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Author  |
Schaffter, T. et al; Albiol, F.; Caballero, L. |
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Title |
Evaluation of Combined Artificial Intelligence and Radiologist Assessment to Interpret Screening Mammograms |
Type |
Journal Article |
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Year |
2020 |
Publication |
JAMA Network Open |
Abbreviated Journal |
JAMA Netw. Open |
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Volume |
3 |
Issue |
3 |
Pages |
e200265 - 15pp |
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Abstract |
Importance Mammography screening currently relies on subjective human interpretation. Artificial intelligence (AI) advances could be used to increase mammography screening accuracy by reducing missed cancers and false positives. Objective To evaluate whether AI can overcome human mammography interpretation limitations with a rigorous, unbiased evaluation of machine learning algorithms. Design, Setting, and Participants In this diagnostic accuracy study conducted between September 2016 and November 2017, an international, crowdsourced challenge was hosted to foster AI algorithm development focused on interpreting screening mammography. More than 1100 participants comprising 126 teams from 44 countries participated. Analysis began November 18, 2016. Main Outcomes and Measurements Algorithms used images alone (challenge 1) or combined images, previous examinations (if available), and clinical and demographic risk factor data (challenge 2) and output a score that translated to cancer yes/no within 12 months. Algorithm accuracy for breast cancer detection was evaluated using area under the curve and algorithm specificity compared with radiologists' specificity with radiologists' sensitivity set at 85.9% (United States) and 83.9% (Sweden). An ensemble method aggregating top-performing AI algorithms and radiologists' recall assessment was developed and evaluated. Results Overall, 144231 screening mammograms from 85580 US women (952 cancer positive <= 12 months from screening) were used for algorithm training and validation. A second independent validation cohort included 166578 examinations from 68008 Swedish women (780 cancer positive). The top-performing algorithm achieved an area under the curve of 0.858 (United States) and 0.903 (Sweden) and 66.2% (United States) and 81.2% (Sweden) specificity at the radiologists' sensitivity, lower than community-practice radiologists' specificity of 90.5% (United States) and 98.5% (Sweden). Combining top-performing algorithms and US radiologist assessments resulted in a higher area under the curve of 0.942 and achieved a significantly improved specificity (92.0%) at the same sensitivity. Conclusions and Relevance While no single AI algorithm outperformed radiologists, an ensemble of AI algorithms combined with radiologist assessment in a single-reader screening environment improved overall accuracy. This study underscores the potential of using machine learning methods for enhancing mammography screening interpretation. Question How do deep learning algorithms perform compared with radiologists in screening mammography interpretation? Findings In this diagnostic accuracy study using 144231 screening mammograms from 85580 women from the United States and 166578 screening mammograms from 68008 women from Sweden, no single artificial intelligence algorithm outperformed US community radiologist benchmarks; including clinical data and prior mammograms did not improve artificial intelligence performance. However, combining best-performing artificial intelligence algorithms with single-radiologist assessment demonstrated increased specificity. Meaning Integrating artificial intelligence to mammography interpretation in single-radiologist settings could yield significant performance improvements, with the potential to reduce health care system expenditures and address resource scarcity experienced in population-based screening programs. This diagnostic accuracy study evaluates whether artificial intelligence can overcome human mammography interpretation limits with a rigorous, unbiased evaluation of machine learning algorithms. |
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Address |
[Schaffter, Thomas; Hoff, Bruce; Yu, Thomas; Neto, Elias Chaibub; Friend, Stephen; Guinney, Justin] Sage Bionetworks, Computat Oncol, Seattle, WA USA, Email: gustavo@us.ibm.com |
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Amer Medical Assoc |
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English |
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2574-3805 |
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WOS:000519249800002 |
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no |
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yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
4683 |
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Author |
Saul-Sala, E.; Sobczyk, J.E.; Rafi Alam, M.; Alvarez-Ruso, L.; Nieves, J. |
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Title |
Weak kaon production off the nucleon and Watson's theorem |
