Abstract: DsixTools is a Mathematica package for the handling of the standard model effective field theory (SMEFT) and the low-energy effective field theory (LEFT) with operators up to dimension six, both at the algebraic and numerical level. DsixTools contains a visually accessible and operationally convenient repository of all operators and parameters of the SMEFT and the LEFT. This repository also provides information concerning symmetry categories and number of degrees of freedom, and routines that allow to implement this information on global expressions (such as decay amplitudes and cross-sections). DsixTools also performs weak basis transformations, and implements the full one-loop Renormalization Group Evolution in both EFTs (with SM beta functions up to five loops in QCD), and the full one-loop SMEFT-LEFT matching at the electroweak scale.