Abstract: In this article, we report phenomenological studies about the impact of O(alpha) corrections to diphoton production at hadron colliders. We explore the application of the Abelianized version of the qT-subtraction method to efficiently compute NLO QED contributions, taking advantage of the symmetries relating QCD and QED corrections. We analyze the experimental consequences due to the selection criteria and we find percent-level deviations for M-gamma gamma > 1TeV. An accurate description of the tail of the invariant mass distribution is very important for new physics searches which have the diphoton process as one of their main backgrounds. Moreover, we emphasize the importance of properly dealing with the observable photons by reproducing the experimental conditions applied to the event reconstruction.