Dorado-Morales, P., Vilanova, C., Pena-Garay, C., Marti, J. M., & Porcar, M. (2015). Unveiling Bacterial Interactions through Multidimensional Scaling and Dynamics Modeling. Sci Rep, 5, 18396–6pp.
Abstract: We propose a new strategy to identify and visualize bacterial consortia by conducting replicated culturing of environmental samples coupled with high-throughput sequencing and multidimensional scaling analysis, followed by identification of bacteria-bacteria correlations and interactions. We conducted a proof of concept assay with pine-tree resin-based media in ten replicates, which allowed detecting and visualizing dynamical bacterial associations in the form of statistically significant and yet biologically relevant bacterial consortia.
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