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Author |
Granero, D.; Perez-Calatayud, J.; Vijande, J.; Ballester, F.; Rivard, M.J. |
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Title |
Limitations of the TG-43 formalism for skin high-dose-rate brachytherapy dose calculations |
Type |
Journal Article |
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Year |
2014 |
Publication |
Medical Physics |
Abbreviated Journal |
Med. Phys. |
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Volume |
41 |
Issue |
2 |
Pages |
021703 - 8pp |
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Keywords |
HDR; brachytherapy; skin; Monte Carlo; Geant4; Co-60; Ir-192; Yb-169 |
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Abstract  |
Purpose: In skin high-dose-rate (HDR) brachytherapy, sources are located outside, in contact with, or implanted at some depth below the skin surface. Most treatment planning systems use the TG-43 formalism, which is based on single-source dose superposition within an infinite water medium without accounting for the true geometry in which conditions for scattered radiation are altered by the presence of air. The purpose of this study is to evaluate the dosimetric limitations of the TG-43 formalism in HDR skin brachytherapy and the potential clinical impact. Methods: Dose rate distributions of typical configurations used in skin brachytherapy were obtained: a 5 cm x 5 cm superficial mould; a source inside a catheter located at the skin surface with and without backscatter bolus; and a typical interstitial implant consisting of an HDR source in a catheter located at a depth of 0.5 cm. Commercially available HDR Co-60 and Ir-192 sources and a hypothetical Yb-169 source were considered. The Geant4Monte Carlo radiation transport code was used to estimate dose rate distributions for the configurations considered. These results were then compared to those obtained with the TG-43 dose calculation formalism. In particular, the influence of adding bolus material over the implant was studied. Results: For a 5 cm x 5 cm Ir-192 superficial mould and 0.5 cm prescription depth, dose differences in comparison to the TG-43 method were about -3%. When the source was positioned at the skin surface, dose differences were smaller than -1% for Co-60 and Ir-192, yet -3% for Yb-169. For the interstitial implant, dose differences at the skin surface were -7% for Co-60, -0.6% for Ir-192, and -2.5% for Yb-169. Conclusions: This study indicates the following: (i) for the superficial mould, no bolus is needed; (ii) when the source is in contact with the skin surface, no bolus is needed for either Co-60 and Ir-192. For lower energy radionuclides like Yb-169, bolus may be needed; and (iii) for the interstitial case, at least a 0.1 cm bolus is advised for Co-60 to avoid underdosing superficial target layers. For Ir-192 and Yb-169, no bolus is needed. For those cases where no bolus is needed, its use might be detrimental as the lack of radiation scatter may be beneficial to the patient, although the 2% tolerance for dose calculation accuracy recommended in the AAPM TG-56 report is not fulfilled. |
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Address |
[Granero, Domingo] Hosp Gen Univ, ERESA, Dept Radiat Phys, Valencia 46014, Spain, Email: dgranero@eresa.com |
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Amer Assoc Physicists Medicine Amer Inst Physics |
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English |
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ISSN |
0094-2405 |
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Notes |
WOS:000331213300006 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
1704 |
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Author |
Koolen, B.B.; Vidal-Sicart, S.; Benlloch, J.M.; Olmos, R.A.V. |
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Title |
Evaluating heterogeneity of primary tumor 18 F-FDG uptake in breast cancer with a dedicated breast PET ( MAMMI): a feasibility study based on correlation with PET/CT |
Type |
Journal Article |
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Year |
2014 |
Publication |
Nuclear Medicine Communications |
Abbreviated Journal |
Nucl. Med. Commun. |
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Volume |
35 |
Issue |
5 |
Pages |
446-452 |
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Keywords |
breast cancer; F-18-FDG; heterogeneity; MAMMI; PET |
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Abstract |
