Torres-Sanchez, P., Lerendegui-Marco, J., Balibrea-Correa, J., Babiano-Suarez, V., Gameiro, B., Ladarescu, I., et al. (2025). The potential of the i-TED Compton camera array for real-time boron imaging and determination during treatments in Boron Neutron Capture Therapy. Appl. Radiat. Isot., 217, 111649–9pp.
Abstract: This paper explores the adaptation and application of i-TED Compton imagers for real-time dosimetry in Boron Neutron Capture Therapy (BNCT). The i-TED array, previously utilized in nuclear astrophysics experiments at CERN, is being optimized for detecting and imaging 478 keV gamma-rays, critical for accurate BNCT dosimetry. Detailed Monte Carlo simulations were used to optimize the i-TED detector configuration and enhance its performance in the challenging radiation environment typical of BNCT. Additionally, advanced 3D image reconstruction algorithms, including a combination of back-projection and List-Mode Maximum Likelihood Expectation Maximization (LM-MLEM), are implemented and validated through simulations. Preliminary experimental tests at the Institut Laue-Langevin (ILL) demonstrate the potential of i-TED in simplified conditions, with ongoing experiments focusing on testing imaging capabilities in realistic BNCT conditions.
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Lerendegui-Marco, J., Hallam, J., Cisterna, G., Sanchis-Molto, A., Balibrea-Correa, J., Babiano-Suarez, V., et al. (2025). First experimental results and optimization study of the portable neutron-gamma imager GN-Vision. Appl. Radiat. Isot., 224, 111826–13pp.
Abstract: GN-Vision is a compact, dual-modality imaging device designed to simultaneously localize the spatial origin of y-ray and slow neutron sources, with potential applications in nuclear safety, security, and hadron therapy. The system utilizes two position-sensitive detection planes, combining Compton imaging techniques for yray visualization with passive collimation for imaging slow and thermal neutrons (energies below 100 eV). This paper presents the first experimental outcomes from the initial GN-Vision prototype, focused on the development of its neutron imaging capabilities. Following this experimental assessment, we explore the device's performance potential and discuss several Monte Carlo simulation-based optimizations aimed at refining the neutron collimation system. These optimizations seek to improve real-time imaging efficiency and cost-effectiveness, enhancing GN-Vision's applicability for future practical deployments.
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Perez-Curbelo, J., Roser, J., Muñoz, E., Barrientos, L., Sanz, V., & Llosa, G. (2025). Improving Compton camera imaging of multi-energy radioactive sources by using machine learning algorithms for event selection. Radiat. Phys. Chem., 226, 112166–11pp.
Abstract: Event selection and background reduction for Compton camera imaging of multi-energy radioactive sources has been performed by employing neural networks. A Compton camera prototype with detectors made of LaBr3 crystals coupled to silicon photomultiplier arrays was used to acquire experimental data from a circular array of Na-22 sources. The prototype and two arrays of Na-22 sources were simulated with GATE v8.2 Monte Carlo code, to obtain data for neural network training. Neural network models were trained on simulated data for event classification. The optimum models were found by using Weights & Biases platform tools. The trained models were used to classify simulated and real data for selecting signal events and rejecting background prior to image reconstruction. The models performed well on simulated data. The image obtained with experimental data showed an improvement with respect to event selection with energy cuts. The method is promising for Compton camera imaging of multi-energy radioactive sources.
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Roser, J., Barrientos, L., Bello, P., Borja-Lloret, M., Calatayud, J. M., Casaña, J. V., et al. (2025). Radiopharmaceutical imaging of phantoms and patients with MACACO III Compton camera. Phys. Medica, 132, 104928–8pp.
Abstract: Background and purpose: The use of Compton cameras for imaging radioisotopes in nuclear medicine offers potential advantages over conventional gamma cameras in some aspects. In this work, we present the first results in this field with the Compton camera prototype MACACO III after a measurement campaign in La Fe Hospital (Valencia, Spain). Methods: Images of Derenzo-like phantoms filled with 18F-FDG and 131I-NaI have been obtained with MACACO III and, in the latter case, with gamma cameras available in the hospital. Subsequently, a metastatic lesion in a patient treated with 131I-NaI after thyroid gland resection was imaged. Results: The 18F-FDG phantom images show the prototype capability of identifying up to 4 mm diameter rods. The measurements with 131I-NaI-filled phantoms demonstrate the clear improvement of the spatial resolution attainable with MACACO III when compared with images obtained with the gamma cameras available in the hospital. Finally, the image of the patient metastatic lesion obtained with the Compton camera was found to be consistent with the gamma camera inspection image. Conclusion: These encouraging results demonstrate MACACO III's capability for radiopharmaceutical imaging and open a door for its application to nuclear medicine.
