Abstract: We consider the possibility of grand unification of the SU(3)(c) circle times SU(3)(L) circle times U(1)(X) model in an SU(6) gauge unification group. Two possibilities arise. Unlike other conventional grand unified theories, in SU(6) one can embed the 331 model as a subgroup such that different multiplets appear with different multiplicities. Such a scenario may emerge from the flux breaking of the unified group in an E(6) F-theory GUT. This provides new ways of achieving gauge coupling unification in 331 models while providing the radiative origin of neutrino masses. Alternatively, a sequential variant of the SU(3)(c) circle times SU(3)(L) circle times U(1)(X) model can fit within a minimal SU(6) grand unification, which in turn can be a natural E(6) subgroup. This minimal SU(6) embedding does not require any bulk exotics to account for the chiral families while allowing for a TeV scale SU(3)(c) circle times SU(3)(L) circle times U(1)(X) model with seesaw-type neutrino masses.