PurposeThe aim of the study was to evaluate the heterogeneity of primary tumor F-18-fluorodeoxyglucose (F-18-FDG) uptake in breast cancer patients using a dedicated breast PET.Patients and methodsA positron emission tomography/computed tomography (PET/CT) of the thorax was performed 60 min after administration of 180-240 MBq of F-18-FDG in patients with breast cancer. Subsequently, 110 min after injection, a scan was taken with a dedicated high-resolution breast PET [MAMmography with Molecular Imaging (MAMMI)]. Both procedures were performed with the patients in the prone position. Four-point scores were used to compare the intensity (0: none; 1: mild; 2: moderate; 3: high) and heterogeneity (0: none; 1: mild; 2: moderate; 3: high) of F-18-FDG uptake between PET/CT and MAMMI images.ResultsThirty-five patients in whom the primary tumor was visualized on both scans were included in this analysis. The mean primary tumor size was 35.1 mm (range 10-108 mm). The mean intensity score was similar on both devices (2.4 for PET/CT and 2.3 for MAMMI; P=0.439), but the mean heterogeneity score on MAMMI images was significantly higher (PET/CT 1.9 vs. MAMMI 2.3; P=0.005). MAMMI showed a higher heterogeneity score in 11 (31%) of 35 patients, especially in tumors with moderate or high intensity. Significantly higher heterogeneity scores on both PET/CT and MAMMI were seen in large tumors (P=0.005 and 0.014, respectively) and in tumors with high intensity scores (P=0.012 and P<0.001, respectively).ConclusionHeterogeneous tumor F-18-FDG uptake in breast cancer is frequently observed, particularly in large tumors with intense F-18-FDG uptake. It is more often seen on MAMMI PET than on conventional PET/CT. Although the observed heterogeneity should be proven histopathologically, this finding offers a rationale for F-18-FDG-guided biopsies. |
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Address |
[Koolen, Bas B.; Vidal-Sicart, Sergi; Olmos, Renato A. Valdes] Antoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Dept Nucl Med, NL-1066 CX Amsterdam, Netherlands, Email: b.koolen@nki.nl |
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Lippincott Williams & Wilkins |
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English |
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ISSN |
0143-3636 |
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Notes |
WOS:000334103800002 |
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no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
1763 |
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Author |
Bernabeu, J.; Botella, F.J.; Nebot, M. |
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Title |
Novel T-Violation observable open to any pair of decay channels at meson factories |
Type |
Journal Article |
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Year |
2014 |
Publication |
Physics Letters B |
Abbreviated Journal |
Phys. Lett. B |
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Volume |
728 |
Issue |
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Pages |
95-98 |
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Abstract |
Quantum entanglement between the two neutral mesons produced in meson factories has allowed the first indisputable direct observation of Time Reversal Violation in the time evolution of the neutral meson between the two decays. The exceptional meson transitions are directly connected to semileptonic and CP eigenstate decay channels. The possibility of extending the observable asymmetries to more decay channels confronts the problem of the “orthogonality condition”, which can be stated with this tonguetwister: Given a decay channel f, which is the decay channel f' such that the meson state not decaying to f is orthogonal to the meson state not decaying to f? In this Letter we propose an alternative T-Violation asymmetry at meson factories which allows its opening to any pair of decay channels. Instead of searching which is the pair of decay channels associated to the T-reverse meson transition, we build an asymmetry which tags the initial states of both the Reference and the T-reverse meson transitions. This observable filters the appropriate final states by means of two measurable survival probabilities. We discuss the methodology to be followed in the analysis of the new observable and the results expected in specific examples. |
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Address |
[Nebot, Miguel] Univ Valencia, Dept Fis Teor, CSIC, E-46100 Burjassot, Spain, Email: Jose.Bernabeu@uv.es; |
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Elsevier Science Bv |
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English |
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0370-2693 |
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Notes |
WOS:000330556000017 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
1705 |
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Author |
Aceti, F.; Oset, E.; Roca, L. |
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Title |
Composite nature of the Lambda (1520) resonance |
Type |
Journal Article |
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Year |
2014 |
Publication |
Physical Review C |
Abbreviated Journal |
Phys. Rev. C |
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Volume |
90 |
Issue |
2 |
Pages |
025208 - 8pp |
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Keywords |
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Abstract |
Recently, the Weinberg compositeness condition of a bound state was generalized to account for resonant states and higher partial waves. We apply this extension to the case of the Lambda (1520) resonance and quantify the weight of the meson-baryon components in contrast to other possible genuine building blocks. This resonance was theoretically obtained from a coupled channels analysis using the s-wave pi Sigma* and K Xi* and the d-wave (K) over bar N and pi Sigma channels, applying the techniques of the chiral unitary approach. We obtain the result that this resonance is essentially dynamically generated from these meson-baryon channels, leaving room for only 15% weight of other kinds of components in its wave function. |
