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Author  |
Di Gregorio, E.; Staelens, M.; Hosseinkhah, N.; Karimpoor, M.; Liburd, J.; Lim, L.; Shankar, K.; Tuszynski, J.A. |
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Title |
Raman Spectroscopy Reveals Photobiomodulation-Induced α-Helix to β-Sheet Transition in Tubulins: Potential Implications for Alzheimer's and Other Neurodegenerative Diseases |
Type |
Journal Article |
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Year |
2024 |
Publication |
Nanomaterials |
Abbreviated Journal |
Nanomaterials |
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Volume |
14 |
Issue |
13 |
Pages |
1093 - 21pp |
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Keywords |
proteins; protein dynamics; protein structure; non-invasive therapies; low-level laser therapy; spectroscopy; amide bands; amide I; spectral decomposition |
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Abstract |
In small clinical studies, the application of transcranial photobiomodulation (PBM), which typically delivers low-intensity near-infrared (NIR) to treat the brain, has led to some remarkable results in the treatment of dementia and several neurodegenerative diseases. However, despite the extensive literature detailing the mechanisms of action underlying PBM outcomes, the specific mechanisms affecting neurodegenerative diseases are not entirely clear. While large clinical trials are warranted to validate these findings, evidence of the mechanisms can explain and thus provide credible support for PBM as a potential treatment for these diseases. Tubulin and its polymerized state of microtubules have been known to play important roles in the pathology of Alzheimer's and other neurodegenerative diseases. Thus, we investigated the effects of PBM on these cellular structures in the quest for insights into the underlying therapeutic mechanisms. In this study, we employed a Raman spectroscopic analysis of the amide I band of polymerized samples of tubulin exposed to pulsed low-intensity NIR radiation (810 nm, 10 Hz, 22.5 J/cm2 dose). Peaks in the Raman fingerprint region (300-1900 cm-1)-in particular, in the amide I band (1600-1700 cm-1)-were used to quantify the percentage of protein secondary structures. Under this band, hidden signals of C=O stretching, belonging to different structures, are superimposed, producing a complex signal as a result. An accurate decomposition of the amide I band is therefore required for the reliable analysis of the conformation of proteins, which we achieved through a straightforward method employing a Voigt profile. This approach was validated through secondary structure analyses of unexposed control samples, for which comparisons with other values available in the literature could be conducted. Subsequently, using this validated method, we present novel findings of statistically significant alterations in the secondary structures of polymerized NIR-exposed tubulin, characterized by a notable decrease in alpha-helix content and a concurrent increase in beta-sheets compared to the control samples. This PBM-induced alpha-helix to beta-sheet transition connects to reduced microtubule stability and the introduction of dynamism to allow for the remodeling and, consequently, refreshing of microtubule structures. This newly discovered mechanism could have implications for reducing the risks associated with brain aging, including neurodegenerative diseases like Alzheimer's disease, through the introduction of an intervention following this transition. |
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Address |
[Di Gregorio, Elisabetta; Staelens, Michael; Tuszynski, Jack A.] Univ Alberta, Fac Sci, Dept Phys, Edmonton, AB T6G 2E1, Canada, Email: michael.staelens@ific.uv.es |
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Mdpi |
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English |
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Notes |
WOS:001269841000001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6204 |
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Author |
Domcke, V.; Ema, Y.; Sandner, S. |
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Title |
Perturbatively including inhomogeneities in axion inflation |
Type |
Journal Article |
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Year |
2024 |
Publication |
Journal of Cosmology and Astroparticle Physics |
Abbreviated Journal |
J. Cosmol. Astropart. Phys. |
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Volume |
03 |
Issue |
3 |
Pages |
019 - 24pp |
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Keywords |
axions; inflation; particle physics- cosmology connection |
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Abstract |
Axion inflation, i.e. an axion-like inflaton coupled to an Abelian gauge field through a Chern-Simons interaction, comes with a rich and testable phenomenology. This is particularly true in the strong backreaction regime, where the gauge field production heavily impacts the axion dynamics. Lattice simulations have recently demonstrated the importance of accounting for inhomogeneities of the axion field in this regime. We propose a perturbative scheme to account for these inhomogeneities while maintaining high computational efficiency. Our goal is to accurately capture deviations from the homogeneous axion field approximation within the perturbative regime as well as self -consistently determine the onset of the nonperturbative regime. |
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Address |
[Domcke, Valerie] CERN, Theoret Phys Dept, Geneva 23, Switzerland, Email: valerie.domcke@cern.ch; |
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IOP Publishing Ltd |
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English |
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ISSN |
1475-7516 |
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Conference |
