Abstract: Purpose This work aims to simulate clustered DNA damage from ionizing radiation and estimate the relative biological effectiveness (RBE) for radionuclide (rBT)- and electronic (eBT)-based surface brachytherapy through a hybrid Monte Carlo (MC) approach, using realistic models of the sources and applicators. Methods Damage from ionizing radiation has been studied using the Monte Carlo Damage Simulation algorithm using as input the primary electron fluence simulated using a state-of-the-art MC code, PENELOPE-2018. Two Ir-192 rBT applicators, Valencia and Leipzig, one Co-60 source with a Freiburg Flap applicator (reference source), and two eBT systems, Esteya and INTRABEAM, have been included in this study implementing full realizations of their geometries as disclosed by the manufacturer. The role played by filtration and tube kilovoltage has also been addressed. Results For rBT, an RBE value of about 1.01 has been found for the applicators and phantoms considered. In the case of eBT, RBE values for the Esteya system show an almost constant RBE value of about 1.06 for all depths and materials. For INTRABEAM, variations in the range of 1.12-1.06 are reported depending on phantom composition and depth. Modifications in the Esteya system, filtration, and tube kilovoltage give rise to variations in the same range. Conclusions Current clinical practice does not incorporate biological effects in surface brachytherapy. Therefore, the same absorbed dose is administered to the patients independently on the particularities of the rBT or eBT system considered. The almost constant RBE values reported for rBT support that assumption regardless of the details of the patient geometry, the presence of a flattening filter in the applicator design, or even significant modifications in the photon energy spectra above 300 keV. That is not the case for eBT, where a clear dependence on the eBT system and the characteristics of the patient geometry are reported. A complete study specific for each eBT system, including detailed applicator characteristics (size, shape, filtering, among others) and common anatomical locations, should be performed before adopting an existing RBE value.

Abstract: Light sources emitting short pulses are needed in many particle physics experiments using optical sensors as they can replicate the light produced by the particles being detected and are also an important calibration and test element. This work presents NOPELED, a light source based on LEDs emitting short optical pulses with typical rise times of less than 3 ns and Full Width at Half Maximum lower than 7 ns. The emission wavelength depends on the model of LED used. Several LED models have been characterized in the range from 405 to 532 nm, although NOPELED can work with LED emitting wavelengths outside of that region. While the wavelength is fixed for a given LED model, the intensity and the frequency of the optical pulse can be controlled. NOPELED, which also has low cost and simple operation, can be operated remotely, making it appropriate for either different physics experiments needing in-place light sources such as astrophysical neutrino detectors using photo-multipliers or positron emission tomography devices using scintillation counters, or, beyond physics, applications needing short pulses of light such as protein fluorescence or chemodetection of heavy metals.

Abstract: Searches for dark matter produced via scalar resonances in final states consisting of Standard Model (SM) particles and missing transverse momentum are of high relevance at the LHC. Motivated by dark-matter portal models, most existing searches are optimized for unbalanced decay topologies for which the missing momentum recoils against the visible SM particles. In this work, we show that existing searches are also sensitive to a wider class of models, which we characterize by a recently presented simplified model framework. We point out that searches for models with a balanced decay topology can be further improved with more dedicated analysis strategies. For this study, we investigate the feasibility of a new search for bottom-quark associated neutral Higgs production with a b (b) over barZ + p(T)(miss) final state and perform a detailed collider analysis. Our projected results in the different simplified model topologies investigated here can be easily reinterpreted in a wide range of models of physics beyond the SM, which we explicitly demonstrate for the example of the Two-Higgs-Doublet model with an additional pseudoscalar Higgs boson.