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Address |
[Aceti, F.; Oset, E.] Univ Valencia, CSIC, Ctr Mixto, Inst Invest Paterna,Dept Fis Teor, E-46071 Valencia, Spain |
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Amer Physical Soc |
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English |
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ISSN |
0556-2813 |
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Notes |
WOS:000341271300006 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
1907 |
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Author |
Wendt, A. et al; Algora, A. |
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Title |
Isospin symmetry in the sd shell: Transition strengths in the neutron-deficient sd shell nucleus Ar-33 |
Type |
Journal Article |
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Year |
2014 |
Publication |
Physical Review C |
Abbreviated Journal |
Phys. Rev. C |
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Volume |
90 |
Issue |
5 |
Pages |
054301 - 7pp |
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Abstract |
Reduced transition strengths of the deexciting transitions from the first two excited states in Ar-33 were measured in a relativistic Coulomb excitation experiment at the GSI Helmholtz center. The radioactive ion beam was produced by fragmentation of a primary Ar-36 beam on a Be-9 target followed by the selection of the reaction product of interest via the GSI Fragment Separator. The (33A)r beam hit a secondary Au-197 target with an energy of approximately 145 MeV/nucleon. An array of high-purity germanium cluster detectors and large-volume BaF2 scintillator detectors were employed for gamma-ray spectroscopy at the secondary target position. The Lund-York-Cologne Calorimeter was used to track the outgoing ions and to identify the nuclear reaction channels. For the two lowest energy excited states of Ar-33 the reduced transition strengths have been determined. With these first results the T-z = -3/2 nucleus Ar-33 is now, together with Na-21 (T-z = -1/2), the only neutron-deficient odd-A sd shell nucleus in which experimental transition strengths are available. The experimental values are compared to results of shell-model calculations which describe simultaneously mirror-energy differences and transition-strength values of mirror pairs in the sd shell in a consistent way. |
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Address |
[Wendt, A.; Taprogge, J.; Reiter, P.; Blazhev, A.; Braun, N.; Geibel, K.; Hackstein, M.; Moschner, K.; Siebeck, B.; Warr, N.] Univ Cologne, Inst Kernphys, Cologne, Germany |
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Amer Physical Soc |
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English |
Summary Language |
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Original Title |
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ISSN |
0556-2813 |
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Notes |
WOS:000344489100002 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
2005 |
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Author |
Lesgourgues, J.; Pastor, S. |
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Title |
Neutrino cosmology and Planck |
Type |
Journal Article |
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Year |
2014 |
Publication |
New Journal of Physics |
Abbreviated Journal |
New J. Phys. |
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Volume |
16 |
Issue |
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Pages |
065002 - 24pp |
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Keywords |
neutrino masses; cosmology; dark matter |
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Abstract |
Relic neutrinos play an important role in the evolution of the Universe, modifying some of the cosmological observables. We summarize the main aspects of cosmological neutrinos and describe how the precision of present cosmological data can be used to learn about neutrino properties. In particular, we discuss how cosmology provides information on the absolute scale of neutrino masses, complementary to beta decay and neutrinoless double-beta decay experiments. We explain why the combination of Planck temperature data with measurements of the baryon acoustic oscillation angular scale provides a strong bound on the sum of neutrino masses, 0.23 eV at the 95% confidence level, while the lensing potential spectrum and the cluster mass function measured by Planck are compatible with larger values. We also review the constraints from current data on other neutrino properties. Finally, we describe the very good perspectives from future cosmological measurements, which are expected to be sensitive to neutrino masses close to the minimum values guaranteed by flavour oscillations. |
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Address |
[Lesgourgues, Julien] Ecole Polytech Fed Lausanne, Inst Theorie Phenomenes Phys, CH-1015 Lausanne, Switzerland, Email: Julien.Lesgourgues@cern.ch; |