Type |
Journal Article |
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Year |
2021 |
Publication |
Physics Letters B |
Abbreviated Journal |
Phys. Lett. B |
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Volume |
817 |
Issue |
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Pages |
136349 - 7pp |
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Abstract |
We have improved the tree-level model of Ref.[1] for weak production of kaons off nucleons by partially restoring unitarity. This is achieved by imposing Watson's theorem to the dominant vector and axial-vector contributions in appropriate angular momentum and isospin quantum number sectors. The observable consequences of this procedure are investigated. |
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Address |
[Saul-Sala, E.; Alvarez-Ruso, L.; Nieves, J.] Univ Valencia, CSIC, Ctr Mixto, Inst Invest Paterna,Dept Fis Teor, E-46071 Valencia, Spain, Email: luis.alvarez@ific.uv.es |
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Elsevier |
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English |
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ISSN |
0370-2693 |
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Notes |
WOS:000657652200060 |
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no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
4867 |
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Author |
Santos, A.C.L.; Muniz, C.R.; Maluf, R.V. |
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Title |
Yang-Mills Casimir wormholes in D=2+1 |
Type |
Journal Article |
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Year |
2023 |
Publication |
Journal of Cosmology and Astroparticle Physics |
Abbreviated Journal |
J. Cosmol. Astropart. Phys. |
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Volume |
09 |
Issue |
9 |
Pages |
022 - 24pp |
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Keywords |
Wormholes; Exact solutions; black holes and black hole thermodynamics in GR and beyond; gravity |
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Abstract |
This work presents new three-dimensional traversable wormhole solutions sourced by the Casimir density and pressures related to the quantum vacuum fluctuations in Yang-Mills (Y-M) theory. We begin by analyzing the noninteracting Y-M Casimir wormholes, initially considering an arbitrary state parameter omega and determine a simple constant wormhole shape function. Next, we introduce a new methodology for deforming the state parameter to find well-behaved redshift functions. The wormhole can be interpreted as a legitimate Casimir wormhole with an expected average state parameter of omega = 2. Then, we investigate the wormhole curvature properties, energy conditions, and stability. Furthermore, we discover a novel family of traversable wormhole solutions sourced by the quantum vacuum fluctuations of interacting Yang-Mills fields with a more complex shape function. Deforming the effective state parameter similarly, we obtain well-behaved redshift functions and traversable wormhole solutions. Finally, we examine the energy conditions and stability of solutions in the interacting scenario and compare to the noninteracting case. |
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Address |
[Santos, Alana C. L.; Maluf, Roberto V.] Univ Fed Ceara UFC, Departamento Fis, Campus Pici,6030, BR-60455760 Fortaleza, Ceara, Brazil, Email: alanasantos@fisica.ufc.br; |
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IOP Publishing Ltd |
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English |
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ISSN |
1475-7516 |
ISBN |
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Notes |
WOS:001196198800004 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6031 |
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Author |
Sandner, S.; Hernandez, P.; Lopez-Pavon, J.; Rius, N. |
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Title |
Predicting the baryon asymmetry with degenerate right-handed neutrinos |
Type |
Journal Article |
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Year |
2023 |
Publication |
Journal of High Energy Physics |
Abbreviated Journal |
J. High Energy Phys. |
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Volume |
11 |
Issue |
11 |
Pages |
153 - 37pp |
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Keywords |
Baryo-and Leptogenesis; Sterile or Heavy Neutrinos; Early Universe Particle Physics |
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Abstract |
We consider the generation of a baryon asymmetry in an extension of the Standard Model with two singlet Majorana fermions that are degenerate above the electroweak phase transition. The model can explain neutrino masses as well as the observed matter-antimatter asymmetry, for masses of the heavy singlets below the electroweak scale. The only physical CP violating phases in the model are those in the PMNS mixing matrix, i.e. the Dirac phase and a Majorana phase that enter light neutrino observables. We present an accurate analytic approximation for the baryon asymmetry in terms of CP flavour invariants, and derive the correlations with neutrino observables. We demonstrate that the measurement of CP violation in neutrino oscillations as well as the mixings of the heavy neutral leptons with the electron, muon and tau flavours suffice to pin down the matter-antimatter asymmetry from laboratory measurements. |
