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Author |
Borys, D. et al; Brzezinski, K. |
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Title |
ProTheRaMon-a GATE simulation framework for proton therapy range monitoring using PET imaging |
Type |
Journal Article |
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Year |
2022 |
Publication |
Physics in Medicine and Biology |
Abbreviated Journal |
Phys. Med. Biol. |
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Volume |
67 |
Issue |
22 |
Pages |
224002 - 15pp |
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Keywords |
proton therapy; GATE; Monte Carlo simulations; J-PET; medical imaging |
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Abstract |
Objective. This paper reports on the implementation and shows examples of the use of the ProTheRaMon framework for simulating the delivery of proton therapy treatment plans and range monitoring using positron emission tomography (PET). ProTheRaMon offers complete processing of proton therapy treatment plans, patient CT geometries, and intra-treatment PET imaging, taking into account therapy and imaging coordinate systems and activity decay during the PET imaging protocol specific to a given proton therapy facility. We present the ProTheRaMon framework and illustrate its potential use case and data processing steps for a patient treated at the Cyclotron Centre Bronowice (CCB) proton therapy center in Krakow, Poland. Approach. The ProTheRaMon framework is based on GATE Monte Carlo software, the CASToR reconstruction package and in-house developed Python and bash scripts. The framework consists of five separated simulation and data processing steps, that can be further optimized according to the user's needs and specific settings of a given proton therapy facility and PET scanner design. Main results. ProTheRaMon is presented using example data from a patient treated at CCB and the J-PET scanner to demonstrate the application of the framework for proton therapy range monitoring. The output of each simulation and data processing stage is described and visualized. Significance. We demonstrate that the ProTheRaMon simulation platform is a high-performance tool, capable of running on a computational cluster and suitable for multi-parameter studies, with databases consisting of large number of patients, as well as different PET scanner geometries and settings for range monitoring in a clinical environment. Due to its modular structure, the ProTheRaMon framework can be adjusted for different proton therapy centers and/or different PET detector geometries. It is available to the community via github (Borys et al 2022). |
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Address |
[Borys, Damian] Silesian Tech Univ, Dept Syst Biol & Engn, Gliwice, Poland, Email: damin.borys@polsl.pl |
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Publisher |
IOP Publishing Ltd |
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English |
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ISSN |
0031-9155 |
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Conference |
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Notes |
WOS:000885248200001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration  |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
5416 |
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Author |
Balibrea-Correa, J.; Lerendegui-Marco, J.; Ladarescu, I.; Guerrero, C.; Rodriguez-Gonzalez, T.; Jimenez-Ramos, M.C.; Fernandez-Martinez, B.; Domingo-Pardo, C. |
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Title |
Hybrid in-beam PET- and Compton prompt-gamma imaging aimed at enhanced proton-range verification |
Type |
Journal Article |
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Year |
2022 |
Publication |
European Physical Journal Plus |
Abbreviated Journal |
Eur. Phys. J. Plus |
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Volume |
137 |
Issue |
11 |
Pages |
1258 - 18pp |
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Keywords |
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Abstract |
We report on a hybrid in-beam PET and prompt-gamma Compton imaging system aimed at quasi real-time ion-range verification in proton-therapy treatments. Proof-of-concept experiments were carried out at the radiobiology beam line of the CNA cyclotron facility using a set of two synchronous Compton imagers and different target materials. The time structure of the 18 MeV proton beam was shaped with a series of beam-on and beam-off intervals, thereby mimicking a pulsed proton beam on a long time scale. During beam-on intervals, Compton imagingwas performed utilizing the high energy. -rays promptly emitted from the nuclear reactions occurring in the targets. In the course of the beam-off intervals in situ positron-emission tomography was accomplished with the same imagers using the beta+ decay of activated nuclei. The targets used were stacks of different materials covering also various proton ranges and energies. A systematic study on the performance of these two complementary imaging techniques is reported and the experimental results interpreted on the basis ofMonte Carlo calculations. The results demonstrate the possibility to combine both imaging techniques in a concomitant way, where high-efficiency prompt-gamma imaging is complemented with the high spatial accuracy of PET. Empowered by these results we suggest that a pulsed beam with a suitable duty cycle, in conjunction with in situ Compton- and PET-imaging may help to attain complementary information and quasi real-time range monitoring with high accuracy. |
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Address |
[Balibrea-Correa, J.; Lerendegui-Marco, J.; Ladarescu, I; Domingo-Pardo, C.] Univ Valencia, CSIC, Inst Fis Corpuscular, Valencia, Spain, Email: javier.balibrea@ific.uv.es |
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Publisher |
Springer Heidelberg |
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English |
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ISSN |
2190-5444 |
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Conference |
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Notes |
WOS:000886327900002 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
5420 |
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Author |
Gonzalez-Iglesias, D.; Esperante, D.; Gimeno, B.; Blanch, C.; Fuster-Martinez, N.; Martinez-Reviriego, P.; Martin-Luna, P.; Fuster, J.; Alesini, D. |
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Title |
Analysis of the Multipactor Effect in an RF Electron Gun Photoinjector |
Type |
Journal Article |
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Year |
2023 |
Publication |
IEEE Transactions on Electron Devices |
Abbreviated Journal |
IEEE Trans. Electron Devices |
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Volume |
70 |
Issue |
1 |
Pages |
288-295 |
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Keywords |
Magnetic tunneling; Multipactor effect; photoinjector; RF breakdown; RF gun |
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Abstract |