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Publisher |
Iop Publishing Ltd |
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English |
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ISSN |
1367-2630 |
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Notes |
WOS:000339083500001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
1854 |
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Author |
LHCb Collaboration (Aaij, R. et al); Martinez-Vidal, F.; Oyanguren, A.; Ruiz Valls, P.; Sanchez Mayordomo, C. |
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Title |
Observation of the Resonant Character of the Z(4430)(-) State |
Type |
Journal Article |
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Year |
2014 |
Publication |
Physical Review Letters |
Abbreviated Journal |
Phys. Rev. Lett. |
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Volume |
112 |
Issue |
22 |
Pages |
222002 - 9pp |
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Keywords |
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Abstract |
Resonant structures in B-0 -> psi'pi K--(+) decays are analyzed by performing a four-dimensional fit of the decay amplitude, using pp collision data corresponding to 3 fb(-1) collected with the LHCb detector. The data cannot be described with K+pi(-) resonances alone, which is confirmed with a model-independent approach. A highly significant Z(4430)(-) -> psi'pi(-) component is required, thus confirming the existence of this state. The observed evolution of the Z(4430)(-) amplitude with the psi'pi(-) mass establishes the resonant nature of this particle. The mass and width measurements are substantially improved. The spin parity is determined unambiguously to be 1(+). |
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Address |
[Bediaga, I.; De Miranda, J. M.; Ferreira Rodrigues, F.; Gomes, A.; Hicheur, A.; Massafferri, A.; dos Reis, A. C.; Rodrigues, A. B.] Ctr Brasileiro Pesquisas Fis, Rio De Janeiro, Brazil |
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Publisher |
Amer Physical Soc |
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English |
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ISSN |
0031-9007 |
ISBN |
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Notes |
WOS:000336920800007 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
1815 |
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Author |
ANTARES Collaboration (Adrian-Martinez, S. et al); Barrios-Marti, J.; Emanuele, U.; Gomez-Gonzalez, J.P.; Hernandez-Rey, J.J.; Lambard, G.; Mangano, S.; Sanchez-Losa, A.; Yepes, H.; Zornoza, J.D.; Zuñiga, J. |
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Title |
A search for time dependent neutrino emission from microquasars with the ANTARES telescope |
Type |
Journal Article |
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Year |
2014 |
Publication |
Journal of High Energy Astrophysics |
Abbreviated Journal |
J. High Ener. Astrophy. |
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Volume |
3 |
Issue |
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Pages |
9-17 |
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Abstract |
Results are presented on a search for neutrino emission from a sample of six microquasars, based on the data collected by the ANTARES neutrino telescope between 2007 and 2010. By means of appropriate time cuts, the neutrino search has been restricted to the periods when the acceleration of relativistic jets was taking place at the microquasars under study. The time cuts have been chosen using the information from the X-ray telescopes RXTE/ASM and Swift/BAT, and, in one case, the gamma-ray telescope Fermi/LAT. No statistically significant excess has been observed, thus upper limits on the neutrino fluences have been derived and compared to the predictions by models. Constraints have been put on the ratio of proton to electron luminosity in the jets. |
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Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
2133 |
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Author |
ATLAS Collaboration (Aad, G. et al); Cabrera Urban, S.; Castillo Gimenez, V.; Costa, M.J.; Fassi, F.; Ferrer, A.; Fiorini, L.; Fuster, J.; Garcia, C.; Garcia Navarro, J.E.; Gonzalez de la Hoz, S.; Hernandez Jimenez, Y.; Higon-Rodriguez, E.; Irles Quiles, A.; Kaci, M.; King, M.; Lacasta, C.; Lacuesta, V.R.; March, L.; Marti-Garcia, S.; Mitsou, V.A.; Moles-Valls, R.; Oliver Garcia, E.; Pedraza Lopez, S.; Perez Garcia-Estañ, M.T.; Romero Adam, E.; Ros, E.; Salt, J.; Sanchez Martinez, V.; Soldevila, U.; Sanchez, J.; Torro Pastor, E.; Valero, A.; Valladolid Gallego, E.; Valls Ferrer, J.A.; Villaplana Perez, M.; Vos, M. |
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Title |
Search for supersymmetry in events with four or more leptons in root s=8 TeV pp collisions with the ATLAS detector |
Type |
Journal Article |
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Year |
2014 |
Publication |
Physical Review D |
Abbreviated Journal |
Phys. Rev. D |
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Volume |
90 |
Issue |
5 |
Pages |
052001 - 33pp |
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Keywords |
