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Di Gregorio, E., Staelens, M., Hosseinkhah, N., Karimpoor, M., Liburd, J., Lim, L., et al. (2024). Raman Spectroscopy Reveals Photobiomodulation-Induced α-Helix to β-Sheet Transition in Tubulins: Potential Implications for Alzheimer's and Other Neurodegenerative Diseases. Nanomaterials, 14(13), 1093–21pp.
Abstract: In small clinical studies, the application of transcranial photobiomodulation (PBM), which typically delivers low-intensity near-infrared (NIR) to treat the brain, has led to some remarkable results in the treatment of dementia and several neurodegenerative diseases. However, despite the extensive literature detailing the mechanisms of action underlying PBM outcomes, the specific mechanisms affecting neurodegenerative diseases are not entirely clear. While large clinical trials are warranted to validate these findings, evidence of the mechanisms can explain and thus provide credible support for PBM as a potential treatment for these diseases. Tubulin and its polymerized state of microtubules have been known to play important roles in the pathology of Alzheimer's and other neurodegenerative diseases. Thus, we investigated the effects of PBM on these cellular structures in the quest for insights into the underlying therapeutic mechanisms. In this study, we employed a Raman spectroscopic analysis of the amide I band of polymerized samples of tubulin exposed to pulsed low-intensity NIR radiation (810 nm, 10 Hz, 22.5 J/cm2 dose). Peaks in the Raman fingerprint region (300-1900 cm-1)-in particular, in the amide I band (1600-1700 cm-1)-were used to quantify the percentage of protein secondary structures. Under this band, hidden signals of C=O stretching, belonging to different structures, are superimposed, producing a complex signal as a result. An accurate decomposition of the amide I band is therefore required for the reliable analysis of the conformation of proteins, which we achieved through a straightforward method employing a Voigt profile. This approach was validated through secondary structure analyses of unexposed control samples, for which comparisons with other values available in the literature could be conducted. Subsequently, using this validated method, we present novel findings of statistically significant alterations in the secondary structures of polymerized NIR-exposed tubulin, characterized by a notable decrease in alpha-helix content and a concurrent increase in beta-sheets compared to the control samples. This PBM-induced alpha-helix to beta-sheet transition connects to reduced microtubule stability and the introduction of dynamism to allow for the remodeling and, consequently, refreshing of microtubule structures. This newly discovered mechanism could have implications for reducing the risks associated with brain aging, including neurodegenerative diseases like Alzheimer's disease, through the introduction of an intervention following this transition.
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Paredes-Torres, G., Gutierrez-Guerrer, L. X., Bashir, A., & Miramontes, A. S. (2024). First radial excitations of mesons and diquarks in a contact interaction. Phys. Rev. D, 109(11), 114006–12pp.
Abstract: We present a calculation for the masses of the first radially excited states of 40 mesons and diquarks made up of u , d , s , c , and b quarks, including states that contain one or both heavy quarks. To this end, we employ a combined analysis of the Bethe-Salpeter and Schwinger-Dyson equations within a self-consistent and symmetry-preserving vector-vector contact interaction. The same set of parameters describes ground and excited states of mesons and their diquark partners. The wave function of the first radial excitation contains a zero whose location is correlated with an additional parameter d F which is a function of dressed quark masses. Our results satisfy the equal spacing rules given by the Gell-Mann Okubo mass relations. Wherever possible, we make comparisons of our findings with known experimental observations as well as theoretical predictions of several other models and approaches including lattice quantum chromodynamics, finding a very good agreement. We report predictions for a multitude of radial excitations not yet observed in experiments.
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Mata, R., Cros, A., Gimeno, B., & Raboso, D. (2024). Secondary electron emission yield in thick dielectric materials: a comparison between Kelvin probe and capacitive methods. J. Phys. D, 57(40), 405302–9pp.
Abstract: The recent high demand of secondary electron emission yield (SEY) measurements in dielectric materials from space industry has driven SEY laboratories to improve their facilities and measurement techniques. SEY determination by the common capacitive method, also known as pulsed method, is well accepted and has given satisfactory results in most cases. Nevertheless, the samples under study must be prepared according to the experimental limitations of the technique, i.e. they should be manufactured separated from the devices representing faithfully the surface state of the own device and be as thin as possible. A method based on the Kelvin probe (KP) is proposed here to obtain the SEY characteristics of electrically floating Platinum, Kapton and Teflon placed over dielectric spacers with thicknesses ranging from 1.6 to 12.1 mm. The results are compared with those of the capacitive method and indicate that KP SEY curves are less sensitive to spacer thickness. An explanation based on the literature is also given. In all, we have established that KP is better suited for the analysis of dielectric samples thicker than 3 mm.
