Abstract: Palliative care is referred to a set of programs for patients that suffer life-limiting illnesses. These programs aim to maximize the quality of life (QoL) for the last stage of life. They are currently based on clinical evaluation of the risk of 1-year mortality. The main aim of this work is to develop and validate machine-learning-based models to predict the exitus of a patient within the next year using data gathered at hospital admission. Five machine-learning techniques were applied using a retrospective dataset. The evaluation was performed with five metrics computed by a resampling strategy: Accuracy, the area under the ROC curve, Specificity, Sensitivity, and the Balanced Error Rate. All models reported an AUC ROC from 0.857 to 0.91. Specifically, Gradient Boosting Classifier was the best model, producing an AUC ROC of 0.91, a sensitivity of 0.858, a specificity of 0.808, and a BER of 0.1687. Information from standard procedures at hospital admission combined with machine learning techniques produced models with competitive discriminative power. Our models reach the best results reported in the state of the art. These results demonstrate that they can be used as an accurate data-driven palliative care criteria inclusion.

Abstract: Recently, the formalism needed to relate the finite-volume spectrum of systems of nondegenerate spinless particles has been derived. In this work we discuss a range of issues that arise when implementing this formalism in practice, provide further theoretical results that can be used to check the implementation, and make available codes for implementing the three-particle quantization condition. Specifically, we discuss the need to modify the upper limit of the cutoff function due to the fact that the left-hand cut in the scattering amplitudes for two nondegenerate particles moves closer to threshold; we describe the decomposition of the three-particle amplitude K-df,K-3 into the matrix basis used in the quantization condition, including both s and p waves, with the latter arising in the amplitude for two nondegenerate particles; we derive the threshold expansion for the lightest three-particle state in the rest frame up to O(1/L-5); and we calculate the leading-order predictions in chiral perturbation theory for K-df,K-3 in the pi(+)pi K-+(+) and pi+K+K+ systems. We focus mainly on systems with two identical particles plus a third that is different (“2+1” systems). We describe the formalism in full detail, and present numerical explorations in toy models, in particular checking that the results agree with the threshold expansion, and making a prediction for the spectrum of pi(+)pi K-+(+) levels using the two- and three-particle interactions predicted by chiral perturbation theory.

Abstract: We present an implementation of the relativistic three-particle quantization condition including both s- and d-wave two-particle channels. For this, we develop a systematic expansion of the three-particle K matrix, K-df,K-3, about threshold, which is the generalization of the effective range expansion of the two-particle K matrix, K-2. Relativistic invariance plays an important role in this expansion. We find that d-wave two-particle channels enter first at quadratic order. We explain how to implement the resulting multichannel quantization condition, and present several examples of its application. We derive the leading dependence of the threshold three-particle state on the two-particle d-wave scattering amplitude, and use this to test our implementation. We show how strong two-particle d-wave interactions can lead to significant effects on the finite-volume three-particle spectrum, including the possibility of a generalized three-particle Efimov-like bound state. We also explore the application to the 3 pi(+) system, which is accessible to lattice QCD simulations, where we study the sensitivity of the spectrum to the components of K-df,K-3. Finally, we investigate the circumstances under which the quantization condition has unphysical solutions.

Abstract: Light axions (m(a) less than or similar to 10(-10) eV) can form dense clouds around rapidly rotating astrophysical black holes via a mechanism known as rotational superradiance. The coupling between axions and photons induces a parametric resonance, arising from the stimulated decay of the axion cloud, which can rapidly convert regions of large axion number densities into an enormous flux of low-energy photons. In this work we consider the phenomenological implications of a superradiant axion cloud undergoing resonant decay. We show that the low-energy photons produced from such events will be absorbed over cosmologically short distances, potentially inducing massive shockwaves that heat and ionize the intergalactic medium over Mpc scales. These shockwaves may leave observable imprints in the form of anisotropic spectral distortions or inhomogeneous features in the optical depth.

Abstract: We present an updated and improved global fit analysis of current flavour and electroweak precision observables to derive bounds on unitarity deviations of the leptonic mixing matrix and on the mixing of heavy neutrinos with the active flavours. This new analysis is motivated by new and updated experimental results on key observables such as V-ud, the invisible decay width of the Z boson and the W boson mass. It also improves upon previous studies by considering the full correlations among the different observables and explicitly calibrating the test statistic, which may present significant deviations from a & chi;(2) distribution. The results are provided for three different Type-I seesaw scenarios: the minimal scenario with only two additional right-handed neutrinos, the next to minimal one with three extra neutrinos, and the most general one with an arbitrary number of heavy neutrinos that we parametrise via a generic deviation from a unitary leptonic mixing matrix. Additionally, we also analyze the case of generic deviations from unitarity of the leptonic mixing matrix, not necessarily induced by the presence of additional neutrinos. This last case relaxes some correlations among the parameters and is able to provide a better fit to the data. Nevertheless, inducing only leptonic unitarity deviations avoiding both the correlations implied by the right-handed neutrino extension as well as more strongly constrained operators is challenging and would imply significantly more complex UV completions.