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Amaldi, U., Bonomi, R., Braccini, S., Crescenti, M., Degiovanni, A., Garlasche, M., et al. (2010). Accelerators for hadrontherapy: From Lawrence cyclotrons to linacs. Nucl. Instrum. Methods Phys. Res. A, 620(2-3), 563–577.
Abstract: Hadrontherapy with protons and carbon ions is a fast developing methodology in radiation oncology. The accelerators used and planned for this purpose are reviewed starting from the cyclotrons used in the thirties. As discussed in the first part of this paper, normal and superconducting cyclotrons are still employed, together with synchrotrons, for proton therapy while for carbon ion therapy synchrotrons have been till now the only option. The latest developments concern a superconducting cyclotron for carbon ion therapy, fast-cycling high frequency linacs and 'single room' proton therapy facilities. These issues are discussed in the second part of the paper by underlining the present challenges, in particular the treatment of moving organs.
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Degiovanni, A., Amaldi, U., Bonomi, R., Garlasche, M., Garonna, A., Verdu-Andres, S., et al. (2011). TERA high gradient test program of RF cavities for medical linear accelerators. Nucl. Instrum. Methods Phys. Res. A, 657(1), 55–58.
Abstract: The scientific community and the medical industries are putting a considerable effort into the design of compact, reliable and cheap accelerators for hadrontherapy. Up to now only circular accelerators are used to deliver beams with energies suitable for the treatment of deep seated tumors. The TERA Foundation has proposed and designed a hadrontherapy facility based on the cyclinac concept: a high gradient linear accelerator placed downstream of a cyclotron used as an injector. The overall length of the linac, and therefore its final cost, is almost inversely proportional to the average accelerating gradient achieved in the linac. TERA, in collaboration with the CLIC RF group, has started a high gradient test program. The main goal is to study the high gradient behavior of prototype cavities and to determine the appropriate linac operating frequency considering important issues such as machine reliability and availability of distributed power sources. A preliminary test of a 3 GHz cavity has been carried out at the beginning of 2010, giving encouraging results. Further investigations are planned before the end of 2011. A set of 5.7 GHz cavities is under production and will be tested in a near future. The construction and test of a multi-cell structure is also foreseen.
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Garonna, A., Amaldi, U., Bonomi, R., Campo, D., Degiovanni, A., Garlasche, M., et al. (2010). Cyclinac medical accelerators using pulsed C6+/H-2(+) ion sources. J. Instrum., 5, C09004–19pp.
Abstract: Charged particle therapy, or so-called hadrontherapy, is developing very rapidly. There is large pressure on the scientific community to deliver dedicated accelerators, providing the best possible treatment modalities at the lowest cost. In this context, the Italian research Foundation TERA is developing fast-cycling accelerators, dubbed 'cyclinacs'. These are a combination of a cyclotron (accelerating ions to a fixed initial energy) followed by a high gradient linac boosting the ions energy up to the maximum needed for medical therapy. The linac is powered by many independently controlled klystrons to vary the beam energy from one pulse to the next. This accelerator is best suited to treat moving organs with a 4D multipainting spot scanning technique. A dual proton/carbon ion cyclinac is here presented. It consists of an Electron Beam Ion Source, a superconducting isochronous cyclotron and a high-gradient linac. All these machines are pulsed at high repetition rate (100-400 Hz). The source should deliver both C6+ and H-2(+) ions in short pulses (1.5 μs flat-top) and with sufficient intensity (at least 10(8) fully stripped carbon ions per pulse at 300 Hz). The cyclotron accelerates the ions to 120 MeV/u. It features a compact design (with superconducting coils) and a low power consumption. The linac has a novel C-band high-gradient structure and accelerates the ions to variable energies up to 400 MeV/u. High RF frequencies lead to power consumptions which are much lower than the ones of synchrotrons for the same ion extraction energy. This work is part of a collaboration with the CLIC group, which is working at CERN on high-gradient electron-positron colliders.
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Verdu-Andres, S., Amaldi, U., & Faus-Golfe, A. (2013). CABOTO, a high-gradient linac for hadrontherapy. J. Radiat. Res., 54, 155–161.
Abstract: The field of hadrontherapy has grown rapidly in recent years. At present the therapeutic beam is provided by a cyclotron or a synchrotron, but neither cyclotrons nor synchrotrons present the best performances for hadrontherapy. The new generation of accelerators for hadrontherapy should allow fast active energy modulation and have a high repetition rate, so that moving organs can be appropriately treated in a reasonable time. In addition, a reduction of the dimensions and cost of the accelerators for hadrontherapy would make the acquisition and operation of a hadrontherapy facility more affordable, which would translate into great benefits for the potential hadrontherapy patients. The 'cyclinac', an accelerator concept that combines a cyclotron with a high-frequency linear accelerator (linac), is a fast-cycling machine specifically conceived to allow for fast active energy modulation. The present paper focuses on CABOTO (CArbon BOoster for Therapy in Oncology), a compact, efficient high-frequency linac that can accelerate C6+ ions and H-2 molecules from 150-410 MeV/u in similar to 24 m. The paper presents the latest design of CABOTO and discusses its performances.
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