Abstract: Hadron therapy exploits the properties of ion beams to treat tumors by maximizing the dose released to the target and sparing healthy tissue. With hadron beams, the dose distribution shows a relatively low entrance dose which rises sharply at the end of the range, providing the characteristic Bragg peak that drops quickly thereafter. It is of critical importance in order not to damage surrounding healthy tissues and/or avoid targeting underdosage to know where the delivered dose profile ends-the location of the Bragg peak. During hadron therapy, short-lived beta(+)-emitters are produced along the beam path, their distribution being correlated with the delivered dose. Following positron annihilation, two photons are emitted, which can be detected using a positron emission tomography (PET) scanner. The low yield of emitters, their short half-life, and the wash out from the target region make the use of PET, even only a few minutes after hadron irradiation, a challenging application. In-beam PET represents a potential candidate to estimate the distribution of beta(+)-emitters during or immediately after irradiation, at the cost of truncation effects and degraded image quality due to the partial rings required of the PET scanner. Time-of-flight (ToF) information can potentially be used to compensate for truncation effects and to enhance image contrast. However, the highly demanding timing performance required in ToF-PET makes this option costly. Alternatively, the use of maximum-a-posteriori-expectation-maximization (MAP-EM), including total variation (TV) in the cost function, produces images with low noise, while preserving spatial resolution. In this paper, we compare data reconstructed with maximum-likelihood-expectation-maximization (ML-EM) and MAP-EM using TV as prior, and the impact of including ToF information, from data acquired with a complete and a partial-ring PET scanner, of simulated hadron beams interacting with a polymethyl methacrylate (PMMA) target. The results show that MAP-EM, in the absence of ToF information, produces lower noise images and more similar data compared to the simulated beta(+) distributions than ML-EM with ToF information in the order of 200-600 ps. The investigation is extended to the combination of MAP-EM and ToF information to study the limit of performance using both approaches.

Abstract: We calculate next-to-leading order (NLO) QCD corrections to electroweak Higgs boson plus three jet production. Both vector boson fusion (VBF) and Higgs-strahlung type contributions are included along with all interferences. The calculation is implemented within the MATCHBOX NLO framework of the HERWIG++ event generator.

Abstract: Higgs production in association with three jets via gluon fusion is an important channel for the measurement of the CP properties of the Higgs particle at the LHC. In this paper, we go beyond the heavy top effective theory approximation and include at LO the full mass dependence of the top- and bottom-quark contributions. We consider the dominant subchannel gg -> Hggg which involves the manipulation of massive rank-5 hexagon integrals. Furthermore, we present results for several differential distributions and show deviations from the effective theory as large as 100% at high p(T) for light Higgs masses.

Abstract: Generally, the dynamics of test particles around galaxies, as well as the corresponding mass deficit, is explained by postulating the existence of a hypothetical dark matter. In fact, the behavior of the rotation curves shows the existence of a constant velocity region, near the baryonic matter distribution, followed by a quick decay at large distances. In this work, we consider the possibility that the behavior of the rotational velocities of test particles gravitating around galaxies can be explained within the framework of the recently proposed hybrid metric-Palatini gravitational theory. The latter is constructed by modifying the metric Einstein-Hilbert action with an f(R) term in the Palatini formalism. It was shown that the theory unifies local constraints and the late-time cosmic acceleration, even if the scalar field is very light. In the intermediate galactic scale, we show explicitly that in the hybrid metric-Palatini model the tangential velocity can be explicitly obtained as a function of the scalar field of the equivalent scalar-tensor description. The model predictions are compared model with a small sample of rotation curves of low surface brightness galaxies, respectively, and a good agreement between the theoretical rotation Curves and the observational data is found. The possibility of constraining the form of the scalar field and the parameters of the model by using the stellar velocity dispersions is also analyzed. Furthermore, the Doppler velocity shifts are also obtained in terms of the scalar field. All the physical and geometrical quantities and the numerical parameters in the hybrid metric-Palatini model can be expressed in terms of observable/measurable parameters, such as the tangential velocity, the baryonic mass of the galaxy, the Doppler frequency shifts, and the stellar dispersion velocity, respectively. Therefore, the obtained results open the possibility of testing the hybrid metric-Palatini gravitational models at the galactic or extra-galactic scale by using direct astronomical and astrophysical observations.

Abstract: Hybrid metric-Palatini gravity is a recently proposed theory, consisting of the superposition of the metric Einstein-Hilbert Lagrangian with an f(R) term constructed a la Palatini. The theory predicts the existence of a long-range scalar field, which passes the Solar System observational constraints, even if the scalar field is very light, and modifies the cosmological and galactic dynamics. Thus, the theory opens new possibilities to approach, in the same theoretical framework, the problems of both dark energy and dark matter. In this work, we consider the generalized virial theorem in the scalar-tensor representation of the hybrid metric-Palatini gravity. More specifically, taking into account the relativistic collisionless Boltzmann equation, we show that the supplementary geometric terms in the gravitational field equations provide an effective contribution to the gravitational potential energy. We show that the total virial mass is proportional to the effective mass associated with the new terms generated by the effective scalar field, and the baryonic mass. In addition to this, we also consider astrophysical applications of the model and show that the model predicts that the mass associated to the scalar field and its effects extend beyond the virial radius of the clusters of galaxies. In the context of the galaxy cluster velocity dispersion profiles predicted by the hybrid metric-Palatini model, the generalized virial theorem can be an efficient tool in observationally testing the viability of this class of generalized gravity models.