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Abstract |
Results from a search for supersymmetry in events with four or more leptons including electrons, muons and taus are presented. The analysis uses a data sample corresponding to 20.3 fb(-1) of proton proton collisions delivered by the Large Hadron Collider at root s = 8 TeV and recorded by the ATLAS detector. Signal regions are designed to target supersymmetric scenarios that can be either enriched in or depleted of events involving the production of a Z boson. No significant deviations are observed in data from standard model predictions and results are used to set upper limits on the event yields from processes beyond the standard model. Exclusion limits at the 95% confidence level on the masses of relevant supersymmetric particles are obtained. In R-parity-violating simplified models with decays of the lightest supersymmetric particle to electrons and muons, limits of 1350 and 750 GeV are placed on gluino and chargino masses, respectively. In R-parity-conserving simplified models with heavy neutralinos decaying to a massless lightest supersymmetric particle, heavy neutralino masses up to 620 GeV are excluded. Limits are also placed on other supersymmetric scenarios. |
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Address |
[Jackson, P.; Soni, N.; White, M. J.] Univ Adelaide, Dept Phys, Adelaide, SA, Australia |
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Publisher |
Amer Physical Soc |
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English |
Summary Language |
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ISSN |
1550-7998 |
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Notes |
WOS:000341264900001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
1900 |
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Author |
ATLAS Collaboration (Aad, G. et al); Cabrera Urban, S.; Castillo Gimenez, V.; Costa, M.J.; Ferrer, A.; Fiorini, L.; Fuster, J.; Garcia, C.; Garcia Navarro, J.E.; Gonzalez de la Hoz, S.; Hernandez Jimenez, Y.; Higon-Rodriguez, E.; Irles Quiles, A.; Kaci, M.; King, M.; Lacasta, C.; Lacuesta, V.R.; March, L.; Marti-Garcia, S.; Mitsou, V.A.; Moles-Valls, R.; Oliver Garcia, E.; Pedraza Lopez, S.; Perez Garcia-Estañ, M.T.; Romero Adam, E.; Ros, E.; Salt, J.; Sanchez Martinez, V.; Soldevila, U.; Sanchez, J.; Torro Pastor, E.; Valero, A.; Valladolid Gallego, E.; Valls Ferrer, J.A.; Vos, M. |
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Title |
Search for pair-produced third-generation squarks decaying via charm quarks or in compressed supersymmetric scenarios in pp collisions at root s = 8 TeV with the ATLAS detector |
Type |
Journal Article |
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Year |
2014 |
Publication |
Physical Review D |
Abbreviated Journal |
Phys. Rev. D |
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Volume |
90 |
Issue |
5 |
Pages |
052008 - 36pp |
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Abstract |
Results of a search for supersymmetry via direct production of third-generation squarks are reported, using 20.3 fb(-1) of proton-proton collision data at root s = 8 TeV recorded by the ATLAS experiment at the LHC in 2012. Two different analysis strategies based on monojetlike and c-tagged event selections are carried out to optimize the sensitivity for direct top squark-pair production in the decay channel to a charm quark and the lightest neutralino ((t) over tilde (1) -> c + (chi) over tilde (0)(1)) across the top squark-neutralino mass parameter space. No excess above the Standard Model background expectation is observed. The results are interpreted in the context of direct pair production of top squarks and presented in terms of exclusion limits in the (m((t) over tilde1), m((chi) over tilde 10)) parameter space. A top squark of mass up to about 240 GeV is excluded at 95% confidence level for arbitrary neutralino masses, within the kinematic boundaries. Top squark masses up to 270 GeV are excluded for a neutralino mass of 200 GeV. In a scenario where the top squark and the lightest neutralino are nearly degenerate in mass, top squark masses up to 260 GeV are excluded. The results from the monojetlike analysis are also interpreted in terms of compressed scenarios for top squark-pair production in the decay channel (t) over tilde (1) -> b + ff' + (chi) over tilde (0)(1) and sbottom pair production with (b) over tilde -> b + (chi) over tilde (0)(1), leading to a similar exclusion for nearly mass-degenerate third-generation squarks and the lightest neutralino. The results in this paper significantly extend previous results at colliders. |
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Address |
[Jackson, P.; Soni, N.; White, M. J.] Univ Adelaide, Dept Phys, Adelaide, SA, Australia |
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Publisher |
Amer Physical Soc |
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Language |
English |
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ISSN |
1550-7998 |
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Notes |
WOS:000342148000001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
1948 |
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