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Notes |
WOS:001185016600002 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6020 |
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Author |
Domcke, V.; Garcia-Cely, C.; Lee, S.M.; Rodd, N.L. |
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Title |
Symmetries and selection rules: optimising axion haloscopes for Gravitational Wave searches |
Type |
Journal Article |
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Year |
2024 |
Publication |
Journal of High Energy Physics |
Abbreviated Journal |
J. High Energy Phys. |
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Volume |
03 |
Issue |
3 |
Pages |
128 - 51pp |
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Keywords |
Axions and ALPs; Early Universe Particle Physics |
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Abstract |
In the presence of electromagnetic fields, both axions and gravitational waves (GWs) induce oscillating magnetic fields: a potentially detectable fingerprint of their presence. We demonstrate that the response is largely dictated by the symmetries of the instruments used to search for it. Focussing on low mass axion haloscopes, we derive selection rules that determine the parametric sensitivity of different detector geometries to axions and GWs, and which further reveal how to optimise the experimental geometry to maximise both signals. The formalism allows us to forecast the optimal sensitivity to GWs in the range of 100 kHz to 100 MHz for instruments such as ABRACADABRA, BASE, ADMX SLIC, SHAFT, WISPLC, and DMRadio. |
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Address |
[Domcke, Valerie; Lee, Sung Mook; Rodd, Nicholas L.] CERN, Theoret Phys Dept, 1 Esplanade Particules, CH-1211 Geneva 23, Switzerland, Email: valerie.domcke@cern.ch; |
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Publisher |
Springer |
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English |
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ISSN |
1029-8479 |
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Conference |
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Notes |
WOS:001189228700003 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6049 |
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Author |
Duan, M.Y.; Bayar, M.; Oset, E. |
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Title |
Precise determination of the ηΛ scattering length and effective range and relationship to the Λ(1670) resonance |
Type |
Journal Article |
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Year |
2024 |
Publication |
Physics Letters B |
Abbreviated Journal |
Phys. Lett. B |
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Volume |
857 |
Issue |
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Pages |
139003 - 5pp |
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Abstract |
We use the Belle data on the K(-)p mass distribution of the Lambda(+)(c)-> pK(-)pi(+) reaction near the eta Lambda threshold to determine the eta Lambda scattering length and effective range. We show that from these data alone we can determine the value of a with better precision than so far determined, and the value of r(0) for the first time. The addition of the K(-)p ->eta Lambda data allows us to improve the precision of these magnitudes, with errors smaller than 15%. We also determine with high precision the pole position of the Lambda(1670). |
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Address |
[Duan, Man-Yu] Southeast Univ, Sch Phys, Nanjing 210094, Peoples R China, Email: duanmy@seu.edu.cn; |
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Publisher |
Elsevier |
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English |
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Edition |
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ISSN |
0370-2693 |
ISBN |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:001312217300001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6257 |
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Author |
Easa, H.; Gregoire, T.; Stolarski, D.; Cosme, C. |
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Title |
Baryogenesis and dark matter in multiple hidden sectors |
Type |
Journal Article |
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Year |
2024 |
Publication |
Physical Review D |
Abbreviated Journal |
Phys. Rev. D |
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Volume |
109 |
Issue |
7 |
Pages |
075003 - 29pp |
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Keywords |
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Abstract |
We explore a mechanism for producing the baryon asymmetry and dark matter in models with multiple hidden sectors that are Standard -Model -like but with varying Higgs mass parameters. If the field responsible for reheating the Standard Model and the exotic sectors carries an asymmetry, it can be converted into a baryon asymmetry using the standard sphaleron process. A hidden sector with positive Higgs mass squared can accommodate dark matter with its baryon asymmetry, and the larger abundance of dark matter relative to baryons is due to dark sphalerons being active all the way down the hidden sector QCD scale. This scenario predicts that dark matter is clustered in large dark nuclei and gives a lower bound on the effective relativistic degrees of freedom, Delta N eff greater than or similar to 0 .05 , which may be observable in the nextgeneration cosmic microwave background experiment CMB-S4. |
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Address |
[Easa, Hassan; Gregoire, Thomas; Stolarski, Daniel; Cosme, Catarina] Carleton Univ, Ottawa Carleton Inst Phys, 1125 Colonel Dr, Ottawa, ON K1S 5B6, Canada, Email: Hassaneasa@cmail.carleton.ca; |
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Publisher |
Amer Physical Soc |
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English |
