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Barrientos, L., Borja-Lloret, M., Casaña, J. V., Dendooven, P., Garcia Lopez, J. G., Hueso-Gonzalez, F., et al. (2024). Gamma-ray sources imaging and test-beam results with MACACO III Compton camera. Phys. Medica, 117, 103199–10pp.
Abstract: Hadron therapy is a radiotherapy modality which offers a precise energy deposition to the tumors and a dose reduction to healthy tissue as compared to conventional methods. However, methods for real-time monitoring are required to ensure that the radiation dose is deposited on the target. The IRIS group of IFIC-Valencia developed a Compton camera prototype for this purpose, intending to image the Prompt Gammas emitted by the tissue during irradiation. The system detectors are composed of Lanthanum (III) bromide scintillator crystals coupled to silicon photomultipliers. After an initial characterization in the laboratory, in order to assess the system capabilities for future experiments in proton therapy centers, different tests were carried out in two facilities: PARTREC (Groningen, The Netherlands) and the CNA cyclotron (Sevilla, Spain). Characterization studies performed at PARTREC indicated that the detectors linearity was improved with respect to the previous version and an energy resolution of 5.2 % FWHM at 511 keV was achieved. Moreover, the imaging capabilities of the system were evaluated with a line source of 68Ge and a point-like source of 241Am-9Be. Images at 4.439 MeV were obtained from irradiation of a graphite target with an 18 MeV proton beam at CNA, to perform a study of the system potential to detect shifts at different intensities. In this sense, the system was able to distinguish 1 mm variations in the target position at different beam current intensities for measurement times of 1800 and 600 s.
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Barrientos, L., Borja-Lloret, M., Etxebeste, A., Muñoz, E., Oliver, J. F., Ros, A., et al. (2021). Performance evaluation of MACACO II Compton camera. Nucl. Instrum. Methods Phys. Res. A, 1014, 165702–7pp.
Abstract: The IRIS group at IFIC-Valencia has developed a second version of a Compton camera prototype for hadron therapy treatment monitoring, with the aim of improving the performance with respect to its predecessor. The system is composed of three Lanthanum (III) bromide (LaBr3) crystals coupled to silicon photomultipliers (SiPMs). The detector energy resolution has been improved to 5.6% FWHM at 511 keV and an angular resolution of 8.0 degrees has been obtained. Images of a Na-22 point-like source have been reconstructed selecting two and three interaction events. Moreover, the experimental data have been reproduced with Monte Carlo simulations using a Compton camera module (CCMod) in GATE v8.2 obtaining a good correlation.
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Garcia Rivas, I., Fernandez Prieto, A., Vazquez Regueiro, P., Garcia Fernandez, D., Kögler, T., Römer, K., et al. (2025). Performance of a CeBr3 scintillator coupled to a photomultiplier tube with an active voltage divider under high bremsstrahlung fluences. J. Instrum., 20(11), P11016–25pp.
Abstract: Proton therapy lacks a standard method to verify the proton range during the treatments in the clinical routine. In this context, the monitoring of prompt gamma-rays in a coaxial geometry using a compact detector based on a CeBr3 scintillator coupled to a commercial photomultiplier tube (PMT) could lead to the identification of proton range deviations. Such detection system could be easily integrated in every treatment room. Although measuring in this geometry profits from an advantageous solid angle, the detector is also exposed to an extreme gamma-ray rate, of up to 10 Mcps. In this work, we present the first experimental performance evaluation for the proposed detector by irradiating it at very high bremsstrahlung rates at the gamma ELBE facility. Using a customized active voltage divider to supply voltage to the PMT, the detection system was able to sustain a photon rate higher than 12 Mcps without dead time while keeping gain drifts below 15% in the best configuration, and to achieve a sub-nanosecond time resolution.
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Garonna, A., Amaldi, U., Bonomi, R., Campo, D., Degiovanni, A., Garlasche, M., et al. (2010). Cyclinac medical accelerators using pulsed C6+/H-2(+) ion sources. J. Instrum., 5, C09004–19pp.
Abstract: Charged particle therapy, or so-called hadrontherapy, is developing very rapidly. There is large pressure on the scientific community to deliver dedicated accelerators, providing the best possible treatment modalities at the lowest cost. In this context, the Italian research Foundation TERA is developing fast-cycling accelerators, dubbed 'cyclinacs'. These are a combination of a cyclotron (accelerating ions to a fixed initial energy) followed by a high gradient linac boosting the ions energy up to the maximum needed for medical therapy. The linac is powered by many independently controlled klystrons to vary the beam energy from one pulse to the next. This accelerator is best suited to treat moving organs with a 4D multipainting spot scanning technique. A dual proton/carbon ion cyclinac is here presented. It consists of an Electron Beam Ion Source, a superconducting isochronous cyclotron and a high-gradient linac. All these machines are pulsed at high repetition rate (100-400 Hz). The source should deliver both C6+ and H-2(+) ions in short pulses (1.5 μs flat-top) and with sufficient intensity (at least 10(8) fully stripped carbon ions per pulse at 300 Hz). The cyclotron accelerates the ions to 120 MeV/u. It features a compact design (with superconducting coils) and a low power consumption. The linac has a novel C-band high-gradient structure and accelerates the ions to variable energies up to 400 MeV/u. High RF frequencies lead to power consumptions which are much lower than the ones of synchrotrons for the same ion extraction energy. This work is part of a collaboration with the CLIC group, which is working at CERN on high-gradient electron-positron colliders.