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Address |
[Sandner, S.] Univ Valencia, Inst Fis Corpuscular, Edificio Inst Invest,Catedrat Jose Beltran 2, Paterna 46980, Spain, Email: stefan.sandner@ific.uv.es; |
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Springer |
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English |
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ISSN |
1029-8479 |
ISBN |
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Notes |
WOS:001111979900002 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
5869 |
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Author |
Sandner, S.; Escudero, M.; Witte, S.J. |
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Title |
Precision CMB constraints on eV-scale bosons coupled to neutrinos |
Type |
Journal Article |
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Year |
2023 |
Publication |
European Physical Journal C |
Abbreviated Journal |
Eur. Phys. J. C |
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Volume |
83 |
Issue |
8 |
Pages |
709 - 12pp |
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Abstract |
The cosmic microwave background (CMB) has proven to be an invaluable tool for studying the properties and interactions of neutrinos, providing insight not only into the sum of neutrino masses but also the free streaming nature of neutrinos prior to recombination. The CMB is a particularly powerful probe of new eV-scale bosons interacting with neutrinos, as these particles can thermalizewith neutrinos via the inverse decay process, v (v) over bar -> X, and suppress neutrino free streaming near recombination – even for couplings as small as lambda(v) similar to O(10(-13)). Here, we revisit CMB constraints on such bosons, improving upon a number of approximations previously adopted in the literature and generalizing the constraints to a broader class of models. This includes scenarios in which the boson is either spin-0 or spin-1, the number of interacting neutrinos is either N-int = 1, 2 or 3, and the case in which a primordial abundance of the species is present. We apply these bounds to well-motivatedmodels, such as the singlet majoron model or a light U(1) L-mu- L-t gauge boson, and find that they represent the leading constraints for masses m(X) similar to 1 eV. Finally, we revisit the extent to which neutrinophilic bosons can ameliorate the Hubble tension, and find that recent improvements in the understanding of how such bosons damp neutrino free streaming reduces the previously found success of this proposal. |
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Address |
[Sandner, Stefan] Univ Valencia, Inst Fis Corpuscular, Edificio Inst Invest,Catedrat Jose Beltran 2, Paterna 46980, Spain, Email: stefan.sandner@ific.uv.es; |
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Springer |
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English |
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ISSN |
1434-6044 |
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Notes |
WOS:001045200700001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
5608 |
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Author |
Sanchis-Lozano, M.A.; Sarkisyan-Grinbaum, E.K.; Domenech-Garret, J.L.; Sanchis-Gual, N. |
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Title |
Cosmological analogies in the search for new physics in high-energy collisions |
Type |
Journal Article |
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Year |
2020 |
Publication |
Physical Review D |
Abbreviated Journal |
Phys. Rev. D |
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Volume |
102 |
Issue |
3 |
Pages |
035013 - 7pp |
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Keywords |
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Abstract |
In this paper, analogies between multiparticle production in high-energy collisions and the time evolution of the early Universe are discussed. A common explanation is put forward under the assumption of an unconventional early state: a rapidly expanding universe before recombination (last scattering surface), followed by the cosmic microwave background, later evolving up to present days, versus the formation of hidden/dark states in hadronic collisions followed by a conventional QCD parton shower yielding final-state particles. In particular, long-range angular correlations are considered pointing out deep connections between the two physical cases potentially useful for the discovery of new physics. |
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Address |
[Sanchis-Lozano, Miguel-Angel] Univ Valencia, CSIC, Inst Fis Corpuscular IFIC, Dr Moliner 50, E-46100 Burjassot, Spain, Email: Miguel.Angel.Sanchis@ific.uv.es; |
