain the SEY characteristics of electrically floating Platinum, Kapton and Teflon placed over dielectric spacers with thicknesses ranging from 1.6 to 12.1 mm. The results are compared with those of the capacitive method and indicate that KP SEY curves are less sensitive to spacer thickness. An explanation based on the literature is also given. In all, we have established that KP is better suited for the analysis of dielectric samples thicker than 3 mm. |
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Address |
[Mata, R.; Gimeno, B.] Ciudad Politecn Innovac, Val Space Consortium, Edificio 8G,Acceso B,Planta B, Valencia 46022, Spain, Email: rafael.mata@uv.es |
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IOP Publishing Ltd |
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English |
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0022-3727 |
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WOS:001269188200001 |
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no |
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yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6203 |
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Author |
Maluf, R.V.; Mora-Perez, G.; Olmo, G.J.; Rubiera-Garcia, D. |
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Title |
Nonsingular, Lump-like, Scalar Compact Objects in (2+1)-Dimensional Einstein Gravity |
Type |
Journal Article |
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Year |
2024 |
Publication |
Universe |
Abbreviated Journal |
Universe |
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Volume |
10 |
Issue |
6 |
Pages |
258 - 13pp |
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Keywords |
Einstein gravity; compact objects; nonlinear scalar field |
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Abstract |
We study the space-time geometry generated by coupling a free scalar field with a noncanonical kinetic term to general relativity in (2+1) dimensions. After identifying a family of scalar Lagrangians that yield exact analytical solutions in static and circularly symmetric scenarios, we classify the various types of solutions and focus on a branch that yields asymptotically flat geometries. We show that the solutions within such a branch can be divided in two types, namely naked singularities and nonsingular objects without a center. In the latter, the energy density is localized around a maximum and vanishes only at infinity and at an inner boundary. This boundary has vanishing curvatures and cannot be reached by any time-like or null geodesic in finite affine time. This allows us to consistently interpret such solutions as nonsingular, lump-like, static compact scalar objects whose eventual extension to the (3+1)-dimensional context could provide structures of astrophysical interest. |
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Address |
[Maluf, Roberto V.; Olmo, Gonzalo J.] Univ Fed Ceara UFC, Dept Fis, Campus Pici, BR-60455760 Fortaleza, Ceara, Brazil, Email: r.v.maluf@fisica.ufc.br; |
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Mdpi |
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English |
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Notes |
WOS:001256495600001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6169 |
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Author |
Chu, X.Y.; Garani, R.; Garcia-Cely, C.; Hambye, T. |
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Title |
Dark matter bound-state formation in the Sun |
Type |
Journal Article |
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Year |
2024 |
Publication |
Journal of High Energy Physics |
Abbreviated Journal |
J. High Energy Phys. |
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Volume |
05 |
Issue |
5 |
Pages |
045 - 32pp |
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Keywords |
Models for Dark Matter; Specific BSM Phenomenology; Neutrino Interactions; Early Universe Particle Physics |
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Abstract |
The Sun may capture asymmetric dark matter (DM), which can subsequently form bound-states through the radiative emission of a sub-GeV scalar. This process enables generation of scalars without requiring DM annihilation. In addition to DM capture on nucleons, the DM-scalar coupling responsible for bound-state formation also induces capture from self-scatterings of ambient DM particles with DM particles already captured, as well as with DM bound-states formed in-situ within the Sun. This scenario is studied in detail by solving Boltzmann equations numerically and analytically. In particular, we take into consideration that the DM self-capture rates require a treatment beyond the conventional Born approximation. We show that, thanks to DM scatterings on bound-states, the number of DM particles captured increases exponentially, leading to enhanced emission of relativistic scalars through bound-state formation, whose final decay products could be observable. We explore phenomenological signatures with the example that the scalar mediator decays to neutrinos. We find that the neutrino flux emitted can be comparable to atmospheric neutrino fluxes within the range of energies below one hundred MeV. Future facilities like Hyper-K, and direct DM detection experiments can further test such scenario. |
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Address |
[Chu, Xiaoyong] Austrian Acad Sci, Inst High Energy Phys, Nikolsdorfer Gasse 18, A-1050 Vienna, Austria, Email: xiaoyong.chu@oeaw.ac.at; |
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Springer |
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English |
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1029-8479 |
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Notes |
WOS:001255993100008 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6172 |
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Author |
Escrihuela, F.J.; Flores, L.J.; Miranda, O.G.; Rendon, J.; Sanchez-Velez, R. |
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Title |
Examining the sensitivity of FASERν to generalized neutrino interactions |
Type |
Journal Article |
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Year |
2024 |
Publication |
Journal of High Energy Physics |
Abbreviated Journal |
J. High Energy Phys. |
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Volume |
04 |
Issue |
4 |
Pages |
102 - 25pp |
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Keywords |