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Series Volume |
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Edition |
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ISSN |
2470-0010 |
ISBN |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:001224349300001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6129 |
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Author |
Escrig, S. et al; Bernabeu, J.; Lacasta, C.; Solaz, C. |
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Title |
First test of energy response of the micro-vertex detection system for the WASA-FRS Experiments |
Type |
Journal Article |
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Year |
2024 |
Publication |
Nuclear Instruments & Methods in Physics Research A |
Abbreviated Journal |
Nucl. Instrum. Methods Phys. Res. A |
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Volume |
1064 |
Issue |
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Pages |
169392 - 4pp |
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Keywords |
Micro-strip silicon sensor; Tracking detector; Micro-vertex detector |
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Abstract |
The hypernuclei, which are nuclei that contain the quark s, have been studied for more than 50 years. Notwithstanding, the recent experiments using high-energy heavy-ion induced reactions have challenged their current understanding. The high multiplicity of particles generated in the reaction allows for the measurement of the interaction point of the primary beam with the target. Then, a micro-vertex detection system for the WASA-FRS Experiments has been developed. Several experimental tests have been performed with Sr-90 and Bi-207 beta sources and a 10-MeV proton beam at the CMAM tandem accelerator, and their results are reported. |
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Address |
[Escrig, S.; Rappold, C.; Ruiz, D. Fernandez; Borge, M. J. Garcia; Tavora, V. Garcia; Aguirre, A. Nerio; Martinez, A. Perea; Sanchez-Prieto, J.; Tengblad, O.] CSIC, IEM, Madrid 28006, Spain, Email: samuel.escrig@csic.es |
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Publisher |
Elsevier |
Place of Publication |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
0168-9002 |
ISBN |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:001301017700001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6242 |
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Author |
Escrihuela, F.J.; Flores, L.J.; Miranda, O.G.; Rendon, J.; Sanchez-Velez, R. |
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Title |
Examining the sensitivity of FASERν to generalized neutrino interactions |
Type |
Journal Article |
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Year |
2024 |
Publication |
Journal of High Energy Physics |
Abbreviated Journal |
J. High Energy Phys. |
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Volume |
04 |
Issue |
4 |
Pages |
102 - 25pp |
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Keywords |
Non-Standard Neutrino Properties; Neutrino Interactions; Electroweak Precision Physics |
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Abstract |
We investigate the sensitivity of the FASER nu detector, a novel experimental setup at the LHC, to probe and constrain generalized neutrino interactions (GNI). Employing a comprehensive theoretical framework, we model the effects of generalized neutrino interactions on neutrino-nucleon deep inelastic scattering processes within the FASER nu detector. By considering all the neutrino channels produced at the LHC, we perform a statistical analysis to determine the sensitivity of FASER nu to constrain these interactions. Our results demonstrate that FASER nu can place stringent constraints on the GNI effective couplings. Additionally, we study the relation between GNI and a minimal Leptoquark model where the SM is augmented by a singlet Leptoquark with hypercharge 1/3. We have found that the sensitivities for various combinations of the Leptoquark Yukawa couplings are approximately O(1), particularly when considering a Leptoquark mass in the TeV range. |
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Address |
[Escrihuela, F. J.] Univ Valencia, CSIC, Inst Fis Corpuscular, AHEP Grp, Parc Cientif Paterna,C Catedrat Jose Beltran 2, E-46980 Paterna, Valencia, Spain, Email: franesfe@alumni.uv.es; |
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Publisher |
Springer |
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Language |
English |
Summary Language |
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Series Editor |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
1029-8479 |
ISBN |
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Medium |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:001255987500005 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6176 |
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Author |
Fajfer, S.; Solomonidi, E.; Vale Silva, L. |
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Title |
S-wave contribution to rare D0 → π+ π- l+ l- decays in the standard model and sensitivity to new physics |
Type |
Journal Article |
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Year |
2024 |
Publication |
Physical Review D |
Abbreviated Journal |
Phys. Rev. D |
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Volume |
109 |
Issue |
3 |
Pages |
036027 - 24pp |
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Keywords |
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Abstract |
