Abstract: The lack of evidence for new physics at the Large Hadron Collider so far has prompted the development of model-independent search techniques. In this study, we compare the anomaly scores of a variety of anomaly detection techniques: an isolation forest, a Gaussian mixture model, a static autoencoder, and a beta-variational autoencoder (VAE), where we define the reconstruction loss of the latter as a weighted combination of regression and classification terms. We apply these algorithms to the 4-vectors of simulated LHC data, but also investigate the performance when the non-VAE algorithms are applied to the latent space variables created by the VAE. In addition, we assess the performance when the anomaly scores of these algorithms are combined in various ways. Using supersymmetric benchmark points, we find that the logical AND combination of the anomaly scores yielded from algorithms trained in the latent space of the VAE is the most effective discriminator of all methods tested.

Abstract: The neutron-rich Pb-213 isotope was produced in the fragmentation of a primary 1 GeV A U-238 beam, separated in FRS in mass and atomic number, and then implanted for isomer decay gamma-ray spectroscopy with the RISING setup at GSI. A newly observed isomer and its measured decay properties indicate that states in Pb-213 are characterized by the seniority quantum number that counts the nucleons not in pairs coupled to angular momentum J = 0. The conservation of seniority is a consequence of a geometric phase associated with particle-hole conjugation, which becomes observable in semi-magic nuclei where nucleons half-fill the valence shell. The gamma-ray spectroscopic observables in Pb-213 are thus found to be driven by two mechanisms, particle-hole conjugation and seniority conservation, which are intertwined through a Berry phase.

Abstract: Urgent theoretical progress is needed in order to provide an estimate in the Standard Model of the recent measurement by LHCb of direct CP violation in charm-meson two-body decays. Rescattering effects must be taken into account for a meaningful theoretical description of the amplitudes involved in such category of observables, as signaled by the presence of large strong phases. We discuss the computation of the latter effects based on a two-channel coupled dispersion relation, which exploits isospin-zero phase shifts and inelasticity parameterizations of data coming from the rescattering processes pi pi ->pi pi, pi K ->pi K, and pi pi -> KK<overline>. The determination of the subtraction constants of the dispersive integrals relies on the leading contributions to the transition amplitudes from the 1/NC counting, where NC is the number of QCD colors. Furthermore, we use the measured values of the branching ratios to help in selecting the non-perturbative inputs in the isospin limit, from which we predict values for the CP asymmetries. We find that the predicted level of CP violation is much below the experimental value.

Abstract: Purpose This work aims to simulate clustered DNA damage from ionizing radiation and estimate the relative biological effectiveness (RBE) for radionuclide (rBT)- and electronic (eBT)-based surface brachytherapy through a hybrid Monte Carlo (MC) approach, using realistic models of the sources and applicators. Methods Damage from ionizing radiation has been studied using the Monte Carlo Damage Simulation algorithm using as input the primary electron fluence simulated using a state-of-the-art MC code, PENELOPE-2018. Two Ir-192 rBT applicators, Valencia and Leipzig, one Co-60 source with a Freiburg Flap applicator (reference source), and two eBT systems, Esteya and INTRABEAM, have been included in this study implementing full realizations of their geometries as disclosed by the manufacturer. The role played by filtration and tube kilovoltage has also been addressed. Results For rBT, an RBE value of about 1.01 has been found for the applicators and phantoms considered. In the case of eBT, RBE values for the Esteya system show an almost constant RBE value of about 1.06 for all depths and materials. For INTRABEAM, variations in the range of 1.12-1.06 are reported depending on phantom composition and depth. Modifications in the Esteya system, filtration, and tube kilovoltage give rise to variations in the same range. Conclusions Current clinical practice does not incorporate biological effects in surface brachytherapy. Therefore, the same absorbed dose is administered to the patients independently on the particularities of the rBT or eBT system considered. The almost constant RBE values reported for rBT support that assumption regardless of the details of the patient geometry, the presence of a flattening filter in the applicator design, or even significant modifications in the photon energy spectra above 300 keV. That is not the case for eBT, where a clear dependence on the eBT system and the characteristics of the patient geometry are reported. A complete study specific for each eBT system, including detailed applicator characteristics (size, shape, filtering, among others) and common anatomical locations, should be performed before adopting an existing RBE value.

Abstract: Background Low-energy x-ray beams used in electronic brachytherapy (eBT) present significant dosimetric challenges due to their high depth-dose gradients, the dependence of detector response on materials, and the lack of standardized dose-to-water references. These challenges have driven the need for Monte Carlo (MC) simulations to ensure accurate dosimetry. However, discrepancies in the physics models used by different MC systems have raised concerns about their dosimetric consistency, particularly in modeling bremsstrahlung interactions. Purpose To assess the dosimetric impact of using different physics approaches in three state-of-the-art MC systems for eBT, focusing on the disagreements observed when different MC methods are used to evaluate bremsstrahlung interactions. Methods The MC studies of the Axxent S700, the Esteya, and the INTRABEAM eBT systems were performed using two EGSnrc applications (egsbrachy and egskerma), TOPAS, and PENELOPE-2018 (PEN18). The fluence spectra and depth doses were compared for simplified x-ray tube models, which maintain the target mode (transmission or reflection), the target material and thickness, and the surface applicators' source-to-surface distance. An extra simulation was made to evaluate the utility of the simplified models as proxies in predicting the most important characteristics of an accurate applicator's simulation (detailed model of INTRABEAM's 30 mm surface applicator). The EGSnrc applications and PEN18 utilized their default bremsstrahlung angular emission approaches. TOPAS used two physics lists: g4em-livermore (TOPAS(liv)) and g4em-penelope (TOPAS(pen)). Results The most significant differences between MC codes were observed for the transmission target mode. The bremsstrahlung component of the fluence spectra differed by about 15% on average, comparing PEN18, EGSnrc applications, and TOPAS(liv), with PEN18's fluences consistently lower. EGSnrc and PEN18 agreed within 3% for their characteristic spectrum components. However, PEN18's characteristic lines overreached TOPAS(liv)'s by 40%. Those spectral characteristics generated depth dose differences, where PEN18, on average, scored 9% lower than EGSnrc and TOPAS(liv). Considering TOPAS(pen) in the transmission mode, PEN18's fluence spectrum presented a lower bremsstrahlung (5%) but a higher characteristic component (10%); these spectral differences compensated, generating depth dose differences within 1% average. In the reflection target mode, EGSnrc and PEN18 agreed within 4% for the bremsstrahlung and characteristic components of the fluence spectra. With TOPAS(pen) in the reflection mode, PEN18 presents 12% lower fluences in the bremsstrahlung component but 6% higher characteristic lines. This spectral behavior diminished the depth dose differences up to 3%. Conclusion This work found considerable disagreements between three state-of-the-art MC systems commonly used in medical applications when simulating bremsstrahlung in eBT. The differences arose when the bremsstrahlung angular distribution and the atomic relaxation processes in the target became relevant. More theoretical and experimental studies are necessary to evaluate the impact of these differences on related calculations.