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Lerendegui-Marco, J., Hallam, J., Cisterna, G., Sanchis-Molto, A., Balibrea-Correa, J., Babiano-Suarez, V., et al. (2025). First experimental results and optimization study of the portable neutron-gamma imager GN-Vision. Appl. Radiat. Isot., 224, 111826–13pp.
Abstract: GN-Vision is a compact, dual-modality imaging device designed to simultaneously localize the spatial origin of y-ray and slow neutron sources, with potential applications in nuclear safety, security, and hadron therapy. The system utilizes two position-sensitive detection planes, combining Compton imaging techniques for yray visualization with passive collimation for imaging slow and thermal neutrons (energies below 100 eV). This paper presents the first experimental outcomes from the initial GN-Vision prototype, focused on the development of its neutron imaging capabilities. Following this experimental assessment, we explore the device's performance potential and discuss several Monte Carlo simulation-based optimizations aimed at refining the neutron collimation system. These optimizations seek to improve real-time imaging efficiency and cost-effectiveness, enhancing GN-Vision's applicability for future practical deployments.
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Llosa, G. (2015). Recent developments in photodetection for medical applications. Nucl. Instrum. Methods Phys. Res. A, 787, 353–357.
Abstract: The use of the most advanced technology in medical imaging results in the development of high performance detectors that can significantly improve the performance of the medical devices employed in hospitals. Scintillator crystals coupled to photodetectors remain to be essential detectors in terms of performance and cost for medical imaging applications in different imaging modalities. Recent advances in photodetectors result in an increase of the performance of the medical scanners. Solid state detectors can provide substantial performance improvement, but are more complex to integrate into clinical detectors due mainly to their higher cost. Solid state photodetectors (APDs, SiPMs) have made new detector concepts possible and have led to improvements in different imaging modalities. Recent advances in detectors for medical imaging are revised.
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Llosa, G., Barrio, J., Cabello, J., Crespo, A., Lacasta, C., Rafecas, M., et al. (2012). Detector characterization and first coincidence tests of a Compton telescope based on LaBr3 crystals and SiPMs. Nucl. Instrum. Methods Phys. Res. A, 695, 105–108.
Abstract: A Compton telescope for dose monitoring in hadron therapy consisting of several layers of continuous LaBr3 crystals coupled to silicon photomultiplier (SiPM) arrays is under development within the ENVISION project. In order to test the possibility of employing such detectors for the telescope, a detector head consisting of a continuous 16 mm x 18 mm x 5 mm LaBr3 crystal coupled to a SiPM array has been assembled and characterized, employing the SPIROC1 ASIC as readout electronics. The best energy resolution obtained at 511 key is 6.5% FWHM and the timing resolution is 3.1 ns FWHM. A position determination method for continuous crystals is being tested, with promising results. In addition, the detector has been operated in time coincidence with a second detector layer, to determine the coincidence capabilities of the system. The first tests are satisfactory, and encourage the development of larger detectors that will compose the telescope prototype.
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Llosa, G., Barrio, J., Lacasta, C., Callier, S., Raux, L., & de La Taille, C. (2011). First tests in the application of silicon photomultiplier arrays to dose monitoring in hadron therapy. Nucl. Instrum. Methods Phys. Res. A, 648, S96–S99.
Abstract: A detector head composed of a continuous LaBr3 crystal coupled to a silicon photomultiplier array has been mounted and tested, for its use in a Compton telescope for dose monitoring in hadron therapy. The LaBr3 crystal has 16 mm x 18 mm x 5 mm size, and it is surrounded with reflecting material in five faces. The SiPM array has 16 (4 x 4) elements of 3 mm x 3 mm size. The SPIROC1 ASIC has been employed as readout electronics. The detector shows a linear behavior up to 1275 keV. The energy resolution obtained at 511 keV is 7% FWHM, and it varies as one over the square root of the energy up to the energies tested. The variations among the detector channels are within 12%. A preliminary measurement of the timing resolution gives 7 ns FWHM. The spatial resolution obtained with the center of gravity method is 1.2 mm FWHM. The tests performed confirm the correct functioning of the detector.
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Llosa, G., Trovato, M., Barrio, J., Etxebeste, A., Muñoz, E., Lacasta, C., et al. (2016). First Images of a Three-layer compton Telescope prototype for Treatment Monitoring in hadron Therapy. Front. Oncol., 6, 14–6pp.
Abstract: A Compton telescope for dose monitoring in hadron therapy is under development at IFIC. The system consists of three layers of LaBr3 crystals coupled to silicon photomulti-plier arrays. Na-22 sources have been successfully imaged reconstructing the data with an ML-EM code. Calibration and temperature stabilization are necessary for the prototype operation at low coincidence rates. A spatial resolution of 7.8 mm FWHM has been obtained in the first imaging tests.
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Martinez-Reviriego, P., Fuster-Martinez, N., Esperante, D., Boronat, M., Gimeno, B., Blanch, C., et al. (2025). High-power performance studies of an S-band high-gradient accelerating cavity for medical applications. Nucl. Eng. Technol., 57(1), 103164–10pp.
Abstract: High-Gradient accelerating cavities are one of the main research lines in the development of compact linear accelerators. However, the operation of such accelerating cavities is currently limited by non-linear electromagnetic effects that are intensified at high electric fields, such as RF breakdowns, dark currents and radiation. A novel normal-conducting High Gradient S-band Backward Travelling Wave accelerating cavity for medical application (v = 0.38c) has been designed and constructed at CERN with a design gradient of 50 MV/m. In this paper, the high-power performance studies of this novel design carried out at the IFIC high-power laboratory are presented, as well as the analysis of the conditioning parameters in combination with numerical simulations.
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