Abstract: Future dedicated radio interferometers, including HERA and SKA, are very promising tools that aim to study the epoch of reionization and beyond via measurements of the 21 cm signal from neutral hydrogen. Dark matter (DM) annihilations into charged particles change the thermal history of the Universe and, as a consequence, affect the 21 cm signal. Accurately predicting the effect of DM strongly relies on the modeling of annihilations inside halos. In this work, we use up-to-date computations of the energy deposition rates by the products from DM annihilations, a proper treatment of the contribution from DM annihilations in halos, as well as values of the annihilation cross section allowed by the most recent cosmological measurements from the Planck satellite. Given current uncertainties on the description of the astrophysical processes driving the epochs of reionization, X-ray heating and Lyman-alpha pumping, we find that disentangling DM signatures from purely astrophysical effects, related to early-time star formation processes or late-time galaxy X-ray emissions, will be a challenging task. We conclude that only annihilations of DM particles with masses of similar to 100 MeV, could leave an unambiguous imprint on the 21 cm signal and, in particular, on the 21cm power spectrum. This is in contrast to previous, more optimistic results in the literature, which have claimed that strong signatures might also be present even for much higher DM masses. Additional measurements of the 21cm signal at different cosmic epochs will be crucial in order to break the strong parameter degeneracies between DM annihilations and astrophysical effects and undoubtedly single out a DM imprint for masses different from similar to 100 MeV.