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LHCb Collaboration(Aaij, R. et al), Jaimes Elles, S. J., Jashal, B. K., Martinez-Vidal, F., Oyanguren, A., Rebollo De Miguel, M., et al. (2023). Test of lepton flavor universality using B0 → D*- τ+ ντ decays with hadronic τ channels. Phys. Rev. D, 108(1), 012018–18pp.
Abstract: The branching fraction B(B-0 -> D*(-)tau(+)nu(tau)) is measured relative to that of the normalization mode B-0 -> D*(-) pi(+)pi(-)pi(+) using hadronic tau(+) -> pi(+)pi(-)pi(+) (pi(0))(nu) over bar (tau) decays in proton-proton collision data at a center-of-mass energy of 13 TeV collected by the LHCb experiment, corresponding to an integrated luminosity of 2 fb(-1). The measured ratio is B(B-0 -> D*(-)tau(+)nu(tau))/B(B-0 -> D*(-) pi(+)pi(-)pi(+)) = 1.70 +/- 0.10(-0.10)(+0.11), where the first uncertainty is statistical and the second is related to systematic effects. Using established branching fractions for the B-0 -> D*(-) pi(+)pi(-)pi(+) and B-0 -> D*(-)mu(+)nu(mu) modes, the lepton universality test R(D*(-)) = B(B-0 -> D*(-)tau(+)nu(tau))/B(B-0 -> D*(-)mu(+)nu(mu)) is calculated, R(D*(-)) = 0.247 +/- 0.015 +/- 0.015 +/- 0.012, where the third uncertainty is due to the uncertainties on the external branching fractions. This result is consistent with the Standard Model prediction and with previous measurements.
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LHCb Collaboration(Aaij, R. et al), Jaimes Elles, S. J., Jashal, B. K., Martinez-Vidal, F., Oyanguren, A., Rebollo De Miguel, M., et al. (2024). Search for CP violation in the phase space of D0 → KS0 K± π∓ decays with the energy test. J. High Energy Phys., 03(3), 107–20pp.
Abstract: A search for CP violation in D-0 -> (KSK+)-K-0 pi(-) and D-0 -> (KSK-)-K-0 pi(+) decays is reported. The search is performed using an unbinned model-independent method known as the energy test that probes local CP violation in the phase space of the decays. The data analysed correspond to an integrated luminosity of 5.4 fb(-1) collected in proton-proton collisions by the LHCb experiment at a centre-of-mass energy of root s = 13TeV, amounting to approximately 950 thousand and 620 thousand signal candidates for the D-0 -> (KSK-)-K-0 pi(+) and D-0 -> (KSK+)-K-0 pi(-) modes, respectively. The method is validated using D-0 -> K-pi(+)pi(-)pi(+) and D-0 -> K-S(0)pi(+)pi(-) decays, where CP-violating effects are expected to be negligible, and using background-enhanced regions of the signal decays. The results are consistent with CP symmetry in both the D-0 -> (KSK-)-K-0 pi(+) and the D-0 -> (KSK+)-K-0 pi(-) decays, with p-values for the hypothesis of no CP violation of 70% and 66%, respectively.
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ATLAS Collaboration(Aad, G. et al), Aikot, A., Amos, K. R., Aparisi Pozo, J. A., Bailey, A. J., Bouchhar, N., et al. (2024). Study of High-Transverse-Momentum Higgs Boson Production in Association with a Vector Boson in the qqbb Final State with the ATLAS Detector. Phys. Rev. Lett., 132(13), 131802–23pp.
Abstract: This Letter presents the first study of Higgs boson production in association with a vector boson (V = W or Z) in the fully hadronic qqbb final state using data recorded by the ATLAS detector at the LHC in ffiffiproton-proton collisions at root root s= 13 TeV and corresponding to an integrated luminosity of 137fb(-1). The vector bosons and Higgs bosons are each reconstructed as large-radius jets and tagged using jet substructure techniques. Dedicated tagging algorithms exploiting b-tagging properties are used to identify jets consistent with Higgs bosons decaying into b (b) over bar. Dominant backgrounds from multijet production are determined directly from the data, and a likelihood fit to the jet mass distribution of Higgs boson candidates is used to extract the number of signal events. The VH production cross section is measured inclusively and differentially in several ranges of Higgs boson transverse momentum: 250-450, 450-650, and greater than 650 GeV. The inclusive signal yield relative to the standard model expectation is observed to be μ= 1.4(-0.9)(+1.0) and the corresponding cross section is 3.1 +/- 1.3(stat)(-1.4)(+1.8) (syst) pb.