Non-Standard Neutrino Properties; Neutrino Interactions; Electroweak Precision Physics |
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Abstract |
We investigate the sensitivity of the FASER nu detector, a novel experimental setup at the LHC, to probe and constrain generalized neutrino interactions (GNI). Employing a comprehensive theoretical framework, we model the effects of generalized neutrino interactions on neutrino-nucleon deep inelastic scattering processes within the FASER nu detector. By considering all the neutrino channels produced at the LHC, we perform a statistical analysis to determine the sensitivity of FASER nu to constrain these interactions. Our results demonstrate that FASER nu can place stringent constraints on the GNI effective couplings. Additionally, we study the relation between GNI and a minimal Leptoquark model where the SM is augmented by a singlet Leptoquark with hypercharge 1/3. We have found that the sensitivities for various combinations of the Leptoquark Yukawa couplings are approximately O(1), particularly when considering a Leptoquark mass in the TeV range. |
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Address |
[Escrihuela, F. J.] Univ Valencia, CSIC, Inst Fis Corpuscular, AHEP Grp, Parc Cientif Paterna,C Catedrat Jose Beltran 2, E-46980 Paterna, Valencia, Spain, Email: franesfe@alumni.uv.es; |
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Springer |
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English |
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1029-8479 |
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Notes |
WOS:001255987500005 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6176 |
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Author |
Giachino, A.; van Hameren, A.; Ziarko, G. |
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Title |
A new subtraction scheme at NLO exploiting the privilege of k<sub>T</sub>-factorization |
Type |
Journal Article |
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Year |
2024 |
Publication |
Journal of High Energy Physics |
Abbreviated Journal |
J. High Energy Phys. |
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Volume |
06 |
Issue |
6 |
Pages |
167 - 39pp |
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Keywords |
Higher-Order Perturbative Calculations; Deep Inelastic Scattering or Small-x Physics; Factorization; Renormalization Group |
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Abstract |
We present a subtraction method for the calculation of real-radiation integrals at NLO in hybrid k(T)-factorization. The main difference with existing methods for collinear factorization is that we subtract the momentum recoil, occurring due to the mapping from an (n + 1)-particle phase space to an n-particle phase space, from the initial-state momenta, instead of distributing it over the final-state momenta. |
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Address |
[Giachino, Alessandro; van Hameren, Andreas; Ziarko, Grzegorz] Polish Acad Sci, Inst Nucl Phys, PL-31342 Krakow, Poland, Email: Alessandro.Giachino@ific.uv.es; |
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Springer |
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English |
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ISSN |
1029-8479 |
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Notes |
WOS:001254801000006 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6175 |
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Author |
Kalliokoski, M.; Mitsou, V.A.; de Montigny, M.; Mukhopadhyay, A.; Ouimet, P.P.A.; Pinfold, J.; Shaa, A.; Staelens, M. |
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Title |
Searching for minicharged particles at the energy frontier with the MoEDAL-MAPP experiment at the LHC |
Type |
Journal Article |
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Year |
2024 |
Publication |
Journal of High Energy Physics |
Abbreviated Journal |
J. High Energy Phys. |
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Volume |
04 |
Issue |
4 |
Pages |
137 - 22pp |
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Keywords |
Dark Matter at Colliders; Models for Dark Matter; New Gauge Interactions; Specific BSM Phenomenology |
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Abstract |
The MoEDAL's Apparatus for Penetrating Particles (MAPP) Experiment is designed to expand the search for new physics at the LHC, significantly extending the physics program of the baseline MoEDAL Experiment. The Phase-1 MAPP detector (MAPP-1) is currently undergoing installation at the LHC's UA83 gallery adjacent to the LHCb/MoEDAL region at Interaction Point 8 and will begin data-taking in early 2024. The focus of the MAPP experiment is on the quest for new feebly interacting particles – avatars of new physics with extremely small Standard Model couplings, such as minicharged particles (mCPs). In this study, we present the results of a comprehensive analysis of MAPP-1's sensitivity to mCPs arising in the canonical model involving the kinetic mixing of a massless dark U(1) gauge field with the Standard Model hypercharge gauge field. We focus on several dominant production mechanisms of mCPs at the LHC across the mass-mixing parameter space of interest to MAPP: Drell-Yan pair production, direct decays of heavy quarkonia and light vector mesons, and single Dalitz decays of pseudoscalar mesons. The 95% confidence level background-free sensitivity of MAPP-1 for mCPs produced at the LHC's Run 3 and the HL-LHC through these mechanisms, along with projected constraints on the minicharged strongly interacting dark matter window, are reported. Our results indicate that MAPP-1 exhibits sensitivity to sizable regions of unconstrained parameter space and can probe effective charges as low as 8 x 10 -4 e and 6 x 10 -4 e for Run 3 and the HL-LHC, respectively. |
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Address |
[Kalliokoski, Matti] Univ Helsinki, Helsinki Inst Phys, Helsinki 00014, Finland, Email: matti.kalliokoski@helsinki.fi; |
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Springer |
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English |
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1029-8479 |
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Notes |
WOS:001232666600002 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6148 |
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Author |
CALICE Collaboration (Lai, S. et al); Irles, A. |
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Title |
