|
Schaffter, T. et al, Albiol, F., & Caballero, L. (2020). Evaluation of Combined Artificial Intelligence and Radiologist Assessment to Interpret Screening Mammograms. JAMA Netw. Open, 3(3), e200265–15pp.
Abstract: Importance Mammography screening currently relies on subjective human interpretation. Artificial intelligence (AI) advances could be used to increase mammography screening accuracy by reducing missed cancers and false positives. Objective To evaluate whether AI can overcome human mammography interpretation limitations with a rigorous, unbiased evaluation of machine learning algorithms. Design, Setting, and Participants In this diagnostic accuracy study conducted between September 2016 and November 2017, an international, crowdsourced challenge was hosted to foster AI algorithm development focused on interpreting screening mammography. More than 1100 participants comprising 126 teams from 44 countries participated. Analysis began November 18, 2016. Main Outcomes and Measurements Algorithms used images alone (challenge 1) or combined images, previous examinations (if available), and clinical and demographic risk factor data (challenge 2) and output a score that translated to cancer yes/no within 12 months. Algorithm accuracy for breast cancer detection was evaluated using area under the curve and algorithm specificity compared with radiologists' specificity with radiologists' sensitivity set at 85.9% (United States) and 83.9% (Sweden). An ensemble method aggregating top-performing AI algorithms and radiologists' recall assessment was developed and evaluated. Results Overall, 144231 screening mammograms from 85580 US women (952 cancer positive <= 12 months from screening) were used for algorithm training and validation. A second independent validation cohort included 166578 examinations from 68008 Swedish women (780 cancer positive). The top-performing algorithm achieved an area under the curve of 0.858 (United States) and 0.903 (Sweden) and 66.2% (United States) and 81.2% (Sweden) specificity at the radiologists' sensitivity, lower than community-practice radiologists' specificity of 90.5% (United States) and 98.5% (Sweden). Combining top-performing algorithms and US radiologist assessments resulted in a higher area under the curve of 0.942 and achieved a significantly improved specificity (92.0%) at the same sensitivity. Conclusions and Relevance While no single AI algorithm outperformed radiologists, an ensemble of AI algorithms combined with radiologist assessment in a single-reader screening environment improved overall accuracy. This study underscores the potential of using machine learning methods for enhancing mammography screening interpretation. Question How do deep learning algorithms perform compared with radiologists in screening mammography interpretation? Findings In this diagnostic accuracy study using 144231 screening mammograms from 85580 women from the United States and 166578 screening mammograms from 68008 women from Sweden, no single artificial intelligence algorithm outperformed US community radiologist benchmarks; including clinical data and prior mammograms did not improve artificial intelligence performance. However, combining best-performing artificial intelligence algorithms with single-radiologist assessment demonstrated increased specificity. Meaning Integrating artificial intelligence to mammography interpretation in single-radiologist settings could yield significant performance improvements, with the potential to reduce health care system expenditures and address resource scarcity experienced in population-based screening programs. This diagnostic accuracy study evaluates whether artificial intelligence can overcome human mammography interpretation limits with a rigorous, unbiased evaluation of machine learning algorithms.
|
|
|
ALEPH, D. E. L. P. H. I., L3 and OPAL Collaborations, LEP Electroweak Working Group(Schael, S. et al), Costa, M. J., Ferrer, A., Fuster, J., Garcia, C., Oyanguren, A., et al. (2013). Electroweak measurements in electron positron collisions at W-boson-pair energies at LEP. Phys. Rep., 532(4), 119–244.
Abstract: Electroweak measurements performed with data taken at the electron positron collider LEP at CERN from 1995 to 2000 are reported. The combined data set considered in this report corresponds to a total luminosity of about 3 fb(-1) collected by the four LEP experiments ALEPH, DELPHI, 13 and OPAL, at centre-of-mass energies ranging from 130 GeV to 209 GeV. Combining the published results of the four LEP experiments, the measurements include total and differential cross-sections in photon-pair, fermion-pair and four-fermion production, the latter resulting from both double-resonant WW and ZZ production as well as singly resonant production. Total and differential cross-sections are measured precisely, providing a stringent test of the Standard Model at centre-of-mass energies never explored before in electron positron collisions. Final-state interaction effects in four-fermion production, such as those arising from colour reconnection and Bose Einstein correlations between the two W decay systems arising in WW production, are searched for and upper limits on the strength of possible effects are obtained. The data are used to determine fundamental properties of the W boson and the electroweak theory. Among others, the mass and width of the W boson, m(w) and Gamma(w), the branching fraction of W decays to hadrons, B(W -> had), and the trilinear gauge-boson self-couplings g(1)(Z), K-gamma and lambda(gamma), are determined to be: m(w) = 80.376 +/- 0.033 GeV Gamma(w) = 2.195 +/- 0.083 GeV B(W -> had) = 67.41 +/- 0.27% g(1)(Z) = 0.984(-0.020)(+0.018) K-gamma – 0.982 +/- 0.042 lambda(gamma) = 0.022 +/- 0.019.
|
|
|
Scandale, W. et al, & Lari, L. (2013). Optimization of the crystal assisted collimation of the SPS beam. Phys. Lett. B, 726(1-3), 182–186.
