Abstract: We discuss the stability of tetraquark systems with two different masses. After some reminders about the stability of very asymmetric QQ (q) over bar(q) over bar tetraquarks, we demonstrate that in the all-heavy limit q -> Q, the system becomes unstable for standard color-additive models. We also analyze the consequences of symmetry breaking for Qq (Q) over bar(q) over bar configurations: we find a kind of metastability between the lowest threshold Q (Q) over bar + q (q) over bar and the highest one, Q (q) over bar + (Q) over barq, and we calculate the width of the resonance. Our results are consistent with the experimental observation of narrow hadrons lying well above their lowest decay threshold.