Abstract: The discovery of a non-zero rate for a lepton flavor violating decay mode of the Higgs boson would definitely be an indication of New Physics. We review the prospects for such signal in Two Higgs Doublet Models, in particular for Higgs boson decays into tau μfinal states. We will show that this scenario contains all the necessary ingredients to provide large flavor violating rates and still be compatible with the stringent limits from direct searches and low-energy flavor experiments.