Software compensation for highly granular calorimeters using machine learning |
Type |
Journal Article |
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Year |
2024 |
Publication |
Journal of Instrumentation |
Abbreviated Journal |
J. Instrum. |
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Volume |
19 |
Issue |
4 |
Pages |
P04037 - 28pp |
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Keywords |
Large detector-systems performance; Pattern recognition; cluster finding; calibration and fitting methods; Performance of High Energy Physics Detectors |
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Abstract |
A neural network for software compensation was developed for the highly granular CALICE Analogue Hadronic Calorimeter (AHCAL). The neural network uses spatial and temporal event information from the AHCAL and energy information, which is expected to improve sensitivity to shower development and the neutron fraction of the hadron shower. The neural network method produced a depth-dependent energy weighting and a time-dependent threshold for enhancing energy deposits consistent with the timescale of evaporation neutrons. Additionally, it was observed to learn an energy-weighting indicative of longitudinal leakage correction. In addition, the method produced a linear detector response and outperformed a published control method regarding resolution for every particle energy studied. |
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Address |
[Lai, S.; Utehs, J.; Wilhahn, A.] Georg August Univ Gottingen, Phys Inst 2, Friedrich Hund Pl 1, D-37077 Gottingen, Germany, Email: jack.rolph@desy.de |
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IOP Publishing Ltd |
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English |
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ISSN |
1748-0221 |
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Notes |
WOS:001230094600001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6128 |
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Author |
De Romeri, V.; Papoulias, D.K.; Ternes, C.A. |
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Title |
Light vector mediators at direct detection experiments |
Type |
Journal Article |
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Year |
2024 |
Publication |
Journal of High Energy Physics |
Abbreviated Journal |
J. High Energy Phys. |
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Volume |
05 |
Issue |
5 |
Pages |
165 - 22pp |
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Keywords |
New Gauge Interactions; New Light Particles; Specific BSM Phenomenology |
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Abstract |
Solar neutrinos induce elastic neutrino-electron scattering in dark matter direct detection experiments, resulting in detectable event rates at current facilities. We analyze recent data from the XENONnT, LUX-ZEPLIN, and PandaX-4T experiments and we derive stringent constraints on several U(1) ' extensions of the Standard Model, accommodating new neutrino-electron interactions. We provide bounds on the relevant coupling and mass of light vector mediators for a variety of models, including the anomaly-free B – L model, lepton flavor-dependent interactions like L alpha – L beta , B – 2L e – L mu,tau , B – 3L alpha , and B + 2L μ+ 2L tau models. We compare our results with other limits obtained in the literature from both terrestrial and astrophysical experiments. Finally, we present forecasts for improving current bounds with a future experiment like DARWIN. |
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Address |
[De Romeri, Valentina] Univ Valencia, Inst Fis Corpuscular, CSIC, Parc Cient UV C Catedrat Jose Beltran 2, E-46980 Paterna, Valencia, Spain, Email: deromeri@ific.uv.es; |
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Springer |
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English |
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1029-8479 |
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Notes |
WOS:001224185000004 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6132 |
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Author |
LHCb Collaboration (Aaij, R. et al); Jaimes Elles, S.J.; Jashal, B.K.; Martinez-Vidal, F.; Oyanguren, A.; Rebollo De Miguel, M.; Sanderswood, I.; Zhuo, J. |
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Title |
Prompt and nonprompt ψ(2S) production in pPb collisions at √sNN = 8.16 TeV |
Type |
Journal Article |
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Year |
2024 |
Publication |
Journal of High Energy Physics |
Abbreviated Journal |
J. High Energy Phys. |
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Volume |
04 |
Issue |
4 |
Pages |
111 - 52pp |
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Keywords |
QCD; Heavy Quark Production; Particle and Resonance Production; Hadron-Hadron Scattering |
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Abstract |
The production of psi(2S) mesons in proton-lead collisions at a centre-of-mass energy per nucleon pair of root s(NN) = 8.16TeV is studied with the LHCb detector using data corresponding to an integrated luminosity of 34 nb(-1). The prompt and nonprompt psi(2S) production cross-sections and the ratio of the psi(2S) to J/psi cross-section are measured as a function of the meson transverse momentum and rapidity in the nucleon-nucleon centre-of-mass frame, together with forward-to-backward ratios and nuclear modification factors. The production of prompt psi(2S) is observed to be more suppressed compared to pp collisions than the prompt J/psi production, while the nonprompt productions have similar suppression factors. |
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Address |
[Egede, U.; Fujii, Y.; Hadavizadeh, T.; Henderson, R. D. L.; Lane, J. J.; Monk, M.; Song, R.; Walton, E. J.; Ward, J. A.] Monash Univ, Sch Phys & Astron, Melbourne, Vic, Australia, Email: gianluca.zunica@epfl.ch |
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Springer |
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English |
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Edition |
|
|
| |
ISSN |
1029-8479 |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
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|
| |
Notes |
WOS:001207701100001 |
Approved |
no |
|
| |
Is ISI |
yes |
International Collaboration |
yes |
|
| |
Call Number |
IFIC @ pastor @ |
Serial |
6116 |
|
| Permanent link to this record |