Physics of the up-type flavor offers unique possibilities of testing the standard model (SM) compared to the down-type flavor sector. Here, we discuss SM and new physics (NP) contributions to the rare charmmeson decay D0 -> x+x- l+l-. In particular, we discuss the effect of including the lightest scalar isoscalar resonance in the SM picture, namely, the f0(500), which manifests in a big portion of the allowed phase space. Other than showing in the total branching ratio at an observable level of about 20%, the f0(500) resonance manifests as interference terms with the vector resonances, such as at high invariant mass of the leptonic pair in distinct angular observables. Recent data from LHCb optimize the sensitivity to P-wave contributions that we analyze in view of the inclusion of vector resonances. We propose the measurement of alternative observables that are sensitive to the S-wave and are straightforward to implement experimentally. This leads to a new set of null observables that vanish in the SM due to its gauge and flavor structures. Finally, we study observables that depend on the SM interference with generic NP contributions from semileptonic four-fermion operators in the presence of the S-wave. |
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Address |
[Fajfer, Svjetlana] Jozef Stefan Inst, Jamova 39,POB 3000, Ljubljana 1001, Slovenia |
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Publisher |
Amer Physical Soc |
Place of Publication |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
2470-0010 |
ISBN |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:001181678500001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
5991 |
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Author |
Falkowski, A.; Gonzalez-Alonso, M.; Palavric, A.; Rodriguez-Sanchez, A. |
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Title |
Constraints on subleading interactions in beta decay Lagrangian |
Type |
Journal Article |
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Year |
2024 |
Publication |
Journal of High Energy Physics |
Abbreviated Journal |
J. High Energy Phys. |
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Volume |
02 |
Issue |
2 |
Pages |
091 - 54pp |
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Keywords |
Effective Field Theories; Hadronic Matrix Elements and Weak Decays; Effective Field Theories of QCD; SMEFT |
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Abstract |
We discuss the effective field theory (EFT) for nuclear beta decay. The general quark-level EFT describing charged-current interactions between quarks and leptons is matched to the nucleon-level non-relativistic EFT at the OMeV momentum scale characteristic for beta transitions. The matching takes into account, for the first time, the effect of all possible beyond-the-Standard-Model interactions at the subleading order in the recoil momentum. We calculate the impact of all the Wilson coefficients of the leading and subleading EFT Lagrangian on the differential decay width in allowed beta transitions. As an example application, we show how the existing experimental data constrain the subleading Wilson coefficients corresponding to pseudoscalar, weak magnetism, and induced tensor interactions. The data display a 3.5 sigma evidence for nucleon weak magnetism, in agreement with the theory prediction based on isospin symmetry. |
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Address |
[Falkowski, Adam; Rodriguez-Sanchez, Antonio] Univ Paris Saclay, IJCLab, CNRS, IN2P3, F-91405 Orsay, France, Email: adam.falkowski@ijclab.in2p3.fr; |
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Publisher |
Springer |
Place of Publication |
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English |
Summary Language |
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Series Editor |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
1029-8479 |
ISBN |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:001163170700004 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
5966 |
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Author |
Feijoo, A.; Dai, L.R.; Abreu, L.M.; Oset, E. |
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Title |
Correlation function for the Tbb state: Determination of the binding, scattering lengths, effective ranges, and molecular probabilities |
Type |
Journal Article |
| |
Year |
2024 |
Publication |
Physical Review D |
Abbreviated Journal |
Phys. Rev. D |
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Volume |
109 |
Issue |
1 |
Pages |
016014 - 8pp |
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Keywords |
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Abstract |
We perform a study of the (B*+B0), (BB+)-B-*0 correlation functions using an extension of the local hidden gauge approach which provides the interaction from the exchange of light vector mesons and gives rise to a bound state of these components in I = 0 with a binding energy of about 21 MeV. After that, we face the inverse problem of determining the low energy observables, scattering length and effective range for each channel, the possible existence of a bound state, and, if found, the couplings of such a state to each (B*+B0), (BB+)-B-*0 component as well as the molecular probabilities of each of the channels. We use the bootstrap method to determine these magnitudes and find that, with errors in the correlation function typical of present experiments, we can determine all these magnitudes with acceptable precision. In addition, the size of the source function of the experiment from where the correlation functions are measured can be also determined with a high precision. |
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Address |
[Feijoo, A.; Dai, L. R.; Oset, E.] Univ Valencia, Inst Invest Paterna, Dept Fis Teor, Ctr Mixto,CSIC, Aptdo 22085, Valencia 46071, Spain, Email: edfeijoo@ific.uv.es; |
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Publisher |
Amer Physical Soc |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
2470-0010 |
ISBN |
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Medium |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:001172361900005 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6078 |
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| Permanent link to this record |
