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Peris, J. B., Davis, P., Cuevas, J. M., Nebot, M., & Sanjuan, R. (2010). Distribution of Fitness Effects Caused by Single-Nucleotide Substitutions in Bacteriophage f1. Genetics, 185(2), 603–U308.
Abstract: Empirical knowledge of the fitness effects of mutations is important for understanding many evolutionary processes, yet this knowledge is often hampered by several sources of measurement error and bias. Most of these problems can be solved using site-directed mutagenesis to engineer single mutations, an approach particularly suited for viruses due to their small genomes. Here, we used this technique to measure the fitness effect of 100 single-nucleotide substitutions in the bacteriophage f1, a filamentous single-strand DNA virus. We found that approximately one-fifth of all mutations are lethal. Viable ones reduced fitness by 11% on average and were accurately described by a log-normal distribution. More than 90% of synonymous substitutions were selectively neutral, while those affecting intergenic regions reduced fitness by 14% on average. Mutations leading to amino acid substitutions had an overall mean deleterious effect of 37%, which increased to 45% for those changing the amino acid polarity. Interestingly, mutations affecting early steps of the infection cycle tended to be more deleterious than those affecting late steps. Finally, we observed at least two beneficial mutations. Our results confirm that high mutational sensitivity is a general property of viruses with small genomes, including RNA and single-strand DNA viruses infecting animals, plants, and bacteria.
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Zhang, X., Chang, C., & Gimeno, B. (2019). Multipactor Analysis in Circular Waveguides Excited by TM01 Mode. IEEE Trans. Electron Devices, 66(11), 4943–4951.
Abstract: A series of detailed numerical simulations are used to investigate the properties ofmultipactor breakdown in circularwaveguidespropagating the TM01 mode. AMonte Carlo model is constructed to track the motion of the electrons, study the multipactor scenarios, and predict the multipactor thresholds. The theoretical and numerical analyses indicate that the product of the frequency and the gap (f . D) affects both the intensity of the ponderomotive force and its spatial distribution, which results from the nonuniformity of the radio frequency (RF) field and significantly influences the electrons' trajectoriesandmultipactor trends. The decrease in f . D results in a remarkable enhancement in the magnitude of the ponderomotive force, while the maximal intensity gradually moves toward the half radius R/2 area. Low values of f . D correspond to high ponderomotive potential, which sustains the short-range electrons and triggers the single-sidedmultipactor. In contrast, high values of f . D correspond to low ponderomotive potential, contributing to long-range electrons and exciting the double-sided multipactor. Fitting to the susceptibility diagram produces the border line and a modified f . D threshold of (f . D) th approximate to 338.4 GHz mm, which separates the susceptibility diagram into single-sided, double-sided, andmixed-sided zones. The initial electron energy influences their trajectories at high f . D and low RF power. This effect tends to dominate the multipactor behavior in the mixed-sided region.
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Zhang, X., Xiao, Y. T., & Gimeno, B. (2020). Multipactor Suppression by a Resonant Static Magnetic Field on a Dielectric Surface. IEEE Trans. Electron Devices, 67(12), 5723–5728.
Abstract: In this article, we study the suppression of the multipactor phenomenon on a dielectric surface by a resonant static magnetic field. A homemade Monte Carlo algorithm is developed for multipactor simulations on a dielectric surface driven by two orthogonal radio frequency (RF) electric field components. When the static magnetic field is perpendicular to the tangential and normal RF electric fields, it is shown that if the normal electric field lags the tangential electric field by pi/2, the superposition of the normal and tangential electric fields will trigger a gyro-acceleration of the electron cloud and restrain the multipactor discharge effectively. By contrast, when the normal electric field is in advance of the tangential electric field by pi/2, the difference between the normal and tangential electric fields drives gyro-motion of the electron cloud. Consequently, two enhanced discharge zones are inevitable. The suppression effects of the resonant static magnetic field that is parallel to the tangential RF electric field or to the normal RF electric field are also presented.
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Gonzalez-Iglesias, D., Esperante, D., Gimeno, B., Blanch, C., Fuster-Martinez, N., Martinez-Reviriego, P., et al. (2023). Analysis of the Multipactor Effect in an RF Electron Gun Photoinjector. IEEE Trans. Electron Devices, 70(1), 288–295.
Abstract: The objective of this work is the evaluation of the risk of suffering a multipactor discharge within an RF electron gun photoinjector. Photoinjectors are a type of source for intense electron beams, which are the main electron source for synchrotron light sources, such as free-electron lasers. The analyzed device consists of 1.6 cells and it has been designed to operate at the S-band. Besides, around the RF gun there is an emittance compensation solenoid, whose magnetic field prevents the growth of the electron beam emittance, and thus the degradation of the properties of the beam. The multipactor analysis is based on a set of numerical simulations by tracking the trajectories of the electron cloud in the cells of the device. To reach this aim, an in-house multipactor code was developed. Specifically, two different cases were explored: with the emittance compensation solenoid assumed to be off and with the emittance compensation solenoid in operation. For both the cases, multipactor simulations were carried out exploring different RF electric field amplitudes. Moreover, for a better understanding of the multipactor phenomenon, the resonant trajectories of the electrons and the growth rate of the electrons population are investigated.
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Martin-Luna, P., Gimeno, B., Gonzalez-Iglesias, D., Esperante, D., Blanch, C., Fuster-Martinez, N., et al. (2023). On the Magnetic Field of a Finite Solenoid. IEEE Trans. Magn., 59(4), 7000106–6pp.
Abstract: The magnetostatic field of a finite solenoid with infinitely thin walls carrying a dc current oriented in the azimuthal direction is calculated everywhere in space in terms of complete elliptic integrals by direct integration of the Biot-Savart law. The solution is particularized near the solenoid axis and in the midplane perpendicular to the axis obtaining expressions that agree with some typical approximations that are made in introductory courses of electromagnetism or in the technical literature. The range of validity of these approximations has been studied comparing them with the obtained general expression.
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