Abstract: The possibility for optimization of crystal assisted collimation has been studied at the CERN SPS for stored beams of protons and Pb ions with 270 GeV/c per unit charge. A bent silicon crystal used as a primary collimator deflects halo particles in the channeling regime, directing them into a tungsten absorber. In channeling conditions a strong reduction of off-momentum particle numbers produced in the crystal and absorber, which form collimation leakage, has been observed in the first high dispersion (HD) area downstream. The present study shows that the collimation leakage is minimal for some values of the absorber offset relative to the crystal. The optimal offset value is larger for Pb ions because of their considerably larger ionization losses in the crystal, which cause large increases of particle betatron oscillation amplitudes. The optimal absorber offset allows obtaining maximal efficiency of crystal-assisted collimation.
|
|
|
Scandale, W. et al, & Lari, L. (2014). Deflection of high energy protons by multiple volume reflections in a modified multi-strip silicon deflector. Nucl. Instrum. Methods Phys. Res. B, 338, 108–111.
Abstract: The effect of multiple volume reflections in one crystal was observed in each of several bent silicon strips for 400 GeV/c protons. This considerably increased the particle deflections. Some particles were also deflected due to channeling in one of the subsequent strips. As a result, the incident beam was strongly spread because of opposite directions of the deflections. A modified multi-strip deflector produced by periodic grooves on the surface of a thick silicon plate was used for these measurements. This technique provides perfect mutual alignment between crystal strips. Such multi-strip deflector may be effective for collider beam halo collimation and a study is planned at the CERN SPS circulating beam.
|
|
|
Scandale, W. et al, & Lari, L. (2015). Observation of nuclear dechanneling length reduction for high energy protons in a short bent crystal. Phys. Lett. B, 743, 440–443.
Abstract: Deflection of 400 GeV/c protons by a short bent silicon crystal was studied at the CERN SPS. It was shown that the dechanneling probability increases while the dechanneling length decreases with an increase of incident angles of particles relative to the crystal planes. The observation of the dechanneling length reduction provides evidence of the particle population increase at the top levels of transverse energies in the potential well of the planar channels. (C) 2015 The Authors. Published by Elsevier B.V.
|
|
|
Sborlini, G. F. R., Driencourt-Mangin, F., & Rodrigo, G. (2016). Four-dimensional unsubtraction with massive particles. J. High Energy Phys., 10(10), 162–34pp.
Abstract: We extend the four-dimensional unsubtraction method, which is based on the loop-tree duality (LTD), to deal with processes involving heavy particles. The method allows to perform the summation over degenerate IR configurations directly at integrand level in such a way that NLO corrections can be implemented directly in four space-time dimensions. We define a general momentum mapping between the real and virtual kinematics that accounts properly for the quasi-collinear configurations, and leads to an smooth massless limit. We illustrate the method first with a scalar toy example, and then analyse the case of the decay of a scalar or vector boson into a pair of massive quarks. The results presented in this paper are suitable for the application of the method to any multipartonic process.
|
|
|
Sborlini, G. F. R., Driencourt-Mangin, F., Hernandez-Pinto, R. J., & Rodrigo, G. (2016). Four-dimensional unsubtraction from the loop-tree duality. J. High Energy Phys., 08(8), 160–42pp.
Abstract: We present a new algorithm to construct a purely four dimensional representation of higher-order perturbative corrections to physical cross-sections at next-to-leading order (NLO). The algorithm is based on the loop-tree duality (LTD), and it is implemented by introducing a suitable mapping between the external and loop momenta of the virtual scattering amplitudes, and the external momenta of the real emission corrections. In this way, the sum over degenerate infrared states is performed at integrand level and the cancellation of infrared divergences occurs locally without introducing subtraction counter-terms to deal with soft and final-state collinear singularities. The dual representation of ultraviolet counter-terms is also discussed in detail, in particular for self-energy contributions. The method is first illustrated with the scalar three-point function, before proceeding with the calculation of the physical cross-section for gamma* -> q (q) over bar (g), and its generalisation to multi-leg processes. The extension to next-to-next-to-leading order (NNLO) is briefly commented.
|
|
|
Sborlini, G. F. R., de Florian, D., & Rodrigo, G. (2014). Triple collinear splitting functions at NLO for scattering processes with photons. J. High Energy Phys., 10(10), 161–29pp.
Abstract: We present splitting functions in the triple collinear limit at next-to-leading order. The computation was performed in the context of massless QCD+QED, considering only processes which include at least one photon. Through the comparison of the IR divergent structure of splitting amplitudes with the expected known behavior, we were able to check our results. Besides that we implemented some consistency checks based on symmetry arguments and cross-checked the results among them. Studying photon-started processes, we obtained very compact results.
|
|
|
Sborlini, G. F. R., de Florian, D., & Rodrigo, G. (2015). Polarized triple-collinear splitting functions at NLO for processes with photons. J. High Energy Phys., 03(3), 021–30pp.
Abstract: We compute the polarized splitting functions in the triple collinear limit at next-to-leading order accuracy (NLO) in the strong coupling alpha(S), for the splitting processes gamma -> qq gamma, gamma -> qqg and g -> qq gamma. The divergent structure of each splitting function was compared to the predicted behaviour according to Catani's formula. The results obtained in this paper are compatible with the unpolarized splitting functions computed in a previous article. Explicit results for NLO corrections are presented in the context of conventional dimensional regularization (CDR).
|
|
|
Sborlini, G. F. R., de Florian, D., & Rodrigo, G. (2014). Double collinear splitting amplitudes at next-to-leading order. J. High Energy Phys., 01(1), 018–55pp.
Abstract: We compute the next-to-leading order (NLO) QCD corrections to the 1 -> 2 splitting amplitudes in different dimensional regularization (DREG) schemes. Besides recovering previously known results, we explore new DREG schemes and analyze their consistency by comparing the divergent structure with the expected behavior predicted by Catani's formula. Through the introduction of scalar-gluons, we show the relation among splittings matrices computed using different schemes. Also, we extended this analysis to cover the double collinear limit of scattering amplitudes in the context of QCD+QED.
|
|