Abstract: Precision measurements of neutrino -electron scattering may provide a viable way to test the nonminimal form of the charged and neutral current weak interactions within a hypothetical near -detector setup for the Deep Underground Neutrino Experiment (DUNE). Although low -statistics, these processes are clean and provide information complementing the results derived from oscillation studies. They could shed light on the scale of neutrino mass generation in low -scale seesaw schemes.

Abstract: Third -generation dark matter detectors will be fully sensitive to the 8 B solar neutrino flux. Because of this, the characterization of such a background has been the subject of extensive analyses over the last few years. In contrast, little is known about the impact of reactor neutrinos. In this paper, we report on the implications of such a flux for dark matter direct -detection searches. We consider five potential detector deployment sites envisioned by the recently established XLZD Consortium: SURF, SNOLAB, Kamioka, LNGS, and Boulby. By using public reactor data, we construct five reactor clusters -involving about 100 currently operating commercial nuclear reactors each -and determine the net neutrino flux at each detector site. Assuming a xenon -based detector and a 50 ton -year exposure, we show that in all cases the neutrino event rate may be sizable, depending on energy recoil thresholds. Of all possible detector sites, SURF and LNGS are those with the smallest reactor neutrino background. On the contrary, SNOLAB and Boulby are subject to the strongest reactor neutrino fluxes, with Kamioka being subject to a more moderate background. Our findings demonstrate that reactor neutrino fluxes should be taken into account in the next round of dark matter searches. We argue that this background may be particularly relevant for directional detectors, provided they meet the requirements we have employed in this analysis.

Abstract: A search for pair-produced scalar or vector leptoquarks decaying into a b-quark and a tau-lepton is presented using the full LHC Run 2 (2015-2018) data sample of 139 fb(-1) collected with the ATLAS detector in proton-proton collisions at a centre-of-mass energy of root s = 13TeV. Events in which at least one tau-lepton decays hadronically are considered, and multivariate discriminants are used to extract the signals. No significant deviations from the Standard Model expectation are observed and 95% confidence-level upper limits on the production cross-section are derived as a function of leptoquark mass and branching ratio B into a tau-lepton and b-quark. For scalar leptoquarks, masses below 1460GeV are excluded assuming B = 100%, while for vector leptoquarks the corresponding limit is 1650GeV (1910GeV) in the minimal-coupling (Yang-Mills) scenario.

Abstract: In small clinical studies, the application of transcranial photobiomodulation (PBM), which typically delivers low-intensity near-infrared (NIR) to treat the brain, has led to some remarkable results in the treatment of dementia and several neurodegenerative diseases. However, despite the extensive literature detailing the mechanisms of action underlying PBM outcomes, the specific mechanisms affecting neurodegenerative diseases are not entirely clear. While large clinical trials are warranted to validate these findings, evidence of the mechanisms can explain and thus provide credible support for PBM as a potential treatment for these diseases. Tubulin and its polymerized state of microtubules have been known to play important roles in the pathology of Alzheimer's and other neurodegenerative diseases. Thus, we investigated the effects of PBM on these cellular structures in the quest for insights into the underlying therapeutic mechanisms. In this study, we employed a Raman spectroscopic analysis of the amide I band of polymerized samples of tubulin exposed to pulsed low-intensity NIR radiation (810 nm, 10 Hz, 22.5 J/cm2 dose). Peaks in the Raman fingerprint region (300-1900 cm-1)-in particular, in the amide I band (1600-1700 cm-1)-were used to quantify the percentage of protein secondary structures. Under this band, hidden signals of C=O stretching, belonging to different structures, are superimposed, producing a complex signal as a result. An accurate decomposition of the amide I band is therefore required for the reliable analysis of the conformation of proteins, which we achieved through a straightforward method employing a Voigt profile. This approach was validated through secondary structure analyses of unexposed control samples, for which comparisons with other values available in the literature could be conducted. Subsequently, using this validated method, we present novel findings of statistically significant alterations in the secondary structures of polymerized NIR-exposed tubulin, characterized by a notable decrease in alpha-helix content and a concurrent increase in beta-sheets compared to the control samples. This PBM-induced alpha-helix to beta-sheet transition connects to reduced microtubule stability and the introduction of dynamism to allow for the remodeling and, consequently, refreshing of microtubule structures. This newly discovered mechanism could have implications for reducing the risks associated with brain aging, including neurodegenerative diseases like Alzheimer's disease, through the introduction of an intervention following this transition.

Abstract: An amplitude analysis of the B-0 -> K*(0) mu(+)mu(-) decay is presented using a dataset corresponding to an integrated luminosity of 4.7 fb(-1) of pp collision data collected with the LHCb experiment. For the first time, the coefficients associated to short-distance physics effects, sensitive to processes beyond the standard model, are extracted directly from the data through a q(2)-unbinned amplitude analysis, where q(2) is the mu(+)mu(-) invariant mass squared. Long-distance contributions, which originate from nonfactorizable QCD processes, are systematically investigated, and the most accurate assessment to date of their impact on the physical observables is obtained. The pattern of measured corrections to the short-distance couplings is found to be consistent with previous analyses of b- to s-quark transitions, with the largest discrepancy from the standard model predictions found to be at the level of 1.8 standard deviations. The global significance of the observed differences in the decay is 1.4 standard deviations.