The objective of this work is the evaluation of the risk of suffering a multipactor discharge within an RF electron gun photoinjector. Photoinjectors are a type of source for intense electron beams, which are the main electron source for synchrotron light sources, such as free-electron lasers. The analyzed device consists of 1.6 cells and it has been designed to operate at the S-band. Besides, around the RF gun there is an emittance compensation solenoid, whose magnetic field prevents the growth of the electron beam emittance, and thus the degradation of the properties of the beam. The multipactor analysis is based on a set of numerical simulations by tracking the trajectories of the electron cloud in the cells of the device. To reach this aim, an in-house multipactor code was developed. Specifically, two different cases were explored: with the emittance compensation solenoid assumed to be off and with the emittance compensation solenoid in operation. For both the cases, multipactor simulations were carried out exploring different RF electric field amplitudes. Moreover, for a better understanding of the multipactor phenomenon, the resonant trajectories of the electrons and the growth rate of the electrons population are investigated. |
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Address |
[Gonzalez-Iglesias, D.; Esperante, D.; Gimeno, B.; Blanch, C.; Fuster-Martinez, N.; Martinez-Reviriego, P.; Martin-Luna, P.; Fuster, J.] Univ Valencia, Inst Fis Corpuscular IFIC, CSIC, Paterna 46980, Spain, Email: Daniel.Gonzalez-Iglesias@uv.es |
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Publisher |
Ieee-Inst Electrical Electronics Engineers Inc |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
0018-9383 |
ISBN |
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Conference |
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Notes |
WOS:000890813600001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
5427 |
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Author |
Hernandez, P.; Lopez-Pavon, J.; Rius, N.; Sandner, S. |
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Title |
Bounds on right-handed neutrino parameters from observable leptogenesis |
Type |
Journal Article |
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Year |
2022 |
Publication |
Journal of High Energy Physics |
Abbreviated Journal |
J. High Energy Phys. |
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Volume |
12 |
Issue |
12 |
Pages |
012 - 58pp |
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Keywords |
Baryo-and Leptogenesis; Early Universe Particle Physics; Sterile or Heavy Neutrinos |
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Abstract |
We revisit the generation of a matter-antimatter asymmetry in the minimal extension of the Standard Model with two singlet heavy neutral leptons (HNL) that can explain neutrino masses. We derive an accurate analytical approximation to the solution of the complete linearized set of kinetic equations, which exposes the non-trivial parameter dependencies in the form of parameterization-independent CP invariants. The identification of various washout regimes relevant in different regions of parameter space sheds light on the relevance of the mass corrections in the interaction rates and clarifies the correlations of baryogenesis with other observables. In particular, by requiring that the measured baryon asymmetry is reproduced, we derive robust upper or lower bounds on the HNL mixings depending on their masses, and constraints on their flavour structure, as well as on the CP-violating phases of the PMNS mixing matrix, and the amplitude of neutrinoless double-beta decay. We also find certain correlations between low and high scale CP phases. Especially emphasizing the testable part of the parameter space we demonstrate that our findings are in very good agreement with numerical results. The methods developed in this work can help in exploring more complex scenarios. |
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Address |
[Hernandez, P.] Univ Valencia, Inst Fis Corpuscular, Edificio Inst Invest,Catedrat Jose Beltran 2, Paterna 46980, Spain, Email: m.pilar.hernandez@uv.es; |
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Publisher |
Springer |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
1029-8479 |
ISBN |
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Conference |
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Notes |
WOS:000914640400003 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
5467 |
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Author |
Mendoza, E.; Alcayne, V.; Cano-Ott, D.; Gonzalez-Romero, E.; Martinez, T.; de Rada, A.P.; Sanchez-Caballero, A.; Balibrea-Correa, J.; Domingo-Pardo, C.; Lerendegui-Marco, J.; Calvino, F.; Guerrero, C. |
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Title |
Neutron capture measurements with high efficiency detectors and the Pulse Height Weighting Technique |
Type |
Journal Article |
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Year |
2023 |
Publication |
Nuclear Instruments & Methods in Physics Research A |
Abbreviated Journal |
Nucl. Instrum. Methods Phys. Res. A |
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Volume |
1047 |
Issue |
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Pages |
167894 - 16pp |
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Keywords |
Neutron capture; Total energy detector; Pulse height weighting technique; 7-ray cascades |
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Abstract |
Neutron capture cross section measurements in time-of-flight facilities are usually performed by detecting the prompt 7-rays emitted in the capture reactions. One of the difficulties to be addressed in these measurements is that the emitted 7-rays may change with the neutron energy, and therefore also the detection efficiency. To deal with this situation, many measurements use the so called Total Energy Detection (TED) technique, usually in combination with the Pulse Height Weighting Technique (PHWT). With it, it is sought that the detection efficiency depends only on the total energy of the 7-ray cascade, which does not vary much with the neutron energy. This technique was developed in the 1960s and has been used in many neutron capture experiments to date. One of the requirements of the technique is that 7-ray detectors have a low efficiency. This has meant that the PHWT has been used with experimental setups with low detection efficiencies. However, this condition does not have to be fulfilled by the experimental system as a whole. The main goal of this work is to show that it is possible to measure with a high efficiency detection system that uses the PHWT, and how to analyze the measured data. |
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Address |
[Mendoza, E.; Alcayne, V; Cano-Ott, D.; Gonzalez-Romero, E.; Martinez, T.; Perez de Rada, A.; Sanchez-Caballero, A.] Ctr Invest Energet Medioambientales & Tecnol CIEM, Madrid, Spain, Email: emilio.mendoza@ciemat.es |
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Corporate Author |
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Thesis |
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Publisher |
Elsevier |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
0168-9002 |
ISBN |
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Area |
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Conference |
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Notes |
WOS:000908431800002 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
5468 |
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