Abstract: Analyzing the neutrino Yukawa effect in the freeze-out process of a generic dark matter candidate with right-handed neutrino portal, we identify the parameter regions satisfying the observed dark matter relic density as well as the current Fermi-LAT and H.E.S.S. limits and the future CTA reach on gamma-ray signals. In this scenario the dark matter couples to the Higgs boson at one-loop level and thus could be detected by spin-independent nucleonic scattering for a reasonable range of the relevant parameters.