Abstract: In the framework of the low -energy effective theory containing, in addition to the Standard -Model fields, heavy neutral leptons (HNLs), we compute the decay rates of neutral and charged kaons into HNLs. We consider both lepton -number -conserving and lepton -number -violating four-fermion operators, taking into account also the contribution of active -heavy neutrino mixing. Assuming that the produced HNLs are longlived, we perform simulations and calculate the sensitivities of future long -lived -particle (LLP) detectors at the high -luminosity LHC as well as the near detector of the Deep Underground Neutrino Experiment (DUNE -ND) to the considered scenario. When applicable, we also recast the existing bounds on the minimal mixing case obtained by NA62, T2K, and PS191. Our findings show that, while the future LHC LLP detectors can probe currently allowed parameter space only in certain benchmark scenarios, DUNE -ND should be sensitive to parameter space beyond the current bounds in almost all the benchmark scenarios, and, for some of the effective operators considered, it can even probe new -physics scales in excess of 3000 TeV.

Abstract: We present a search for magnetic monopoles and high-electric-charge objects using LHC Run 2 root s = 13TeV proton-proton collisions recorded by the ATLAS detector. A total integrated luminosity of 138 fb(-1) was collected by a specialized trigger. No highly ionizing particle candidate was observed. Considering the Drell-Yan and photon-fusion pair production mechanisms as benchmark models, cross-section upper limits are presented for spin-0 and spin-1/2 magnetic monopoles of magnetic charge 1g(D) and 2g(D) and for high-electric-charge objects of electric charge 20 <= vertical bar z vertical bar <= 100, for masses between 200 GeV and 4000 GeV. The search improves by approximately a factor of three the previous cross-section limits on the Drell-Yan production of magnetic monopoles and high-electric charge objects. Also, the first ATLAS limits on the photon-fusion pair production mechanism of magnetic monopoles and high-electric-charge objects are obtained.

Abstract: In small clinical studies, the application of transcranial photobiomodulation (PBM), which typically delivers low-intensity near-infrared (NIR) to treat the brain, has led to some remarkable results in the treatment of dementia and several neurodegenerative diseases. However, despite the extensive literature detailing the mechanisms of action underlying PBM outcomes, the specific mechanisms affecting neurodegenerative diseases are not entirely clear. While large clinical trials are warranted to validate these findings, evidence of the mechanisms can explain and thus provide credible support for PBM as a potential treatment for these diseases. Tubulin and its polymerized state of microtubules have been known to play important roles in the pathology of Alzheimer's and other neurodegenerative diseases. Thus, we investigated the effects of PBM on these cellular structures in the quest for insights into the underlying therapeutic mechanisms. In this study, we employed a Raman spectroscopic analysis of the amide I band of polymerized samples of tubulin exposed to pulsed low-intensity NIR radiation (810 nm, 10 Hz, 22.5 J/cm2 dose). Peaks in the Raman fingerprint region (300-1900 cm-1)-in particular, in the amide I band (1600-1700 cm-1)-were used to quantify the percentage of protein secondary structures. Under this band, hidden signals of C=O stretching, belonging to different structures, are superimposed, producing a complex signal as a result. An accurate decomposition of the amide I band is therefore required for the reliable analysis of the conformation of proteins, which we achieved through a straightforward method employing a Voigt profile. This approach was validated through secondary structure analyses of unexposed control samples, for which comparisons with other values available in the literature could be conducted. Subsequently, using this validated method, we present novel findings of statistically significant alterations in the secondary structures of polymerized NIR-exposed tubulin, characterized by a notable decrease in alpha-helix content and a concurrent increase in beta-sheets compared to the control samples. This PBM-induced alpha-helix to beta-sheet transition connects to reduced microtubule stability and the introduction of dynamism to allow for the remodeling and, consequently, refreshing of microtubule structures. This newly discovered mechanism could have implications for reducing the risks associated with brain aging, including neurodegenerative diseases like Alzheimer's disease, through the introduction of an intervention following this transition.

Abstract: This letter presents a measurement of the nuclear modification factor of large-radius jets in root s(NN) = 5.02 TeV Pb thorn Pb collisions by the ATLAS experiment. The measurement is performed using 1.72 nb(-1) and 257 pb(-1) of Pb thorn Pb and pp data, respectively. The large-radius jets are reconstructed with the anti-kt algorithm using a radius parameter of R = 1.0, by reclustering anti-k(t) R = 0.2 jets, and are measured over the transverse momentum (p(T)) kinematic range of 158 < p(T) < 1000 GeV and absolute pseudorapidity |y| < 2.0. The large-radius jet constituents are further reclustered using the k(t) algorithm in order to obtain the splitting parameters, root d(12) and Delta R-12, which characterize the transverse momentum scale and angular separation for the hardest splitting in the jet, respectively. The nuclear modification factor, R-AA, obtained by comparing the Pb thorn Pb jet yields to those in pp collisions, is measured as a function of jet transverse momentum (p(T)) and root d(12) or Delta R-12. A significant difference in the quenching of large-radius jets having single subjet and those with more complex substructure is observed. Systematic comparison of jet suppression in terms of R-AA for different jet definitions is also provided. Presented results support the hypothesis that jets with hard internal splittings lose more energy through quenching and provide a new perspective for understanding the role of jet structure in jet suppression.

Abstract: Lifetime measurements of low-lying excited states in the semimagic ( N = 50) nucleus 95 Rh have been performed by means of the fast -timing technique. The experiment was carried out using gamma -ray detector arrays consisting of LaBr 3 (Ce) scintillators and germanium detectors integrated into the DESPEC experimental setup commissioned for the Facility for Antiproton and Ion Research ( FAIR ) Phase -0, Darmstadt, Germany. The excited states in 95 Rh were populated primarily via the /3 decays of 95 Pd nuclei, produced in the projectile fragmentation of a 850 MeV / nucleon 124 Xe beam impinging on a 4 g / cm 2 9 Be target. The deduced electromagnetic E2 transition strengths for the gamma -ray cascade within the multiplet structure depopulating from the isomeric I pi = 21 / 2 + state are found to exhibit strong deviations from predictions of standard shell model calculations which feature approximately conserved seniority symmetry. In particular, the observation of a strongly suppressed E2 strength for the 13 / 2 + -> 9 / 2 + ground state transition cannot be explained by calculations employing standard interactions. This remarkable result may require revision of the nucleon-nucleon interactions employed in state-of-the-art theoretical model calculations, and might also point to the need for including three-body forces in the Hamiltonian.