Abstract: Purpose Monte Carlo (MC) simulation studies, aimed at evaluating the magnitude of tissue heterogeneity in I-125 prostate permanent seed implant brachytherapy (BT), customarily use clinical post-implant CT images to generate a virtual representation of a realistic patient model (virtual patient model). Metallic artifact reduction (MAR) techniques and tissue assignment schemes (TAS) are implemented on the post-implant CT images to mollify metallic artifacts due to BT seeds and to assign tissue types to the voxels corresponding to the bright seed spots and streaking artifacts, respectively. The objective of this study is to assess the combined influence of MAR and TAS on MC absorbed dose calculations in post-implant CT-based phantoms. The virtual patient models used for I-125 prostate implant MC absorbed dose calculations in this study are derived from the CT images of an external radiotherapy prostate patient without BT seeds and prostatic calcifications, thus averting the need to implement MAR and TAS. Methods The geometry of the IsoSeed I25.S17plus source is validated by comparing the MC calculated results of the TG-43 parameters for the line source approximation with the TG-43U1S2 consensus data. Four MC absorbed dose calculations are performed in two virtual patient models using the egs_brachy MC code: (1) TG-43-based D-w,w-TG(43), (2) D-w,D-w-MBDC that accounts for interseed scattering and attenuation (ISA), (3) D-m,D-m that examines ISA and tissue heterogeneity by scoring absorbed dose in tissue, and (4) D-w,D-m that unlike D-m,D-m scores absorbed dose in water. The MC absorbed doses (1) and (2) are simulated in a TG-43 patient phantom derived by assigning the densities of every voxel to 1.00 g cm(-3) (water), whereas MC absorbed doses (3) and (4) are scored in the TG-186 patient phantom generated by mapping the mass density of each voxel to tissue according to a CT calibration curve. The MC absorbed doses calculated in this study are compared with VariSeed v8.0 calculated absorbed doses. To evaluate the dosimetric effect of MAR and TAS, the MC absorbed doses of this work (independent of MAR and TAS) are compared to the MC absorbed doses of different I-125 source models from previous studies that were calculated with different MC codes using post-implant CT-based phantoms generated by implementing MAR and TAS on post-implant CT images. Results The very good agreement of TG-43 parameters of this study and the published consensus data within 3% validates the geometry of the IsoSeed I25.S17plus source. For the clinical studies, the TG-43-based calculations show a D-90 overestimation of more than 4% compared to the more realistic MC methods due to ISA and tissue composition. The results of this work generally show few discrepancies with the post-implant CT-based dosimetry studies with respect to the D-90 absorbed dose metric parameter. These discrepancies are mainly Type B uncertainties due to the different I-125 source models and MC codes. Conclusions The implementation of MAR and TAS on post-implant CT images have no dosimetric effect on the I-125 prostate MC absorbed dose calculation in post-implant CT-based phantoms.

Abstract: Quantum chromodynamics, the theory of the strong force, describes interactions of coloured quarks and gluons and the formation of hadronic matter. Conventional hadronic matter consists of baryons and mesons made of three quarks and quark-antiquark pairs, respectively. Particles with an alternative quark content are known as exotic states. Here a study is reported of an exotic narrow state in the (DD0)-D-0 pi(+) mass spectrum just below the D*+D-0 mass threshold produced in proton-proton collisions collected with the LHCb detector at the Large Hadron Collider. The state is consistent with the ground isoscalar T-cc(+), tetraquark with a quark content of cc (u) over bar(d) over bar and spin-parity quantum numbers J(P) =1(+). Study of the DD mass spectra disfavours interpretation of the resonance as the isovector state. The decay structure via intermediate off-shell D*(+) mesons is consistent with the observed D-0 pi(+) mass distribution. To analyse the mass of the resonance and its coupling to the DID system, a dedicated model is developed under the assumption of an isoscalar axial-vector T-cc(+), state decaying to the D*D channel. Using this model, resonance parameters including the pole position, scattering length, effective range and compositeness are determined to reveal important information about the nature of the T-cc(+), state. In addition, an unexpected dependence of the production rate on track multiplicity is observed.

Abstract: Recent measurements at the Large Hadron Collider allow for a robust and precise characterisation of the electro-weak interactions of the top quark. We present the results of a global analysis at next-to-leading order precision including LHC, LEP/SLD and Tevatron data in the framework of the Standard Model Effective Field Theory. We include a careful analysis of the impact of correlations among measurements, as well as of the uncertainties in the Effective Field Theory setup itself. We find remarkably robust global fit results, with central values in good agreement with the Standard Model prediction, and 95% probability bounds on Wilson coefficients that range from +/- 0.35 to +/- 8 TeV-2. This result represents a considerable improvement over previous studies, thanks to the addition of differential cross-section measurements in associated production processes of top quarks and neutral gauge bosons.

Abstract: Recently, the formalism needed to relate the finite-volume spectrum of systems of nondegenerate spinless particles has been derived. In this work we discuss a range of issues that arise when implementing this formalism in practice, provide further theoretical results that can be used to check the implementation, and make available codes for implementing the three-particle quantization condition. Specifically, we discuss the need to modify the upper limit of the cutoff function due to the fact that the left-hand cut in the scattering amplitudes for two nondegenerate particles moves closer to threshold; we describe the decomposition of the three-particle amplitude K-df,K-3 into the matrix basis used in the quantization condition, including both s and p waves, with the latter arising in the amplitude for two nondegenerate particles; we derive the threshold expansion for the lightest three-particle state in the rest frame up to O(1/L-5); and we calculate the leading-order predictions in chiral perturbation theory for K-df,K-3 in the pi(+)pi K-+(+) and pi+K+K+ systems. We focus mainly on systems with two identical particles plus a third that is different (“2+1” systems). We describe the formalism in full detail, and present numerical explorations in toy models, in particular checking that the results agree with the threshold expansion, and making a prediction for the spectrum of pi(+)pi K-+(+) levels using the two- and three-particle interactions predicted by chiral perturbation theory.

Abstract: Scatterings of galactic dark matter (DM) particles with the constituents of celestial bodies could result in their accumulation within these objects. Nevertheless, the finite temperature of the medium sets a minimum mass, the evaporation mass, that DM particles must have in order to remain trapped. DM particles below this mass are very likely to scatter to speeds higher than the escape velocity, so they would be kicked out of the capturing object and escape. Here, we compute the DM evaporation mass for all spherical celestial bodies in hydrostatic equilibrium, spanning the mass range [10(-)(10) – 10(2)] M-circle dot, for constant scattering cross sections and s-wave annihilations. We illustrate the critical importance of the exponential tail of the evaporation rate, which has not always been appreciated in recent literature, and obtain a robust result: for the geometric value of the scattering cross section and for interactions with nucleons, at the local galactic position, the DM evaporation mass for all spherical celestial bodies in hydrostatic equilibrium is approximately given by E-c/T-chi similar to 30, where E-c is the escape energy of DM particles at the core of the object and T-chi is their temperature. In that case, the minimum value of the DM evaporation mass is obtained for super-Jupiters and brown dwarfs, m(ev)(ap) similar or equal to 0.7 GeV. For other values of the scattering cross section, the DM evaporation mass only varies by a factor smaller than three within the range 10(-41) cm(2) <= sigma(p) <= 10(-31) cm(2), where sigma(p) is the spin-independent DM-nucleon scattering cross section. Its dependence on parameters such as the galactic DM density and velocity, or the scattering and annihilation cross sections is only logarithmic, and details on the density and temperature profiles of celestial bodies have also a small impact.