Abstract: We quantify the impact of massive neutrinos on the statistics of low-density regions in the intergalactic medium as probed by the Lyman alpha forest at redshifts z = 2.2-4. Based on mock but realistic quasar (QSO) spectra extracted from hydrodynamic simulations with cold dark matter, baryons and neutrinos, we find that the probability distribution of weak Lyman alpha absorption features, as sampled by Lyman alpha flux regions at high transmissivity, is strongly affected by the presence of massive neutrinos. We show that systematic errors affecting the Lyman alpha forest reduce but do not erase the neutrino signal. Using the Fisher matrix formalism, we conclude that the sum of the neutrino masses can be measured, using the method proposed in this paper, with a precision smaller than 0.4 eV using a catalogue of 200 high-resolution (signal-to-noise ratio similar to 100) QSO spectra. This number reduces to 0.27 eV by making use of reasonable priors in the other parameters that also affect the statistics of the high-transitivity regions of the Lyman alpha forest. The constraints obtained with this method can be combined with independent bounds from the cosmic microwave background, large-scale structures and measurements of the matter power spectrum from the Lyman alpha forest to produce tighter upper limits on the sum of the masses of the neutrinos.

Abstract: In this work, the development and characterization of a multiple synchronous registers interface communicating with a high-speed serial link and using the Aurora protocol is presented. A detailed description of the developing process and the characterization methods and hardware test benches are also included. This interface will implement the slow control buses of the digitizer cards for the second generation of electronics for the Advanced GAmma Tracking Array (AGATA).

Abstract: Hadron therapy exploits the properties of ion beams to treat tumors by maximizing the dose released to the target and sparing healthy tissue. With hadron beams, the dose distribution shows a relatively low entrance dose which rises sharply at the end of the range, providing the characteristic Bragg peak that drops quickly thereafter. It is of critical importance in order not to damage surrounding healthy tissues and/or avoid targeting underdosage to know where the delivered dose profile ends-the location of the Bragg peak. During hadron therapy, short-lived beta(+)-emitters are produced along the beam path, their distribution being correlated with the delivered dose. Following positron annihilation, two photons are emitted, which can be detected using a positron emission tomography (PET) scanner. The low yield of emitters, their short half-life, and the wash out from the target region make the use of PET, even only a few minutes after hadron irradiation, a challenging application. In-beam PET represents a potential candidate to estimate the distribution of beta(+)-emitters during or immediately after irradiation, at the cost of truncation effects and degraded image quality due to the partial rings required of the PET scanner. Time-of-flight (ToF) information can potentially be used to compensate for truncation effects and to enhance image contrast. However, the highly demanding timing performance required in ToF-PET makes this option costly. Alternatively, the use of maximum-a-posteriori-expectation-maximization (MAP-EM), including total variation (TV) in the cost function, produces images with low noise, while preserving spatial resolution. In this paper, we compare data reconstructed with maximum-likelihood-expectation-maximization (ML-EM) and MAP-EM using TV as prior, and the impact of including ToF information, from data acquired with a complete and a partial-ring PET scanner, of simulated hadron beams interacting with a polymethyl methacrylate (PMMA) target. The results show that MAP-EM, in the absence of ToF information, produces lower noise images and more similar data compared to the simulated beta(+) distributions than ML-EM with ToF information in the order of 200-600 ps. The investigation is extended to the combination of MAP-EM and ToF information to study the limit of performance using both approaches.

Abstract: Spectroscopy is used to measure the elemental abundances in the outer layers of the Sun, whereas helioseismology probes the interior. It is well known that current spectroscopic determinations of the chemical composition are starkly at odds with the metallicity implied by helioseismology. We investigate whether the discrepancy may be due to conversion of photons to a new light boson in the solar photosphere. We examine the impact of particles with axion-like interactions with the photon on the inferred photospheric abundances, showing that resonant axion-photon conversion is not possible in the region of the solar atmosphere in which line formation occurs. Although non-resonant conversion in the line-forming regions can in principle impact derived abundances, constraints from axion-photon conversion experiments rule out the couplings necessary for these effects to be detectable. We show that this extends to hidden photons and chameleons (which would exhibit similar phenomenological behaviour), ruling out known theories of new light bosons as photospheric solutions to the solar abundance problem.

Abstract: Monte Carlo simulations play a crucial role for in-vivo treatment monitoring based on PET and prompt gamma imaging in proton and carbon-ion therapies. The accuracy of the nuclear fragmentation models implemented in these codes might affect the quality of the treatment verification. In this paper, we investigate the nuclear models implemented in GATE/Geant4 and FLUKA by comparing the angular and energy distributions of secondary particles exiting a homogeneous target of PMMA. Comparison results were restricted to fragmentation of O-16 and C-12. Despite the very simple target and set-up, substantial discrepancies were observed between the two codes. For instance, the number of high energy (>1 MeV) prompt gammas exiting the target was about twice as large with GATE/Geant4 than with FLUKA both for proton and carbon ion beams. Such differences were not observed for the predicted annihilation photon production yields, for which ratios of 1.09 and 1.20 were obtained between GATE and FLUKA for the proton beam and the carbon ion beam, respectively. For neutrons and protons, discrepancies from 14% (exiting protons-carbon ion beam) to 57% (exiting neutrons-proton beam) have been identified in production yields as well as in the energy spectra for neutrons.