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Carrasco-Ribelles, L. A., Pardo-Mas, J. R., Tortajada, S., Saez, C., Valdivieso, B., & Garcia-Gomez, J. M. (2021). Predicting morbidity by local similarities in multi-scale patient trajectories. J. Biomed. Inform., 120, 103837–9pp.
Abstract: Patient Trajectories (PTs) are a method of representing the temporal evolution of patients. They can include information from different sources and be used in socio-medical or clinical domains. PTs have generally been used to generate and study the most common trajectories in, for instance, the development of a disease. On the other hand, healthcare predictive models generally rely on static snapshots of patient information. Only a few works about prediction in healthcare have been found that use PTs, and therefore benefit from their temporal dimension. All of them, however, have used PTs created from single-source information. Therefore, the use of longitudinal multi-scale data to build PTs and use them to obtain predictions about health conditions is yet to be explored. Our hypothesis is that local similarities on small chunks of PTs can identify similar patients concerning their future morbidities. The objectives of this work are (1) to develop a methodology to identify local similarities between PTs before the occurrence of morbidities to predict these on new query individuals; and (2) to validate this methodology on risk prediction of cardiovascular diseases (CVD) occurrence in patients with diabetes. We have proposed a novel formal definition of PTs based on sequences of longitudinal multi-scale data. Moreover, a dynamic programming methodology to identify local alignments on PTs for predicting future morbidities is proposed. Both the proposed methodology for PT definition and the alignment algorithm are generic to be applied on any clinical domain. We validated this solution for predicting CVD in patients with diabetes and we achieved a precision of 0.33, a recall of 0.72 and a specificity of 0.38. Therefore, the proposed solution in the diabetes use case can result of utmost utility to secondary screening.
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Mena, O., Razzaque, S., & Villaescusa-Navarro, F. (2011). Signatures of photon and axion-like particle mixing in the gamma-ray burst jet. J. Cosmol. Astropart. Phys., 02(2), 030–16pp.
Abstract: Photons couple to Axion-Like Particles (ALPs) or more generally to any pseudo Nambu-Goldstone boson in the presence of an external electromagnetic field. Mixing between photons and ALPs in the strong magnetic field of a Gamma-Ray Burst (GRB) jet during the prompt emission phase can leave observable imprints on the gamma-ray polarization and spectrum. Mixing in the intergalactic medium is not expected to modify these signatures for ALP mass > 10(-14) eV and/or for < nG magnetic field. We show that the depletion of photons due to conversion to ALPs changes the linear degree of polarization from the values predicted by the synchrotron model of gamma ray emission. We also show that when the magnetic field orientation in the propagation region is perpendicular to the field orientation in the production region, the observed synchrotron spectrum becomes steeper than the theoretical prediction and as detected in a sizable fraction of GRB sample. Detection of the correlated polarization and spectral signatures from these steep-spectrum GRBs by gamma-ray polarimeters can be a very powerful probe to discover ALPs. Measurement of gamma-ray polarization from GRBs in general, with high statistics, can also be useful to search for ALPs.
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NEXT Collaboration(Ghosh, S. et al), Martin-Albo, J., Carcel, S., Carrion, J. V., Diaz, J., Felkai, R., et al. (2020). Dependence of polytetrafluoroethylene reflectance on thickness at visible and ultraviolet wavelengths in air. J. Instrum., 15(11), P11031–16pp.
Abstract: Polytetrafluoroethylene (PTFE) is an excellent diffuse reflector widely used in light collection systems for particle physics experiments. However, the reflectance of PTFE is a function of its thickness. In this work, we investigate this dependence in air for light of wavelengths 260 nm and 450 nm using two complementary methods. We find that PTFE reflectance for thicknesses from 5 mm to 10 mm ranges from 92.5% to 94.5% at 450 nm, and from 90.0% to 92.0% at 260 nm We also see that the reflectance of PIFE of a given thickness can vary by as much as 2.7% within the same piece of material. Finally, we show that placing a specular reflector behind the PTFE can recover the loss of reflectance in the visible without introducing a specular component in the reflectance.
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NEXT Collaboration(Haefner, J. et al), Benlloch-Rodriguez, J. M., Carcel, S., Carrion, J. V., Martin-Albo, J., Martinez-Vara, M., et al. (2023). Reflectance and fluorescence characteristics of PTFE coated with TPB at visible, UV, and VUV as a function of thickness. J. Instrum., 18(3), P03016–21pp.
Abstract: Polytetrafluoroethylene (PTFE) is an excellent diffuse reflector widely used in light collection systems for particle physics experiments. In noble element systems, it is often coated with tetraphenyl butadiene (TPB) to allow detection of vacuum ultraviolet scintillation light. In this work this dependence is investigated for PTFE coated with TPB in air for light of wavelengths of 200 nm, 260 nm, and 450 nm. The results show that TPB-coated PTFE has a reflectance of approximately 92% for thicknesses ranging from 5 mm to 10 mm at 450 nm, with negligible variation as a function of thickness within this range. A cross-check of these results using an argon chamber supports the conclusion that the change in thickness from 5 mm to 10 mm does not affect significantly the light response at 128 nm. Our results indicate that pieces of TPB-coated PTFE thinner than the typical 10 mm can be used in particle physics detectors without compromising the light signal.
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T2K Collaboration(Abe, K. et al), Cervera-Villanueva, A., Escudero, L., Gomez-Cadenas, J. J., Hansen, C., Monfregola, L., et al. (2012). Measurements of the T2K neutrino beam properties using the INGRID on-axis near detector. Nucl. Instrum. Methods Phys. Res. A, 694, 211–223.
Abstract: Precise measurement of neutrino beam direction and intensity was achieved based on a new concept with modularized neutrino detectors. INGRID (Interactive Neutrino GRID) is an on-axis near detector for the T2K long baseline neutrino oscillation experiment. INGRID consists of 16 identical modules arranged in horizontal and vertical arrays around the beam center. The module has a sandwich structure of iron target plates and scintillator trackers. INGRID directly monitors the muon neutrino beam profile center and intensity using the number of observed neutrino events in each module. The neutrino beam direction is measured with accuracy better than 0.4 mrad from the measured profile center. The normalized event rate is measured with 4% precision. (C) 2012 Elsevier B.V. All rights reserved.
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