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Amer Physical Soc |
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English |
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ISSN |
1550-7998 |
ISBN |
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Notes |
WOS:000558084500004 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
4498 |
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Author |
Sanchis-Lozano, M.A.; Sanz, V. |
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Title |
Observable imprints of primordial gravitational waves on the temperature anisotropies of the cosmic microwave background |
Type |
Journal Article |
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Year |
2024 |
Publication |
Physical Review D |
Abbreviated Journal |
Phys. Rev. D |
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Volume |
109 |
Issue |
6 |
Pages |
063529 - 11pp |
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Abstract |
We examine the contribution of tensor modes, in addition to the dominant scalar ones, on the temperature anisotropies of the cosmic microwave background (CMB). To this end, we analyze in detail the temperature two -point angular correlation function C(Theta) from the Planck 2018 dataset, focusing on large angles (Theta greater than or similar to 120 degrees) corresponding to small l multipoles. A hierarchical set of infrared cutoffs are naturally introduced to the scalar and tensor power spectra of the CMB by invoking an extra Kaluza-Klein spatial dimension compactifying at about the grand unified theory scale between the Planck epoch and the start of inflation. We associate this set of lower scalar and tensor cutoffs with the parity of the multipole expansion of the C(Theta) function. By fitting the Planck 2018 data we compute the multipole coefficients, thereby reproducing the well-known odd -parity preference in angular correlations seen by all three satellite missions: Cosmic Background Explorer, WMAP, and Planck. Our fits improve significantly once tensor modes are included in the analysis, hence providing a hint of the imprints of primordial gravitational waves on the temperature correlations observed in the CMB today. To conclude, we suggest a relationship between, on the one hand, the lack of (positive) large -angle correlations and the odd -parity dominance in the CMB and, on the other hand, the effect of primordial gravitational waves on the CMB temperature anisotropies. |
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Address |
[Sanchis-Lozano, Miguel -Angel; Sanz, Veronica] Univ Valencia, Dept Fis Teor, CSIC, Valencia 46100, Spain, Email: miguel.angel.sanchis@ific.uv.es; |
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Publisher |
Amer Physical Soc |
Place of Publication |
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English |
Summary Language |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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ISSN |
2470-0010 |
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Conference |
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Notes |
WOS:001195716600006 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
6038 |
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Author |
Sanchis-Lozano, M.A.; Melia, F.; Lopez-Corredoira, M.; Sanchis-Gual, N. |
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Title |
Missing large-angle correlations versus even-odd point-parity imbalance in the cosmic microwave background |
Type |
Journal Article |
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Year |
2022 |
Publication |
Astronomy & Astrophysics |
Abbreviated Journal |
Astron. Astrophys. |
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Volume |
660 |
Issue |
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Pages |
A121 - 10pp |
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Keywords |
cosmological parameters; cosmic background radiation; cosmology: observations; cosmology: theory; inflation; large-scale structure of Universe |
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Abstract |
Context. The existence of a maximum correlation angle (theta(max) & 60 greater than or similar to degrees) in the two-point angular temperature correlations of cosmic microwave background (CMB) radiation, measured by WMAP and Planck, stands in sharp contrast to the prediction of standard inflationary cosmology, in which the correlations should extend across the full sky (i.e., 180 degrees). The introduction of a hard lower cuto ff (k(min)) in the primordial power spectrum, however, leads naturally to the existence of theta(max). Among other cosmological anomalies detected in these data, an apparent dominance of odd-over-even parity multipoles has been seen in the angular power spectrum of the CMB. This feature, however, may simply be due to observational contamination in certain regions of the sky. Aims. In attempting to provide a more detailed assessment of whether this odd-over-even asymmetry is intrinsic to the CMB, we therefore proceed in this paper, first, to examine whether this odd-even parity imbalance also manifests itself in the angular correlation function and, second, to examine in detail the interplay between the presence of theta(max) and this observed anomaly. Methods. We employed several parity statistics and recalculated the angular correlation function for di fferent values of the cuto ff kmin in order to optimize the fit to the di fferent Planck 2018 data. Results. We find a phenomenological connection between these features in the data, concluding that both must be considered together in order to optimize the theoretical fit to the Planck 2018 data. Conclusions. This outcome is independent of whether the parity imbalance is intrinsic to the CMB, but if it is, the odd-over-even asymmetry would clearly point to the emergence of new physics. |