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Linhart, V., Burdette, D., Chessi, E., Cindro, V., Clinthorne, N. H., Cochran, E., et al. (2011). Spectroscopy study of imaging devices based on silicon Pixel Array Detector coupled to VATAGP7 read-out chips. J. Instrum., 6, C01092–8pp.
Abstract: Spectroscopic and timing response studies have been conducted on a detector module consisting of a silicon Pixel Array Detector bonded on two VATAGP7 read-out chips manufactured by Gamma-Medica Ideas using laboratory gamma sources and the internal calibration facilities (the calibration system of the read-out chips). The performed tests have proven that the chips have (i) non-linear calibration curves which can be approximated by power functions, (ii) capability to measure the energy of photons with energy resolution better than 2 keV (exact range and resolution depend on experimental setup), (iii) the internal calibration facility which provides 6 out of 16 available internal calibration charges within our region of interest (spanning the Compton edge of 511 keV photons). The peaks induced by the internal calibration facility are suitable for a fit of the calibration curves. However, they are not suitable for measurements of equivalent noise charge because their full width at half maximum varies with their amplitude. These facts indicate that the VATAGP7 chips are useful and precise tools for a wide variety of spectroscopic devices. We have also explored time walk of the module and peaking time of the spectroscopy signals provided by the chips. We have observed that (iv) the time walk is caused partly by the peaking time of the signals provided by the fast shaper of the chips and partly by the timing uncertainty related to the varying position of the photon interaction, (v) the peaking time of the spectroscopy signals provided by the chips increases with increasing pulse height.
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NEXT Collaboration(Alvarez, V. et al), Ball, M., Carcel, S., Cervera-Villanueva, A., Diaz, J., Ferrario, P., et al. (2013). Design and characterization of the SiPM tracking system of NEXT-DEMO, a demonstrator prototype of the NEXT-100 experiment. J. Instrum., 8, T05002–18pp.
Abstract: NEXT-100 experiment aims at searching the neutrinoless double-beta decay of the Xe-136 isotope using a TPC filled with a 100 kg of high-pressure gaseous xenon, with 90% isotopic enrichment. The experiment will take place at the Laboratorio Subterraneo de Canfranc (LSC), Spain. NEXT-100 uses electroluminescence (EL) technology for energy measurement with a resolution better than 1% FWHM. The gaseous xenon in the TPC additionally allows the tracks of the two beta particles to be recorded, which are expected to have a length of up to 30 cm at 10 bar pressure. The ability to record the topological signature of the beta beta 0 nu events provides a powerful background rejection factor for the beta beta experiment. In this paper, we present a novel 3D imaging concept using SiPMs coated with tetraphenyl butadiene (TPB) for the EL read out and its first implementation in NEXT-DEMO, a large-scale prototype of the NEXT-100 experiment. The design and the first characterization measurements of the NEXT-DEMO SiPM tracking system are presented. The SiPM response uniformity over the tracking plane drawn from its gain map is shown to be better than 4%. An automated active control system for the stabilization of the SiPMs gain was developed, based on the voltage supply compensation of the gain drifts. The gain is shown to be stabilized within 0.2% relative variation around its nominal value, provided by Hamamatsu, in a temperature range of 10 degrees C. The noise level from the electronics and the SiPM dark noise is shown to lay typically below the level of 10 photoelectrons (pe) in the ADC. Hence, a detection threshold at 10 pe is set for the acquisition of the tracking signals. The ADC full dynamic range (4096 channels) is shown to be adequate for signal levels of up to 200 pe/mu s, which enables recording most of the tracking signals.
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NEXT Collaboration(Simon, A. et al), Gomez-Cadenas, J. J., Alvarez, V., Benlloch-Rodriguez, J. M., Botas, A., Carcel, S., et al. (2017). Application and performance of an ML-EM algorithm in NEXT. J. Instrum., 12, P08009–22pp.
