Abstract: The NA62 experiment at the CERN SPS reports the first search for K+ -> pi(+) nu(nu) over bar using the decay-in-flight technique, based on a sample of 1.21 x10(11) K+ decays collected in 2016. The single event sensitivity is 3.15 x10(-10), corresponding to 0.267 Standard Model events. One signal candidate is observed while the expected background is 0.152 events. This leads to an upper limit of 14 x10(-10) on the K+ -> pi(+) nu(nu) over bar branching ratio at 95% CL.