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Address |
[Sanchis-Lozano, M-A] Ctr Mixto Univ Valencia, Inst Fis Corpuscular IFIC, CSIC, Dr Moliner 50, Burjassot, Spain, Email: Miguel.Angel.Sanchis@ific.uv.es; |
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Edp Sciences S A |
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English |
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0004-6361 |
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Notes |
WOS:000786712000002 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
5211 |
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Author |
Sanchis-Lozano, M.A. |
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Title |
Stringy Signals from Large-Angle Correlations in the Cosmic Microwave Background? |
Type |
Journal Article |
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Year |
2022 |
Publication |
Universe |
Abbreviated Journal |
Universe |
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Volume |
8 |
Issue |
8 |
Pages |
396 - 13pp |
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Keywords |
cosmic microwave background; angular correlations; inflation; string theory |
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Abstract |
We interpret the lack of large-angle temperature correlations and the even-odd parity imbalance observed in the cosmic microwave background (CMB) by COBE, WMAP and Planck satellite missions as a possible stringy signal ultimately stemming from a composite inflaton field (e.g., a fermionic condensate). Based on causality arguments and a Fourier analysis of the angular two-point correlation function, two infrared cutoffs k(min)(even,odd) (satisfying k(min)(even) similar or equal to 2k(min)(odd)) are introduced to the CMB power spectrum associated, respectively, with periodic and antiperiodic boundary conditions of the fermionic constituents (echoing the Neveu-Schwarz-Ramond model in superstring theory), without resorting to any particular model. |
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Address |
[Sanchis-Lozano, Miguel-Angel] Univ Valencia, Dept Theoret Phys, Doctor Moliner 50, Burjassot 46011, Spain, Email: miguel.angel.sanchis@ific.uv.es |
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Mdpi |
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English |
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WOS:000845107300001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
5344 |
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Author |
Sanchis-Gual, N.; del Rio, A. |
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Title |
Precessing binary black holes as engines of electromagnetic helicity |
Type |
Journal Article |
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Year |
2023 |
Publication |
Physical Review D |
Abbreviated Journal |
Phys. Rev. D |
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Volume |
108 |
Issue |
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Pages |
044052 - 11pp |
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Abstract |
We show that binary black hole mergers with precessing evolution can potentially excite photons from the quantum vacuum in such a way that total helicity is not preserved in the process. Helicity violation is allowed by quantum fluctuations that spoil the electric-magnetic duality symmetry of the classical Maxwell theory without charges. We show here that precessing binary black hole systems in astrophysics generate a flux of circularly polarized gravitational waves which, in turn, provides the required helical background that triggers this quantum effect. Solving the fully nonlinear Einstein’s equations with numerical relativity we explore the parameter space of binary systems and extract the detailed dependence of the quantum effect with the spins of the two black holes. We also introduce a set of diagrammatic techniques that allows us to predict when a binary black hole merger can or cannot emit circularly polarized gravitational radiation, based on mirror-symmetry considerations. This framework allows to understand and to interpret correctly the numerical results, and to predict the outcomes in potentially interesting astrophysical systems. |
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Notes |
|
Approved |
no |
|
| |
Is ISI |
yes |
International Collaboration |
yes |
|
| |
Call Number |
IFIC @ pastor @ |
Serial |
6092 |
|
| Permanent link to this record |