Abstract: The goal of the NEXT experiment is the observation of neutrinoless double beta decay in Xe-136 using a gaseous xenon TPC with electroluminescent amplification and specialized photodetector arrays for calorimetry and tracking. The NEXT Collaboration is exploring a number of reconstruction algorithms to exploit the full potential of the detector. This paper describes one of them: the Maximum Likelihood Expectation Maximization (ML-EM) method, a generic iterative algorithm to find maximum-likelihood estimates of parameters that has been applied to solve many different types of complex inverse problems. In particular, we discuss a bi-dimensional version of the method in which the photosensor signals integrated over time are used to reconstruct a transverse projection of the event. First results show that, when applied to detector simulation data, the algorithm achieves nearly optimal energy resolution (better than 0.5% FWHM at the Q value of 136Xe) for events distributed over the full active volume of the TPC.
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Olleros, P., Caballero, L., Domingo-Pardo, C., Babiano, V., Ladarescu, I., Calvo, D., et al. (2018). On the performance of large monolithic LaCl3(Ce) crystals coupled to pixelated silicon photosensors. J. Instrum., 13, P03014–17pp.
Abstract: We investigate the performance of large area radiation detectors, with high energy-and spatial-resolution, intended for the development of a Total Energy Detector with gamma-ray imaging capability, so-called i-TED. This new development aims for an enhancement in detection sensitivity in time-of-flight neutron capture measurements, versus the commonly used C6D6 liquid scintillation total-energy detectors. In this work, we study in detail the impact of the readout photosensor on the energy response of large area (50 x 50 mm(2)) monolithic LaCl3(Ce) crystals, in particular when replacing a conventional mono-cathode photomultiplier tube by an 8 x 8 pixelated silicon photomultiplier. Using the largest commercially available monolithic SiPM array (25 cm(2)), with a pixel size of 6 x 6 mm(2), we have measured an average energy resolution of 3.92% FWHM at 662 keV for crystal thick-nesses of 10, 20 and 30 mm. The results are confronted with detailed Monte Carlo (MC) calculations, where optical processes and properties have been included for the reliable tracking of the scintillation photons. After the experimental validation of the MC model, we use our MC code to explore the impact of a smaller photosensor segmentation on the energy resolution. Our optical MC simulations predict only a marginal deterioration of the spectroscopic performance for pixels of 3 x 3 mm(2).
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Muñoz, E., Barrio, J., Bemmerer, D., Etxebeste, A., Fiedler, F., Hueso-Gonzalez, F., et al. (2018). Tests of MACACO Compton telescope with 4.44 MeV gamma rays. J. Instrum., 13, P05007–13pp.
Abstract: Hadron therapy offers the possibility of delivering a large amount of radiation dose to tumors with minimal absorption by the surrounding healthy tissue. In order to fully exploit the advantages of this technique, the use of real-time beam monitoring devices becomes mandatory. Compton imaging devices can be employed to map the distribution of prompt gamma emission during the treatment and thus assess its correct delivery. The Compton telescope prototype developed at IFIC-Valencia for this purpose is made of three layers of LaBr3 crystals coupled to silicon photomultipliers. The system has been tested in a 4.44 MeV gamma field at the 3 MV Tandetron accelerator at HZDR, Dresden. Images of the target with the system in three different positions separated by 10 mm were successfully reconstructed. This indicates the ability of MACACO for imaging the prompt gamma rays emitted at such energies.
Keywords: Compton imaging; Instrumentation for hadron therapy; Gamma detectors (scintillators, CZT, HPG, HgI etc); Photon detectors for UV, visible and IR photons (solid state) (PIN diodes, APDs, Si PMTs, G APDs, CCDs, EBCCDs, EMCCDs etc)
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NEXT Collaboration(Simon, A. et al), Felkai, R., Martinez-Lema, G., Sorel, M., Gomez-Cadenas, J. J., Alvarez, V., et al. (2018). Electron drift properties in high pressure gaseous xenon. J. Instrum., 13, P07013–23pp.
Abstract: Gaseous time projection chambers (TPC) are a very attractive detector technology for particle tracking. Characterization of both drift velocity and diffusion is of great importance to correctly assess their tracking capabilities. NEXT-White is a High Pressure Xenon gas TPC with electroluminescent amplification, a 1:2 scale model of the future NEXT-100 detector, which will be dedicated to neutrinoless double beta decay searches. NEXT-White has been operating at Canfranc Underground Laboratory (LSC) since December 2016. The drift parameters have been measured using Kr-83(m) for a range of reduced drift fields at two different pressure regimes, namely 7.2 bar and 9.1 bar. The results have been compared with Magboltz simulations. Agreement at the 5% level or better has been found for drift velocity, longitudinal diffusion and transverse diffusion.
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