Abstract: Measuring temperature fluctuations in the 21 cm signal from the epoch of reionization and the cosmic dawn is one of the most promising ways to study the universe at high redshifts. Unfortunately, the 21 cm signal is affected by both cosmology and astrophysics processes in a nontrivial manner. We run a suite of 1000 numerical simulations with different values of the main astrophysical parameters. From these simulations we produce tens of thousands of 21 cm maps at redshifts 10 <= z <= 20. We train a convolutional neural network to remove the effects of astrophysics from the 21 cm maps and output maps of the underlying matter field. We show that our model is able to generate 2D matter fields not only that resemble the true ones visually but whose statistical properties agree with the true ones within a few percent down to scales 2 Mpc(-1). We demonstrate that our neural network retains astrophysical information that can be used to constrain the value of the astrophysical parameters. Finally, we use saliency maps to try to understand which features of the 21 cm maps the network is using in order to determine the value of the astrophysical parameters.