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D'Auria, G. et al, Gonzalez-Iglesias, D., Gimeno, B., & Pereira, D. E. (2024). The CompactLight Design Study. Eur. Phys. J.-Spec. Top., , 1–208.
Abstract: CompactLight is a Design Study funded by the European Union under the Horizon 2020 research and innovation funding programme, with Grant Agreement No. 777431. CompactLight was conducted by an International Collaboration of 23 international laboratories and academic institutions, three private companies, and five third parties. The project, which started in January 2018 with a duration of 48 months, aimed to design an innovative, compact, and cost-effective hard X-ray FEL facility complemented by a soft X-ray source to pave the road for future compact accelerator-based facilities. The result is an accelerator that can be operated at up to 1 kHz pulse repetition rate, beyond today's state of the art, using the latest concepts for high brightness electron photoinjectors, very high gradient accelerating structures in X-band, and novel short-period undulators. In this report, we summarize the main deliverable of the project: the CompactLight Conceptual Design Report, which overviews the current status of the design and addresses the main technological challenges.
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Nacher, E., Briz, J. A., Nerio, A. N., Perea, A., Tavora, V. G., Tengblad, O., et al. (2024). Characterization of a novel proton-CT scanner based on Silicon and LaBr3(Ce) detectors. Eur. Phys. J. Plus, 139(5), 404–9pp.
Abstract: Treatment planning systems at proton-therapy centres entirely use X-ray computed tomography (CT) as primary imaging technique to infer the proton treatment doses to tumour and healthy tissues. However, proton stopping powers in the body, as derived from X-ray images, suffer from important proton-range uncertainties. In order to reduce this uncertainty in range, one could use proton-CT images instead. The main goal of this work is to test the capabilities of a newly-developed proton-CT scanner, based on the use of a set of tracking detectors and a high energy resolution scintillator for the residual energy of the protons. Different custom-made phantoms were positioned at the field of view of the scanner and were irradiated with protons at the CCB proton-therapy center in Krakow. We measured with the phantoms at different angles and produced sinograms that were used to obtain reconstructed images by Filtered Back-Projection. The obtained images were used to determine the capabilities of our scanner in terms of spatial resolution and proton Relative Stopping Power (RSP) mapping and validate its use as proton-CT scanner. The results show that the scanner can produce medium-high quality images, with spatial resolution better than 2 mm in radiography, below 3 mm in tomography and resolving power in the RSP comparable to other state-of-the-art pCT scanners.
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Chen, M. C., Li, X. Q., Liu, X. G., Medina, O., & Ratz, M. (2024). Modular invariant holomorphic observables. Phys. Lett. B, 852, 138600–13pp.
Abstract: In modular invariant models of flavor, observables must be modular invariant. The observables discussed so far in the literature are functions of the modulus tau and its conjugate, (tau) over bar. We point out that certain combinations of observables depend only on tau , i.e. are meromorphic, and in some cases even holomorphic functions of tau. These functions, which we dub “invariants” in this Letter, are highly constrained, renormalization group invariant, and allow us to derive many of the models' features without the need for extensive parameter scans. We illustrate the robustness of these invariants in two existing models in the literature based on modular symmetries, Gamma(3) and Gamma(5). We find that, in some cases, the invariants give rise to robust relations among physical observables that are independent of tau. Furthermore, there are instances where additional symmetries exist among the invariants. These symmetries are relevant phenomenologically and may provide a dynamical way to realize symmetries of mass matrices.
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LHCb Collaboration(Aaij, R. et al), Jaimes Elles, S. J., Jashal, B. K., Martinez-Vidal, F., Oyanguren, A., Rebollo De Miguel, M., et al. (2024). Amplitude Analysis of the B0 -> K*0 μ+μ- Decay. Phys. Rev. Lett., 132(13), 131801–13pp.
Abstract: An amplitude analysis of the B-0 -> K*(0) mu(+)mu(-) decay is presented using a dataset corresponding to an integrated luminosity of 4.7 fb(-1) of pp collision data collected with the LHCb experiment. For the first time, the coefficients associated to short-distance physics effects, sensitive to processes beyond the standard model, are extracted directly from the data through a q(2)-unbinned amplitude analysis, where q(2) is the mu(+)mu(-) invariant mass squared. Long-distance contributions, which originate from nonfactorizable QCD processes, are systematically investigated, and the most accurate assessment to date of their impact on the physical observables is obtained. The pattern of measured corrections to the short-distance couplings is found to be consistent with previous analyses of b- to s-quark transitions, with the largest discrepancy from the standard model predictions found to be at the level of 1.8 standard deviations. The global significance of the observed differences in the decay is 1.4 standard deviations.
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