Abstract: The physics responsible for gauge coupling unification may also induce small neutrino masses. We propose a novel gauge-mediated radiative seesaw mechanism for calculable neutrino masses. These arise from quantum corrections mediated by new SU(3)(C) circle times SU(3)(L) circle times U(1)(X) (3-3-1) gauge bosons and the physics driving gauge coupling unification. Gauge couplings unify for a 3-3-1 scale in the TeV range, making the model directly testable at the LHC.